Abstract:
:Biologic tissues are complex materials that come in many forms and perform a variety of functions. They vary widely in composition and mechanical properties, and determination of the mechanical properties of tissues is of interest to those trying to engineer tissues to restore missing function. In performing experiments to characterize the mechanical properties of biologic tissues, there is no single solution to clamping tissues or tissue engineered constructs for mechanical testing. Various clamping techniques have been developed over the past few decades to address the difficulty of imposing appropriate boundary conditions on particular soft tissues during mechanical testing. Two criteria for a successful clamping mechanism are (i) prevention of test specimen slippage, and (ii) prevention of test specimen failure outside the gage region. Herein we present a novel clamping mechanism design developed for the mechanical testing of abdominal wall tissue as an example. This design incorporates pins with serrated clamps to successfully decrease the occurrence of test sample slippage while reducing imposed stress concentrations at the clamping sites. This design was evaluated by performing 40 uniaxial tensile tests on rat abdominal wall muscles using strain rates of 1% per second or 10% per second. Load and displacement data were acquired at the grips. The clamping area on the tissue sample was marked with India ink to track potential slippage of the sample during testing. Ultimate tensile strength and the corresponding stretch were calculated when the maximum load was achieved. With fine-tuning of the torque applied to the clamping grips, the success rate of the tensile tests reached over 90%.
journal_name
J Mech Behav Biomed Materauthors
Jiang M,Lawson ZT,Erel V,Pervere S,Nan T,Robbins AB,Feed AD,Moreno MRdoi
10.1016/j.jmbbm.2019.103503subject
Has Abstractpub_date
2020-03-01 00:00:00pages
103503eissn
1751-6161issn
1878-0180pii
S1751-6161(19)31062-8journal_volume
103pub_type
杂志文章abstract::Trans femoral amputation is one of the most uncomfortable surgeries in patient׳s life, where the prosthesis consisting of a socket, knee joint, pylon and foot is used to do the walking activities. The artificial prosthetic knee joint imitates the functions of human knee to achieve the flexion-extension for the above k...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.06.002
更新日期:2015-10-01 00:00:00
abstract::Metallic implant materials are biomaterials that have experienced major development over the last fifty years, yet some demands posed to them have not been addressed. For the osseointegration process and the outcome of endosseous implantation, it is crucial to reduce the stress shielding effect and achieve sufficient ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.10.008
更新日期:2019-02-01 00:00:00
abstract::Despite the great potential of Mg and its alloys as material for biodegradable implants, their low resistance to the simultaneous action of corrosion and mechanical stresses in the human body have hampered their use. Stress Corrosion Cracking has been reported as one of the most critical failure modes to overcome to a...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2020.103724
更新日期:2020-06-01 00:00:00
abstract::Fibrin and hyaluronic acid are important components of the provisional wound matrix. Through interactions with fibroblasts, they provide biophysical cues that regulate the viscoelastic properties of the extracellular matrix. To understand the roles of fibrin and hyaluronic acid in a collagenous environment, we used fi...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.03.042
更新日期:2018-06-01 00:00:00
abstract::The mechanisms giving rise to vein tortuosity, which is often associated with varicosis, are poorly understood. Recent works suggest that significant biological changes in the wall of varicose veins may precede the mechanical aspects of the disease. To test the hypothesis of tortuosity being a consequence of these cha...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.05.006
更新日期:2013-10-01 00:00:00
abstract::The goal of this study was to investigate the effect of resveratrol treatment on the osteogenic potential of human and rat adipose derived stem cells in a 3-D culture environment. Adipose derived stem cells (ADSCs) have been widely studied and have shown promise as a potential source of osteogenic progenitor cells. Pr...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2011.08.014
更新日期:2012-07-01 00:00:00
abstract::This paper presents an improved identification method of the constitutive properties of lung parenchyma. We aim to determine the non-linear viscoelastic behavior of lung parenchyma with a particular focus on the compressible properties - i.e. the ability to change volume. Uniaxial tensile tests are performed on living...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.09.018
更新日期:2014-01-01 00:00:00
abstract::A laser based surface nitriding process was adopted to further enhance the osseo-integration, corrosion resistance, and tribological properties of the commonly used bioimplant alloy, Ti-6Al-4V. Earlier preliminary osteoblast, electrochemical, and corrosive wear studies of laser nitrided titanium in simulated body flui...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.05.017
更新日期:2014-09-01 00:00:00
abstract::Hygiene products such as incontinence pads bring nonwoven fabrics into contact with users' skin, which can cause damage in various ways, including the nonwoven abrading the skin by friction. The aim of the work described here was to develop and use methods for understanding the origin of friction between nonwoven fabr...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.04.024
更新日期:2013-12-01 00:00:00
abstract::We report linear and non-linear shear tests on rat skin, evidencing a strain-softening regime, from 1% to 50% strain, followed by a strong strain-hardening regime, leading to a 'deck chair-shaped' stress-strain curve. The strain-softening regime was never reported as such in the literature, possibly mistaken for the l...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.12.021
更新日期:2017-05-01 00:00:00
abstract::Total Knee Arthroplasty is a well-established surgical procedure performed to relieve pain and to restore function in knee osteoarthritis. A proper choice of the implant size is mandatory in order to guarantee the success of the implant and to respect the bone stock of tibial plateau and femoral condyles. The aim of t...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.06.012
更新日期:2014-10-01 00:00:00
abstract::Anterior cruciate ligament (ACL) is a key fibrous connective tissue that maintains the stability of a knee joint and it is the most commonly injured ligament of the knee. A synthetic prosthesis in the form of a braided structure can be an attractive alternative to biological grafts provided that the mechanical propert...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.09.018
更新日期:2016-02-01 00:00:00
abstract::This study aims to evaluate the flexural fatigue strength and survival estimates of an Y-TZP monolithic ceramic after grinding and aging. Ceramic discs (1.2 mm thickness × 15.0 mm diameter - ISO, 6872, 2015) of zirconia (Zirlux FC2 - Ardent; Ivoclar Vivadent) were made and randomly allocated into 6 groups (n = 10), ac...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.07.041
更新日期:2018-11-01 00:00:00
abstract::This work is part of an ongoing program to develop a new carbon fiber/flax/epoxy (CF/flax/epoxy) hybrid composite material for use as an orthopaedic long bone fracture plate, instead of a metal plate. The purpose of this study was to evaluate the mechanical properties of this new novel composite material. The composit...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2012.12.013
更新日期:2013-04-01 00:00:00
abstract::With the aim to prepare antibacterial acrylic bone cements, a series of imidazolium-containg mono-methacrylates with N-alkyl chain length varied from 10 to 18 (MEIM-x) were synthesized as polymerizable antibacterial agents through a two-step reaction. The structures of the monomers were confirmed by 1H NMR. Methyl met...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.06.003
更新日期:2017-10-01 00:00:00
abstract::The adhesion of bovine chondrocytes and human osteoblasts to three titania-based coatings, formed by plasma electrolytic oxidation (PEO), was compared to that on uncoated Ti-6Al-4V substrates, and some comparisons were also made with plasma sprayed hydroxyapatite (HA) coatings. This was done using a centrifuge, with a...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2011.07.009
更新日期:2011-11-01 00:00:00
abstract::The surface of commercially pure Ti (cp-Ti) substrate was grit-blasted with Al(2)O(3) powders and then wet-blasted with HAp/Ti mixed powders at room temperature. Then plasma spraying with Ti powders or HAp/Ti mixed powders on the blasted surface was carried out to form a bond coat layer, denoted as T50 and T100 bond c...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2008.11.001
更新日期:2009-10-01 00:00:00
abstract::Cell seeding of 3D scaffolds is a critical step in tissue engineering since the final tissue properties are related to the initial cell distribution and density within the scaffold unit. Perfusion systems can transport cells to the scaffold however; the fact that cells flow inside the scaffold pores does not guarantee...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2017.08.003
更新日期:2017-11-01 00:00:00
abstract::As a substitute for 2,2-bis[4-(2-hydroxy-3- methacryloxypropoxy)phenyl] propane (Bis-GMA) in dental materials, a new dimethacrylate monomer TDDMMA without bisphenol-A structure was synthesized through the reaction between tricyclo[5.2.1.0(2,6)]- decanedimethanol and 2-isocyanatoethyl methacrylate. The TDDMMA was mixed...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.11.020
更新日期:2016-04-01 00:00:00
abstract::There is no consensus over the optimal criterion to define the fatigue life of bone cement in vitro. Fatigue testing samples have been made into various shapes using different surface preparation techniques with little attention being paid to the importance of these variations on the fatigue results. The present study...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2013.08.023
更新日期:2014-01-01 00:00:00
abstract::An improved understanding of bone mechanics is vital in the development of evaluation strategies for patients at risk of bone fracture. The current evaluation approach based on bone mineral density (BMD) measurements lacks sensitivity, and it has become clear that as well as bone mass, bone quality should also be eval...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2012.08.016
更新日期:2013-01-01 00:00:00
abstract::Vascular calcification is a complex molecular process that exhibits a number of relatively characteristic morphology patterns in atherosclerotic plaques. Treatment of arterial stenosis by endovascular intervention, involving forceful circumferential expansion of the plaque, can be unpredictable in calcified lesions. T...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2015.11.001
更新日期:2016-03-01 00:00:00
abstract::Bone is a complex material showing a hierarchical and porous structure but also a natural ability to remodel thanks to cells sensitive to fluid flows. Based on these characteristics, a multiscale numerical model has been developed in order to represent the bone response under mechanical solicitation. It relies on the ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2018.12.015
更新日期:2019-03-01 00:00:00
abstract::The age-related deterioration in the quality (e.g., strength and fracture resistance) and quantity (e.g., bone-mineral density) of human bone, together with increased life expectancy, is responsible for increasing incidence of bone fracture in the elderly. The present study describes ex vivo fracture experiments to qu...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2011.05.020
更新日期:2011-10-01 00:00:00
abstract::Infusion of vitamin E (α-tocopherol) in highly crosslinked ultra-high molecular weight polyethylene (UHMWPE) liners has been conceived to achieve superior oxidation stability while preserving enhanced mechanical properties as compared to post-irradiation remelted liners. However, the presence of an antioxidant in the ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2012.12.009
更新日期:2014-03-01 00:00:00
abstract::Continuous fibre distribution models can be applied to a variety of biological tissues with both charged and neutral extracellular matrices. In particular, ellipsoidal models have been used to describe the complex material behaviour of tissues such as articular cartilage and their engineered tissue equivalents. The ch...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2012.01.006
更新日期:2012-05-01 00:00:00
abstract::The lumbar facet capsular ligament (FCL) articulates with six degrees of freedom during spinal motions of flexion/extension, lateral bending, and axial rotation. The lumbar FCL is composed of highly aligned collagen fiber bundles on the posterior surface (oriented primarily laterally between the rigid articular facets...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.08.019
更新日期:2017-01-01 00:00:00
abstract::This paper deals with the effects of dehydration on the mechanical properties of biological soft tissues and with the validity of methods used in previous works such as a coat of petroleum jelly or silicon oil to minimise the drying of the tissue during mechanical testing. We find that the samples get stiffer as they ...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2010.07.010
更新日期:2010-11-01 00:00:00
abstract::We hypothesized that female gender may have a specific negative impact on the mechanical characteristics, composition, and expression of matrix metalloproteinases/tissue inhibitors (MMPs/TIMPs) in the wall of ascending thoracic aortic aneurysms (ATAAs). Degenerative ATAAs were resected from 35 patients (age: 67±2 year...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2014.02.015
更新日期:2014-06-01 00:00:00
abstract::The negative impact of metastases on the mechanical performance of vertebral bone is often attributed to reduced bone density and/or compromised architecture. However limited characterization has been done on the impact of metastasis on the mineralization of bone tissue and resulting changes in material behaviour. Thi...
journal_title:Journal of the mechanical behavior of biomedical materials
pub_type: 杂志文章
doi:10.1016/j.jmbbm.2016.12.017
更新日期:2017-05-01 00:00:00