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Androgen-suppression therapy for prostate cancer and the risk of death in men with a history of myocardial infarction or stroke.

Abstract：

OBJECTIVE:To examine the effect of short-course androgen-suppression therapy (AST) before brachytherapy on all-cause mortality (ACM) rates, stratified by the presence or absence of a history of myocardial infarction (MI) or stroke. AST is used to reduce prostate size to enable men with favourable-risk prostate cancer to undergo brachytherapy, but no disease-specific benefit has been reported for this practice, and AST use has been associated with an increased risk of ACM in some men with pre-existing cardiovascular disease. PATIENTS AND METHODS:The study comprised 12792 men with favourable-risk disease, i.e. a prostate-specific antigen (PSA) level of <20 ng/mL, Gleason score ≤7 and clinical category ≤T2c, treated between 1991 and 2007 at community-based medical centres with brachytherapy ± neoadjuvant AST. Multivariable Cox regression analysis was used to assess whether there were significant associations between AST use in men with a history of MI or stroke and the risk of ACM, adjusting for age, treatment year, and known prognostic factors of prostate cancer. RESULTS:After a median (interquartile range) follow-up of 3.8 (2.0-5.9) years there were 1557 deaths. The risk of ACM was lower in men with no history of MI or stroke than in those with this history, whether AST was used (adjusted hazard ratio 0.79, 95% confidence interval 0.67-0.92; P= 0.003) or not (0.74, 0.65-0.85; P < 0.001). However, men with a history of MI or stroke treated with AST had a greater risk of ACM than those not treated with AST (1.2, 1.05-1.38; P= 0.008). CONCLUSION:The use of short-course AST in men with a history of MI or stroke is associated with a greater risk of ACM in men with favourable-risk prostate cancer.

journal_name

BJU Int

journal_title

BJU international

authors

Hayes JH,Chen MH,Moran BJ,Braccioforte MH,Dosoretz DE,Salenius S,Katin MJ,Ross R,Choueiri TK,D'Amico AV

doi

10.1111/j.1464-410X.2010.09273.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

979-85

issue

eissn

1464-4096

issn

1464-410X

pii

BJU9273

journal_volume

106

pub_type

杂志文章,多中心研究

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Androgen-suppression therapy for prostate cancer and the risk of death in men with a history of myocardial infarction or stroke.