Abstract:
OBJECTIVE:To investigate the effect of dutasteride and tamsulosin as combined therapy compared with each monotherapy for improving patient-reported health outcomes in men with moderate-to-severe urinary symptoms and prostate enlargement, reporting the pre-planned 2-year analyses from the CombAT trial.
PATIENTS AND METHODS:The CombAT study is an ongoing, international, double-blind, randomized, parallel-group trial. Men aged >or=50 years with a clinical diagnosis of benign prostatic hyperplasia (BPH), an International Prostate Symptom Score (IPSS) of >or=12 units, a prostate volume of >or=30 mL, a total serum prostate-specific antigen level of 1.5-10 ng/mL and a peak urinary flow of >5 and
journal_name
BJU Intjournal_title
BJU internationalauthors
Barkin J,Roehrborn CG,Siami P,Haillot O,Morrill B,Black L,Montorsi F,CombAT Study Group.doi
10.1111/j.1464-410X.2009.08196.xsubject
Has Abstractpub_date
2009-04-01 00:00:00pages
919-26issue
7eissn
1464-4096issn
1464-410Xpii
BJU8196journal_volume
103pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:To determine the effect of various treatments for benign prostatic hyperplasia (BPH) on sexual function. PATIENTS AND METHODS:In a longitudinal multicentre study carried out in the Netherlands, 670 consecutive patients with BPH (aged > or = 50 years) were examined at baseline and 9 months after inclusion. Al...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-4096.2001.01817.x
更新日期:2002-02-01 00:00:00
abstract::• Renal angiomyolipomas (AMLs) are usually easy to diagnose with imaging alone. They have unique characteristics on ultrasonography, computerised tomography and magnetic resonance imaging that usually allow AMLs to be differentiated from other renal masses. • If this is not possible on imaging criteria then biopsy can...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11618.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:To investigate the effects of a selective type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, IC486051, on bladder activity in normal rats and those with and bladder outlet obstruction (BOO), as inhibition of PDE4 leads to elevation of intracellular cAMP levels and relaxation of smooth muscle. MATER...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06643.x
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (case series) Level of Evidence 4. What's known on the subject? and What does the study add? Previous reports showed controversial evidence supporting the role of sex steroids, mainly testosterone, in the etiology and pathogenesis of prostate cancer (PCa). The bioavailability of sex stero...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09582.x
更新日期:2011-04-01 00:00:00
abstract::To establish a set of consensus statements to facilitate physician management strategies for patients with metastatic prostate cancer (mPCa) in Hong Kong. A local expert consensus was organized jointly by the two main professional organizations representing prostate cancer specialists in Hong Kong. A total of 12 exper...
journal_title:BJU international
pub_type: 共识发展会议,杂志文章
doi:10.1111/bju.14091
更新日期:2018-05-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of sildenafil on noradrenaline- and potassium-induced contractions of isolated human seminal vesicles (SVs), as premature ejaculation is a relatively common male sexual dysfunction that currently lacks an adequate therapy, and recent in vitro tests showed that sildenafil induces rel...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07260.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVES:• To investigate a new method of vas deferens radiography for ejaculatory duct obstruction (EDO). • To evaluate the effect of a procedure involving dilation of the ejaculatory duct by F9 seminal vesicoscopy. PATIENTS AND METHODS:• Twenty-two patients with EDO were diagnosed using semen analysis, semen fruct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09775.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:To evaluate robotic dry laboratory (dry lab) exercises in terms of their face, content, construct and concurrent validities. To evaluate the applicability of the Global Evaluative Assessment of Robotic Skills (GEARS) tool to assess dry lab performance. MATERIALS AND METHODS:Participants were prospectively c...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12559
更新日期:2014-05-01 00:00:00
abstract::The aim of revalidation (or maintenance of certification) is to reassure patients, the general public, employers and other healthcare professionals that an individual is fit to practice. It may lead to a reduction in near misses or adverse events. The process of revalidation entails a commitment to the provision of li...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10375.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To determine the 5-year oncological outcomes of endoscopic extraperitoneal radical prostatectomy (EERPE) from a medium-volume centre, thereby providing much needed data on outcomes from the UK. PATIENTS AND METHODS:From January 2006 to January 2012, 575 patients underwent EERPE for localized prostate cancer,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12260
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVES:To evaluate retrospectively the surgical, symptomatic and oncological outcomes of pelvic exenteration surgery (PES) in men with significant intrapelvic complications of locally advanced castration-sensitive (CSPC) and castration-resistant prostate cancer (CRPC). PATIENTS AND METHODS:A total of 103 patients ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15088
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVES:To assess the safety and feasibility of early single-dose mitomycin C (MMC) bladder instillation after robot-assisted radical nephroureterectomy (RARNU) at a tertiary kidney cancer centre. RARNU with bladder cuff excision and subsequent MMC bladder instillation to reduce recurrence risk is the 'gold standard...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15162
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To review the clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis reporting to a tertiary care hospital in Riyadh, and to compare these with other cases reported previously. PATIENTS AND METHODS:In this retrospective study, records of all 26 adult pa...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02243.x
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVES:To determine whether interstitial cystitis is associated with the increased release of substance P from the bladder wall into urine, by measuring urinary excretion rates of substance P and its metabolites in women with interstitial cystitis and in a control group of women with stress incontinence and normal ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00990.x
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To present the results of endopyelotomy using endoluminal ultrasonography (EUS) to identify crossing vessels, as the success rates of endopyelotomy are generally lower than pyeloplasty, especially in patients with crossing vessels. PATIENTS AND METHODS:Forty-one consecutive patients who underwent EUS before ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04103.x
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2002.02674.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To examine the prognostic significance of the expression of platelet-derived growth factor-BB (PDGF-BB) and differentiated microvascular density (MVD) in patients with clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:We used the vascular marker cluster of differentiation 34 (CD34) to identify tu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12191
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVES:To determine the effectiveness of Uromune® in preventing recurrent urinary tract infections (UTIs) in women. PATIENTS AND METHODS:A total of 77 women with microbiology-proven recurrent UTIs were given Uromune sublingual vaccine for a period of 3 months. Time to first UTI recurrence since treatment and adver...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14067
更新日期:2018-02-01 00:00:00
abstract::There is ample evidence from many epidemiological studies that lower urinary tract symptoms (LUTS) and sexual dysfunction are strongly linked, independently of age and comorbidities such as hypertension, diabetes, dyslipidaemia and coronary heart disease. However, a causal link between both conditions is not yet estab...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2006.06102.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVES:To investigate scores and predictors of patient satisfaction at 1 year after penile prosthesis implantation (PPI) using the validated Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) questionnaire. PATIENTS AND METHODS:Analyses were performed for 142 patients prospectively included in the natio...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.14462
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To compare prospectively obtained symptom scores (pre-tests) with retrospective assessment (then-tests) in patients with newly diagnosed advanced prostate cancer. PATIENTS AND METHODS:Patients with newly diagnosed locally advanced or metastatic prostate cancer were recruited. They completed the International...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2003.04462.x
更新日期:2003-11-01 00:00:00
abstract:OBJECTIVE:To study scrotal microvascularization and apply the findings to the design of reliable skin flaps for reconstructive surgery of complex urethral or panurethral stenoses. MATERIALS AND METHODS:In 15 cryopreserved male cadavers, scrotal skin vascularization was explored using macro- and microdissections, and t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08167.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To determine whether heat, used in transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia and which causes necrotic lesions within the adenoma, induces apoptosis in benign human prostatic stromal cells. Materials and methods Prostatic stromal cells were cultured from benign human prosta...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00473.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To review a series of children with anterior urethral valves and diverticula, to elucidate the pathophysiology and optimal management of this entity. PATIENTS AND METHODS:Nine cases (all boys; 1963 to 2003) were reviewed retrospectively. RESULTS:Seven of nine boys had bulbar diverticula. Continuity between ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04854.x
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of different risk factors and symptoms on the performance characteristics of the nuclear matrix protein 22 (NMP22) BladderChek test (Matritech Inc., Newton, MA, USA) for the detection of bladder cancer, as this is a point-of-care assay that measures NMPs in voided urine. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07473.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To identify and describe changes to the motor component of the motor/sensory system, which contributes to sensation during the filling phase of the micturition cycle, as a result of surgically induced bladder pathology, i.e. damage to the bladder neck and outlet obstruction. MATERIALS AND METHODS:Adult male ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07129.x
更新日期:2007-10-01 00:00:00
abstract:OBJECTIVES:To re-evaluate the role of diabetes mellitus (DM) as a risk factor for penile implant infection by exploring the association between glycated haemoglobin (HbA1c) levels and penile implant infection rates and to define a threshold value that predicts implant infection. PATIENTS AND METHODS:We conducted a mul...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.14076
更新日期:2018-02-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the degree of preoperative bladder trabeculation in neurogenic bladder (NB) patients is a marker of significant outlet resistance. If so, severe trabeculation may obviate the need for concomitant bladder outlet procedure (BOP) during augmentation cystoplasty (AC). PATIENTS AND METHODS:We ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07164.x
更新日期:2008-01-01 00:00:00
abstract::Urothelial cell carcinomas (UCC), including bladder cancer and upper urinary tract cancer, are the second most common malignancy of the urogenital tract after prostate cancer. It is a critical issue to differentiate accurately those patients whose tumour will recur and/or progress after initial treatment from those wi...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08696.x
更新日期:2009-10-01 00:00:00