Abstract:
:Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor quality of life. There is no standard treatment for CP/CPPS. Patients report only transient relief of symptoms from currently available therapies and are frequently required to change treatments. The origin of LUTS and possibly the pelvic pain (e.g. on ejaculation) is thought to be prolonged smooth muscle contraction in the bladder and prostate, caused by alpha(1)-adrenoceptor activation. alpha(1)-Blockers are not indicated in the treatment of CP/CPPS but clinical experience suggests that they might be of benefit, possibly by promoting smooth muscle relaxation. Encouraging results of three phase II, randomized, placebo-controlled trials evaluating (using a validated instrument) the efficacy of alfuzosin, tamsulosin and terazosin in alpha(1)-blocker-naïve patients with CP/CPPS, support this hypothesis. The National Institute of Health and the National Institute of Diabetes and Digestive and Kidney Diseases are currently conducting a large phase III trial in 272 newly diagnosed and alpha(1)-blocker-naïve CP/CPPS patients randomized to received alfuzosin 10 mg once daily or placebo for 12 weeks.
journal_name
BJU Intjournal_title
BJU internationalauthors
Nickel JCdoi
10.1111/j.1464-410X.2008.07496.xsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
11-6eissn
1464-4096issn
1464-410Xpii
BJU7496journal_volume
101 Suppl 3pub_type
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pub_type: 临床试验,杂志文章
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更新日期:2006-11-01 00:00:00
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