Abstract:
OBJECTIVE:To characterise the incidence, onset, management, predictors, and clinical impact of mammalian target of rapamycin (mTOR) inhibitor-associated non-infectious pneumonitis (NIP) on patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:Retrospective review of 310 patients with mRCC who received temsirolimus and/or everolimus between June 2007 and October 2010. Clinical correlations were made with serial radiological imaging. Fisher's exact, Wilcoxon rank-sum, and logistic regression analyses were used to evaluate the association of NIP with demographic or clinical factors. Log-rank and Cox proportional hazards regression analyses were used for the time-to-event analysis. RESULTS:NIP occurred in 6% of temsirolimus-treated and 23% of everolimus-treated patients. Symptoms included cough, dyspnoea, and fever (median of two and three symptoms per patient, respectively). The median National Cancer Institute Common Toxicity Criteria for Adverse Events pneumonitis grade was 2 for both groups. Older age and everolimus treatment were predictive of NIP. Patients who developed NIP had a significantly longer time on treatment (median 4.1 vs 2 months) and overall survival (OS) (median 15.4 vs 7.4 months). NIP was a predictor of improved OS by multivariate analysis. CONCLUSIONS:There was an increased incidence of NIP in everolimus-treated patients. Improved OS in patients who developed NIP is an intriguing finding and should be further investigated. Given the incidence, morbidity, and outcomes seen in patients on everolimus who develop NIP, management should include proactive monitoring and treatment of NIP with the goal of preserving mTOR inhibitor therapy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Atkinson BJ,Cauley DH,Ng C,Millikan RE,Xiao L,Corn P,Jonasch E,Tannir NMdoi
10.1111/bju.12420subject
Has Abstractpub_date
2014-03-01 00:00:00pages
376-82issue
3eissn
1464-4096issn
1464-410Xjournal_volume
113pub_type
杂志文章abstract:OBJECTIVE:• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic. PATIENTS AND METHODS:• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 c...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2010.09801.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00028.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To assess the potential of p21 as a gene therapy treatment for prostate cancer, by introducing p21 into both androgen-dependent (AD) and -independent (AI) human prostate cancer cell lines via a recombinant adenoviral vector, Ad5CMV-p21, carrying human p21 cDNA. MATERIALS AND METHODS:The LNCaP, DU145 and PC-3...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04318.x
更新日期:2003-08-01 00:00:00
abstract:OBJECTIVE:To characterise the surgical feasibility and outcomes of robot-assisted radical cystectomy (RARC) for pathological T4 bladder cancer. PATIENTS AND METHODS:Retrospective evaluation of a prospectively maintained International Radical Cystectomy Consortium database was conducted for 1118 patients who underwent ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12569
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the use of commercially available single-layer small intestinal submucosa (SIS) for urethral replacement, both as an onlay and as a tube, in a rabbit model. MATERIALS AND METHODS:Thirty-six male rabbits were assigned to four experimental groups. Group 1 had the ventral wall of the penile urethra ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05115.x
更新日期:2004-11-01 00:00:00
abstract:OBJECTIVE:To examine and quantify the contemporary association between androgen-deprivation therapy (ADT) and three separate endpoints: coronary artery disease (CAD), acute myocardial infarction (AMI), and sudden cardiac death (SCD), in a large USA contemporary cohort of patients with prostate cancer. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12732
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO). PATIENTS AND METHODS:In all, 255 children and adolescents (aged 1-18 years) with NDO ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.08093.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVE:To investigate the immunology of host-tumour interaction, critical for the development of immunotherapy against cancers, by assessing the major histocompatibility complex (MHC) class I expression in both benign and malignant prostate disease, and the relationship between their expression and degree of tumour-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02993.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To determine the changes in body composition, muscle function and energy expenditure after radical cystectomy (RC). PATIENTS AND METHODS:Eleven consecutive men (median age 66 years, range 44-79) who had a RC over a 1-year period had measurements made of their total body protein, by neutron-activation analysi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07337.x
更新日期:2008-04-01 00:00:00
abstract::Detailed molecular insights into bladder cancer biology might allow more detailed prognostication and optimization of treatment with the objective of improving patient outcome and quality of life. However, in bladder cancer research the search for biomarkers has been called into question and has even obtained notoriet...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08880.x
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:To examine the effect of age on the biochemical and functional properties, and regional distribution of endothelin (ET) receptors in the rabbit renal pelvis. MATERIALS AND METHODS:The properties of ET receptors in 6-week-old and 6-month-old male rabbit renal pelves were examined using isolated muscle-bath an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.2441.x
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVE:To assess the use of mitomycin C, by urologists within the UK, as a single-dose intravesical agent. Current European recommendations are to use one dose after any new tumour resection. METHODS:We assessed the current patterns of mitomycin C usage amongst British urologists, particularly with reference to one...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05970.x
更新日期:2006-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Photovaporization of the prostate (PVP) is now challenging TURP as the standard treatment for lower LUTS caused by BPH. The learning curve for PVP is short and the main advantages of this method over TURP are a shorter period of hospitalization, a sho...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10878.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To assess whether under- or overweight at the time of surgery has any effect on the survival of the patients with renal cell carcinoma (RCC), as obesity increases the risk of developing RCC. PATIENTS AND METHODS:We prospectively evaluated 780 patients who had nephrectomy for RCC between 1990 and 2005. We use...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07375.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of a magnetic resonance imaging (MRI)-based Likert scoring system in the detection of clinically significant prostate cancer (CSPC), using MRI/ultrasonography (US) image-fusion targeted biopsy (FTB) as a reference standard. PATIENTS AND METHODS:We retrospectively reviewed 1218 MRI-de...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13972
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To determine the long-term results of constructing a sigmoid neobladder after radical cystectomy for transitional cell carcinoma (TCC) of the urinary bladder. PATIENTS AND METHODS:The study included 170 patients with TCC of the bladder and a normal sigmoid colon. After radical cystectomy the neobladder was f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06541.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To describe metoidioplasty, a technique for creating a neophallus from an enlarged clitoris in female transsexuals, without needing the complex, multi-staged surgical construction of a large phallus, as this reconstruction is one of the most difficult in female transsexuals. PATIENTS AND METHODS:From Septemb...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2003.04524.x
更新日期:2003-12-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10813.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To validate high-sensitivity C-reactive protein (hs-CRP) serum levels as an independent marker for disease-free survival (DFS) in clinically localised clear cell renal cell carcinoma (ccRCC). PATIENTS AND METHODS:In all, 403 consecutive patients with clinically localised (T1-3N0M0) ccRCC treated by radical o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12067
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To investigate long-term oncological outcomes after laparoscopic radical prostatectomy (LRP). To identify parameters influencing recurrence-free survival in a single-institution series. PATIENTS AND METHODS:All patients underwent LRP using the transperitoneal retrograde Heilbronn technique. High-risk patien...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11317.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To develop a core outcome set (COS) applicable for effectiveness trials of all interventions for localised prostate cancer. Many treatments exist for localised prostate cancer, although it is unclear which offers the optimal therapeutic ratio; which is confounded by inconsistencies in the selection, definitio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13854
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To describe the surgical technique and report early outcomes of transurethral assisted laparoendoscopic single-site (LESS) radical prostatectomy (RP) and LESS radical cystectomy (RC) in a single institution. MATERIALS AND METHODS:Between December 2014 and March 2016, a total of 114 LESS RPs and RCs were perf...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13965
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To retrospectively review the long-term activity, efficacy and toxicity of the combination of paclitaxel, cisplatin and gemcitabine (TPG) as third- or further-line chemotherapy in patients with germ-cell tumours (GCTs) who are not cured after at least two courses of standard-dose chemotherapy, high-dose chemo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08453.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVES:To assess the utility of perceived control over ejaculation ('control') in the evaluation of treatment benefit in men with premature ejaculation (PE), and to compare effects associated with a two-category or greater increase in this variable between men receiving dapoxetine and placebo. PATIENTS AND METHODS...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2008.07845.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To determine, in a randomized controlled clinical trial, the effect of extracorporeal shock wave lithotripsy (ESWL) on blood pressure. PATIENTS AND METHODS:The trial included 228 patients with small (< 15 mm) asymptomatic calyceal stones who were randomised to undergo ESWL (113 patients) or to an untreated (...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00571.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To collect data on voiding patterns at baseline (no treatment) and during short-term desmopressin treatment, with special reference to the functional and the mean bladder capacity. PATIENTS AND METHODS:The study included 120 children (aged 6-16 years) with monosymptomatic nocturnal enuresis. While at home th...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1046/j.1464-410x.2002.02788.x
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVE:• To report outcomes for patients with localized prostate cancer managed using a watchful waiting strategy at an American centre and to explore factors that have triggered intervention. PATIENTS AND METHODS:• From 1991 to 2005, 218 patients diagnosed with untreated localized prostate cancer were followed at ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09652.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of MN-001, a novel orally active anti-inflammatory agent, in suppressing the bladder hyperactivity resulting from ovalbumin (OA)-induced mast-cell stimulation in a rat model. MATERIALS AND METHODS:Sprague-Dawley rats of both sexes were divided into five groups of 10 each, with group 1...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06274.x
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVES:To compare the performance of two established androgen receptor splice variant 7 (AR-V7) mRNA detection systems, as paradoxical responses to next-generation androgen-deprivation therapy in AR-V7 mRNA-positive circulating tumour cells (CTC) of patients with castration-resistant prostate cancer (CRPC) could be...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14146
更新日期:2018-08-01 00:00:00
abstract::The decision to take a prostate biopsy is traditionally guided by a digital rectal examination and measurement of serum total prostate-specific antigen (tPSA). However, both techniques are subject to inherent weaknesses. The prostate cancer gene 3 (PCA3), a gene-based marker, specific for prostate cancer, supplements ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.08280.x
更新日期:2009-02-01 00:00:00