Abstract：
:Bone is characterized with an optimized combination of high stiffness and toughness. The understanding of bone nanomechanics is critical to the development of new artificial biological materials with unique properties. In this work, the mechanical characteristics of the interfaces between osteopontin (OPN, a noncollagenous protein in extrafibrillar protein matrix) and hydroxyapatite (HA, a mineral nanoplatelet in mineralized collagen fibrils) were investigated using molecular dynamics method. We found that the interfacial mechanical behavior is governed by the electrostatic attraction between acidic amino acid residues in OPN and calcium in HA. Higher energy dissipation is associated with the OPN peptides with a higher number of acidic amino acid residues. When loading in the interface direction, new bonds between some acidic residues and HA surface are formed, resulting in a stick-slip type motion of OPN peptide on the HA surface and high interfacial energy dissipation. The formation of new bonds during loading is considered to be a key mechanism responsible for high fracture resistance observed in bone and other biological materials.
journal_name
J Mech Behav Biomed Materauthors
Lai ZB,Wang M,Yan C,Oloyede Adoi
10.1016/j.jmbbm.2014.04.002subject
Has Abstractpub_date
2014-08-01 00:00:00pages
12-20eissn
1751-6161issn
1878-0180pii
S1751-6161(14)00094-0journal_volume
36pub_type
杂志文章abstract：OBJECTIVES:The aim of the present study was to investigate the surface characteristic, biomechanical behavior, hemocompatibility, bone tissue response and osseointegration of the optimal micro-arc oxidation surface-treated titanium (MST-Ti) dental implant. MATERIALS AND METHODS:The surface characteristic, biomechanica...
journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.07.005
更新日期：2016-01-01 00:00:00
abstract：:Titanium alloys (Ti-6Al-4V) are promising materials as bone implants in clinical surgeries owing to their excellent performances. However, wear debris caused by the tribological behavior of the cortical bone and titanium alloy interface were found to be paramount for implant stability. The contact environment between ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.01.005
更新日期：2013-04-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.01.006
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.07.010
更新日期：2013-12-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.08.003
更新日期：2017-11-01 00:00:00
abstract：:The medial patello-femoral ligament is considered the most important passive patellar stabilizer and its proper functionality is essential for the patello-femoral joint stability. In this work, 18 human knees were randomly divided into two groups and reconstructed through two different surgical techniques: the "Throug...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.02.009
更新日期：2016-06-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2008.11.001
更新日期：2009-10-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.10.014
更新日期：2015-02-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
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doi：10.1016/j.jmbbm.2019.103541
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.04.004
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journal_title：Journal of the mechanical behavior of biomedical materials
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pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.08.019
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.05.038
更新日期：2011-11-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2010.07.010
更新日期：2010-11-01 00:00:00
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journal_title：Journal of the mechanical behavior of biomedical materials
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章,评审
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journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.08.004
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abstract：:In the present study, inflation tests with free axial extension of 15 human vena saphena magna were conducted ex vivo to obtain data suitable for multi-axial constitutive modeling at overloading conditions (pressures up to approximately 15kPa). Subsequently the data were fitted with a hyperelastic, nonlinear and aniso...
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