Prostate cancer diagnosis in the new millennium: strengths and weaknesses of prostate-specific antigen and the discovery and clinical evaluation of prostate cancer gene 3 (PCA3).

abstract：OBJECTIVES:To determine the risk of failure during drug development in castration-resistant prostate cancer (CRPC) and to identify factors that could improve outcomes. METHODS:We investigated CRPC by analysing compounds in phase I to phase III clinical trials between 1998 and April 2011. Drug development failures were...

journal_title：BJU international

authors： Tenuta A,Klotz L,Parker JL

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test. MATERIALS AND METH...

journal_title：BJU international

authors： Seif C,Cherwon E,Martinez Portilló FJ,Alken P,Jünemann KP,Braun PM

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:To evaluate the relative merits of robotically assisted partial nephrectomy (RPN), using a matched-pair analysis, with laparoscopic PN (LPN). PATIENTS AND METHODS:Between July 2006 and August 2007, 12 patients had RPN for tumour; the outcomes were compared retrospectively with 12 matched patients who had LP...

journal_title：BJU international

authors： Aron M,Koenig P,Kaouk JH,Nguyen MM,Desai MM,Gill IS

更新日期：2008-07-01 00:00:00

abstract：OBJECTIVES:To validate a flexible cystoscopy simulator by determining if it could differentiate between expert and novice cystoscopists. SUBJECTS AND METHODS:Seventeen subjects (10 novices with no previous endoscopic experience and seven urologists who had all carried out > 1000 flexible cystoscopies each) were asked ...

journal_title：BJU international

authors： Shah J,Darzi A

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:To investigate the expression of thymidylate synthase (TS), a key enzyme in DNA synthesis that is over-expressed in several cancer cells, in bladder cancer and its association with patient prognosis and the response to adjuvant therapy. PATIENTS AND METHODS:In all, 67 bladder tissue specimens were obtained f...

journal_title：BJU international

authors： Li Y,Li X,Dai H,Sun X,Li J,Yang F,Gu H,Yang Y,Jin Z,Chu Y,Jin X,Kakehi Y,Wu X

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...

journal_title：BJU international

authors： Gordetsky J,Gorin MA,Canner J,Ball MW,Pierorazio PM,Allaf ME,Epstein JI

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To evaluate the accuracy of various prostate tumour volume (TV) estimation methods. To determine the most appropriate estimation method for current clinical practice. PATIENTS AND METHODS:Radical prostatectomy (RP) specimens from multiple institutions were analysed by a single uro-pathologist between Septemb...

journal_title：BJU international

authors： Perera M,Lawrentschuk N,Bolton D,Clouston D

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder...

journal_title：BJU international

authors： Sánchez-Carbayo M,Herrero E,Megías J,Mira A,Soria F

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To investigate the feasibility and clinical outcome of extracorporeal shock-wave therapy (ESWT) for patients suffering from chronic pelvic pain syndrome (CPPS). PATIENTS AND METHODS:The study included 34 patients who had had CPPS for >or=3 months, who were investigated in two subsequent studies. ESWT was adm...

journal_title：BJU international

authors： Zimmermann R,Cumpanas A,Hoeltl L,Janetschek G,Stenzl A,Miclea F

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVES:To determine whether modified transperineal template prostate-mapping (TTPM) biopsy protocols, altering the template or the biopsy density, have sensitivity and negative predictive value (NPV) equal to full 5-mm TTPM. PATIENTS AND METHODS:Retrospective analysis of an institutional registry including treatme...

journal_title：BJU international

authors： Valerio M,Anele C,Charman SC,van der Meulen J,Freeman A,Jameson C,Singh PB,Emberton M,Ahmed HU

更新日期：2016-09-01 00:00:00

abstract：OBJECTIVE:To evaluate prospectively the accuracy of computer-aided three-dimensional (3D) volume-rendered computed tomography (CT) in determining the appropriate anatomical limits (tumour size, tumour location, multifocality and vascular supply) and as a potential tool in the preoperative simulation of nephron-sparing ...

journal_title：BJU international

authors： Wunderlich H,Reichelt O,Schubert R,Zermann DH,Schubert J

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVE:To determine disease progression and survival in patients with lymph node-positive prostate carcinoma after ascending radical retropubic prostatectomy (RP) and pelvic lymphadenectomy with different forms of postoperative adjuvant treatment. PATIENTS AND METHODS:We analysed 82 patients with lymph node metasta...

journal_title：BJU international

authors： Kroepfl D,Loewen H,Roggenbuck U,Musch M,Klevecka V

更新日期：2006-05-01 00:00:00

abstract：UNLABELLED:Study Type--Clinical (prospective trial) Level of Evidence 2b. What's known on the subject? and What does the study add? In clinical practice, we know that it is necessary to identify new biomarkers that can better detect prostate cancer (PC), at the same time as reducing the number of unnecessary biopsies. ...

journal_title：BJU international

authors： Sciarra A,Panebianco V,Cattarino S,Busetto GM,De Berardinis E,Ciccariello M,Gentile V,Salciccia S

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:To identify a phenotype that could be informative and prognostic in patients with renal cell carcinoma (RCC) peripheral blood was evaluated for TH1, TH2, regulatory T cells (Tregs), natural killer (NK) and NKT cells and for cytokines/chemokines. PATIENTS AND METHODS:Peripheral blood from 77 patients with RCC...

journal_title：BJU international

authors： Polimeno M,Napolitano M,Costantini S,Portella L,Esposito A,Capone F,Guerriero E,Trotta A,Zanotta S,Pucci L,Longo N,Perdonà S,Pignata S,Castello G,Scala S

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To apply the standard PADUA and RENAL nephrometry score variables to three-dimensional (3D) virtual models (VMs) produced from standard bi-dimensional imaging, thereby creating three-dimensional (3D)-based (PADUA and RENAL) nephrometry scores/categories for the reclassification of the surgical complexity of ...

journal_title：BJU international

authors： Porpiglia F,Amparore D,Checcucci E,Manfredi M,Stura I,Migliaretti G,Autorino R,Ficarra V,Fiori C

更新日期：2019-12-01 00:00:00

abstract：:Category III chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is the most commonly diagnosed prostatitis syndrome. CP/CPPS is characterized by lower urinary tract symptoms (LUTS) of which pain (particularly perineal pain and pain on ejaculation) and dysfunctional voiding cause the greatest morbidity and poor...

journal_title：BJU international

authors： Nickel JC

更新日期：2008-03-01 00:00:00

abstract：:There is ample evidence from many epidemiological studies that lower urinary tract symptoms (LUTS) and sexual dysfunction are strongly linked, independently of age and comorbidities such as hypertension, diabetes, dyslipidaemia and coronary heart disease. However, a causal link between both conditions is not yet estab...

journal_title：BJU international

authors： McVary K

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:The aim of the present paper was to determine the impact of testicular cancer (TC) and its treatments on fertility and to review the current management options for the infertile patient with TC, both before diagnosis and after treatment, with the aim of providing practical recommendations to update contempor...

journal_title：BJU international

authors： Moody JA,Ahmed K,Yap T,Minhas S,Shabbir M

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent...

journal_title：BJU international

authors： Delongchamps NB,Rouanne M,Flam T,Beuvon F,Liberatore M,Zerbib M,Cornud F

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:• To study the association between specific clinical symptoms (e.g. low libido and erectile dysfunction) and testosterone levels and age in order to define symptom-specific testosterone thresholds. MATERIALS AND METHODS:• Serum samples for testosterone determination were obtained from 675 healthy men. • Part...

journal_title：BJU international

authors： Lackner JE,Rücklinger E,Schatzl G,Lunglmayr G,Kratzik CW

更新日期：2011-10-01 00:00:00

abstract：:To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...

journal_title：BJU international

authors： Cussans A,Somani BK,Basarab A,Dudderidge TJ

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To examine the relationship between the presence of high-grade prostatic intraepithelial neoplasia (HGPIN) in retropubic radical prostatectomy (RP) specimens and cancer-specific outcomes, including pathological variables and biochemical disease-free survival (bDFS), as HGPIN shares many histopathological char...

journal_title：BJU international

authors： Pierorazio PM,Lambert SM,Matsukhani M,Sprenkle PC,McCann TR,Katz AE,Olsson CA,Benson MC,McKiernan JM

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To characterize the effect of preserving the neurovascular bundle (NVB) and of potency on urinary continence after open radical retropubic prostatectomy (ORRP). PATIENTS AND METHODS:Between October 2000 to September 2005, 1110 consecutive continent men had ORRP by one surgeon. The University of California Lo...

journal_title：BJU international

authors： Marien TP,Lepor H

更新日期：2008-12-01 00:00:00

abstract：OBJECTIVE:To quantify in absolute terms the potential benefit of regionalisation of care from low- to high-volume hospitals. PATIENTS AND METHODS:Patients with a primary diagnosis of bladder cancer treated with radical cystectomy (RC) were identified within the Nationwide Inpatient Sample, a retrospective observationa...

journal_title：BJU international

authors： Ravi P,Bianchi M,Hansen J,Trinh QD,Tian Z,Meskawi M,Abdollah F,Briganti A,Shariat SF,Perrotte P,Montorsi F,Karakiewicz PI,Sun M

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:To determine the safety, efficacy and pharmacokinetics of tolterodine in children with an overactive bladder. PATIENTS AND METHODS:Thirty-three children (20 boys and 13 girls, aged 5-10 years) with an overactive bladder and symptoms of urgency, frequency and/or urge incontinence were enrolled in an open, dos...

journal_title：BJU international

authors： Hjälmås K,Hellström AL,Mogren K,Läckgren G,Stenberg A

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To determine the metabolic characteristics of elderly patients with recurrent calcium oxalate stones. PATIENTS AND METHODS:Metabolic abnormalities were investigated in 88 patients with recurrent calcium oxalate stones, including 70 aged <60 years and 18 aged >/=60 years. The frequency of each metabolic abnor...

journal_title：BJU international

authors： Yagisawa T,Hayashi T,Yoshida A,Okuda H,Kobayashi H,Ishikawa N,Goya N,Toma H

更新日期：1999-06-01 00:00:00

abstract：:Tribute to Professor Pieter De Mulder, from Martin Gore. Pieter and I were often pitted against each other in debates at international meetings on the role of cytokine therapy. The truth is that there was little disagreement between us, but we both thought such set pieces were a good way to highlight the issues surrou...

journal_title：BJU international

authors： Gore ME,De Mulder P

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To compare directly the performance of the ADXBLADDER test with that of cytology in the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences. BACKGROUND:ADXBLADDER is a urine test based on the detection of MCM5, a DNA licensing factor expressed in all cells capable of dividing. Expression is u...

journal_title：BJU international

authors： Gontero P,Montanari E,Roupret M,Longo F,Stockley J,Kennedy A,Rodriguez O,McCracken SRC,Dudderidge T,Sieverink C,Vanié F,Allasia M,Witjes JA,Sylvester R,Colombel M,Palou J

更新日期：2020-08-03 00:00:00

abstract：OBJECTIVE:To assess the impact on patterns of recurrence of adjuvant chemotherapy in patients with stage 1 nonseminomatous germ cell tumours (NSGCT) of the testis, who have a high likelihood of relapse on surveillance if certain risk factors are identified in the orchidectomy specimen, and thus the theoretical need for...

journal_title：BJU international

authors： Hendry WF,Norman A,Nicholls J,Dearnaley DP,Peckham MJ,Horwich A

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To prospectively investigate the association of endothelial nitric oxide synthase (eNOS) G894T gene polymorphism with responsiveness to a selective α1 -blocker in men with benign prostatic hyperplasia related lower urinary tract symptoms (BPH/LUTS), as nitric oxide has recently gained increasing recognition a...

journal_title：BJU international

authors： Lee YC,Juan YS,Liu CC,Bao BY,Wang CJ,Wu WJ,Huang CN,Huang SP

更新日期：2016-08-01 00:00:00