Abstract:
OBJECTIVES:To evaluate the impact of different risk factors and symptoms on the performance characteristics of the nuclear matrix protein 22 (NMP22) BladderChek test (Matritech Inc., Newton, MA, USA) for the detection of bladder cancer, as this is a point-of-care assay that measures NMPs in voided urine. PATIENTS AND METHODS:In all, 23 academic, private practice and veterans' facilities in 10 states prospectively enrolled consecutive patients from September 2001 to May 2002. Participants included 1328 patients at elevated risk of bladder cancer from factors such as a history of smoking or symptoms including haematuria and/or dysuria. Patients at risk of malignancy of the urinary tract provided a voided urine sample for analysis of NMP22 protein and cytology before cystoscopy. RESULTS:Of the 1328 patients: no urinary disease, benign disease and malignancy were found in 545 (41%), 704 (53%) and 79 (6%) patients, respectively. Overall, the positive predictive value (PPV) for detection of bladder cancer was 20.3% (45/222) and negative predictive value (NPV) was 96.9% (1072/1106). The PPV was higher in men (24.0%) than women (13.2%). In men, the PPV increased with smoking (35.4%), gross haematuria (51.2%) and a combination of both factors (70.6%). The impact on the PPV of smoking (9.7%) and gross haematuria (28.6%) was less dramatic in women. The PPV increased from 16.8% in patients aged <65 years to 23.5% in those aged >65 years. The NPV remained almost always >95% except in men with gross haematuria where it decreased to 77% in smokers and 94% in non-smokers. CONCLUSION:The PPV of the BladderChek test improves in patients at higher risk of bladder cancer reaching 77% in men presenting with gross haematuria who are aged >65 years and smoke. The NPV is highest in women aged <65 years, up to 100%.
journal_name
BJU Intjournal_title
BJU internationalauthors
Lotan Y,Shariat SF,NMP22 Study Group.doi
10.1111/j.1464-410X.2008.07473.xsubject
Has Abstractpub_date
2008-06-01 00:00:00pages
1362-7issue
11eissn
1464-4096issn
1464-410Xpii
BJU7473journal_volume
101pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHO...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06496.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the diffusion of nephron-sparing modalities (NSM) for the treatment of renal neoplasms in the USA over the last decade and to identify the factors associated with renal procedure selection. PATIENTS AND METHODS:The Nationwide Inpatient Sample was utlized to identify patients undergoing cryo/radio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11497.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To assess the outcome of different forms of urinary drainage, particularly for urinary tract infection (UTI), operative findings and patient preference, in patients treated for acute urinary retention (AUR). PATIENTS AND METHODS:A feasibility trial was conducted of men presenting with AUR; after a short peri...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02253.x
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To investigate whether the antioxidant protection attributed to small heat-shock proteins (sHSPs) affects calcium oxalate stone formation, a pro-oxidant disease. MATERIALS AND METHODS:Canine distal tubular epithelial cells (Madin-Darby canine kidney, MDCK cells) were grown as confluent monolayers. Treatment ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06478.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To assess the use of the Clavien classification system in documenting the complications related to open retropubic radical prostatectomy (RRP). PATIENTS AND METHODS:The medical records of 995 patients, who had open RRP during a period of 7 years, were reviewed retrospectively. Short- and long-term complicati...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.08080.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To examine the effect of short-course androgen-suppression therapy (AST) before brachytherapy on all-cause mortality (ACM) rates, stratified by the presence or absence of a history of myocardial infarction (MI) or stroke. AST is used to reduce prostate size to enable men with favourable-risk prostate cancer t...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2010.09273.x
更新日期:2010-10-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? It is known that the kidney damage continues even after release of ureteric obstruction. This study found that giving ferulic acid, antioxidant, after release of ureteric obstruction enhanced the recovery of kidney functions in solitary kidney. OBJEC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10848.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To review long-term oncological and functional outcomes of testicular-sparing surgery (TSS) in men presenting with bilateral or monorchide testicular tumours at one of five reference centres for testicular neoplasm and infertility. PATIENTS AND METHODS:We review 25 cases of bilateral synchrone and metachrone...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12549
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To determine if antibiotic prophylaxis is required for intradetrusor botulinum toxin A (BoNT-A) injections. PATIENTS AND METHODS:This was a prospective non-randomized study. Inclusion criteria were adult patients with neurogenic detrusor overactivity who failed anticholinergic-based first-line treatment and ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09435.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10968.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To compare clinical features, treatments and outcomes in men with non-metastatic prostate cancer (PCa) according to whether they were referred for symptoms or elevated prostate-specific antigen (PSA) level. PATIENTS AND METHODS:This study used data from the South Australia Prostate Cancer Clinical Outcomes C...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13622
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:To determine whether heat, used in transurethral microwave thermotherapy (TUMT) for benign prostatic hyperplasia and which causes necrotic lesions within the adenoma, induces apoptosis in benign human prostatic stromal cells. Materials and methods Prostatic stromal cells were cultured from benign human prosta...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00473.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the level of symptoms of lower urinary tract dysfunction (LUTD) in orphans in institutions, and compare these data with schoolchildren of the same age group who were not institutionalised, as LUTD in children is related to factors such as social isolation and low self-esteem, with other psycholog...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06034.x
更新日期:2006-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of urethral ultrasonography (sono-urethrography, SUG) in determining the length of anterior urethral strictures, and for predicting the degree of spongiofibrosis. PATIENTS AND METHODS:In all, 52 patients with anterior urethral strictures detected on retrograde urethrography (RUG) wer...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06234.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To correlate the results of intraoperative cavernous nerve stimulation (CaNS) at radical prostatectomy (RP), with preoperative erectile function (EF) and to determine the significance of the results of stimulation after RP in predicting the recovery of EF. PATIENTS AND METHODS:The study included 183 potent m...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08519.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To ascertain the urological complications of coitus, as the proximity of the lower urinary tract to the organs of coitus exposes the tract to coital trauma. MATERIALS AND METHODS:Medline was searched from 1966 to 2000 to identify reports on coital injuries. Publications and relevant references were retrieved...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-4096.2001.01458.x
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To investigate long-term oncological outcomes after laparoscopic radical prostatectomy (LRP). To identify parameters influencing recurrence-free survival in a single-institution series. PATIENTS AND METHODS:All patients underwent LRP using the transperitoneal retrograde Heilbronn technique. High-risk patien...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11317.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:•To determine the optimal treatment for incidentally detected small renal masses between radical nephrectomy, partial nephrectomy, ablative therapy (AT) and active surveillance (AS) using a decision-analytic Markov model. SUBJECTS AND METHODS:•The reference case was an otherwise healthy 60-year-old patient. ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10115.x
更新日期:2011-10-01 00:00:00
abstract::Interactive case studies formed a key feature of the third annual Interactive Genitourinary Cancer Conference held in April/May 2011 in Budapest, Hungary. These cases were used to discuss the practical aspects of the management of metastatic castration-resistant prostate cancer (mCRPC). Particular emphasis was placed ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10872.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVE:To determine the value of gene-expression profiling as a predictor of the status of the regional nodes in patients with penile carcinoma. PATIENTS AND METHODS:Tumour samples of 56 patients with penile squamous cell carcinoma were analysed for the gene expression on 35 k oligoarrays; 32 were from patients wit...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07697.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:•To compare the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in a single-institution Canadian cohort. PATIENTS AND METHODS:•At Princess Margaret Hospital, 982 consecutive patients with PCPT-RC and ERSPC-RC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10207.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:To report the use of a novel donor source as a further option to increase the number of patients who might be able to receive a renal transplant. PATIENTS AND METHODS:Between May 1996 and July 2007, 43 kidneys were transplanted using kidneys obtained from patients with small (<3 cm diameter) incidentally det...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07562.x
更新日期:2008-07-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10965.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of various prostate tumour volume (TV) estimation methods. To determine the most appropriate estimation method for current clinical practice. PATIENTS AND METHODS:Radical prostatectomy (RP) specimens from multiple institutions were analysed by a single uro-pathologist between Septemb...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12458
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To evaluate whether the degree of preoperative bladder trabeculation in neurogenic bladder (NB) patients is a marker of significant outlet resistance. If so, severe trabeculation may obviate the need for concomitant bladder outlet procedure (BOP) during augmentation cystoplasty (AC). PATIENTS AND METHODS:We ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07164.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To determine the proportion of solitary rib lesions on pre-treatment 68 Gallium-labelled prostate-specific membrane antigen (PSMA)/computed tomography (CT) scans in men with prostate cancer that are malignant and examine any predictive factors. PATIENTS AND METHODS:This retrospective single tertiary referra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15152
更新日期:2020-09-01 00:00:00
abstract:OBJECTIVE:To describe the clinical and magnetic resonance imaging (MRI) characteristics of vaginal and paraurethral leiomyomas. PATIENTS AND METHODS:All patients with pathologically confirmed paraurethral and vaginal wall leiomyomas from January 2006 to August 2007 were reviewed. Patients with no preoperative MRI of t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09046.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00075.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To explore the safety and clinical efficacy of continuous-wave laser vaporesection for the treatment of obstructive benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:We treated 72 consecutive patients with obstructive BPH using a 70 W 2-microm continuous-wave laser. The mean (range) age of the patient...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2008.08040.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To describe the pattern and prevalence of lower urinary tract symptoms (LUTS) and related help-seeking behaviour in men of South Asian origin living in the UK, and to compare this to the white population. SUBJECTS AND METHODS:Data were obtained as part of the Leicestershire MRC Incontinence Study. Community-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06377.x
更新日期:2006-09-01 00:00:00