Discrimination of Transgenic Rice containing the Cry1Ab Protein using Terahertz Spectroscopy and Chemometrics.

abstract：:The presenilin 1 (PSEN1) L271V mutation causes early-onset familial Alzheimer's disease by disrupting the alternative splicing of the PSEN1 gene, producing some transcripts harboring the L271V point mutation and other transcripts lacking exon 8 (PS1(∆exon8)). We previously reported that PS1 L271V increased amyloid bet...

journal_title：Scientific reports

authors： Brautigam H,Moreno CL,Steele JW,Bogush A,Dickstein DL,Kwok JB,Schofield PR,Thinakaran G,Mathews PM,Hof PR,Gandy S,Ehrlich ME

更新日期：2015-11-26 00:00:00

abstract：:There is strong in vitro cell survival evidence that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors such as linear energy transfer (LET) and dose. This is coupled with the growing in vivo evidence, from post-treatment image change analysis, of a variable RBE. Despite thi...

journal_title：Scientific reports

authors： Smith EAK,Henthorn NT,Warmenhoven JW,Ingram SP,Aitkenhead AH,Richardson JC,Sitch P,Chadwick AL,Underwood TSA,Merchant MJ,Burnet NG,Kirkby NF,Kirkby KJ,Mackay RI

更新日期：2019-12-27 00:00:00

abstract：:The Vacuole Membrane Protein 1 -VMP1- is a pancreatitis-associated transmembrane protein whose expression triggers autophagy in several human diseases. In the current study, we unveil the mechanism through which this protein induces autophagosome formation in mammalian cells. We show that VMP1 autophagy-related functi...

journal_title：Scientific reports

authors： Molejon MI,Ropolo A,Re AL,Boggio V,Vaccaro MI

更新日期：2013-01-01 00:00:00

abstract：:Nanospheres of lead (Pb) have recently been identified in zircon (ZrSiO4) with the potential to compromise the veracity of U-Pb age determinations. The key assumption that the determined age is robust against the effects of Pb mobility, as long as Pb is not lost from the zircon during subsequent geological events, is ...

journal_title：Scientific reports

authors： Lyon IC,Kusiak MA,Wirth R,Whitehouse MJ,Dunkley DJ,Wilde SA,Schaumlöffel D,Malherbe J,Moore KL

更新日期：2019-09-23 00:00:00

abstract：:Promoter CpG methylation is a fundamental regulatory process of gene expression. TET proteins are active CpG demethylases converting 5-methylcytosine to 5-hydroxymethylcytosine, with loss of 5 hmC as an epigenetic hallmark of cancers, indicating critical roles of TET proteins in epigenetic tumorigenesis. Through analy...

journal_title：Scientific reports

authors： Li L,Li C,Mao H,Du Z,Chan WY,Murray P,Luo B,Chan AT,Mok TS,Chan FK,Ambinder RF,Tao Q

更新日期：2016-05-26 00:00:00

abstract：:El Niño-Southern Oscillation (ENSO), which is one of the main drivers of Earth's inter-annual climate variability, often causes a wide range of climate anomalies, and the advance prediction of ENSO is always an important and challenging scientific issue. Since a unified and complete ENSO theory has yet to be establish...

journal_title：Scientific reports

authors： Yan J,Mu L,Wang L,Ranjan R,Zomaya AY

更新日期：2020-05-15 00:00:00

abstract：:Increasing attention is given to personalized tumour therapy, where α-emitters can potentially play an important role. Alpha particles are ideal for localized cell killing because of their high linear energy transfer and short ranges. However, upon the emission of an α particle the daughter nuclide experiences a recoi...

journal_title：Scientific reports

authors： Kruijff RM,Raavé R,Kip A,Molkenboer-Kuenen J,Morgenstern A,Bruchertseifer F,Heskamp S,Denkova AG

更新日期：2019-08-12 00:00:00

abstract：:Shiga toxin-producing Escherichia coli (STEC) is an important foodborne pathogen. The increasing incidence of non-O157 STEC has posed a great risk to public health. Besides the Shiga toxin (Stx), the adherence factor, intimin, coded by eae gene plays a critical role in STEC pathogenesis. In this study, we investigated...

journal_title：Scientific reports

authors： Yang X,Sun H,Fan R,Fu S,Zhang J,Matussek A,Xiong Y,Bai X

更新日期：2020-02-24 00:00:00

abstract：:The microbial community during fermented vegetable production has a large impact on the quality of the final products. Lactic acid bacteria have been well-studied in such processes, but knowledge about the roles of non-lactic acid bacteria is limited. This study aimed to provide useful knowledge about the relationship...

journal_title：Scientific reports

authors： Sawada K,Koyano H,Yamamoto N,Yamada T

更新日期：2021-01-19 00:00:00

abstract：:Phosphoinositide-3 kinase (PI3K) signaling is important for the survival of numerous cell types and class IA of PI3K is specifically required for the development of B cells but not for T cell development. Here, we show that class IA PI3K-mediated signals induce the expression of the transcription factor Pax5, which pl...

journal_title：Scientific reports

authors： Abdelrasoul H,Werner M,Setz CS,Okkenhaug K,Jumaa H

更新日期：2018-01-22 00:00:00

abstract：:Metabolic syndrome (MS) and Framingham risk score (FRS) can be used for predicting the risk of developing cardiovascular diseases (CVD). Previous studies that compared FRS and MS have focused on high-income urban areas. This study focused on the comparison between FRS and MS when used in nomadic minorities in mountain...

journal_title：Scientific reports

authors： Yang W,Ma R,Zhang X,Guo H,He J,Mao L,Mu L,Hu Y,Yan Y,Liu J,Ma J,Li S,Ding Y,Zhang M,Zhang J,Guo S

更新日期：2018-11-07 00:00:00

abstract：:Perinatally HIV-infected patients face the consequences of both chronic infection effects per se and long-term combination antiretroviral therapy (cART) on immunosenescence. Aims of our study were to evaluate which factors independently contribute to immunosenescence in HIV-infected young adults with a very different ...

journal_title：Scientific reports

authors： Quiros-Roldan E,Properzi M,Paghera S,Raffetti E,Castelli F,Imberti L

更新日期：2020-06-22 00:00:00

abstract：:Lateral flow strip tests are a cost-effective method for detecting specific proteins in biological samples, which can be performed in the field without specialized expertise. While most recognizable in the pregnancy tests, there are many other applications for lateral flow strip technology. The pest control industry h...

journal_title：Scientific reports

authors： Ko A,Choe DH

更新日期：2020-08-07 00:00:00

abstract：:The effects of sea salt aerosols (SSA) on cloud microphysical processes, precipitation, and upper troposphere/lower stratosphere water vapour in tropical cyclones were studied with the Weather Research and Forecasting with Chemistry model. Two numerical experiments were conducted: a control experiment (CTL) and an exp...

journal_title：Scientific reports

authors： Jiang B,Wang D,Shen X,Chen J,Lin W

更新日期：2019-10-22 00:00:00

abstract：:Enzymatic gold nanoparticles (B-GNPs) have been synthesized using a natural anticancer agent bromelain (a cysteine protease) and these nanoparticles were used to bioconjugate Cisplatin (highly effective against osteosarcoma and lung cancer). Cisplatin bioconjugated bromelain encapsulated gold nanoparticles (B-C-GNPs) ...

journal_title：Scientific reports

authors： Iram S,Zahera M,Wahid I,Baker A,Raish M,Khan A,Ali N,Ahmad S,Khan MS

更新日期：2019-09-25 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal forms of cancer. One major reason for this is that PDAC quickly metastasizes to other organs, thereby making its treatment difficult. The molecular machinery driving PDAC metastasis is still poorly understood. In this study, we applied an unbiased appro...

journal_title：Scientific reports

authors： Oladimeji PO,Bakke J,Wright WC,Chen T

更新日期：2020-01-30 00:00:00

abstract：:FTY720 is a sphingoid base analog that acts as an anticancer agent in animal models. Its effect on tumor cells stems largely from its ability to trigger endocytosis of several nutrient transporters. The observation that FTY720 similarly stimulates downregulation of amino acid permeases in yeast suggests that the cellu...

journal_title：Scientific reports

authors： Barthelemy C,Barry AO,Twyffels L,André B

更新日期：2017-10-23 00:00:00

abstract：:To investigate the potential role of vitamin D (1,25(OH)2D3) in preventing the development of nasal polyps, we examined the effect of vitamin D on myofibroblast differentiation and extracellular matrix (ECM) production in TGF-β1-induced nasal polyp-derived fibroblasts (NPDFs) and elucidated the mechanisms underlying i...

journal_title：Scientific reports

authors： Lee SA,Yang HW,Um JY,Shin JM,Park IH,Lee HM

更新日期：2017-08-04 00:00:00

abstract：:Delivery and expression of recombinant genes, a key methodology for many applications in biological research, remains a challenge especially for mature neurons. Here, we report easy, highly efficient and well tolerated transduction of adult peripheral and central neuronal populations of diverse species in culture usin...

journal_title：Scientific reports

authors： Levin E,Diekmann H,Fischer D

更新日期：2016-12-13 00:00:00

abstract：ABSTARCT:The stability and reactivity of clusters are closely related to their valence electronic configuration. Doping is a most efficient method to modify the electronic configuration and properties of a cluster. Considering that Cu and S posses one and six valence electrons, respectively, the S doped Cu clusters wit...

journal_title：Scientific reports

authors： Li CG,Shen ZG,Hu YF,Tang YN,Chen WG,Ren BZ

更新日期：2017-05-02 00:00:00

abstract：:Antigen (Ag)-mediated crosslinking of IgE-loaded high-affinity receptors for IgE (FcεRI) on mast cells (MCs) triggers activation of proinflammatory effector functions relevant for IgE-associated allergic disorders. The cytosolic tyrosine kinase BTK and the SH2-containing inositol-5'-phosphatase SHIP1 are central posit...

journal_title：Scientific reports

authors： Zorn CN,Simonowski A,Huber M

更新日期：2018-10-19 00:00:00

abstract：:Non-Alcoholic Fatty Liver Disease (NAFLD) represents the most common form of chronic liver injury and can progress to cirrhosis and hepatocellular carcinoma. A "multi-hit" theory, involving high fat diet and signals from the gut-liver axis, has been hypothesized. The role of the NLRP3-inflammasome, which senses danger...

journal_title：Scientific reports

authors： Pierantonelli I,Rychlicki C,Agostinelli L,Giordano DM,Gaggini M,Fraumene C,Saponaro C,Manghina V,Sartini L,Mingarelli E,Pinto C,Buzzigoli E,Trozzi L,Giordano A,Marzioni M,Minicis S,Uzzau S,Cinti S,Gastaldelli A,Sveg

更新日期：2017-09-22 00:00:00

abstract：:Among the biologically active triterpenes, friedelin has the most-rearranged structure produced by the oxidosqualene cyclases and is the only one containing a cetonic group. In this study, we cloned and functionally characterized friedelin synthase and one cycloartenol synthase from Maytenus ilicifolia (Celastraceae)....

journal_title：Scientific reports

authors： Souza-Moreira TM,Alves TB,Pinheiro KA,Felippe LG,De Lima GM,Watanabe TF,Barbosa CC,Santos VA,Lopes NP,Valentini SR,Guido RV,Furlan M,Zanelli CF

更新日期：2016-11-22 00:00:00

abstract：:Current literature suggests that epigenetically regulated super-enhancers (SEs) are drivers of aberrant gene expression in cancers. Many tumor types are still missing chromatin data to define cancer-specific SEs and their role in carcinogenesis. In this work, we develop a simple pipeline, which can utilize chromatin d...

journal_title：Scientific reports

authors： Flam EL,Danilova L,Kelley DZ,Stavrovskaya E,Guo T,Considine M,Qian J,Califano JA,Favorov A,Fertig EJ,Gaykalova DA

更新日期：2019-10-21 00:00:00

abstract：:Antimicrobial resistant infections are a serious public health threat worldwide. Whole genome sequencing approaches to rapidly identify pathogens and predict antibiotic resistance phenotypes are becoming more feasible and may offer a way to reduce clinical test turnaround times compared to conventional culture-based m...

journal_title：Scientific reports

authors： Nguyen M,Brettin T,Long SW,Musser JM,Olsen RJ,Olson R,Shukla M,Stevens RL,Xia F,Yoo H,Davis JJ

更新日期：2018-01-11 00:00:00

abstract：:gH625 constitutes a promising delivery vehicle for the transport of therapeutic biomacromolecules across membrane barriers. We report an application of multivalency to create a complex nanosystem for delivery and to elucidate the mechanism of peptide-lipid bilayer interactions. Multivalency may offer a route to enhanc...

journal_title：Scientific reports

authors： Falanga A,Valiante S,Galdiero E,Franci G,Scudiero O,Morelli G,Galdiero S

更新日期：2017-08-25 00:00:00

abstract：:It is challenging to create artificial catalysts that approach enzymes with regard to catalytic efficiency and selectivity. The enantioselective catalysis ranks the privileged characteristic of enzymatic transformations. Here, we report two pyridine-linked bis(β-cyclodextrin) (bisCD) copper(II) complexes that enantios...

journal_title：Scientific reports

authors： Xue SS,Zhao M,Ke ZF,Cheng BC,Su H,Cao Q,Cao ZK,Wang J,Ji LN,Mao ZW

更新日期：2016-02-26 00:00:00

abstract：:Transgenic sexing strains (TSS) that carry conditional female lethal genes are advantageous for genetic control programs based on the sterile insect technique (SIT). It is desirable if females die early in development as larval diet is a major cost for mass production facilities. This can be achieved by using a gene p...

journal_title：Scientific reports

authors： Yan Y,Linger RJ,Scott MJ

更新日期：2017-05-31 00:00:00

abstract：:Extraction of mouse spinal motor neurons from transgenic mouse embryos recapitulating some aspects of neurodegenerative diseases like amyotrophic lateral sclerosis has met with limited success. Furthermore, extraction and long-term culture of adult mouse spinal motor neurons and glia remain also challenging. We presen...

journal_title：Scientific reports

authors： Beaudet MJ,Yang Q,Cadau S,Blais M,Bellenfant S,Gros-Louis F,Berthod F

更新日期：2015-11-18 00:00:00

abstract：:Implantable 3D engineered vascular tissue constructs can be formed by co-culturing endothelial and fibroblast cells on macroporous scaffolds. Here we show that these constructs can be used for studying the dynamics of neovascular formation in-vitro by a combination of live confocal imaging and an array of image proces...

journal_title：Scientific reports

authors： Blinder YJ,Freiman A,Raindel N,Mooney DJ,Levenberg S

更新日期：2015-12-09 00:00:00