Abstract:
OBJECTIVE:To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management. PATIENTS AND METHODS:We report a single-centre series of de novo RCC in allografts from a cohort of 2396 consecutive renal transplant recipients. RESULTS:In all, 17 RCCs were detected in 12 patients, representing 0.5% of kidney recipients. The mean patient age was 55 years and the time to RCC diagnosis since transplantation was 13 years. The mean diameter of the RCC was 23 mm. Biopsies were taken in all cases. Concordance between biopsy and surgical specimens was 100% for nuclear grade and pathological type. Four graft removals were performed and six patients underwent nephron-sparing surgery (NSS). Two cryoablations were performed. Overall, nine papillary RCC, five clear cell carcinomas, and one chromophobe cell carcinoma were removed surgically. The mean follow-up was 43 months. One local recurrence was reported in a patient treated by NSS. CONCLUSIONS:Our findings support evidence that radiological screening of kidney recipients allows the detection of small tumours for which a conservative management by NSS or non-surgically destructive techniques can be proposed with mid-term oncological safety. Systematic tumour biopsy may help in the management and treatment decision. Several questions remain unanswered such as the importance of mammalian target of rapamycin inhibitors in the chemoprevention of the recurrence and the genetic cell origin of RCC in renal grafts.
journal_name
BJU Intjournal_title
BJU internationalauthors
Ploussard G,Chambade D,Meria P,Gaudez F,Tariel E,Verine J,De Bazelaire C,Peraldi MN,Glotz D,Desgrandchamps F,Mongiat-Artus Pdoi
10.1111/j.1464-410X.2011.10315.xsubject
Has Abstractpub_date
2012-01-01 00:00:00pages
195-9issue
2eissn
1464-4096issn
1464-410Xjournal_volume
109pub_type
杂志文章abstract:OBJECTIVE:To describe a clinical subtype of urinary incontinence (UI) after a stroke, i.e. with impaired awareness of the need to void (IA-UI), and to compare it to urge UI after a stroke for the risk factors and medium-term outcome. PATIENTS AND METHODS:In a consecutive sample of 315 hospitalized stroke patients who ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06754.x
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:To compare the serum levels of insulin-like growth factor-1 (IGF-1) in patients with prostate cancer and in control patients with no malignancy, and to evaluate any possible influence of testicular androgen withdrawal on the level of IGF-1 in patients with prostate cancer. PATIENTS AND METHODS:IGF-1 was mea...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00350.x
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:To determine whether the temperature of 2% lignocaine hydrochloride gel affects the initial discomfort during instillation into the male urethra. PATIENTS AND METHODS:Sixty consenting men were randomized to receive 11 mL of 2% lignocaine hydrochloride gel (Instillagel, Farco-Pharma GmbH, Cologne, Germany) at...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.1999.00346.x
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract::OBJECTIVE To investigate the incidence of new-onset diabetes mellitus (NODM) and of worsening glycaemic control in established DM after starting androgen-deprivation therapy (ADT) for prostate cancer, as ADT is associated with altered body composition, potentially influencing insulin sensitivity. PATIENTS AND METHODS ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07184.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between symptom severity and patient perceptions in patients with overactive bladder (OAB), as estimated by OAB Symptom Score (OABSS) and patient-reported outcome measures, respectively. PATIENTS AND METHODS:Post-hoc analyses were conducted on the existing data from patients with O...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08498.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between renal tumour complexity and outcomes in a large cohort of patients undergoing percutaneous cryoablation (PCA). PATIENTS AND METHODS:Patients with renal tumours treated with PCA were identified using our prospectively maintained ablation registry (2003-2015). Salvage proced...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13841
更新日期:2017-06-01 00:00:00
abstract::Prostate cancer (PCa) is the most common form of cancer in men in the developed world and the second leading cause of cancer-related deaths. While advanced PCa is initially controlled with hormonal therapies targeting the androgen receptor (AR) pathway, recurrence occurs because of the emergence of lethal castration-r...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14207
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To purify human muscle-derived cells (hMDCs) that could be used for managing urinary incontinence, erectile dysfunction and for bladder reconstitution. MATERIALS AND METHODS:hMDCs isolated by a modified preplate technique (MPT) from skeletal muscles of limbs were purified by CD34 antibody and magnetic Dynabe...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09032.x
更新日期:2010-06-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Sunitinib and sorafenib are orally administered multikinase inhibitors approved for the treatment of advanced RCC. The limited pharmacokinetics data on sunitinib and sorafenib suggest that haemodialysis does not significantly alter plasma concentratio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10946.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To examine patterns of care among women with urogenital fistula treated in the English National Health Service (NHS) between 2000 and 2009. To assess whether failure of repair was associated with hospital or surgeon workload. PATIENTS AND METHODS:We conducted a retrospective cohort study using data from Hos...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11483.x
更新日期:2013-04-01 00:00:00
abstract:OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2002.02674.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To report the incidence, risk factors, and outcomes of subcapsular renal haematoma (SRH) after ureteroscopic lithotripsy (URSL) using holmium:yttrium-aluminum-garnet (Ho:YAG) laser to treat ureteric stones. PATIENTS AND METHODS:Prospective data from 2848 URSLs performed between January 2003 and September 201...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10490.x
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVE:To report our experience with the Safyre (Promedon, Cordoba, Argentina), a new re-adjustable and minimally invasive sling for treating stress urinary incontinence (SUI), which combines the efficacy of slings with re-adjustability. PATIENTS AND METHODS:In all, 126 consecutive patients with a clinical and urod...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05295.x
更新日期:2005-02-01 00:00:00
abstract:UNLABELLED:Study Type--Clinical (prospective trial) Level of Evidence 2b. What's known on the subject? and What does the study add? In clinical practice, we know that it is necessary to identify new biomarkers that can better detect prostate cancer (PC), at the same time as reducing the number of unnecessary biopsies. ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2012.11146.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To determine the role of hypoxia-inducible factor-2alpha (HIF2alpha) on the sensitivity of renal cell carcinoma (RCC) cell lines to ionizing radiation and to determine if the mTOR antagonist, rapamycin, could decrease HIF2alpha protein levels. MATERIALS AND METHODS:Cell lines expressing stable short-hairpin ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07558.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To examine, in a retrospective analysis of outcome based on prostate-specific antigen (PSA) levels, whether the 1992 and revised 1997 staging criteria for prostate cancer can be used to predict progression-free survival for patients after radical prostatectomy for pT2 and pT3 prostate cancer. PATIENTS AND ME...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.02420.x
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08984.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To aid the interpretation of the trends in prostate cancer mortality, which declined in the UK in the early 1990 s for unknown reasons, by investigating prostate cancer death rates, incidence and treatments in England and Wales in 1975-2004. METHODS:Join-point regression was used to assess secular trends in ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07338.x
更新日期:2008-03-01 00:00:00
abstract:OBJECTIVE:To present our initial experience in children undergoing single-port laparoscopic varicocelectomy (SPLV) using a new approach in which the entire procedure is performed through a multichannel single laparoscopic port inserted in the umbilicus rather than the traditional LV performed through three abdominal po...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07584.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To compare the effectiveness and safety of standard percutaneous nephrolithotomy (sPCNL) and super-mini PCNL (SMP). PATIENTS AND METHODS:A total of 150 patients presenting with renal calculi of <2 cm were randomised to either sPCNL (Group 1) or SMP (Group 2). Randomisation was based on centralised computer-g...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.15144
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To investigate the diagnostic performance of gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA PET/CT) in patients with recurrent prostate cancer with regard to the presence of lymph node metastases (LNM) and local recurrences after primary radiotherapy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15135
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. PATIENTS AND METHODS:From 2002 to 2007, 1256 men ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08845.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To investigate whether the antioxidant protection attributed to small heat-shock proteins (sHSPs) affects calcium oxalate stone formation, a pro-oxidant disease. MATERIALS AND METHODS:Canine distal tubular epithelial cells (Madin-Darby canine kidney, MDCK cells) were grown as confluent monolayers. Treatment ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06478.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To compare the demographic, behavioural, clinical and medical history characteristics of men with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and asymptomatic controls, to identify characteristics that might be associated with this syndrome. PATIENTS AND METHODS:Self-administered epidemiologic...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05684.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06350.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVE:To evaluate both the patterns of prescription of androgen deprivation therapy (ADT) in patients with prostate cancer (PCa) and the adherence to European Association of Urology (EAU) guidelines for ADT prescription. METHODS:The Choosing Treatment for Prostate Cancer (CHOICE) study was an Italian multicentre c...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13307
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:ERG-gene rearrangement defines a distinct molecular subtype of PCA with potential biological and clinical implications. To identify a molecular signature reflective of the downstream effects of ERG-mediated transcriptional regulation with prognostic implication in patients with prostate cancer (PCA). MATERI...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12262
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the proportion of patients achieving clinically meaningful improvement of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH-LUTS) with tadalafil using two definitions of response. PATIENTS AND METHODS:Post hoc integrated analysis of four placebo-controlled studies in m...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.12926
更新日期:2015-05-01 00:00:00
abstract:OBJECTIVE:To report our 5-year experience with laparoscopic and percutaneous cryoablation (LCA and PCA) for managing small renal masses. PATIENTS AND METHODS:We retrospectively analysed patients undergoing LCA and PCA between October 2000 and March 2006 at our institution. After approval from the Institutional Review ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07158.x
更新日期:2007-10-01 00:00:00