DNA damage and Repair Modify DNA methylation and Chromatin Domain of the Targeted Locus: Mechanism of allele methylation polymorphism.

abstract：:We present a new model of ESR1 network regulation based on analysis of Doxorubicin, Estradiol, and TNFα combination treatment in MCF-7. We used Doxorubicin as a therapeutic agent, TNFα as marker and mediator of an inflammatory microenvironment and 17β-Estradiol (E2) as an agonist of Estrogen Receptors, known predispos...

journal_title：Scientific reports

authors： Nassiri I,Inga A,Meškytė EM,Alessandrini F,Ciribilli Y,Priami C

更新日期：2019-10-23 00:00:00

abstract：:Thermodynamics is a branch of science blessed by an unparalleled combination of generality of scope and formal simplicity. Based on few natural assumptions together with the four laws, it sets the boundaries between possible and impossible in macroscopic aggregates of matter. This triggered groundbreaking achievements...

journal_title：Scientific reports

authors： Correa LA,Palao JP,Alonso D,Adesso G

更新日期：2014-02-04 00:00:00

abstract：:Kinetic restriction of a thermodynamically favourable equilibrium is a common theme in materials processing. The interfacial instability in systems where rate of material exchange is far greater than the mass transfer through respective bulk phases is of specific interest when tracking the transient interfacial area, ...

journal_title：Scientific reports

authors： Spooner S,Rahnama A,Warnett JM,Williams MA,Li Z,Sridhar S

更新日期：2017-10-30 00:00:00

abstract：:We report the observation of replica symmetry breaking (RSB) in a weakly scattering optofluidic random laser (ORL). Coherent random lasing is indicated by the presence of narrow peaks rising out of the spectral background. This coherence helps to identify a random laser threshold, which is expected to be gradual with ...

journal_title：Scientific reports

authors： Sarkar A,Bhaktha BNS,Andreasen J

更新日期：2020-02-14 00:00:00

abstract：:Hepatocyte-specific HMGB1 deletion has been found to worsen the injury and inflammation in liver ischemia-reperfusion injury (IRI), highlighting a role for intracellular HMGB1 in cellular protection. Down-regulation of nuclear HMGB1 by small interfering RNA (siRNA) might not only decrease its injurious extracellular r...

journal_title：Scientific reports

authors： Zhao G,Fu C,Wang L,Zhu L,Yan Y,Xiang Y,Zheng F,Gong F,Chen S,Chen G

更新日期：2017-04-06 00:00:00

abstract：:No standard treatment has been accepted widely for the first-/second-line therapy for advanced gastric cancer (AGC). The current study aimed to determine a preferred strategy between FOLFIRI (fluorouracil, leucovorin, and irinotecan) and ECX (epirubicin, cisplatin,and capecitabine) for AGC from the cost-effectiveness ...

journal_title：Scientific reports

authors： Wen F,Zheng H,Wu Y,Wheeler J,Zeng X,Fu P,Li Q

更新日期：2016-11-08 00:00:00

abstract：:After spinal cord injury (SCI) chronic inflammation hampers regeneration. Influencing the local microenvironment after SCI may provide a strategy to modulate inflammation and the immune response. The objectives of this work were to determine whether bone or spinal cord derived ECM hydrogels can deliver human mesenchym...

journal_title：Scientific reports

authors： Tatic N,Rose FRAJ,des Rieux A,White LJ

更新日期：2019-09-30 00:00:00

abstract：:The general model presented here for the formation of chromatin domains, LADs and TADs, is primarily based on the 3-D structures of the corresponding DNA sequences, the GC-poor and GC-rich isochores. Indeed, the low-heterogeneity GC-poor isochores locally are intrinsically stiff and curved because of the presence of i...

journal_title：Scientific reports

authors： Bernardi G

更新日期：2018-12-13 00:00:00

abstract：:Plant defensins (PDFs) are cysteine-rich peptides that have a range of biological functions, including defence against fungal pathogens. However, little is known about their role in defence against bacteria. In this study, we showed that the protein encoded by ARABIDOPSIS THALIANA PLANT DEFENSIN TYPE 1.1 (AtPDF1.1) is...

journal_title：Scientific reports

authors： Hsiao PY,Cheng CP,Koh KW,Chan MT

更新日期：2017-08-23 00:00:00

abstract：:We propose a polarization beam splitter (PBS) with a footprint of only 600 × 790 nm2 operating at a wavelength of λ = 1550 nm, which is the smallest PBS ever demonstrated. This device uses CMOS-compatible materials, namely, silicon and silica. The present PBS comprises two Si waveguides with different geometrical aspe...

journal_title：Scientific reports

authors： Lai MS,Huang CC

更新日期：2017-07-03 00:00:00

abstract：:Accurate cancer diagnosis often requires extraction and purification of genetic materials from cells, and sophisticated instrumentations that follow. Otherwise in order to directly treat the diagnostic materials to cells, multiple steps to optimize dose concentration and treatment time are necessary due to diversity i...

journal_title：Scientific reports

authors： Park KS,Shin SW,Jang MS,Shin W,Yang K,Min J,Cho SW,Oh BK,Bae JW,Jung S,Choi JW,Um SH

更新日期：2015-12-18 00:00:00

abstract：:There is increasing demand for safe and effective sanitizers for irrigation water disinfection to prevent transmission of foodborne pathogens to fresh produce. Here we compared the efficacy of pH-neutral electrolyzed oxidizing water (EOW), sodium hypochlorite (NaClO) and chlorine dioxide (ClO2) against single and mixe...

journal_title：Scientific reports

authors： Ogunniyi AD,Dandie CE,Ferro S,Hall B,Drigo B,Brunetti G,Venter H,Myers B,Deo P,Donner E,Lombi E

更新日期：2019-12-27 00:00:00

abstract：:Nisin inhibits bacterial growth by generating pores in cell membrane and interrupting cell-wall biosynthesis through specific lipid II interaction. However, the role of the hinge region and C-terminus residues of the peptide in antibacterial action of nisin is largely unknown. Here, using molecular dynamics simulation...

journal_title：Scientific reports

authors： Prince A,Sandhu P,Ror P,Dash E,Sharma S,Arakha M,Jha S,Akhter Y,Saleem M

更新日期：2016-11-29 00:00:00

abstract：:The F1F0-ATP synthase, an enzyme complex, is mainly located on the mitochondrial inner membrane or sometimes cytomembrane to generate or hydrolyze ATP, play a role in cell proliferation. This study focused on the role of F1F0-ATP synthase in keratinocyte differentiation, and its relationship with intracellular and ext...

journal_title：Scientific reports

authors： Xiaoyun X,Chaofei H,Weiqi Z,Chen C,Lixia L,Queping L,Cong P,Shuang Z,Juan S,Xiang C

更新日期：2017-02-17 00:00:00

abstract：:Flexible thermoelectric generators (TEGs) can provide uninterrupted, green energy from body-heat, overcoming bulky battery configurations that limit the wearable-technologies market today. High-throughput production of flexible TEGs is currently dominated by printing techniques, limiting material choices and performan...

journal_title：Scientific reports

authors： Morgan KA,Tang T,Zeimpekis I,Ravagli A,Craig C,Yao J,Feng Z,Yarmolich D,Barker C,Assender H,Hewak DW

更新日期：2019-03-13 00:00:00

abstract：:Reef sharks are vulnerable predators experiencing severe population declines mainly due to overexploitation. However, beyond direct exploitation, human activities can produce indirect or sub-lethal effects such as behavioral alterations. Such alterations are well known for terrestrial fauna but poorly documented for m...

journal_title：Scientific reports

authors： Juhel JB,Vigliola L,Wantiez L,Letessier TB,Meeuwig JJ,Mouillot D

更新日期：2019-02-27 00:00:00

abstract：:The Dirac materials, such as graphene and three-dimensional topological insulators, have attracted much attention because they exhibit novel quantum phenomena with their low energy electrons governed by the relativistic Dirac equations. One particular interest is to generate Dirac cone anisotropy so that the electrons...

journal_title：Scientific reports

authors： Feng Y,Wang Z,Chen C,Shi Y,Xie Z,Yi H,Liang A,He S,He J,Peng Y,Liu X,Liu Y,Zhao L,Liu G,Dong X,Zhang J,Chen C,Xu Z,Dai X,Fang Z,Zhou XJ

更新日期：2014-06-20 00:00:00

abstract：:Advanced electron microscopy technologies have made it possible to perform precise double-slit interference experiments. We used a 1.2-MV field emission electron microscope providing coherent electron waves and a direct detection camera system enabling single-electron detections at a sub-second exposure time. We devel...

journal_title：Scientific reports

authors： Harada K,Akashi T,Niitsu K,Shimada K,Ono YA,Shindo D,Shinada H,Mori S

更新日期：2018-01-17 00:00:00

abstract：:Schiff-based complexes as a source of cancer chemotherapeutic compounds have been subjected to the variety of anticancer studies. The in-vitro analysis confirmed the CdCl2(C14H21N3O2) complex possess cytotoxicity and apoptosis induction properties in colon cancer cells, so lead to investigate the inhibitory efficiency...

journal_title：Scientific reports

authors： Hajrezaie M,Shams K,Moghadamtousi SZ,Karimian H,Hassandarvish P,Emtyazjoo M,Zahedifard M,Majid NA,Mohd Ali H,Abdulla MA

更新日期：2015-07-23 00:00:00

abstract：:Carbon nanomaterials' reactivity towards oxygen is very poor, limiting their potential applications. However, nitrogen doping is an established way to introduce active sites that facilitate interaction with gases. This boosts the materials' reactivity for bio-/gas sensing and enhances their catalytic performance for t...

journal_title：Scientific reports

authors： Scardamaglia M,Susi T,Struzzi C,Snyders R,Di Santo G,Petaccia L,Bittencourt C

更新日期：2017-08-11 00:00:00

abstract：:Electrospun gelatin nanofibers attract great interest as a natural biomaterial for cartilage and tendon repair despite their high solubility in aqueous solution, which makes them also difficult to crosslink by means of chemical agents. In this work, we explore the efficiency of non-equilibrium atmospheric pressure pla...

journal_title：Scientific reports

authors： Liguori A,Bigi A,Colombo V,Focarete ML,Gherardi M,Gualandi C,Oleari MC,Panzavolta S

更新日期：2016-12-07 00:00:00

abstract：:Clostridium difficile infection (CDI) is associated with risk for severe disease and high mortality. Little is known about the extent of hospital-acquired CDI in Mainland China. In this study, we aimed to investigate the annual CDI incidence, bacterial genotypes, risk factors for severe CDI and survival over a 7-year ...

journal_title：Scientific reports

authors： Xu Q,Chen Y,Gu S,Lv T,Zheng B,Shen P,Quan J,Fang Y,Li L

更新日期：2017-08-29 00:00:00

abstract：:By using silver nanoplatelets with a widely tunable localized surface plasmon resonance (LSPR), and their corresponding local field enhancement, here we show large manipulation of plasmonic enhanced upconversion in NaYF4:Yb(3+)/Er(3+) nanocrystals at the single particle level. In particular, we show that when the plas...

journal_title：Scientific reports

authors： Wang YL,Mohammadi Estakhri N,Johnson A,Li HY,Xu LX,Zhang Z,Alù A,Wang QQ,Shih CK

更新日期：2015-05-15 00:00:00

abstract：:Cholesterol 25-hydroxylase (CH25H) encodes the enzyme that converts cholesterol to 25-hydroxycholesterol (25-HC). 25-HC has been demonstrated to be involved in the pathogenesis of inflammatory bowel disease. However, the role of CH25H in experimental colitis remains unknown. Dextran sulfate sodium (DSS)-induced coliti...

journal_title：Scientific reports

authors： Sheng N,Ma Z,Zhou Y,Xu J,Gao Y,Fu XY

更新日期：2020-08-28 00:00:00

abstract：:Prostate cancer (PCa) is the most common malignancy and second leading cause of cancer-related deaths in American men. Proliferating cells have higher need for nutrients and oxygen, triggering angiogenesis that plays a critical role in tumor growth, progression and metastasis. Consequently, immense focus has converged...

journal_title：Scientific reports

authors： da Silva RF,Dhar D,Raina K,Kumar D,Kant R,Cagnon VHA,Agarwal C,Agarwal R

更新日期：2018-06-22 00:00:00

abstract：:Using species distribution models and information on genetic structure and within-population variance observed in a series of common garden trials, we reconstructed a historical biogeography of trembling aspen in North America. We used an ensemble classifier modelling approach (RandomForest) to reconstruct palaeoclima...

journal_title：Scientific reports

authors： Ding C,Schreiber SG,Roberts DR,Hamann A,Brouard JS

更新日期：2017-07-05 00:00:00

abstract：:The epidermis of snakes efficiently protects against dehydration and mechanical stress. However, only few proteins of the epidermal barrier to the environment have so far been identified in snakes. Here, we determined the organization of the Epidermal Differentiation Complex (EDC), a cluster of genes encoding protein ...

journal_title：Scientific reports

authors： Holthaus KB,Mlitz V,Strasser B,Tschachler E,Alibardi L,Eckhart L

更新日期：2017-03-27 00:00:00

abstract：:Observations and modeling studies have shown that during CO2 injection into underground carbonate reservoirs, the dissolution of CO2 into formation water forms acidic brine, leading to fluid-rock interactions that can significantly impact the hydraulic properties of the host formation. However, the impacts of these in...

journal_title：Scientific reports

authors： Seyyedi M,Mahmud HKB,Verrall M,Giwelli A,Esteban L,Ghasemiziarani M,Clennell B

更新日期：2020-02-27 00:00:00

abstract：:To further expand the substrate range of the cyclohexylamine oxidase (CHAO) from Brevibacterium oxydans, a library of diverse mutants was created and assayed toward a group of structurally diverse substrates. Among them, mutants T198A and M226A exhibited enhanced activity relative to wt CHAO for most (S)-enantiomers o...

journal_title：Scientific reports

authors： Li G,Yao P,Cong P,Ren J,Wang L,Feng J,Lau PC,Wu Q,Zhu D

更新日期：2016-05-03 00:00:00

abstract：:Inosine-5'-monophosphate dehydrogenase (IMPDH) is an essential enzyme for nucleotide metabolism and cell proliferation. Despite IMPDH is the target of drugs with antiviral, immunosuppressive and antitumor activities, its physiological mechanisms of regulation remain largely unknown. Using the enzyme from the industria...

journal_title：Scientific reports

authors： Buey RM,Fernández-Justel D,Marcos-Alcalde Í,Winter G,Gómez-Puertas P,de Pereda JM,Luis Revuelta J

更新日期：2017-06-01 00:00:00