Abstract：
:The application of orthopaedic implants is associated with risks of bacterial infection and long-term antibiotic therapy. This problem has led to the study of implants with nano-textured surfaces as a method of inhibiting bacterial adhesion and reducing implant failure due to infection. In this research, various nano-textured surfaces of TiO2 were synthesised using hydrothermal synthesis, by varying NaOH concentration, reaction time and reaction temperature. Their correlations to mechanical, morphological, bactericidal and osteogenic properties of the surfaces were investigated. It was found that high alkaline concentrations produced large nanowire mesh arrays, while short reaction time and low temperature produced comparatively smaller arrays. The highly dense morphology formed at higher NaOH concentrations has resulted in high elastic modulus and hardness values, compared to surfaces produced at lower NaOH concentrations. Viability tests of the TiO2 nanowire array against gram-positive Staphylococcus aureus cells showed a bactericidal efficiency of 54% and 33% after 3 and 18 h, respectively. This nano-textured surface produces an osteoblast cellular metabolic activity of 71% after 24 h, compared to 67% when exposed to a flat Ti control surface. This preliminary work demonstrates an excellent outcome in producing bactericidal surfaces that promoted metabolic activity of human osteoblast cells for potential use in orthopaedic implants.
journal_name
J Mech Behav Biomed Materauthors
Jaggessar A,Mathew A,Wang H,Tesfamichael T,Yan C,Yarlagadda PKdoi
10.1016/j.jmbbm.2018.02.011subject
Has Abstractpub_date
2018-04-01 00:00:00pages
311-319eissn
1751-6161issn
1878-0180pii
S1751-6161(18)30101-2journal_volume
80pub_type
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