Cost-effectiveness Analysis of Fluorouracil, Leucovorin, and Irinotecan versus Epirubicin, Cisplatin, and Capecitabine in Patients with Advanced Gastric Adenocarcinoma.

abstract：:Human NAD-dependent isocitrate dehydrogenase catalyzes the decarboxylation of isocitrate (ICT) into α-ketoglutarate in the Krebs cycle. It exists as the α2βγ heterotetramer composed of the αβ and αγ heterodimers. Previously, we have demonstrated biochemically that the α2βγ heterotetramer and αγ heterodimer can be allo...

journal_title：Scientific reports

authors： Ma T,Peng Y,Huang W,Ding J

更新日期：2017-01-18 00:00:00

abstract：:Airway mucus overproduction is one of the most common symptoms of asthma that causes severe clinical outcomes in patients. Despite the effectiveness of general asthma therapies, specific treatments that prevent mucus overproduction in asthma patients remain lacking. Recent studies have found that activation of GABAA r...

journal_title：Scientific reports

authors： Shen ML,Wang CH,Lin CH,Zhou N,Kao ST,Wu DC

更新日期：2016-09-06 00:00:00

abstract：:There is an unmet need for treatments to reduce abdominal aortic aneurysm (AAA) progression. Vascular smooth muscle cell (VSMC) apoptosis precipitates AAA formation, whereas VSMC proliferation repairs the vessel wall. We previously demonstrated that over-expression of EC4-Fc (truncated N-cadherin), or deletion of matr...

journal_title：Scientific reports

authors： Lyon CA,Williams H,Bianco R,Simmonds SJ,Brown BA,Wadey KS,Smith FCT,Johnson JL,George SJ

更新日期：2017-12-11 00:00:00

abstract：:Small bowel capsule endoscopy (SBCE) and balloon-assisted endoscopy (BAE) have revolutionized the diagnosis and treatment of small bowel bleeding (SBB), allowing access to the small bowel and identification of specific bleeding lesions. However, some patients experience rebleeding after small bowel investigation, and ...

journal_title：Scientific reports

authors： Uchida G,Hirooka Y,Nakamura M,Watanabe O,Yamamura T,Matsushita M,Suhara H,Ishikawa T,Furukawa K,Funasaka K,Ohno E,Kawashima H,Miyahara R,Goto H

更新日期：2018-04-23 00:00:00

abstract：:High-risk human papillomavirus (HPV) type 16, which is responsible for greater than 50% of cervical cancer cases, is the most prevalent and lethal HPV type. However, the molecular mechanisms of cervical carcinogenesis remain elusive, particularly the early steps of HPV infection that may transform normal cervical epit...

journal_title：Scientific reports

authors： Liu C,Lin J,Li L,Zhang Y,Chen W,Cao Z,Zuo H,Chen C,Kee K

更新日期：2015-01-07 00:00:00

abstract：:The southeastern Mediterranean Sea (SEMS) is a warm and sunlit marine environment with low ambient N concentration, thus considered ideal for diazotrophy by autotrophic diazotrophs such as Trichodesmium. Despite the favorable conditions, N2 fixation rates are often low and Trichodesmium has hardly been spotted in the ...

journal_title：Scientific reports

authors： Rahav E,Bar-Zeev E

更新日期：2017-06-29 00:00:00

abstract：:Due to the substantial limitation of study population, Spindle cell sarcoma (SCS) was unexplored comprehensively. In this study, we investigated the clinical characteristics and disease specific prognostic factors of SCS. 3299 SCS cases were identified and extracted from Surveillance, Epidemiology, and End Results (SE...

journal_title：Scientific reports

authors： Feng L,Wang M,Yibulayin F,Zhang H,Yang YL,Ren F,Wushou A

更新日期：2018-03-22 00:00:00

abstract：:Aerosol nanoparticle injectors are fundamentally important for experiments where container-free sample handling is needed to study isolated nanoparticles. The injector consists of a nebuliser, a differential pumping unit, and an aerodynamic lens to create and deliver a focused particle beam to the interaction point in...

journal_title：Scientific reports

authors： Klimešová E,Kulyk O,Gu Y,Dittrich L,Korn G,Hajdu J,Krikunova M,Andreasson J

更新日期：2019-06-20 00:00:00

abstract：:The study of mechanisms that govern feeding behaviour and its related disorders is a matter of global health interest. The roundworm Caenorhabditis elegans is becoming a model organism of choice to study these conserved pathways. C. elegans feeding depends on the contraction of the pharynx (pumping). Thanks to the wor...

journal_title：Scientific reports

authors： Rodríguez-Palero MJ,López-Díaz A,Marsac R,Gomes JE,Olmedo M,Artal-Sanz M

更新日期：2018-02-26 00:00:00

abstract：:Mammalian innate and acquired immune responses involve a coordinated, sequential, and self limiting sequence of events controlled by positive and negative regulatory mechanism. MicroRNAs have been implicated as a negative regulator for diverse biological events including immune responses. However, the involvement of m...

journal_title：Scientific reports

authors： Jun H,Ying H,Daiwen C,Bing Y,Xiangbing M,Ping Z,Jie Y,Zhiqing H,Junqiu L

更新日期：2015-07-31 00:00:00

abstract：:Spectroscopic techniques combined with chemometrics methods have proven to be effective tools for the discrimination of objects with similar properties. In this work, terahertz time-domain spectroscopy (THz-TDS) combined with discriminate analysis (DA) and principal component analysis (PCA) with derivative pretreatmen...

journal_title：Scientific reports

authors： Xu W,Xie L,Ye Z,Gao W,Yao Y,Chen M,Qin J,Ying Y

更新日期：2015-07-08 00:00:00

abstract：:Mechanical function of the heart during open-chest cardiac surgery is exclusively monitored by echocardiographic techniques. However, little is known about local kinematics, particularly for the reperfused regions after ischemic events. We report a novel imaging modality, which extracts local and global kinematic para...

journal_title：Scientific reports

authors： Fassina L,Rozzi G,Rossi S,Scacchi S,Galetti M,Lo Muzio FP,Del Bianco F,Colli Franzone P,Petrilli G,Faggian G,Miragoli M

更新日期：2017-04-11 00:00:00

abstract：:In lung cancer a deregulation of Transforming Growth Factor-β (TGFβ) signaling has been observed. Yet, the impact of TGFβ in squamous cell carcinoma of the lung (LUSC) remained to be determined. We combined phenotypic and transcriptome-wide studies and showed that the stimulation of the LUSC cell line SK-MES1 with TGF...

journal_title：Scientific reports

authors： Dvornikov D,Schneider MA,Ohse S,Szczygieł M,Titkova I,Rosenblatt M,Muley T,Warth A,Herth FJ,Dienemann H,Thomas M,Timmer J,Schilling M,Busch H,Boerries M,Meister M,Klingmüller U

更新日期：2018-06-22 00:00:00

abstract：:Electronic textiles have garnered significant attention as smart technology for next-generation wearable electronic devices. The existing power sources lack compatibility with wearable devices due to their limited flexibility, high cost, and environment unfriendliness. In this work, we demonstrate bamboo fabric as a s...

journal_title：Scientific reports

authors： Sundriyal P,Bhattacharya S

更新日期：2020-08-06 00:00:00

abstract：:Multifunctional nanocarriers harbouring specific targeting moieties and with pH-responsive properties offer great potential for targeted cancer therapy. Several synthetic drug carriers have been studied extensively as drug delivery systems but not much information is available on the application of virus-like nanopart...

journal_title：Scientific reports

authors： Biabanikhankahdani R,Alitheen NBM,Ho KL,Tan WS

更新日期：2016-11-24 00:00:00

abstract：:Emotional expressions of others are salient biological stimuli that automatically capture attention and prepare us for action. We investigated the early cortical dynamics of automatic visual discrimination of fearful body expressions by monitoring cortical activity using magnetoencephalography. We show that right pari...

journal_title：Scientific reports

authors： Meeren HK,Hadjikhani N,Ahlfors SP,Hämäläinen MS,de Gelder B

更新日期：2016-04-20 00:00:00

abstract：:This corrects the article DOI: 10.1038/srep42133. ...

journal_title：Scientific reports

authors： Niu C,Yang P,Luo H,Huang H,Wang Y,Yao B

更新日期：2017-06-30 00:00:00

abstract：:A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

journal_title：Scientific reports

authors： Sagers JE,Brown AS,Vasilijic S,Lewis RM,Sahin MI,Landegger LD,Perlis RH,Kohane IS,Welling DB,Patel CJ,Stankovic KM

更新日期：2018-11-23 00:00:00

abstract：:Assistive wearable soft robotic systems have recently made a surge in the field of biomedical robotics, as soft materials allow safe and transparent interactions between the users and devices. A recent interest in the field of soft pneumatic actuators (SPAs) has been the introduction of a new class of actuators called...

journal_title：Scientific reports

authors： Nguyen PH,Zhang W

更新日期：2020-06-15 00:00:00

abstract：:CDK5 Regulatory Subunit-Associated Protein 1-like 1 (CDKAL1) was identified as a susceptibility gene for type 2 diabetes and body mass index in genome-wide association studies. Although it was reported that CDKAL1 is a methylthiotransferase essential for tRNALys(UUU) and faithful translation of proinsulin generated in...

journal_title：Scientific reports

authors： Take K,Waki H,Sun W,Wada T,Yu J,Nakamura M,Aoyama T,Yamauchi T,Kadowaki T

更新日期：2017-08-04 00:00:00

abstract：:Oviposition site-selection in insects is mediated through innate recognition templates (IRTs) tuned to specific chemical cues. These cues aid gravid insects in choosing suitable oviposition sites and may even enhance the fitness of their offspring by warding off predators and parasitoids. However, studies on the evolu...

journal_title：Scientific reports

authors： Damodaram KJ,Kempraj V,Aurade RM,Rajasekhar SB,Venkataramanappa RK,Nandagopal B,Verghese A

更新日期：2014-12-15 00:00:00

abstract：:Screening and in silico modeling are critical activities for the reduction of experimental costs. They also speed up research notably and strengthen the theoretical framework, thus allowing researchers to numerically quantify the importance of a particular subset of information. For example, in fields such as cancer a...

journal_title：Scientific reports

authors： Blanco JL,Porto-Pazos AB,Pazos A,Fernandez-Lozano C

更新日期：2018-10-24 00:00:00

abstract：:Escherichia coli lac repressor (LacI) is a paradigmatic transcriptional factor that controls the expression of lacZYA in the lac operon. This tetrameric protein specifically binds to the O1, O2 and O3 operators of the lac operon and forms a DNA loop to repress transcription from the adjacent lac promoter. In this arti...

journal_title：Scientific reports

authors： Fulcrand G,Dages S,Zhi X,Chapagain P,Gerstman BS,Dunlap D,Leng F

更新日期：2016-01-14 00:00:00

abstract：:R-loops are RNA-DNA hybrid sequences that are emerging players in various biological processes, occurring in both prokaryotic and eukaryotic cells. In viruses, R-loop investigation is limited and functional importance is poorly understood. Here, we performed a computational approach to investigate prevalence, distribu...

journal_title：Scientific reports

authors： Wongsurawat T,Gupta A,Jenjaroenpun P,Owens S,Forrest JC,Nookaew I

更新日期：2020-04-14 00:00:00

abstract：:We investigate the timescales of the horizontal mass flux decay of wind remobilised volcanic particles in Argentina, associated with the tephra-fallout deposit produced by the 2011-2012 Cordón Caulle (Chile) eruption. Particle removal processes are controlled by complex interactions of meteorological conditions, surfa...

journal_title：Scientific reports

authors： Dominguez L,Rossi E,Mingari L,Bonadonna C,Forte P,Panebianco JE,Bran D

更新日期：2020-09-02 00:00:00

abstract：:To characterize the molecular mechanisms underlying life-stage transitions in Phytophthora infestans, we initiated a chemical genetics approach by screening for a stage-specific inhibitor of morphological development from microbial culture extracts prepared mostly from actinomycetes from soil in Japan. Of the more tha...

journal_title：Scientific reports

authors： Tani S,Nishio N,Kai K,Hagiwara D,Ogata Y,Tojo M,Sumitani JI,Judelson HS,Kawaguchi T

更新日期：2020-12-18 00:00:00

abstract：:Acyl-CoA:diacylglycerol acyltransferase I (DGAT1) is a key enzyme in lipogenesis which is increased in metabolically active cells to meet nutrient requirements. DGAT1 has been recognized as an anti-obesity target; however, its role in the tumor microenvironment remains unclear. We postulated that, in prostate cancer (...

journal_title：Scientific reports

authors： Nardi F,Franco OE,Fitchev P,Morales A,Vickman RE,Hayward SW,Crawford SE

更新日期：2019-02-28 00:00:00

abstract：:We here investigated whether the unique capacity of mesenchymal stem cells (MSCs) to re-establish tissue homeostasis depends on their potential to sense danger associated molecular pattern (DAMP) and to mount an adaptive response in the interest of tissue repair. Unexpectedly, after injection of MSCs which had been pr...

journal_title：Scientific reports

authors： Basu A,Munir S,Mulaw MA,Singh K,Crisan D,Sindrilaru A,Treiber N,Wlaschek M,Huber-Lang M,Gebhard F,Scharffetter-Kochanek K

更新日期：2018-04-18 00:00:00

abstract：:Mobility of people and goods during the Upper Paleolithic has proven difficult to reconstruct given the relative rareness of remains. Nevertheless, archaeological contexts like the Late Pleistocene horizon of Borsuka Cave (Southern Poland) represent a unique opportunity to explore patterns of objects' transportation a...

journal_title：Scientific reports

authors： Kowalik N,Anczkiewicz R,Wilczyński J,Wojtal P,Müller W,Bondioli L,Nava A,Gasparik M

更新日期：2020-06-25 00:00:00

abstract：:An individual's immune system is driven by both genetic and environmental factors that vary over time. To better understand the temporal and inter-individual variability of gene expression within distinct immune cell types, we developed a platform that leverages multiplexed single-cell sequencing and out-of-clinic cap...

journal_title：Scientific reports

authors： Dobreva T,Brown D,Park JH,Thomson M

更新日期：2020-11-25 00:00:00