Abstract:
OBJECTIVE:To determine if a decrease in oestrogen (E) levels increases activity in bladder afferent nerves, by investigating the effects of E loss on afferent nerve activity in ovariectomized (OVX) rats, and making comparisons with findings in ageing female rats. MATERIALS AND METHODS:Female Sprague-Dawley rats were divided into four groups: ageing; OVX+ E; OVX+ vehicle (V); and sham-operated (SHAM) + V. The E (250 µg/kg) or V (cottonseed oil) was injected s.c. once a week for 8 weeks. Frequency-volume recordings were performed with the rats in metabolic cages, and single Aδ- or C-fibre activities from the bladder were measured. After measurements, the blood serum was collected and the estradiol (E2) level was measured. RESULTS:The C-fibre activity of OVX + V rats was significantly lower than in the other groups. Aδ-fibre activity was unchanged. Despite low E2 levels, ageing rats showed high afferent activity and voiding frequency. CONCLUSION:Although a low E level may affect storage function, it is unlikely that it is the main cause of the high afferent activity and voiding frequency observed in the ageing female rat.
journal_name
BJU Intjournal_title
BJU internationalauthors
Aizawa N,Iijima K,Rosenbaum JS,Downs TR,Igawa Y,Andersson KE,Wyndaele JJdoi
10.1111/j.1464-410X.2010.09689.xsubject
Has Abstractpub_date
2011-07-01 00:00:00pages
E10-6issue
2 Pt 2eissn
1464-4096issn
1464-410Xjournal_volume
108pub_type
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