Abstract:
OBJECTIVE:To assess prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG scores in patients with advanced and metastatic prostate cancer at baseline and after 6 months of treatment with triptorelin 22.5 mg, and analyse these scores in patient-groups defined by different disease characteristics. PATIENTS AND METHODS:The Triptocare study was a prospective, open-label, multicentre, single-arm, Phase III study of triptorelin 22.5 mg in men with locally advanced or metastatic prostate cancer, who were naïve to androgen-deprivation therapy (ADT). The primary objective was to model the urinary PCA3 change at 6 months, according to baseline variables. Other outcome measures included urinary PCA3 and TMPRSS2-ERG scores and statuses, and serum testosterone and prostate-specific antigen (PSA) levels at baseline and at 1, 3 and 6 months after initiation of ADT. Safety was assessed by recording adverse events and changes in laboratory parameters. RESULTS:The intent-to-treat population comprised 322 patients; 39 (12.1%) had non-assessable PCA3 scores at baseline, and 109/322 (33.9%), 215/313 (68.7%) and 232/298 (77.9%) had non-assessable PCA3 scores at 1, 3 and 6 months, respectively. Baseline Gleason score was the only variable associated with non-assessability of PCA3 score at 6 months (P = 0.017) - the hazard of having a non-assessable PCA3 score at 6 months was 1.824-fold higher (95% confidence interval 1.186-2.805) in patients with a Gleason score ≥8 vs those with a Gleason score ≤6. The median PCA3 scores at baseline were significantly higher in patients aged ≥65 years vs those aged <65 years and in patients with a serum PSA level <100 ng/mL vs those with serum PSA level of >200 ng/mL. The median PCA3 score was significantly lower in patients with metastasis than in patients with no metastasis or unknown metastasis status. TMPRSS2-ERG scores ≥35 were considered positive (n = 149 [51.6%]). Age, presence of metastasis, PSA level and Gleason score at baseline were not associated with a significant difference in the proportion of TMPRSS2-ERG-positive scores. The median serum PSA levels decreased from 45.5 ng/mL at baseline to 1.2 ng/mL after 6 months, and as expected, >90% of patients achieved castrate levels of testosterone (<50 ng/dL) at 1, 3, and 6 months during triptorelin treatment. The safety profile reported from this study is consistent with the known safety profile of triptorelin. CONCLUSION:These data from the Triptocare study suggest that urinary PCA3 or TMPRSS2-ERG score are not reliable markers of cancer stage in advanced prostate cancer. Urinary PCA3 and TMPRSS2-ERG scores do not appear to be useful in assessing response to ADT in advanced prostate cancer, with most patients having non-assessable scores after 6 months of treatment.
journal_name
BJU Intjournal_title
BJU internationalauthors
Martínez-Piñeiro L,Schalken JA,Cabri P,Maisonobe P,de la Taille A,Triptocare Study Group.doi
10.1111/bju.12542subject
Has Abstractpub_date
2014-10-01 00:00:00pages
608-16issue
4eissn
1464-4096issn
1464-410Xjournal_volume
114pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To define changes in the clinical pathway for open radical retropubic prostatectomy (RRP) and to determine their impact on patient care under the indirect influence of minimally invasive prostatectomy after implementing robotically assisted laparoscopic prostatectomy (RALP) at our institution and modifying th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05993.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To determine the angiogenic profiles in the bladder of patients with bladder pain syndrome (BPS)/interstitial cystitis (IC), and to evaluate the relationship between these profiles and associated clinical features including pelvic pain and glomerulations. PATIENTS AND METHODS:Angiogenesis and angiogenic comp...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08467.x
更新日期:2009-09-01 00:00:00
abstract::For the delivery of good-quality external beam radiotherapy (EBRT) in localized prostate cancer, under-dosage to the peripheral zone (tumour) is one likely cause of poor results. The quality is improved by daily verification of the position of the prostate, and the use of magnetic resonance imaging (MRI) in delineatio...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07346.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:To describe metoidioplasty, a technique for creating a neophallus from an enlarged clitoris in female transsexuals, without needing the complex, multi-staged surgical construction of a large phallus, as this reconstruction is one of the most difficult in female transsexuals. PATIENTS AND METHODS:From Septemb...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2003.04524.x
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To assess atypical cytology as a positive bladder tumour marker and to determine if indexing atypical cytology to nuclear matrix protein-22 (NMP22) can decrease the false-positive results or increase the positive predictive value (PPV). PATIENTS AND METHODS:In all, 197 patients at risk of bladder cancer wer...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07789.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To establish the predictive accuracy of the Kattan preoperative nomogram by comparing predictions at 5 years with actual progression in patients who had a radical prostatectomy (RP). MATERIALS AND METHODS:We reviewed the data for 928 patients treated by RP as a first-line treatment for localized prostate can...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08473.x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To assess the feasibility of a pure endoscopic closure method for vesical perforations using fully absorbable material. MATERIALS AND METHODS:A pilot experimental study was performed in eight anaesthetized female pigs. Four 10-mm and four 20-mm endoscopic full thickness cystotomies were created. An endoscopi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12688
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To describe the characteristics of patients with and without positive surgical margins (PSMs) and to analyse the impact of PSMs on secondary cancer treatment after radical prostatectomy (RP), with short-term follow-up. PATIENTS AND METHODS:We analysed data from 2385 consecutive patients treated using RP, who...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12509
更新日期:2014-11-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of dutasteride and tamsulosin as combined therapy compared with each monotherapy for improving patient-reported health outcomes in men with moderate-to-severe urinary symptoms and prostate enlargement, reporting the pre-planned 2-year analyses from the CombAT trial. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2009.08196.x
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database. PATIENTS AND METHODS:The B...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07574.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of the learning curve on operative, postoperative, and pathological outcomes of the first 67 totally intracorporeal robot-assisted radical cystectomies (RARCs) with neobladders performed by two lead surgeons at Karolinska University Hospital. PATIENTS AND METHODS:Between December 2003 ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12347
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To investigate the possible protective role of insulin-like growth factor-1 (IGF-1, reported to have a protective effect in experimental models of hypoxic ischaemia), and the involvement of apoptotic cell death in a model of torsion/detorsion of the rat testis. MATERIALS AND METHODS:Adult male Wistar rats we...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04787.x
更新日期:2004-05-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Percutaneous renal cryoablation is a safe and effective treatment for patients with small renal masses, who are poor surgical candidates. Oncological outcomes from previous percutaneous ablation studies are difficult to interpret because of the large ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11230.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To report the experience of the last 4 years from a centre to which women with voiding difficulties and urinary retention were referred nationally, describing what investigations were helpful in making a diagnosis and the management strategies used. PATIENTS AND METHODS:Women with voiding difficulties and ur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06009.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of a genomic classifier (GC) test for predicting metastasis risk after radical prostatectomy (RP) on urologists' decision-making about adjuvant treatment of patients with high-risk prostate cancer. SUBJECTS AND METHODS:Patient case history was extracted from the medical records of eac...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12789
更新日期:2015-03-01 00:00:00
abstract:OBJECTIVE:We evaluated the current evidence for the use of acupuncture to treat erectile dysfunction (ED). METHODS:Systematic searches were conducted in 15 electronic databases, with no language restrictions. Hand-searches included conference proceedings and our files. All clinical studies of acupuncture as a treatmen...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2009.08422.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To investigate the correlation of transient receptor potential vanilloid subfamily 1 (TRPV1) mRNA expression levels and the clinical outcome of intravesical resiniferatoxin treatment in patients with idiopathic detrusor overactivity (IDO), as such treatment with vanilloids can be effective for DO. PATIENTS ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07151.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one of five reference centres for testicular neoplasm and infertility. PATIENTS AND METHODS:We review 25 cases of bilateral synchrone and metachrone...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12549
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To retrospectively review the long-term activity, efficacy and toxicity of the combination of paclitaxel, cisplatin and gemcitabine (TPG) as third- or further-line chemotherapy in patients with germ-cell tumours (GCTs) who are not cured after at least two courses of standard-dose chemotherapy, high-dose chemo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08453.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. PATIENTS AND METHODS:After obtaining ethical approval, 265 patients with locally confined or locally advanced/metastatic prostate cancer were identified and evaluated for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02981.x
更新日期:2002-10-01 00:00:00
abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To determine if patients who undergo tubularized incised-plate (TIP) urethroplasty need regular dilatation to prevent neourethral strictures or meatal stenosis. PATIENTS AND METHODS:The follow-up of two consecutive series of patients who underwent primary TIP hypospadias repair by one surgeon was reviewed. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01901.x
更新日期:2002-01-01 00:00:00
abstract:OBJECTIVE:To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy. PATIENTS AND METHODS:Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tula...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.09042.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To study the role of peroperative transrectal ultrasonography (peTRUS) for the dissection of the bladder neck during robot-assisted laparoscopic prostatectomy (RALP). PATIENTS AND METHODS:Integrated peTRUS in the da Vinci S system (Intuitive Surgical, Sunnyvale, CA, USA) was used for bladder neck identificat...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07830.x
更新日期:2008-09-01 00:00:00
abstract::OBJECTIVE To assess the effect of age and comorbidity on short-term complications, long-term continence and oncological outcome after laparoscopic radical prostatectomy (LRP) for localized prostate cancer. PATIENTS AND METHODS In all, 2048 consecutive men underwent LRP for localized prostate cancer in one institution....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09295.x
更新日期:2010-11-01 00:00:00
abstract::OBJECTIVE To evaluate the indications for penile prosthesis implantation in the treatment of erectile dysfunction (ED) before and after the introduction of sildenafil. PATIENTS AND METHODS Penile prosthesis implantation was indicated in 144 men with ED at our institution between 1992 and 2007; 83 (55.6%) accepted the ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08356.x
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:To present our initial operative experience in which single-port-light endoscopic robot-assisted reconstructive and extirpative urological surgery was performed by one surgeon, using a pig model. MATERIALS AND METHODS:This pilot study was conducted in male farm pigs to determine the feasibility and safety o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08955.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To characterize the clinical outcomes of androgen deprivation therapy (ADT) as the sole therapy for localized prostate cancer, and to determine independent predictors of disease progression, as recent studies indicate an increasing use of ADT. PATIENTS AND METHODS:The records of all patients with cT1-4NXM0 a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05674.x
更新日期:2005-09-01 00:00:00