Abstract:
OBJECTIVES:To present long-term oncological outcomes of patients with paratesticular sarcoma treated by a multidisciplinary team. PATIENTS AND METHODS:Patients managed at the Princess Margaret Cancer Centre, between 1990 and 2012, were analysed. A sarcoma expert performed central pathology review. Kaplan-Meier graphs compared local recurrence (LR), metastasis, and overall survival (OS) of patients treated with hemiscrotectomy vs those who did not. Univariable Cox proportional hazards analysis was performed to delineate predictors of LR, metastasis, and OS. RESULTS:Overall, 51 patients with a median (interquartile range) follow-up of 132 (51.6-226.8) months were analysed. At presentation, 92.2% (47 patients) had localised disease. Only five patients (9.8%) had undergone initially planned hemiscrotectomy. Completion and salvage hemiscrotectomy was performed in 25 (54.3%) and seven (15.2%) patients, respectively. Recurrence and metastasis occurred in 12 (25.5%) and 10 patients (19.6%), respectively. At the last follow-up, 21.6% (11 patients) had died, with eight dying from their disease. Kaplan-Meyer graphs demonstrated that hemiscrotectomy improved LR (median not reached vs 62.4 months, log-rank P = 0.008) and OS (median not reached vs 168 months, log-rank P = 0.081). Univariable analysis found hemiscrotectomy to be associated with a lower LR rate (hazard ratio [HR] 0.21, P = 0.02), whilst positive margins at initial surgery were associated with increased LR (HR 4.81, P = 0.047). No metastasis predictors were found, but age (HR 1.04, 95% confidence interval [CI] 1.0-1.08; P = 0.02) and non-localised disease at presentation (HR5.17, 95% CI 1.33-20.06; P = 0.017) were associated with worse OS. CONCLUSION:Paratesticular sarcoma is a rare tumour, predominantly manifesting as localised disease. Most patients receive an initial suboptimal oncological surgery. Improved long-term outcomes are demonstrated following early hemiscrotectomy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Goldberg H,Wong LM,Dickson B,Catton C,Yap SA,Alkasab T,Evans A,van der Kwast T,Jewett MAS,Hamilton RJdoi
10.1111/bju.14775subject
Has Abstractpub_date
2019-11-01 00:00:00pages
801-810issue
5eissn
1464-4096issn
1464-410Xjournal_volume
124pub_type
杂志文章abstract:OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cance...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07474.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:• To examine how the introduction of medical therapy for symptomatic benign prostatic hyperplasia (BPH) might have changed the indications, patient characteristics and outcomes in men undergoing transurethral resection of the prostate (TURP) over two decades (1988-2008). PATIENTS AND METHODS:• All patients w...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09737.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To conduct a meta-analysis of the literature on the peri-operative outcomes of both robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN). MATERIALS AND METHODS:An electronic database search of MEDLINE, EMBASE, Google Scholar and the Cochrane Library was performed for publicati...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/bju.12255
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To report on the failure of thalidomide to inhibit tumour growth in an animal model of human renal cell carcinoma (RCC). MATERIALS AND METHODS:An orthotopic xenograft model of human RCC was used in which tumour cells were implanted in the left kidney of male 'severe combined immunodeficient' mice. Thalidomid...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02666.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09808.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:To determine the most frequent urodynamic observations associated with bladder calculi, and to assess whether the presence of calculi alters these observations. PATIENTS AND METHODS:Fifty patients with bladder stones were included in a prospective study in which two urodynamic tests were used, one at inclus...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04815.x
更新日期:2004-06-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (economic analysis). LEVEL OF EVIDENCE:1b. OBJECTIVE:To assess and compare the costs and effects value of either starting with sacral neuromodulation (SNM) or botulinum toxin A (BTX) treatment in patients with refractory idiopathic overactive bladder from a societal perspective. MATER...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09905.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To compare prospectively obtained symptom scores (pre-tests) with retrospective assessment (then-tests) in patients with newly diagnosed advanced prostate cancer. PATIENTS AND METHODS:Patients with newly diagnosed locally advanced or metastatic prostate cancer were recruited. They completed the International...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2003.04462.x
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To evaluate whether injection with pericapsular lignocaine before transrectal ultrasonography (TRUS)-guided biopsy reduces the perceived pain of prostatic biopsy. PATIENTS AND METHODS:The study included 121 patients referred for TRUS-guided biopsy of the prostate; 27 underwent biopsy with no previous injecti...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2002.03025.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To aid the interpretation of the trends in prostate cancer mortality, which declined in the UK in the early 1990 s for unknown reasons, by investigating prostate cancer death rates, incidence and treatments in England and Wales in 1975-2004. METHODS:Join-point regression was used to assess secular trends in ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07338.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test. MATERIALS AND METH...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04185.x
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS:Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybri...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00654.x
更新日期:2000-06-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (outcomes) Level of Evidence 2b What's known on the subject? and What does the study add? Data on the oncological outcomes in patients undergoing salvage cystectomy for recurrent disease following bladder-sparing treatment is limited and mostly based on case reports. We present the clini...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11438.x
更新日期:2013-03-01 00:00:00
abstract::The development of new imaging techniques and the refinement of established methods in uroradiological imaging is proceeding rapidly. In the last few years several important developments have been implemented in the routine diagnostic evaluation of urological patients.A milestone is the recent advent of multidetector ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2002.02620.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:To compare targeted, transperineal magnetic resonance imaging (MRI)/ultrasound (US)-fusion biopsy to systematic transrectal biopsy in patients with previous negative or first prostate biopsy and to evaluate the gain in diagnostic information with systematic biopsies in addition to targeted MRI/US-fusion biop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13023
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To test the replicability and robustness of findings about urological symptoms in men and women, classified using an objective statistical method, cluster analysis, by planned sensitivity analyses conducted within and across two large, epidemiological studies of lower urinary tract symptoms. METHODS:Sensitiv...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07653.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08359.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To report our 12-year experience with radiological treatment (ureteric embolization) for refractory urinary fistula, as malignancy, radiation therapy, and/or chronic inflammation increase the risk of lower urinary tract fistula after surgical urinary diversion, which can lead to significant morbidity, and for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06569.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To accurately define the anatomy of the neurovascular bundle (NVB) in men. MATERIALS AND METHODS:The NVB was microdissected in detail bilaterally in 12 fixed human male adult cadavers. The anatomy of the NVB and its relationship to surrounding pelvic structures was ascertained in each specimen. RESULTS:Prev...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05106.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of dutasteride and tamsulosin as combined therapy compared with each monotherapy for improving patient-reported health outcomes in men with moderate-to-severe urinary symptoms and prostate enlargement, reporting the pre-planned 2-year analyses from the CombAT trial. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2009.08196.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To explore the effect of intravesical instillation of green tea extract (GTE) on a rat model of bacterial cystitis. MATERIALS AND METHODS:In vitro bactericidal properties of GTE were analysed by adding GTE to a suspension of uropathogenic E. coli (UPEC), streaking on MacConkey agar, and incubating overnight....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12544
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:• To report outcomes for patients with localized prostate cancer managed using a watchful waiting strategy at an American centre and to explore factors that have triggered intervention. PATIENTS AND METHODS:• From 1991 to 2005, 218 patients diagnosed with untreated localized prostate cancer were followed at ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09652.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between renal tumour complexity and outcomes in a large cohort of patients undergoing percutaneous cryoablation (PCA). PATIENTS AND METHODS:Patients with renal tumours treated with PCA were identified using our prospectively maintained ablation registry (2003-2015). Salvage proced...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13841
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To propose a standardisable composite method for reporting outcomes of radical cystectomy (RC) that incorporates both perioperative morbidity and oncological adequacy. PATIENTS AND METHODS:From July 2010 to December 2017, 277 consecutive patients who underwent robot-assisted RC with intracorporeal urinary di...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14861
更新日期:2020-01-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and what does the study add?: Variations in the type of urinary diversion exist for patients undergoing radical cystectomy. Although its use has been increasing from 2001 to 2008, patients who are older, female, and primary insured by Medicaid are less likely to receive continent...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11508.x
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00028.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVES:• To investigate whether cysteine-rich secretory protein 3 (CRISP-3) and/or β-microseminoprotein (β-MSP) expression in diagnostic prostate needle biopsies have predictive value for prostate cancer (PC) on radical prostatecomy (RP). • To evaluate their potential clinical implementation in a preoperative setti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10059.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To describe a technique for transurethral tumour inoculation, bioluminescence imaging (BLI) and validation of this approach using ex vivo magnetic resonance imaging (MRI), as a reproducible and quantifiable model of orthotopic bladder cancer is required to enable preclinical pharmacological studies of intrav...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07165.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:To investigate the effect of patient age on the stone-free rate (SFR) in patients with urinary calculi treated by extracorporeal shockwave lithotripsy (ESWL). PATIENTS AND METHODS:In all, 2192 solitary radio-opaque urinary stones of 5-15 mm were identified in adult patients receiving primary ESWL. Patients ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06909.x
更新日期:2007-08-01 00:00:00
abstract::Erectile dysfunction is common in the ageing man and reliable therapies are needed. The pathophysiology of erectile dysfunction in this group mainly includes chronic ischaemia, which triggers the deterioration of cavernosal smooth muscle and the development of corporeal fibrosis. Assessing the ageing man with erectile...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2003.04378.x
更新日期:2003-09-01 00:00:00