Abstract:
OBJECTIVE:To measure skin wrinkles and rigidity in menopausal women of varying race/ethnicity with or without hormone therapy (HT) for up to four years. DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:Academic medical centers. PATIENT(S):Women (42-58 years of age) within 36 months of last menstrual period and enrolled in the Kronos Early Estrogen Prevention Study (KEEPS). INTERVENTION(S):Treatment with 0.45 mg oral conjugated equine estrogens (CEE), transdermal E2 (50 μg/d) with micronized P (200 mg daily), or placebo for 4 years. MAIN OUTCOME MEASURE(S):Skin wrinkles were assessed at 11 locations on the face and neck, and skin rigidity was assessed at the forehead and cheek at baseline and yearly for 4 years. RESULT(S):Neither total wrinkle score nor total rigidity score was significantly different at baseline or over the 4-year follow-up among patients randomized to CEE, E2, or placebo. Skin wrinkle and rigidity scores were primarily affected by race/ethnicity, with scores being significantly different between races for almost all of the wrinkle parameters and for all of the rigidity measures. There was no association between race and response to HT for total wrinkle or rigidity scores. Black women had the lowest wrinkle scores compared with white women across all 4 years. In general, skin rigidity decreased in all groups over time, but black women had significantly reduced total facial rigidity compared with white women after 4 years. CONCLUSION(S):Race is the strongest predictor of the advancement of skin aging in the 4 years following menopause. HT does not appear to affect skin wrinkles or rigidity at most facial locations. CLINICAL TRIAL REGISTRATION NUMBER:NCT00154180.
journal_name
Fertil Steriljournal_title
Fertility and sterilityauthors
Owen CM,Pal L,Mumford SL,Freeman R,Isaac B,McDonald L,Santoro N,Taylor HS,Wolff EFdoi
10.1016/j.fertnstert.2016.06.023subject
Has Abstractpub_date
2016-10-01 00:00:00pages
1170-1175.e3issue
5eissn
0015-0282issn
1556-5653pii
S0015-0282(16)61352-3journal_volume
106pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:To evaluate the expression of type IV collagen [alpha1(IV) to alpha6(IV)] in testes and the association with spermatogenesis. DESIGN:Retrospective immunohistochemical study. SETTING:Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, in a university hospital. PATIENT(S):Testicular ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00775-1
更新日期:2003-09-01 00:00:00
abstract::A case-control study was conducted to determine whether use of oral contraceptives (OCs) is associated with an increased risk of prolactin-secreting pituitary adenomas. Two hundred twelve women with such adenomas (140 of which were surgically confirmed) were recruited from four clinical centers and interviewed and mat...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1983-06-01 00:00:00
abstract:OBJECTIVE:To report our experience with genetic screening of oocyte donor candidates and to determine the frequency with which significant genetic issues are identified. DESIGN:Prospective genetic screening of oocyte donor candidates. SETTING:University hospital oocyte donation program. PATIENT(S):Women presenting c...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章
doi:10.1016/s0015-0282(98)00109-5
更新日期:1998-07-01 00:00:00
abstract:OBJECTIVE:To review the discovery of chromothripsis and analyze its impact on human reproduction. DESIGN:Database and literature analysis. SETTING:University hospital. PATIENT(S):Carriers of massive and complex chromosomal rearrangements. INTERVENTION(S):Cytogenetic analysis and molecular testing (fluorescence in s...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2014.09.006
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the heparin-glutathione test (HEGLUT) for the selection of viable sperm for intracytoplasmic sperm injection (ICSI). DESIGN:A prospective study. SETTING:Department of Pediatrics, Obstetrics and Gynecology, University of Valencia and Instituto Valenciano de Infertilidad. PATIENT(S):Semen samples...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(98)00334-3
更新日期:1998-12-01 00:00:00
abstract:OBJECTIVE:To identify transcripts whose expression is restricted to germ cells. DESIGN:Expressed sequence tags (ESTs) from unfertilized egg libraries were utilized to perform in silico subtraction and identify germ cell-specific transcripts. SETTING:Baylor College of Medicine, Houston, Texas. ANIMAL(S):C57BL/6J/129S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01966-5
更新日期:2001-09-01 00:00:00
abstract::Two hundred twenty consecutive in vitro fertilization (IVF) conception cycles were studied prospectively in order to examine the predictive value of serum human chorionic gonadotropin beta-subunit (beta-hCG), estradiol (E2), and progesterone (P) in predicting pregnancy outcome between 2 and 4 weeks after oocyte collec...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)60495-8
更新日期:1989-02-01 00:00:00
abstract:OBJECTIVE:To investigate the serum pattern of free leptin, bound leptin, and soluble leptin receptor throughout the physiological menstrual cycle. DESIGN:Prospective observational study. SETTING:Tertiary care center for gynecological endocrinology and reproductive medicine and a university research laboratory. PATIE...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2003.06.020
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To determine whether the peripheral blood concentration of CD56(+)/CD16(-)/CD3(-) cells, the main natural killer (NK) subpopulation that colonizes the endometrium in the middle and late secretory phase, can be related to fertility or infertility status. DESIGN:A case control study. SETTING:Immunopathology d...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00778-7
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To assess the relevant factors affecting patients' decision when choosing a clinic for private, self-funded IVF treatment. DESIGN:Prospective anonymous closed questionnaires. SETTING:Single tertiary-care private IVF center. PATIENT(S):New patients attending primary consultation in a period of 7 months from...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(01)01751-4
更新日期:2001-05-01 00:00:00
abstract::Fresh and aged (24 hours after ovulation) human oocytes and recently ovulated mouse oocytes may be activated by exposure to acidified Tyrode's solution. No activation of either type of human oocyte was observed after exposure to hyaluronidase or pronase, but significant numbers of fresh mouse oocytes were activated af...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)53279-8
更新日期:1990-02-01 00:00:00
abstract:OBJECTIVE:To study the expression and function of adiponectin and its receptors in mouse and human follicle cells and in early embryo development. DESIGN:Whole ovaries, granulosa cells, and cumulus-oocyte complexes isolated from immature mice before and during hormone-induced ovulation were used to analyze the express...
journal_title:Fertility and sterility
pub_type: 杂志文章,多中心研究
doi:10.1016/j.fertnstert.2012.04.050
更新日期:2012-08-01 00:00:00
abstract:OBJECTIVE:To investigate endometrial dating during the conception cycle. DESIGN:Endometrial biopsies of the last half of the luteal phase of conception cycles were dated based on urinary luteinizing hormone (LH) surges. SETTING:Endometrial samples were obtained from women attending the fertility clinic of the Departm...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:
更新日期:1992-12-01 00:00:00
abstract::This article provides a summary of the biopsychosocial model and the assessment and treatment of male sexual dysfunction as manifested in cases of infertility. In couples trying to get pregnant, a unique set of psychosocial and behavioral changes may evolve that directly interferes with a couple's usual pattern of sex...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2015.07.1155
更新日期:2015-11-01 00:00:00
abstract::In response to large numbers of requests for laparoscopic sterilization, the University of North Carolina began a training program to provide this service on a regional basis throughout the state. This report reviews the final distribution of centers providing these services: one within 50 miles of every person in the...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)42312-5
更新日期:1977-01-01 00:00:00
abstract::This case-control study evaluated the effect of hysteroscopically identified endometrial polyps on endometrium by means of HOXA10 and HOXA11, known molecular markers of endometrial receptivity. Uteri with endometrial polyps demonstrated a marked decrease in HOXA10 and HOXA11 messenger RNA levels, which may impair impl...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2010.12.034
更新日期:2011-06-30 00:00:00
abstract::Danazol and gestrinone are effective drugs in the treatment of endometriosis. Their mechanism of action remains uncertain, but may be related to their androgenic activity. The authors examined the effect of danazol on human endometrial cells cultured in vitro, its two major metabolites, ethisterone and 2 hydroxymethyl...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)59706-4
更新日期:1988-02-01 00:00:00
abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2013.08.053
更新日期:2013-10-07 00:00:00
abstract:OBJECTIVE:To compare sperm characteristics among: patients undergoing infertility evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with proven fertility; to examine the overlap of sperm characteristics in all four of these groups; and to identify good discriminators of fertility ve...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2005.08.024
更新日期:2006-03-01 00:00:00
abstract::Seminiferous tubules from rats killed 24 hours after injection of pargyline, a monoamine oxidase inhibitor, did not grow well in tissue culture when compared to control tubules. Treated tubules showed severe tubular degeneration and loss of cellular detail after nine days in culture. Animals injected with pargyline fo...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)40992-1
更新日期:1975-03-01 00:00:00
abstract::Osteoporosis continues to be a major public health challenge in both women and men. There are more than 2 million low-impact fractures in the United States every year, 39% of which occur in men. The mortality rate in the first year after hip fracture is estimated at 20% to 25% in women and is even higher in men. The g...
journal_title:Fertility and sterility
pub_type:
doi:10.1016/j.fertnstert.2019.10.004
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To determine whether NR5A1 (SF-1) variants are a cause of primary ovarian insufficiency (POI) in 26 young women with similar genetic background. DESIGN:Genetic and functional mutation study. SETTING:University hospitals. PATIENT(S):Genetic analysis of the NR5A1 gene in 26 XX girls with POI. INTERVENTION(S...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.10.026
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To report an unusual case of embryo implantation and superfetation. DESIGN:Retrospective case analysis. SETTING:Oak Brook Fertility Center. PATIENT(S):A 41-year-old woman underwent two consecutive ovarian stimulation cycles interrupted by a normal menstrual period. Ovulation and implantation occurred durin...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(97)00244-6
更新日期:1997-09-01 00:00:00
abstract:OBJECTIVE:To investigate the utility of random anti-Müllerian hormone (AMH) in assessing ovarian response among women with diminished ovarian reserve (DOR) diagnosed by elevated early follicular-phase FSH levels. DESIGN:Retrospective study. SETTING:Academic and academically affiliated assisted reproductive technology...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2011.03.071
更新日期:2011-06-01 00:00:00
abstract::The postoperative time course of healing following tubal microsurgery was examined in the rabbit by transmission electron microscopy (TEM) and scanning electron microscopy (SEM) and was correlated with changes in fertility. Groups of animals were bred or used for morphologic studies on days 1, 2, 3, 4, 7, and 14 after...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(16)46519-2
更新日期:1982-09-01 00:00:00
abstract:OBJECTIVE:To investigate hypoestrogenic "inactive phases" (IP) in the follicular phase of the menstrual cycle, with respect to age, reproductive stage, and follicular depletion. DESIGN:Analysis of prospectively collected menstrual bleed and estrone-3-glucuronide data. SETTING:Center for Population and Health, Georget...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2012.07.1101
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To determine whether blood leukocyte populations could be modulated in endometriosis. DESIGN:Case-control study. SETTING:Eight clinical institutions of the Montreal area. PATIENT(S):Women with regular menstrual cycles who underwent laparoscopy or laparotomy between 1997 and 2001 and who were not under horm...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/s0015-0282(03)00552-1
更新日期:2003-07-01 00:00:00
abstract::Seminal fluid is often viewed as simply a vehicle to carry sperm to fertilize the oocyte, but a more complex function in influencing female reproductive physiology is now evident. Remarkably, seminal fluid contains soluble and exosome-born signaling agents that interact with the female reproductive tract to prime the ...
journal_title:Fertility and sterility
pub_type: 杂志文章,评审
doi:10.1016/j.fertnstert.2016.07.1101
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the reproductive outcome of infertile couples undergoing assisted reproduction techniques (ART) with or without human papillomavirus (HPV) semen infection. DESIGN:Cross-sectional clinical study. SETTING:Units of andrology, reproductive medicine, and gynecology. PATIENT(S):A total of 226 inferti...
journal_title:Fertility and sterility
pub_type: 杂志文章
doi:10.1016/j.fertnstert.2015.09.018
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:To assess the safety and effectiveness of a sprayable, site-specific adhesion barrier system (SprayGel; Confluent Surgical, Waltham, MA) for reduction of adhesion formation. DESIGN:Prospective, randomized, controlled phase III trial. SETTING:University clinic (Kiel, Germany) and private clinic (Bordeaux, Fr...
journal_title:Fertility and sterility
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1016/j.fertnstert.2003.12.046
更新日期:2004-08-01 00:00:00