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Damage initiation and progression in the cartilage surface probed by nonlinear optical microscopy.

Abstract：

:With increasing interest in treating osteoarthritis at its earliest stages, it has become important to understand the mechanisms by which the disease progresses across a joint. Here, second harmonic generation (SHG) microscopy, coupled with a two-dimensional spring-mass network model, was used to image and investigate the collagen meshwork architecture at the cartilage surface surrounding osteoarthritic lesions. We found that minor weakening of the collagen meshwork leads to the bundling of fibrils at the surface under normal loading. This bundling appears to be an irreversible step in the degradation process, as the stress concentrations drive the progression of damage, forming larger bundles and cracks that eventually form lesions.

journal_name

J Mech Behav Biomed Mater

journal_title

Journal of the mechanical behavior of biomedical materials

authors

Brown CP,Houle MA,Chen M,Price AJ,Légaré F,Gill HS

doi

10.1016/j.jmbbm.2011.08.004

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

62-70

issue

1

eissn

1751-6161

issn

1878-0180

pii

S1751-6161(11)00208-6

journal_volume

5

pub_type

杂志文章

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