Abstract:
OBJECTIVES:To determine the proportion of solitary rib lesions on pre-treatment 68 Gallium-labelled prostate-specific membrane antigen (PSMA)/computed tomography (CT) scans in men with prostate cancer that are malignant and examine any predictive factors. PATIENTS AND METHODS:This retrospective single tertiary referral institution cohort study of men reviewed the results of 68 Ga-PSMA-11 positron emission tomography (PET)/CT scans performed for primary staging prior to treatment of prostate cancer from July 2014 to September 2019. Men with PSMA uptake outside the prostate in only the rib lesion were included. A solitary rib lesion was considered to be malignant if it increased in size on follow-up imaging. A lesion was considered benign if the prostate-specific antigen (PSA) level remained <0.1 µg/L following a radical prostatectomy (RP), <2 µg/L above nadir following radiotherapy (RT) as per the Phoenix criteria, histology was benign on rib biopsy, or follow-up imaging showed no growth of the rib lesion. If a lesion did not meet these criteria it was considered indeterminate. RESULTS:A total of 62 men had PSMA uptake in a solitary rib lesion; 54 went on to have RPs and eight underwent RT. In all, 61 of the men (98.4%) met the criteria for a benign rib lesion. Only one man had a false-negative malignant lesion. This man had a rib lesion with a low maximum standardised uptake value (SUVmax ) of 2.21 reported as benign, but the postoperative PSA level was 0.67 µg/L and the rib lesion progressed on follow-up imaging, with development of widespread metastases. Of the benign rib lesions, there were four false positives reported as possible metastases. Three had percutaneous rib biopsies, two of which came back with benign histology and one was indeterminate. The indeterminate biopsy patient had a RP and his postoperative PSA level was <0.1 µg/L. A total of 43 (69.4%) men with benign rib lesions had a SUVmax greater than the SUVmax of the malignant lesion. CONCLUSION:To our knowledge, this is the first cohort study of men with PSMA-avid solitary rib lesions on pre-treatment 68 Ga-PSMA PET/CT staging scans for prostate cancer. Our results indicate that the vast majority of these lesions have low-intensity uptake and are benign. Intervention to confirm this is not usually required.
journal_name
BJU Intjournal_title
BJU internationalauthors
Chen MY,Franklin A,Yaxley J,Gianduzzo T,McBean R,Wong D,Tatkovic A,McEwan L,Walters J,Kua Bdoi
10.1111/bju.15152subject
Has Abstractpub_date
2020-09-01 00:00:00pages
396-401issue
3eissn
1464-4096issn
1464-410Xjournal_volume
126pub_type
杂志文章abstract:OBJECTIVE:To determine whether the temperature of 2% lignocaine hydrochloride gel affects the initial discomfort during instillation into the male urethra. PATIENTS AND METHODS:Sixty consenting men were randomized to receive 11 mL of 2% lignocaine hydrochloride gel (Instillagel, Farco-Pharma GmbH, Cologne, Germany) at...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.1999.00346.x
更新日期:1999-12-01 00:00:00
abstract:OBJECTIVE:To evaluate two methods of reducing the urine output during treatment (the most easily manipulated variable) in patients undergoing intravesical instillation with mitomycin C, where the concentration-time curve also depends upon dose, diluent volume, residual urine volume, and drug absorption and degradation....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00869.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To document the workload of bladder cancer surveillance on the British urologist. Methods Thirty-one consultant urologists serving a population of 4.8 million were sent postal questionnaires eliciting their views on the management of superficial bladder cancer. The number, type and outcome of cystoscopies per...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00467.x
更新日期:2000-03-01 00:00:00
abstract:OBJECTIVE:To develop a canine model of external urinary sphincter insufficiency by creating irreversible damage to the sphincter, because there is a need for a reliable and reproducible large animal model for the study of stress urinary incontinence (SUI) caused by deficient sphincter function. MATERIALS AND METHODS:A...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08001.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of a transportable extracorporeal shock wave lithotripsy (ESWL) machine, the Modulith SLX-F2(TM) (Storz Medical Italia, Rome, Italy), in the management of solitary urinary calculi. PATIENTS AND METHODS:The study included 233 patients (mean age 51 years; 172 male, 61 female) ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07039.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVES:To help clarify which small renal cortical neoplasms (RCNs) require surgery by using office-based, ultrasonography-guided percutaneous renal biopsy. PATIENTS AND METHODS:Biopsies were performed using facilitated ultrasound targeting (FUT) technology, which incorporates a needle guide and onscreen beam-steer...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12489
更新日期:2016-06-01 00:00:00
abstract:OBJECTIVES:To describe temporal changes in patient characteristics and outcomes for radical cystectomy (RC) in England between 1995 and 2002, using routinely collected administrative data. PATIENTS AND METHODS:Data were extracted from the Hospital Episode Statistics database of the Department of Health in England, des...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05329.x
更新日期:2005-03-01 00:00:00
abstract::Androgen-deprivation therapy (ADT) is an effective treatment for men with advanced prostate cancer, but loss of bone mineral density (BMD) is a major risk factor for fractures. This review compared the efficacy of available treatments to provide prescribing guidance to healthcare professionals. This is the first revie...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14015
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14393
更新日期:2019-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04009.x
更新日期:2003-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07909.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To compare clinical features, treatments and outcomes in men with non-metastatic prostate cancer (PCa) according to whether they were referred for symptoms or elevated prostate-specific antigen (PSA) level. PATIENTS AND METHODS:This study used data from the South Australia Prostate Cancer Clinical Outcomes C...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13622
更新日期:2017-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09695.x
更新日期:2011-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07386.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02033.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To develop and validate an Arabic version of the International Prostate Symptom Score (IPSS). PATIENTS, SUBJECTS AND METHODS:An Arabic version of the IPSS (IPSS-Arb) was developed through a series of translations and modifications which involved the authors, urology and non-urology medical and nursing staff....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08984.x
更新日期:2010-05-01 00:00:00
abstract:OBJECTIVE:To determine the outcome 10 years after an individual course of pelvic floor muscle (PFM) exercises for genuine stress incontinence. PATIENTS AND METHODS:Postal questionnaires were sent to 52 women who had undergone PFM training 10 years earlier, and their medical files were reviewed. The main outcome measur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00506.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To report our experience with laparoscopic robotic-assisted management of pelvi-ureteric junction obstruction (PUJO) in patients with horseshoe kidneys. PATIENTS AND METHODS:Between January 2002 and May 2003, two men and a woman with horseshoe kidneys (mean age 44.6 years) had laparoscopic dismembered pyelop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05967.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:To compare the effects of taking tadalafil 5 mg and placebo once daily on post-micturition dribble (PMD) in men with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS:Our prospective, randomized, double-blind, placebo-controlled, multicentre trial enrolled 102 men with PMD and other LUTS. PMD was as...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14849
更新日期:2019-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09665.x
更新日期:2010-09-01 00:00:00
abstract:OBJECTIVE:To analyse tumour extent as a predictor of cancer progression after radical prostatectomy (RP), using a multivariate Cox regression model, as several variables (e.g. Gleason grade and tumour stage) are well-established prognostic factors in prostate cancer but it is uncertain if the visual estimation of tumou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05825.x
更新日期:2005-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.15342
更新日期:2021-01-19 00:00:00
abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To assess the impact on patterns of recurrence of adjuvant chemotherapy in patients with stage 1 nonseminomatous germ cell tumours (NSGCT) of the testis, who have a high likelihood of relapse on surveillance if certain risk factors are identified in the orchidectomy specimen, and thus the theoretical need for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00722.x
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mic...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07793.x
更新日期:2008-11-01 00:00:00
abstract:OBJECTIVE:To report our experience with the Safyre (Promedon, Cordoba, Argentina), a new re-adjustable and minimally invasive sling for treating stress urinary incontinence (SUI), which combines the efficacy of slings with re-adjustability. PATIENTS AND METHODS:In all, 126 consecutive patients with a clinical and urod...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05295.x
更新日期:2005-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07941.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVE:To report the 2-year follow-up results on patients treated with a novel minimally invasive outpatient procedure for placing a mid-urethral sling, using porcine small intestinal submucosa (SIS). PATIENTS AND METHODS:Thirty-four women with urodynamic evidence of stress urinary incontinence (SUI, 19) or of SUI ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05576.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To describe the surgical management of patients with renal cell carcinoma (RCC) in a solitary kidney (managed preferentially by nephron-sparing surgery, NSS, to avoid dialysis) and extending into the renal vein or inferior vena cava (T3b). PATIENTS AND METHODS:We identified 13 patients treated surgically bet...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05566.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To explore the expression of transforming growth factor-beta(1) (TGF-beta1) in penile tissue from rats after bilateral cavernosal nerve (CN) ablation, mimicking patients who have had no nerve-sparing during prostatectomy. MATERIALS AND METHODS:Ten adult male rats (neurectomy group) had a bilateral CN resecti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04969.x
更新日期:2004-08-01 00:00:00