Thrombotic risk factors associated with transurethral prostatectomy.

Abstract:

OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after TURP (anova, P=0.01) combined with a significant decrease in activated partial thromboplastin time (anova, P=0.006), suggesting a postoperative hypercoagulable state. The significant increase in d-dimer 24 h after TURP (anova, P=0.015) in the absence of any significant rise in tissue plasminogen activator antigen levels perioperatively (anova, P=0.737) suggests a physiological fibrinolytic response to the developing procoagulant state. The absence of any significant increase in plasminogen activator inhibitor-1 antigen perioperatively (anova, P=0.348) suggests the observed hypercoagulability is not due to a 'fibrinolytic shutdown' reported in other forms of surgery. CONCLUSION:TURP is associated with a hypercoagulable prothrombotic state; aspirin withdrawal perioperatively may be hazardous, and low-dose heparin prophylaxis for venous thrombosis should be considered.

journal_name

BJU Int

journal_title

BJU international

authors

Bell CR,Murdock PJ,Pasi KJ,Morgan RJ

doi

10.1046/j.1464-410x.1999.00075.x

keywords:

subject

Has Abstract

pub_date

1999-06-01 00:00:00

pages

984-9

issue

9

eissn

1464-4096

issn

1464-410X

pii

bju075

journal_volume

83

pub_type

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