High resolution iridocorneal angle imaging system by axicon lens assisted gonioscopy.

Abstract:

:Direct visualization and assessment of the iridocorneal angle (ICA) region with high resolution is important for the clinical evaluation of glaucoma. However, the current clinical imaging systems for ICA do not provide sufficient structural details due to their poor resolution. The key challenges in achieving high quality ICA imaging are its location in the anterior region of the eye and the occurrence of total internal reflection due to refractive index difference between cornea and air. Here, we report an indirect axicon assisted gonioscopy imaging probe with white light illumination. The illustrated results with this probe shows significantly improved visualization of structures in the ICA including TM region, compared to the current available tools. It could reveal critical details of ICA and expected to aid management by providing information that is complementary to angle photography and gonioscopy.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Perinchery SM,Shinde A,Fu CY,Jeesmond Hong XJ,Baskaran M,Aung T,Murukeshan VM

doi

10.1038/srep30844

subject

Has Abstract

pub_date

2016-07-29 00:00:00

pages

30844

issn

2045-2322

pii

srep30844

journal_volume

6

pub_type

杂志文章
  • Alteration of contrast enhanced ultrasound (CEUS) of hepatocellular carcinoma in patients with cirrhosis and transjugular intrahepatic portosystemic shunt (TIPS).

    abstract::Transjugular intrahepatic portosystemic shunt (TIPS) can treat portal hypertensive complications and modifies hepatic hemodynamics. Modification of liver perfusion can alter contrast enhancement dynamics of liver nodules. This study investigated the diagnostic performance of contrast-enhanced ultrasound (CEUS) to diag...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-77801-9

    authors: Chang J,Dumitrache A,Böhling N,Abu-Omar J,Meyer C,Strobel D,Luetkens J,Luu AM,Rockstroh J,Strassburg CP,Trebicka J,Gonzalez-Carmona MA,Marinova M,Praktiknjo M

    更新日期:2020-11-26 00:00:00

  • Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo.

    abstract::Tail-anchored (TA) proteins are post-translationally inserted into membranes. The TRC40 pathway targets TA proteins to the endoplasmic reticulum via a receptor comprised of WRB and CAML. TRC40 pathway clients have been identified using in vitro assays, however, the relevance of the TRC40 pathway in vivo remains unknow...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep39464

    authors: Rivera-Monroy J,Musiol L,Unthan-Fechner K,Farkas Á,Clancy A,Coy-Vergara J,Weill U,Gockel S,Lin SY,Corey DP,Kohl T,Ströbel P,Schuldiner M,Schwappach B,Vilardi F

    更新日期:2016-12-21 00:00:00

  • Pregabalin: Potential for Addiction and a Possible Glutamatergic Mechanism.

    abstract::Drug addiction remains a prevalent and fatal disease worldwide that carries significant social and economic impacts. Recent reports suggest illicit pregabalin (Lyrica) use may be increasing among youth, however the addictive potential of pregabalin has not been well established. Drug seeking behavior and chronic drug ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51556-4

    authors: Althobaiti YS,Almalki A,Alsaab H,Alsanie W,Gaber A,Alhadidi Q,Hardy AMG,Nasr A,Alzahrani O,Stary CM,Shah ZA

    更新日期:2019-10-22 00:00:00

  • Comprehensive profiling of lysine ubiquitome reveals diverse functions of lysine ubiquitination in common wheat.

    abstract::Protein ubiquitination, which is a major post-translational modifications that occurs in eukaryotic cells, is involved in diverse biological processes. To date, large-scale profiling of the ubiquitome in common wheat has not been reported, despite its status as the major cereal crop in the world. Here, we performed th...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-13992-y

    authors: Zhang N,Zhang L,Shi C,Tian Q,Lv G,Wang Y,Cui D,Chen F

    更新日期:2017-10-19 00:00:00

  • Volcanic glass properties from 1459 C.E. volcanic event in South Pole ice core dismiss Kuwae caldera as a potential source.

    abstract::A large volcanic sulfate increase observed in ice core records around 1450 C.E. has been attributed in previous studies to a volcanic eruption from the submarine Kuwae caldera in Vanuatu. Both EPMA-WDS (electron microprobe analysis using a wavelength dispersive spectrometer) and SEM-EDS (scanning electron microscopy a...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-50939-x

    authors: Hartman LH,Kurbatov AV,Winski DA,Cruz-Uribe AM,Davies SM,Dunbar NW,Iverson NA,Aydin M,Fegyveresi JM,Ferris DG,Fudge TJ,Osterberg EC,Hargreaves GM,Yates MG

    更新日期:2019-10-08 00:00:00

  • Multiscale Modeling of Fiber Fragmentation Process in Aligned ZnO Nanowires Enhanced Single Fiber Composites.

    abstract::A three-dimensional multiscale modeling framework is developed to analyze the failure procedure of radially aligned zinc oxide (ZnO) enhanced single fiber composites (SFC) under tensile loading to understand the interfacial improvement between the fiber and the matrix. The model introduces four levels in the computati...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-56503-x

    authors: Marashizadeh P,Abshirini M,Wang J,C Saha M,Liu Y

    更新日期:2019-12-27 00:00:00

  • YqfB protein from Escherichia coli: an atypical amidohydrolase active towards N4-acylcytosine derivatives.

    abstract::Human activating signal cointegrator homology (ASCH) domain-containing proteins are widespread and diverse but, at present, the vast majority of those proteins have no function assigned to them. This study demonstrates that the 103-amino acid Escherichia coli protein YqfB, previously identified as hypothetical, is a u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-57664-w

    authors: Stanislauskienė R,Laurynėnas A,Rutkienė R,Aučynaitė A,Tauraitė D,Meškienė R,Urbelienė N,Kaupinis A,Valius M,Kaliniene L,Meškys R

    更新日期:2020-01-21 00:00:00

  • The alleviating effect of exogenous polyamines on heat stress susceptibility of different heat resistant wheat (Triticum aestivum L.) varieties.

    abstract::High temperature inhibits wheat grain filling. Polyamines (PAs) are closely associated with plant resistance caused by abiotic stress. However, little is known about the effect of PAs on the grain filling of wheat under heat stress. Two wheat varieties differing in heat resistance were used, and endogenous PAs levels ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-64468-5

    authors: Jing J,Guo S,Li Y,Li W

    更新日期:2020-05-04 00:00:00

  • Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression.

    abstract::Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg). ASS1 is silenced in many human malignancies therefore, these tumors require extracellular Arg for growth. The Arg-degrading recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in clinical trials fo...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-11445-0

    authors: Tsai WB,Long Y,Chang JT,Savaraj N,Feun LG,Jung M,Chen HHW,Kuo MT

    更新日期:2017-09-07 00:00:00

  • Surface-modified Ba(Zr0.3Ti0.7)O3 nanofibers by polyvinylpyrrolidone filler for poly(vinylidene fluoride) composites with enhanced dielectric constant and energy storage density.

    abstract::Ferroelectric-relaxor behavior of Ba(Zr0.3Ti0.7)O3 nanofibers (BZT NF) with a large aspect ratio were prepared via electrospinning and surface modified by PVP as dielectric fillers. The nanocomposite flexible films based on surface modified BZT NF and polyvinylidene fluoride (PVDF) were fabricated via a solution casti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep26198

    authors: Liu S,Xue S,Xiu S,Shen B,Zhai J

    更新日期:2016-05-17 00:00:00

  • Anomalous wind triggered the largest phytoplankton bloom in the oligotrophic North Pacific Subtropical Gyre.

    abstract::In summer 2010, a massive bloom appeared in the middle (16-25°N, 160-200°E) of the North Pacific Subtropical Gyre (NPSG) creating a spectacular oasis in the middle of the largest oceanic desert on Earth. Peaked in June 2010 covering over two million km2 in space, this phytoplankton bloom is the largest ever recorded b...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-51989-x

    authors: Chow CH,Cheah W,Tai JH,Liu SF

    更新日期:2019-10-29 00:00:00

  • (Neo)adjuvant chemotherapy and interdigitated split-course hyperfractionated radiation in high risk soft tissue sarcoma - Results from a large single-institution series.

    abstract::A single-institution series using a (neo)adjuvant chemotherapy and interdigitated hyperfractionated split-course radiation therapy (CRT) treatment protocol for soft tissue sarcoma was reviewed. Our specific aims were to study recurrence rates and long-term toxicity. Between 1998 and 2016, 89 patients with non-metastat...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-43794-3

    authors: Nevala R,Tukiainen E,Tarkkanen M,Böhling T,Blomqvist C,Sampo M

    更新日期:2019-05-13 00:00:00

  • Discovery, screening and evaluation of a plasma biomarker panel for subjects with psychological suboptimal health state using (1)H-NMR-based metabolomics profiles.

    abstract::Individuals in the state of psychological suboptimal health keep increasing, only scales and questionnaires were used to diagnose in clinic under current conditions, and symptoms of high reliability and accuracy are destitute. Therefore, the noninvasive and precise laboratory diagnostic methods are needed. This study ...

    journal_title:Scientific reports

    pub_type: 临床试验,杂志文章

    doi:10.1038/srep33820

    authors: Tian JS,Xia XT,Wu YF,Zhao L,Xiang H,Du GH,Zhang X,Qin XM

    更新日期:2016-09-21 00:00:00

  • Experimental Realization of a Quantum Pentagonal Lattice.

    abstract::Geometric frustration, in which competing interactions give rise to degenerate ground states, potentially induces various exotic quantum phenomena in magnetic materials. Minimal models comprising triangular units, such as triangular and Kagome lattices, have been investigated for decades to realize novel quantum phase...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep15327

    authors: Yamaguchi H,Okubo T,Kittaka S,Sakakibara T,Araki K,Iwase K,Amaya N,Ono T,Hosokoshi Y

    更新日期:2015-10-15 00:00:00

  • On the first evidence of exchange-bias feature in magnetically contrasted consolidates made from CoFe2O4-CoO core-shell nanoparticles.

    abstract::Hetero-nanostructures based on magnetic contrast oxides have been prepared as highly dense nanoconsolidates. Cobalt ferrite-cobalt oxide core-shell type nanoparticles (NPs) were synthesized by seed mediated growth in polyol and subsequently consolidated by Spark Plasma Sintering (SPS) at 500 °C for a few minutes while...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-55649-y

    authors: Flores-Martinez N,Franceschin G,Gaudisson T,Haj-Khlifa S,Derouich SG,Yaacoub N,Grenèche JM,Menguy N,Valenzuela R,Ammar S

    更新日期:2019-12-19 00:00:00

  • Learning to use vestibular sense for spatial updating is context dependent.

    abstract::As we move, perceptual stability is crucial to successfully interact with our environment. Notably, the brain must update the locations of objects in space using extra-retinal signals. The vestibular system is a strong candidate as a source of information for spatial updating as it senses head motion. The ability to u...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-47675-7

    authors: Mackrous I,Carriot J,Simoneau M

    更新日期:2019-08-01 00:00:00

  • Author Correction: A large-scale RNA interference screen identifies genes that regulate autophagy at different stages.

    abstract::A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper. ...

    journal_title:Scientific reports

    pub_type: 已发布勘误

    doi:10.1038/s41598-019-42889-1

    authors: Guo S,Pridham KJ,Virbasius CM,He B,Zhang L,Varmark H,Green MR,Sheng Z

    更新日期:2019-06-10 00:00:00

  • Mapping plasmonic near-field profiles and interferences by surface-enhanced Raman scattering.

    abstract::Mapping near-field profiles and dynamics of surface plasmon polaritons is crucial for understanding their fundamental optical properties and designing miniaturized photonic devices. This requires a spatial resolution on the sub-wavelength scale because the effective polariton wavelength is shorter than free-space exci...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep03064

    authors: Du L,Lei DY,Yuan G,Fang H,Zhang X,Wang Q,Tang D,Min C,Maier SA,Yuan X

    更新日期:2013-10-29 00:00:00

  • Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment.

    abstract::Cancer immunotherapy, including immune checkpoint inhibitors, exerts beneficial effects in cancer patients. However, immune checkpoint inhibitors are only advantageous for a limited population of cancer patients. Therefore, companion diagnostics are needed in order to identify patients for whom these therapies are eff...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-39345-5

    authors: Iwahori K,Shintani Y,Funaki S,Yamamoto Y,Matsumoto M,Yoshida T,Morimoto-Okazawa A,Kawashima A,Sato E,Gottschalk S,Okumura M,Kumanogoh A,Wada H

    更新日期:2019-02-22 00:00:00

  • Structural and functional investigation of graphene oxide-Fe3O4 nanocomposites for the heterogeneous Fenton-like reaction.

    abstract::Graphene oxide-iron oxide (GO-Fe3O4) nanocomposites were synthesised by co-precipitating iron salts onto GO sheets in basic solution. The results showed that formation of two distinct structures was dependent upon the GO loading. The first structure corresponds to a low GO loading up to 10 wt%, associated with the ben...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep04594

    authors: Zubir NA,Yacou C,Motuzas J,Zhang X,Diniz da Costa JC

    更新日期:2014-04-04 00:00:00

  • Assessment of post-harvest losses and carbon footprint in intensive lowland rice production in Myanmar.

    abstract::This paper examines how a move from traditional post-harvest operations of smallholder rice farms in the Ayeyarwaddy delta, Myanmar, to improved post-harvest operations affected income, energy efficiency and greenhouse gas emissions (GHGE). Harvest and post-harvest losses were investigated in a field experiment with 5...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-020-76639-5

    authors: Gummert M,Nguyen-Van-Hung,Cabardo C,Quilloy R,Aung YL,Thant AM,Kyaw MA,Labios R,Htwe NM,Singleton GR

    更新日期:2020-11-13 00:00:00

  • A model of the entrance pupil of the human eye.

    abstract::The aperture stop of the iris is subject to refraction by the cornea, and thus an outside observer sees a virtual image: the "entrance pupil" of the eye. When viewed off-axis, the entrance pupil has an elliptical form. The precise appearance of the entrance pupil is a consequence of the anatomical and optical properti...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-019-45827-3

    authors: Aguirre GK

    更新日期:2019-06-27 00:00:00

  • Investigation of neuronal pathfinding and construction of artificial neuronal networks on 3D-arranged porous fibrillar scaffolds with controlled geometry.

    abstract::Herein, we investigated the neurite pathfinding on electrospun microfibers with various fiber densities, diameters, and microbead islands, and demonstrated the development of 3D connected artificial neuronal network within a nanofiber-microbead-based porous scaffold. The primary culture of rat hippocampal embryonic ne...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-017-08231-3

    authors: Kim D,Kim SM,Lee S,Yoon MH

    更新日期:2017-08-10 00:00:00

  • Targeting BMK1 Impairs the Drug Resistance to Combined Inhibition of BRAF and MEK1/2 in Melanoma.

    abstract::Combined inhibition of BRAF and MEK1/2 (CIBM) improves therapeutic efficacy of BRAF-mutant melanoma. However, drug resistance to CIBM is inevitable and the drug resistance mechanisms still remain to be elucidated. Here, we show that BMK1 pathway contributes to the drug resistance to CIBM. Considering that ERK1/2 pathw...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep46244

    authors: Song C,Wang L,Xu Q,Wang K,Xie D,Yu Z,Jiang K,Liao L,Yates JR,Lee JD,Yang Q

    更新日期:2017-04-07 00:00:00

  • Development of Alendronate-conjugated Poly (lactic-co-glycolic acid)-Dextran Nanoparticles for Active Targeting of Cisplatin in Osteosarcoma.

    abstract::In this study, we developed a novel poly (lactic-co-glycolic acid)-dextran (PLD)-based nanodelivery system to enhance the anticancer potential of cisplatin (CDDP) in osteosarcoma cells. A nanosized CDDP-loaded PLGA-DX nanoparticle (PLD/CDDP) controlled the release rate of CDDP up to 48 h. In vitro cytotoxicity assay s...

    journal_title:Scientific reports

    pub_type: 杂志文章,收录出版

    doi:10.1038/srep17387

    authors: Liu P,Sun L,Zhou DS,Zhang P,Wang YH,Li D,Li QH,Feng RJ

    更新日期:2015-12-01 00:00:00

  • Analyzing the genes related to nicotine addiction or schizophrenia via a pathway and network based approach.

    abstract::The prevalence of tobacco use in people with schizophrenia is much higher than in general population, which indicates a close relationship between nicotine addiction and schizophrenia. However, the molecular mechanism underlying the high comorbidity of tobacco smoking and schizophrenia remains largely unclear. In this...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-21297-x

    authors: Hu Y,Fang Z,Yang Y,Rohlsen-Neal D,Cheng F,Wang J

    更新日期:2018-02-13 00:00:00

  • Improving catalytic activity of the Baeyer-Villiger monooxygenase-based Escherichia coli biocatalysts for the overproduction of (Z)-11-(heptanoyloxy)undec-9-enoic acid from ricinoleic acid.

    abstract::Baeyer-Villiger monooxygenases (BVMOs) can be used for the biosynthesis of lactones and esters from ketones. However, the BVMO-based biocatalysts are not so stable under process conditions. Thereby, this study focused on enhancing stability of the BVMO-based biocatalysts. The biotransformation of ricinoleic acid into ...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-28575-8

    authors: Woo JM,Jeon EY,Seo EJ,Seo JH,Lee DY,Yeon YJ,Park JB

    更新日期:2018-07-06 00:00:00

  • The microfluidic multitrap nanophysiometer for hematologic cancer cell characterization reveals temporal sensitivity of the calcein-AM efflux assay.

    abstract::Cytometric studies utilizing flow cytometry or multi-well culture plate fluorometry are often limited by a deficit in temporal resolution and a lack of single cell consideration. Unfortunately, many cellular processes, including signaling, motility, and molecular transport, occur transiently over relatively short peri...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep05117

    authors: Byrd TF 4th,Hoang LT,Kim EG,Pfister ME,Werner EM,Arndt SE,Chamberlain JW,Hughey JJ,Nguyen BA,Schneibel EJ,Wertz LL,Whitfield JS,Wikswo JP,Seale KT

    更新日期:2014-05-30 00:00:00

  • Gravity modeling finds a large magma body in the deep crust below the Gulf of Naples, Italy.

    abstract::We analyze a wide gravity low in the Campania Active Volcanic Area and interpret it by a large and deep source distribution of partially molten, low-density material from about 8 to 30 km depth. Given the complex spatial-temporal distribution of explosive volcanism in the area, we model the gravity data consistently w...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/s41598-018-26346-z

    authors: Fedi M,Cella F,D'Antonio M,Florio G,Paoletti V,Morra V

    更新日期:2018-05-29 00:00:00

  • Tracking of Normal and Malignant Progenitor Cell Cycle Transit in a Defined Niche.

    abstract::While implicated in therapeutic resistance, malignant progenitor cell cycle kinetics have been difficult to quantify in real-time. We developed an efficient lentiviral bicistronic fluorescent, ubiquitination-based cell cycle indicator reporter (Fucci2BL) to image live single progenitors on a defined niche coupled with...

    journal_title:Scientific reports

    pub_type: 杂志文章

    doi:10.1038/srep23885

    authors: Pineda G,Lennon KM,Delos Santos NP,Lambert-Fliszar F,Riso GL,Lazzari E,Marra MA,Morris S,Sakaue-Sawano A,Miyawaki A,Jamieson CH

    更新日期:2016-04-04 00:00:00