Abstract：
:In this study, the bone mineral density (BMD), geometry, macroscopic viscoelastic properties and mechanical strength in five different groups of Sprague-Dawley rats (sham operated, ovariectomized with vehicle, parathyroid hormone and/or ibandronate administration) were examined by peripheral quantitative computed tomography (pQCT), dynamic mechanical analysis (DMA) and three-point bending test. At the end of the study, storage modulus (E'), loss tangent (tanδ), ultimate force (Fu) and stiffness (S) had greatly decreased in vehicle-treated ovariectomized group as compared to sham group (p<0.05). The concurrent administration of parathyroid hormone and ibandronate group exhibited the largest cortical area (Ct.Ar) and thickness (Ct.Th), E', tanδ (0.3Hz) and subsequently highest Fu as compared to the mono-therapy groups (p<0.05). However, significant changes were not observed in the BMD values of different groups (p>0.05). The relationships between these potential predictors of bone strength (E', tanδ, BMD and Ct.Ar) and bone mechanical strength parameters (Fu, S and ultimate stress σu) were also examined. Interestingly, during normal daily activity frequency range (0.9-6Hz), tanδ and Fu were positively correlated. Taken together, these data suggest that DMA can serve as an effective tool to assess bone strength which would be ignored under the normal clinical screenings due to an unchanged BMD. DMA can therefore be used as a better tool to assess the osteoporotic drug efficacy.
journal_name
J Mech Behav Biomed Materauthors
Yang X,Teoh SH,DasDe S,Lee Tdoi
10.1016/j.jmbbm.2013.03.009subject
Has Abstractpub_date
2013-06-01 00:00:00pages
51-8eissn
1751-6161issn
1878-0180pii
S1751-6161(13)00095-7journal_volume
22pub_type
杂志文章abstract：PURPOSE:To compare osseointegration and implant stability of two types of laser-etched (LE) Ti implants with a chemically-modified, sandblasted, large-grit and acid-etched (SLA) Ti implant (SLActive(®), Straumann, Basel, Switzerland), by evaluating removal torque and resonance frequency between the implant surface and ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.03.034
更新日期：2016-08-01 00:00:00
abstract：:In this study, the fabrication and properties of a synthetic keratoprosthesis skirt for use in osteo-odonto-keratoprosthesis (OOKP) surgery are discussed. In the search for a new material concept, bioactive glass and polymethyl methacrylate (PMMA)-based composites were prepared. Three different bioactive glasses (i.e....
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.05.025
更新日期：2011-11-01 00:00:00
abstract：:Even though bariatric surgery is one of the most effective treatment option of obesity, post-surgical weight loss is not always ensured, especially in the long term, when many patients experience weight regain. Bariatric procedures are largely based on surgeon's expertise and intra-operative decisions, while an integr...
journal_title：Journal of the mechanical behavior of biomedical materials
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doi：10.1016/j.jmbbm.2020.103883
更新日期：2020-10-01 00:00:00
abstract：:The negative impact of metastases on the mechanical performance of vertebral bone is often attributed to reduced bone density and/or compromised architecture. However limited characterization has been done on the impact of metastasis on the mineralization of bone tissue and resulting changes in material behaviour. Thi...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.12.017
更新日期：2017-05-01 00:00:00
abstract：:With the aim to prepare antibacterial acrylic bone cements, a series of imidazolium-containg mono-methacrylates with N-alkyl chain length varied from 10 to 18 (MEIM-x) were synthesized as polymerizable antibacterial agents through a two-step reaction. The structures of the monomers were confirmed by 1H NMR. Methyl met...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.06.003
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Perfusion bioreactors are used to solve problems in critical size bone tissue engineering. Biominerizable and biocompatible nanocomposites are suitable scaffold materials for this purpose because they offer mineral components in organic carriers. Human adipose derived stem cells (ASCs) can potentially be use...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.03.022
更新日期：2015-07-01 00:00:00
abstract：:Yttria stabilized zirconia reinforced hydroxyapatite coatings were deposited by a gas tunnel type plasma spray torch under optimum spraying conditions. For this purpose, 10, 20 and 30 wt% of yttria stabilized zirconia (YSZ) powders were premixed individually with hydroxyapatite (HA) powder and were used as the feedsto...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.11.002
更新日期：2012-05-01 00:00:00
abstract：:Titanium alloys (Ti-6Al-4V) are promising materials as bone implants in clinical surgeries owing to their excellent performances. However, wear debris caused by the tribological behavior of the cortical bone and titanium alloy interface were found to be paramount for implant stability. The contact environment between ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.10.031
更新日期：2019-02-01 00:00:00
abstract：:Hydrogels are more and more attractive in biomedical fields, since they can be used as injectable scaffolds, drugs and gene carriers and smart sensors. The highly hydrated hydrogels, however, generally have low mechanical strength. In this work, a composite chitosan hydrogel was prepared by blending water soluble and ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2008.02.001
更新日期：2008-10-01 00:00:00
abstract：:Restitution of the natural organization and orientation of cells is imperative for the construction of functional tissue scaffolds. While numerous studies have exploited mechanical methods to engineer tissues with the desired cellular architecture, fundamental knowledge is still lacking in understanding the manner in ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.09.018
更新日期：2018-01-01 00:00:00
abstract：:Sylgard((R)) is a biocompatible elastomer which has been widely used in biomedical applications including in simulations of the mechanical response of soft tissues and mechanotransduction investigations. In this study the effect of fabrication parameters including base to curing agent ratio and curing time on the mech...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2010.04.003
更新日期：2010-08-01 00:00:00
abstract：:Biochemical signals related to a mechanosensory mechanism by which cells sense mechanical stimuli have been gradually clarified by biological approaches such as blocking specific signaling pathways; however, mechanical signals such as deformation/strain, which is transduced into biochemical signals through this mechan...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2007.06.003
更新日期：2008-01-01 00:00:00
abstract：:Experimental investigations for anatomic variation in the magnitude and anisotropy of elastic constants in human femoral cortical bone tissue have typically focused on a limited number of convenient sites near the mid-diaphysis. However, the proximal and distal ends of the diaphysis are more clinically relevant to com...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2008.08.005
更新日期：2009-07-01 00:00:00
abstract：:Triceps surae (TS) and tibialis anterior (TA) activation patterns have not yet been studied under different types of sport shoes. We hypothesized that sports shoes may reduce the activity patterns of these muscles in relation to barefoot condition. Thus, our main aim was to evaluate the activity patterns of TS and TA ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.05.039
更新日期：2018-10-01 00:00:00
abstract：:A new type of constitutive model and its computational implementation procedure for the simulation of a trabecular bone are proposed in the present study. A yield surface-independent Frank-Brockman elasto-viscoplastic model is introduced to express the nonlinear material behavior such as softening beyond yield point, ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2016.08.028
更新日期：2017-01-01 00:00:00
abstract：:The mechanisms giving rise to vein tortuosity, which is often associated with varicosis, are poorly understood. Recent works suggest that significant biological changes in the wall of varicose veins may precede the mechanical aspects of the disease. To test the hypothesis of tortuosity being a consequence of these cha...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.05.006
更新日期：2013-10-01 00:00:00
abstract：:The hierarchical architecture of the collagen fibril is well understood, involving non-integer staggering of collagen molecules which results in a 67 nm periodic molecular density variation termed D-banding. Other than this variation, collagen fibrils are considered to be homogeneous at the micro-scale and beyond. Int...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103849
更新日期：2020-10-01 00:00:00
abstract：:Zirconia implants are becoming a preference choice for different applications such as knee, dental, among others. In order to improve osseointegration, implant's surfaces are usually coated with bioactive materials like hydroxyapatite (HAp) and beta-tricalcium phosphate (β-TCP) that are very similar to the calcium pho...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2019.02.022
更新日期：2019-06-01 00:00:00
abstract：:Bone fracture is a major health issue worldwide and consequently there have been extensive investigations into the fracture behavior of human cortical bone. However, the fracture properties of human cortical bone under fall-like loading conditions remains poorly documented. Further, most published research has been pe...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2017.03.015
更新日期：2017-07-01 00:00:00
abstract：AIM:For the proper function of small diameter vascular grafts their mechanical properties are essential. A variety of testing methods and protocols exists to measure tensile strength, compliance and viscoelastic material behavior. In this study the impact of the measurement protocol in hoop tensile tests on the measure...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2020.103652
更新日期：2020-04-01 00:00:00
abstract：:Geometric confinement to the nanoscale, a concept that refers to the characteristic dimensions of structural features of materials at this length scale, has been shown to control the mechanical behavior of many biological materials or their building blocks, and such effects have also been suggested to play a crucial r...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2012.12.005
更新日期：2013-04-01 00:00:00
abstract：:A severe shortage of good quality donor cornea is now an international crisis in public health. Alternatives for donor tissue need to be urgently developed to meet the increasing demand for corneal transplantation. Hydrogels have been widely used as scaffolds for corneal tissue regeneration due to their large water co...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2013.03.001
更新日期：2013-05-01 00:00:00
abstract：:A discrete network model (DNM) to represent the mechanical behavior of the human amnion is proposed. The amnion is modeled as randomly distributed points interconnected with connector elements representing collagen crosslinks and fiber segments, respectively. This DNM is computationally efficient and allows simulation...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.11.009
更新日期：2016-05-01 00:00:00
abstract：:The work proposes the development of heterogeneous bio-implants with the aim to minimize stress shielding effect and enhance bone ingrowth. Stress shielding in the implant can be minimized by reducing the overall stiffness of the implant, which is achieved here by varying the material based on stress distribution acro...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2018.07.029
更新日期：2018-11-01 00:00:00
abstract：:Bone is characterized with an optimized combination of high stiffness and toughness. The understanding of bone nanomechanics is critical to the development of new artificial biological materials with unique properties. In this work, the mechanical characteristics of the interfaces between osteopontin (OPN, a noncollag...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.04.002
更新日期：2014-08-01 00:00:00
abstract：BACKGROUND AND AIMS:The course and outcome of pregnancy is closely correlated to change of biomechanical properties of the uterine cervix. The aim of this study was to build a non-linear, fiber reinforced mechanical model of the cervix for estimation of mechanical characteristics of the cervix in early- and term-pregna...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2014.07.005
更新日期：2014-11-01 00:00:00
abstract：:We use the existing data of force-extension experiments on F-actin molecules tied into knots to compute a value of 0.15 for the static friction coefficient for contact between different parts of the same molecule with itself. This estimate for protein-protein friction is relevant for the stabilization of the 273 known...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2009.08.005
更新日期：2010-01-01 00:00:00
abstract：:Measurement of mechanical properties of thin-layered tissues has broad applications in the diagnosis of several pathologies. Ultrasound shear wave elastography (SWE) measures the shear wave speed as a means of estimating the mechanical properties of tissues. However, the wave speed in thin-layered tissues is affected ...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2019.103502
更新日期：2020-02-01 00:00:00
abstract：:The study concerns the determination of mechanical properties of human coronary arterial walls with both experimental and constitutive modeling approaches. The research material was harvested from 18 patients (range 50-84 years). On the basis of hospital records and visual observation, each tissue sample was classifie...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2015.05.021
更新日期：2015-10-01 00:00:00
abstract：:The adhesion of bovine chondrocytes and human osteoblasts to three titania-based coatings, formed by plasma electrolytic oxidation (PEO), was compared to that on uncoated Ti-6Al-4V substrates, and some comparisons were also made with plasma sprayed hydroxyapatite (HA) coatings. This was done using a centrifuge, with a...
journal_title：Journal of the mechanical behavior of biomedical materials
pub_type： 杂志文章
doi：10.1016/j.jmbbm.2011.07.009
更新日期：2011-11-01 00:00:00
