Abstract:
OBJECTIVE:To determine the relationship of age to side-effects leading to discontinuation of treatment in patients with stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with maintenance bacille Calmette-Guérin (BCG). PATIENTS AND METHODS:We evaluated toxicity for 487 eligible patients with intermediate- or high-risk Ta-T1 (without carcinoma in situ) NMIBC randomised to receive 3 years of maintenance BCG therapy (247 BCG alone and 240 BCG + isoniazid) in European Organisation for Research and Treatment of Cancer Genito-Urinary Group trial 30911. The percentage of patients who stopped for toxicity and the number of treatment cycles that they received were compared in four age groups, ≤60, 61-70, 71-75 and >75 years, using the Mantel-Haenszel chi-square test for trend. RESULTS:The percentage of patients stopping BCG for toxicity was 17.9% in patients aged ≤60 years, 21.9% in patients aged 61-70 years, 22.9% in patients aged 71-75 years, and 16.4% in patients aged >75 years (P = 0.90). For both systemic and local side-effects, there was likewise no significant difference. CONCLUSION:In patients with intermediate- and high-risk Ta-T1 NMIBC treated with BCG, no differences in toxicity as a reason for stopping treatment were detected based on patient age.
journal_name
BJU Intjournal_title
BJU internationalauthors
Oddens JR,Sylvester RJ,Brausi MA,Kirkels WJ,van de Beek C,van Andel G,de Reijke TM,Prescott S,Alfred Witjes J,Oosterlinck Wdoi
10.1111/bju.13474subject
Has Abstractpub_date
2016-09-01 00:00:00pages
423-8issue
3eissn
1464-4096issn
1464-410Xjournal_volume
118pub_type
杂志文章,随机对照试验abstract:OBJECTIVES:To evaluate the safety and efficacy of stereotactic radiotherapy (SRT) in patients with metastatic renal cell carcinoma (mRCC) concurrently receiving targeted therapy (TT) or immunotherapy. PATIENTS AND METHODS:Data on patients with mRCC were extracted from a retrospective international multicentre register...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15284
更新日期:2020-10-28 00:00:00
abstract::OBJECTIVE To evaluate the indications for penile prosthesis implantation in the treatment of erectile dysfunction (ED) before and after the introduction of sildenafil. PATIENTS AND METHODS Penile prosthesis implantation was indicated in 144 men with ED at our institution between 1992 and 2007; 83 (55.6%) accepted the ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08356.x
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14393
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To assess the effect of antimuscarinic treatment with tolterodine combined with behavioural modification as a first-line treatment, before invasive investigation, in children with non-neurogenic voiding dysfunction but no obvious anatomical or neurogenic cause. PATIENTS AND METHODS:The study comprised 44 chi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05641.x
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVE:To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHO...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06496.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To determine the sensitivity of the direct radionuclide cystogram (DRC) in detecting vesico-ureteric reflux compared with the micturating cysto-urethrogram (MCU) in the same initial setting, in infants younger than one year. PATIENTS AND METHODS:The results from the dual cystograms of 62 refluxing infants < ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00997.x
更新日期:2001-01-01 00:00:00
abstract::The first two reviews are from the same unit in Germany and describe the well-known but still much discussed ways of improving the prognosis of patients undergoing cystectomy for bladder cancer. The authors review the roles of lymph node dissection and perioperative chemotherapy, and draw conclusions which will be of ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07114.x
更新日期:2007-12-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (case series). Level of Evidence 4. What's known on the subject? And what does the study add? Adverse outcomes after radical prostatectomy are more often recorded in the elderly. In the USA, elderly patients undergoing radical prostatectomy are treated at institutions where suboptimal out...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10554.x
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of hypoxia-inducible factor-1alpha (HIF-1alpha) over-expression on the invasion-associated proteins in human prostate cancer cells, as HIF-1alpha is a transcriptional factor that could activate genes involved in the response to hypoxia, but might also enhance the invasive potency of pro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06480.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To investigate in a prospective, observational study whether transperineal prostate biopsy (TPbx) results in patient-reported quality-of-life (QoL) changes from baseline in the first 3-months after TPbx. PATIENTS AND METHODS:Consenting patients completed the 26-item Expanded Prostate cancer Index Composite (...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13413
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:To identify predictors for long-term urinary leakage after radical prostatectomy. PATIENTS AND METHODS:A consecutive series of 1411 patients who underwent radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital between 2002 and 2006 were invited to comple...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10231.x
更新日期:2011-11-01 00:00:00
abstract::The development of new imaging techniques and the refinement of established methods in uroradiological imaging is proceeding rapidly. In the last few years several important developments have been implemented in the routine diagnostic evaluation of urological patients.A milestone is the recent advent of multidetector ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2002.02620.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO). PATIENTS AND METHODS:In all, 255 children and adolescents (aged 1-18 years) with NDO ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.08093.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13011
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management. PATIENTS AND METHODS:We report a single-centre series of de novo RCC in allografts from a cohort of 2396 consecutive renal transplant recipients. RESULTS:In all, 17 RCCs were detected in 12 patients,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10315.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVES:To present long-term oncological outcomes of patients with paratesticular sarcoma treated by a multidisciplinary team. PATIENTS AND METHODS:Patients managed at the Princess Margaret Cancer Centre, between 1990 and 2012, were analysed. A sarcoma expert performed central pathology review. Kaplan-Meier graphs ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14775
更新日期:2019-11-01 00:00:00
abstract::Lower urinary tract symptoms (LUTS), benign prostatic obstruction (BPO), and the overactive bladder have increasing prevalence with age in both men and women (with the obvious exception). The question is, are they interrelated or independently related to age? The specific issue is whether BPO causes the overactive bla...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410x.2000.tb16953.x
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVES:To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00990.x
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVES:To externally validate the currently available nomograms for predicting lymph node invasion (LNI) in patients with prostate cancer (PCa) and to assess the potential risk of complications of extended pelvic lymph node dissection (ePLND) when using the recommended threshold. METHODS:A total of 14 921 patients...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15220
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and effectiveness of the Seldinger technique by non-urology trained (NUT) doctors for difficult male indwelling urinary catheter (IDC) insertions. PATIENTS AND METHODS:In all, 115 patients and 57 participating NUT doctors were recruited by the urologist or urology registrar, when conta...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13928
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:To explore the spontaneous regeneration, over a long period, of the seriously injured sympathetic pathway controlling the prostate. MATERIALS AND METHODS:The hypogastric nerve (HGN), which is part of the sympathetic pathway from the spinal cord to the prostate, was partly removed over half of its length on ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04222.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To compare changes in regional cerebral blood flow (rCBF), using positron emission tomography (PET), during chronic and acute sacral neuromodulation (SN). SN is an effective long-term treatment for chronic urge incontinence due to urinary bladder hyperactivity, as sensory nerves, spinal and supraspinal struct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06521.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the comparative effectiveness of electromyographic (EMG) biofeedback with verbal instructions as learning tools of pelvic muscle exercises (PMEs) in the early management of urinary incontinence after radical prostatectomy. PATIENTS AND METHODS:Forty-two consecutive patients (mean age 64 years, sd...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1046/j.1464-410x.2002.02721.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVES:To retrospectively review hypogonadal men receiving testosterone replacement therapy (TRT), and evaluate the changes in prostate-specific antigen (PSA) levels over an extended period, and thus evaluate the occurrence of prostate cancer, as a primary concern in treating late-onset hypogonadism (LOH) is the po...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08240.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To assess the clinical pattern of progression and prostate-specific antigen doubling time (PSA-DT) after exposure to docetaxel-based chemotherapy in patients with androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:Fifty-five patients received docetaxel-based chemotherapy; data were collected r...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2007.07037.x
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:To review our experience of using the tubularized incised plate (TIP) urethroplasty (useful in the treatment of distal hypospadias) to treat proximal hypospadias. MATERIALS AND METHODS:From March 1997 to March 2000 primary repairs were carried out on 40 boys (mean age 4.5 years) with proximal hypospadias. Af...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00966.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To determine if FK506-binding proteins (FKBPs) are localized to the autonomic nerve supply of the human penis because FK506 (an immunosuppressant drug) has been linked to enhanced nerve regeneration after nerve injury and neurodegenerative diseases by binding to FKBPs, a select group of immunophilins. MATERI...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07290.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To test the hypothesis that benign prostatic hyperplasia (BPH) robotic surgery with aquablation would have a more pronounced benefit in certain patient subgroups, such as men with more challenging anatomies (e.g. large prostates, large middle lobes) and men with moderate BPH. METHODS:We conducted prespecifie...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14426
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between adult male circumcision and sexual satisfaction and function in men, as observational studies on the effect of adult male circumcision on sexual satisfaction show conflicting results. SUBJECTS AND METHODS:We investigated self-reported sexual satisfaction and function a...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2007.07369.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To evaluate the reliability and validity of the Premature Ejaculation Profile (PEP), a self-reported outcome instrument for evaluating domains of PE and its treatment, comprised of four single-item measures, a profile, and an index score. SUBJECTS AND METHODS:Data were from men participating in observational...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2008.08041.x
更新日期:2009-02-01 00:00:00