Abstract：
OBJECTIVE:To assess the relationship between symptom severity and patient perceptions in patients with overactive bladder (OAB), as estimated by OAB Symptom Score (OABSS) and patient-reported outcome measures, respectively. PATIENTS AND METHODS:Post-hoc analyses were conducted on the existing data from patients with OAB. In addition to the OABSS, patients completed three patient-reported outcome measures, the OAB questionnaire (OAB-q), Patient Perception of Bladder Condition (PPBC) and Medical Outcomes Study Short-Form 36 (SF-36). Relationships of the OABSS were assessed through correlations with the OAB-q, PPBC and SF-36; all analyses were exploratory. RESULTS:In all, 194 participants were analysed; the OABSS correlated relatively closely with the PPBC and OAB-q subscales of health-related quality of life (r = 0.36-0.57). There was a particularly good correlation with the OAB-q symptom bother (r = 0.73). However, the OABSS correlated somewhat less with the SF-36 subscales (r = 0.16-0.27). There were fairly close correlations between the OABSS and the OAB-q items; for daytime frequency with 'frequency of urination during daytime hours' (r = 0.44); night-time frequency with 'night-time urination' (r = 0.44), 'waking up at night because you had to urinate' (r = 0.51) and 'awakening from sleep' (r = 0.44); urgency with 'a sudden urge to urinate with little or no warning' (r = 0.65) and 'an uncontrollable urge to urinate' (r = 0.69), urgency incontinence with 'accidental loss of small amounts of urine' (r = 0.74) and 'urine loss associated with a strong desire to urinate' (r = 0.79). All the items except 'awakening from sleep' belonged to the OAB-q symptom bother domain. CONCLUSIONS:It is possible to roughly but sufficiently infer patient perceptions of bladder condition and symptom bother by measuring symptom severity, as estimated by the OABSS.
journal_name
BJU Intjournal_title
BJU internationalauthors
Homma Y,Gotoh Mdoi
10.1111/j.1464-410X.2009.08498.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
968-72issue
7eissn
1464-4096issn
1464-410Xpii
BJU8498journal_volume
104pub_type
杂志文章abstract：OBJECTIVE:To explore whether a panel of kallikrein markers in blood: total, free and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2, could be used as a non-invasive alternative for predicting prostate cancer on biopsy in a screening setting. SUBJECTS AND METHODS:The study cohort comprised pr...
journal_title：BJU international
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1464-410X.2012.11690.x
更新日期：2013-09-01 00:00:00
abstract：UNLABELLED:Study Type--Clinical (prospective trial) Level of Evidence 2b. What's known on the subject? and What does the study add? In clinical practice, we know that it is necessary to identify new biomarkers that can better detect prostate cancer (PC), at the same time as reducing the number of unnecessary biopsies. ...
journal_title：BJU international
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1464-410X.2012.11146.x
更新日期：2012-12-01 00:00:00
abstract：OBJECTIVE:To evaluate changes in protein leakage in the glomerular filtration barrier, and in the ability of the tubule to reabsorb proteins during and after acute urinary retention (AUR). PATIENTS AND METHODS:Glomerular and tubular function was investigated in 24 men during AUR (mean age 68 years, mean retention time...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2001.02047.x
更新日期：2001-02-01 00:00:00
abstract：OBJECTIVE:To investigate the effect on cancer detection by varying the number of cores taken for prostate biopsy according to the size of the prostate. PATIENTS AND METHODS:A retrospective review of a prospectively registered prostate biopsy database identified 3040 consecutive patients undergoing prostate biopsy at a...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2011.10239.x
更新日期：2011-11-01 00:00:00
abstract：OBJECTIVE:To retrospectively review the long-term activity, efficacy and toxicity of the combination of paclitaxel, cisplatin and gemcitabine (TPG) as third- or further-line chemotherapy in patients with germ-cell tumours (GCTs) who are not cured after at least two courses of standard-dose chemotherapy, high-dose chemo...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2009.08453.x
更新日期：2009-08-01 00:00:00
abstract：OBJECTIVE:To evaluate how many patients could have undergone partial nephrectomy (PN) rather than radical nephrectomy (RN) before and after neoadjuvant axitinib therapy, as assessed by five independent urological oncologists, and to study the variability of inter-observer agreement. PATIENTS AND METHODS:Pre- and post-...
journal_title：BJU international
pub_type： 杂志文章,随机对照试验
doi：10.1111/bju.13188
更新日期：2016-04-01 00:00:00
abstract：:Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor...
journal_title：BJU international
pub_type： 杂志文章,meta分析,评审
doi：10.1111/j.1464-410X.2008.07496.x
更新日期：2008-03-01 00:00:00
abstract：OBJECTIVES:To describe temporal changes in patient characteristics and outcomes for radical cystectomy (RC) in England between 1995 and 2002, using routinely collected administrative data. PATIENTS AND METHODS:Data were extracted from the Hospital Episode Statistics database of the Department of Health in England, des...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2005.05329.x
更新日期：2005-03-01 00:00:00
abstract：OBJECTIVE:To purify human muscle-derived cells (hMDCs) that could be used for managing urinary incontinence, erectile dysfunction and for bladder reconstitution. MATERIALS AND METHODS:hMDCs isolated by a modified preplate technique (MPT) from skeletal muscles of limbs were purified by CD34 antibody and magnetic Dynabe...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2009.09032.x
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To determine whether robotic-assisted laparoscopic radical prostatectomy (RALP) is associated with a lower transfusion rate than radical retropubic prostatectomy (RRP). PATIENTS AND METHODS:In this cohort study, we evaluated 1244 consecutive patients who underwent RALP (830) or RRP (414) between June 2003 an...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2010.09233.x
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:• To investigate the relationship between pretreatment testosterone levels and pathological specimen characteristics, by prospectively examining serum androgen concentrations in a well-studied cohort of patients who underwent radical prostatectomy (RP) for localized prostate cancer. PATIENTS AND METHODS:• A ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2010.09816.x
更新日期：2011-05-01 00:00:00
abstract：OBJECTIVES:To investigate whether micronutrients in support of the one-carbon cycle and glutathione synthesis are effective in improving sperm damage after surgical varicocoele induction in rats and whether any effect is achieved without a rebound reductive stress as seen with oral antioxidants. MATERIALS AND METHODS:...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.14385
更新日期：2018-09-01 00:00:00
abstract：OBJECTIVE:To evaluate whether the position of the working channel affects the effectiveness of flexible ureteroscopy. MATERIALS AND METHODS:We compared the ureteroscopes Flex-X2S and Flex-XC (working channel at the 9 and 3 o'clock positions, respectively) in eight cavities of a K-Box model, simulating the distribution...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.14923
更新日期：2020-03-01 00:00:00
abstract：OBJECTIVE:To present our experience of cavernous nerve graft reconstruction, using an autologous nerve vein-guide technique, to restore potency. PATIENTS AND METHODS:Prostate cancers frequently require radical resection involving one or both cavernous nerves that usually results in erectile dysfunction; nerve grafting...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2007.07068.x
更新日期：2007-11-01 00:00:00
abstract：:Docetaxel-based therapy is established as the standard first-line chemotherapy in patients with metastatic castration-resistant prostate cancer (mCRPC), based on results from two landmark Phase III studies. However, prognosis remains poor, with a median survival of less than 2 years. There is no standard of care for p...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2010.10036.x
更新日期：2011-04-01 00:00:00
abstract：OBJECTIVE:To validate a hypothesis that prostate cancer can be detected non-invasively by a simple and reliable assay by targeting genomic VPAC receptors expressed on malignant prostate cancer cells shed in voided urine. PATIENTS/SUBJECTS AND METHODS:VPAC receptors were targeted with a specific biomolecule, TP4303, de...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.13775
更新日期：2017-06-01 00:00:00
abstract：UNLABELLED:Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen de...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2011.10728.x
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To obtain community-based information about the incidence of interstitial cystitis, a chronic disabling condition of the bladder where knowledge is limited because there are no definitive diagnostic criteria. PATIENTS AND METHODS:All residents of Olmsted County, MN, USA who had received a physician-assigned ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2003.04060.x
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:To assess the prevalence of obstructive sleep apnoea (OSA) in men presenting with erectile dysfunction (ED) at a single centre. PATIENTS AND METHODS:All men attending a specialised andrology outpatient department with a new diagnosis of ED were included in this prospective study. All patients completed three...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/bju.13961
更新日期：2017-12-01 00:00:00
abstract：OBJECTIVE:To evaluate whether the degree of preoperative bladder trabeculation in neurogenic bladder (NB) patients is a marker of significant outlet resistance. If so, severe trabeculation may obviate the need for concomitant bladder outlet procedure (BOP) during augmentation cystoplasty (AC). PATIENTS AND METHODS:We ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2007.07164.x
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:To describe the preclinical pharmacology of Ro 115-1240, a peripherally acting selective alpha1A/1L-adrenoceptor (AR) partial agonist, compared with the alpha1A/1L-AR full agonist amidephrine, as AR agonists have some utility in the treatment of stress urinary incontinence (SUI) but are limited by undesirable...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410x.2004.04577.x
更新日期：2004-01-01 00:00:00
abstract：OBJECTIVE:To confirm abnormal glycosylation of Tamm-Horsfall protein (THP) in patients with interstitial cystitis (IC). PATIENTS, SUBJECTS AND METHODS:The sialic acid content of THP, a critical component of its biological activity, is reduced in patients with IC. N-glycan shows reduced levels of high molecular weight ...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2008.08163.x
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVES:To compare the serum levels of insulin-like growth factor-1 (IGF-1) in patients with prostate cancer and in control patients with no malignancy, and to evaluate any possible influence of testicular androgen withdrawal on the level of IGF-1 in patients with prostate cancer. PATIENTS AND METHODS:IGF-1 was mea...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.2000.00350.x
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To determine whether conformity to standard recommendations of retroperitoneal lymph node dissection (RPLND) after chemotherapy for testicular and primary retroperitoneal nonseminomatous germ cell tumours (NSGCT) and completeness of surgical excision have an effect on oncological outcome. PATIENTS AND METHOD...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2009.09175.x
更新日期：2010-09-01 00:00:00
abstract：:Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1111/j.1464-410X.2008.07594.x
更新日期：2008-07-01 00:00:00
abstract：UNLABELLED:To determine whether dendritic cells (DC) transduced with the prostate-specific antigen (PSA) gene can induce PSA-specific cytotoxic lymphocytes (CTL) against prostate cancer cells, and whether bacillus Calmette-Guérin (BCG) cell-wall skeleton (CWS) can enhance the maturation of DC-PSA and the killing activi...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410x.2009.08703.x
更新日期：2009-12-01 00:00:00
abstract：OBJECTIVE:To investigate the effects of sildenafil on noradrenaline- and potassium-induced contractions of isolated human seminal vesicles (SVs), as premature ejaculation is a relatively common male sexual dysfunction that currently lacks an adequate therapy, and recent in vitro tests showed that sildenafil induces rel...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2007.07260.x
更新日期：2007-12-01 00:00:00
abstract：OBJECTIVE:To review the clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis reporting to a tertiary care hospital in Riyadh, and to compare these with other cases reported previously. PATIENTS AND METHODS:In this retrospective study, records of all 26 adult pa...
journal_title：BJU international
pub_type： 杂志文章,评审
doi：10.1046/j.1464-410x.2001.02243.x
更新日期：2001-07-01 00:00:00
abstract：OBJECTIVE:To describe our experience of penile urethral repair and reconstruction, cataloguing the change in practice from one-stage flap to two-stage free graft procedures for anterior urethroplasty. PATIENTS AND METHODS:Between January 1992 and December 1996, 79 patients underwent anterior urethroplasty. Of the 45 o...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1046/j.1464-410x.1999.00010.x
更新日期：1999-04-01 00:00:00
abstract：OBJECTIVE:To evaluate the effect of low-dose rate prostate brachytherapy on the sexual health of men with > or = 7 years of prospective evaluation and optimum sexual function before treatment. PATIENTS AND METHODS:In all, 223 patients with T1b to T3a prostate cancer and a median (range) age of 66 (50-82) years were tr...
journal_title：BJU international
pub_type： 杂志文章
doi：10.1111/j.1464-410X.2007.07016.x
更新日期：2007-08-01 00:00:00
