Abstract:
OBJECTIVE:To isolate new cDNAs corresponding to genes whose expression is increased during castration-induced rat prostate apoptosis. MATERIALS AND METHODS:Differential display of mRNAs from 3-day castrated and normal rat ventral prostates was used to identify differentially expressed clones. Northern blots were hybridized to confirm the positive regulation of the candidates and to follow the change in their expression in the involuting rat prostate, and in thymocytes of dexamethazone-treated rats. RESULTS:Five cDNAs were cloned: one encoding ribosomal protein L7, one coding for the insulin-like growth factor binding protein-3 (IGFBP-3), and three whose products are unknown. After castration, all five genes had expression kinetics that closely paralleled the proportion of prostatic epithelial cells undergoing apoptosis. The gene encoding L7 and two of the unknown genes were also upregulated in glucocorticoid-induced programmed death in thymocytes. In addition to the IGFBP-3 gene, those coding for proteins IGFBP-4, -5 and -6 were also overexpressed in the involuting prostate of androgen-deprived rats. CONCLUSION:Five new genes were identified that are up-regulated during castration-induced rat prostate apoptosis, three of which are potentially involved in the common intracellular pathway leading to programmed cell death.
journal_name
BJU Intjournal_title
BJU internationalauthors
Bruyninx M,Ammar H,Reiter E,Cornet A,Closset Jdoi
10.1046/j.1464-410x.2000.00654.xkeywords:
subject
Has Abstractpub_date
2000-06-01 00:00:00pages
1134-42issue
9eissn
1464-4096issn
1464-410Xpii
bju654journal_volume
85pub_type
杂志文章abstract:OBJECTIVES:To determine the prognostic utility of the cell cycle progression (CCP) score in men with National Comprehensive Cancer Network (NCCN)-defined low-risk prostate cancer (PCa) undergoing radical prostatectomy (RP). PATIENTS AND METHODS:Men who underwent RP for Gleason score ≤6 PCa at three institutions (Marti...
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journal_title:BJU international
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2020-12-01 00:00:00
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更新日期:2009-04-01 00:00:00