Prostate cancer diagnosis in the new millennium: strengths and weaknesses of prostate-specific antigen and the discovery and clinical evaluation of prostate cancer gene 3 (PCA3).


:The decision to take a prostate biopsy is traditionally guided by a digital rectal examination and measurement of serum total prostate-specific antigen (tPSA). However, both techniques are subject to inherent weaknesses. The prostate cancer gene 3 (PCA3), a gene-based marker, specific for prostate cancer, supplements the predictive power of tPSA to improve diagnosis of disease. Including this new marker in the standard of care for men at risk of prostate cancer should be considered, as it presents marked potential for better decision making for a prostate biopsy and for improving overall patient care.




BJU international


Kirby RS,Fitzpatrick JM,Irani J




Has Abstract


2009-02-01 00:00:00














  • Gene expression signatures prognostic for relapse in stage I testicular germ cell tumours.

    abstract:OBJECTIVES:To identify differentially expressed genes between relapsed and non-relapsed clinical stage I testicular germ cell tumours (TGCTs). MATERIALS AND METHODS:We reviewed patients with clinical stage I non-seminoma and seminoma from an institutional database (2000-2012) who were managed by active surveillance. P...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Lewin J,Soltan Ghoraie L,Bedard PL,Hamilton RJ,Chung P,Moore M,Jewett MAS,Anson-Cartwright L,Virtanen C,Winegarden N,Tsao J,Warde P,Sweet J,Haibe-Kains B,Hansen AR

    更新日期:2018-11-01 00:00:00

  • Multicentre prospective evaluation of the learning curve of holmium laser enucleation of the prostate (HoLEP).

    abstract:OBJECTIVES:To describe the step-by-step learning curve of the holmium laser enucleation of the prostate (HoLEP) surgical technique. SUBJECTS/PATIENTS AND METHODS:A prospective, multicentre observational study was conducted, involving surgeons experienced in transurethral resection of the prostate and open prostatectom...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Robert G,Cornu JN,Fourmarier M,Saussine C,Descazeaud A,Azzouzi AR,Vicaut E,Lukacs B

    更新日期:2016-03-01 00:00:00

  • Treatment of symptomatic simple renal cysts by percutaneous aspiration and ethanol sclerotherapy.

    abstract:OBJECTIVE:To report our experience with the use of 95% ethanol as sclerotherapy for symptomatic simple renal cysts. PATIENTS AND METHODS:Sixty patients with 64 symptomatic simple renal cysts were treated by ultrasonography (US)-guided percutaneous aspiration and injection of 95% ethanol (31 men and 29 women, mean age ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Mohsen T,Gomha MA

    更新日期:2005-12-01 00:00:00

  • Benign scrotal pathology: should all patients undergo surgery?

    abstract:OBJECTIVE:To evaluate the justification for operative intervention in patients undergoing surgery for benign scrotal pathology, and to assess the associated morbidity. PATIENTS AND METHODS:Consecutive patients in two surgical firms who underwent surgery for benign intrascrotal pathology over a 5-year period were studi...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Menon VS,Sheridan WG

    更新日期:2001-08-01 00:00:00

  • TURP and sex: patient and partner prospective 12 years follow-up study.

    abstract:OBJECTIVE:• To evaluate the effect of transurethral resection of the prostate (TURP) on sexual function in the short (6 months), medium (6 years) and long (12 years) term and assess the conformity between patient and partner regarding sexual function. PATIENTS AND METHODS:• A prospective cohort study set at the Aberde...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Mishriki SF,Grimsley SJ,Lam T,Nabi G,Cohen NP

    更新日期:2012-03-01 00:00:00

  • Relationship between prostate cancer mortality and number of unfavourable risk factors in men treated with definitive brachytherapy.

    abstract:OBJECTIVE:To explore whether the number of unfavourable pretreatment risk factors predicts cause-specific mortality in men treated with prostate brachytherapy. PATIENTS AND METHODS:Between April 1995 and March 2006, 739 patients were treated who had at least one of the following adverse risk factors: pretreatment pros...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Taira AV,Merrick GS,Galbreath RW,Butler WM,Lief JH,Wallner KE

    更新日期:2010-09-01 00:00:00

  • Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imaging.

    abstract:OBJECTIVE:To investigate the validity of prostate-specific antigen (PSA) as a tumour marker in men with clinically localized prostate cancer who have selected watchful waiting, by determining if serial PSA level measurements are correlated with findings of malignancy or benign prostatic hyperplasia (BPH) at serial endo...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Coakley FV,Chen I,Qayyum A,Westphalen AC,Carroll PR,Hricak H,Chen MH,Kurhanewicz J

    更新日期:2007-01-01 00:00:00

  • Increased expression of transient receptor potential vanilloid subfamily 1 in the bladder predicts the response to intravesical instillations of resiniferatoxin in patients with refractory idiopathic detrusor overactivity.

    abstract:OBJECTIVES:To investigate the correlation of transient receptor potential vanilloid subfamily 1 (TRPV1) mRNA expression levels and the clinical outcome of intravesical resiniferatoxin treatment in patients with idiopathic detrusor overactivity (IDO), as such treatment with vanilloids can be effective for DO. PATIENTS ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Liu HT,Kuo HC

    更新日期:2007-11-01 00:00:00

  • Thrombotic risk factors associated with transurethral prostatectomy.

    abstract:OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Bell CR,Murdock PJ,Pasi KJ,Morgan RJ

    更新日期:1999-06-01 00:00:00

  • Focal laser interstitial thermotherapy (LITT) at 980 nm for prostate cancer: treatment feasibility in Dunning R3327-AT2 rat prostate tumour.

    abstract:OBJECTIVE:To examine the feasibility and reproducibility of laser interstitial thermotherapy (LITT) as a minimally invasive method for the treatment of prostate cancer. MATERIALS AND METHODS:Heterotopic tumours of prostatic adenocarcinoma (Dunning R3327-AT2) were induced in 10 male Copenhagen rats. After preoperative ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Colin P,Nevoux P,Marqa M,Auger F,Leroy X,Villers A,Puech P,Mordon S,Betrouni N

    更新日期:2012-02-01 00:00:00

  • Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder.

    abstract:OBJECTIVE:To assess the potential use of bone marrow stromal cell (BMSC)-seeded biodegradable scaffold for bladder regeneration in a canine model, by characterizing BMSCs and comparing them to bladder smooth muscle cells (SMCs) by immunohistochemistry, growth capability, and contractility. MATERIALS AND METHODS:Bone m...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Zhang Y,Lin HK,Frimberger D,Epstein RB,Kropp BP

    更新日期:2005-11-01 00:00:00

  • The Premature Ejaculation Profile: validation of self-reported outcome measures for research and practice.

    abstract:OBJECTIVE:To evaluate the reliability and validity of the Premature Ejaculation Profile (PEP), a self-reported outcome instrument for evaluating domains of PE and its treatment, comprised of four single-item measures, a profile, and an index score. SUBJECTS AND METHODS:Data were from men participating in observational...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Patrick DL,Giuliano F,Ho KF,Gagnon DD,McNulty P,Rothman M

    更新日期:2009-02-01 00:00:00

  • Contemporaneous comparison of open vs minimally-invasive radical prostatectomy for high-risk prostate cancer.

    abstract:OBJECTIVES:To analyze pathological and short-term oncological outcomes in men undergoing open and minimally-invasive radical prostatectomy (MIRP) for high-risk prostate cancer (HRPC; prostate-specific antigen level [PSA] >20 ng/mL, ≥ cT2c, Gleason score 8-10) in a contemporaneous series. PATIENTS AND METHODS:In total,...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Pierorazio PM,Mullins JK,Eifler JB,Voth K,Hyams ES,Han M,Pavlovich CP,Bivalacqua TJ,Partin AW,Allaf ME,Schaeffer EM

    更新日期:2013-10-01 00:00:00

  • Changing USA national trends for adrenalectomy: the influence of surgeon and technique.

    abstract:OBJECTIVE:To explain differences over time between operative approach and surgeon type for adrenal surgery in the USA. PATIENTS AND METHODS:A retrospective cohort analysis was performed on all patients undergoing adrenalectomy between 2002 and 2011 using the Nationwide Inpatient Sample. Patients undergoing concurrent ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Monn MF,Calaway AC,Mellon MJ,Bahler CD,Sundaram CP,Boris RS

    更新日期:2015-02-01 00:00:00

  • Health-related quality of life and psychosocial factors in patients with prostate cancer scheduled for radical prostatectomy or external radiation therapy.

    abstract:OBJECTIVE:To assess whether baseline health-related quality of life (HRQOL) and psychosocial profiles differ in patients with prostate cancer scheduled for radical prostatectomy (RP) or external radiation therapy (ERT), as there is evidence that HRQOL is influenced by psychosocial factors (PFs), so that any variation a...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Van Andel G,Visser AP,Hulshof MC,Horenblas S,Kurth KH

    更新日期:2003-08-01 00:00:00

  • Anaemia in men receiving combined finasteride and flutamide therapy for advanced prostate cancer.

    abstract:OBJECTIVE:To determine the effect of combined finasteride and flutamide therapy on haemoglobin and haematocrit values in men with advanced prostate cancer. PATIENTS AND METHODS:Nineteen men, previously untreated by hormone therapy, with histologically confirmed adenocarcinoma of the prostate and clinical evidence of a...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Ornstein DK,Beiser JA,Andriole GL

    更新日期:1999-01-01 00:00:00

  • Contrast-enhanced ultrasonography using cadence-contrast pulse sequencing technology for targeted biopsy of the prostate.

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Aigner F,Pallwein L,Mitterberger M,Pinggera GM,Mikuz G,Horninger W,Frauscher F

    更新日期:2009-02-01 00:00:00

  • Transcorporal artificial urinary sphincter implantation as a salvage surgical procedure for challenging cases of male stress urinary incontinence: surgical technique and functional outcomes in a contemporary series.

    abstract:OBJECTIVES:To describe the surgical technique of transcorporal artificial urinary sphincter (AUS) implantation. To assess the efficacy of the AUS on continence and erectile function. PATIENTS AND METHODS:A prospective evaluation was conducted between December 2007 and October 2012 at a tertiary referral centre of all ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Wiedemann L,Cornu JN,Haab E,Peyrat L,Beley S,Cathelineau X,Haab F

    更新日期:2013-12-01 00:00:00

  • Female sexual dysfunction: a new urogynaecological research field.

    abstract:OBJECTIVE:To critically review published data on the urogynaecological aspects of female sexual dysfunction (FSD), as FSD is a developing multidisciplinary issue associated with several biological, medical and psychological factors. METHODS:The reported prevalence of FSD is 19-50% and women with lower urinary tract sy...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Dalpiaz O,Kerschbaumer A,Mitterberger M,Pinggera GM,Colleselli D,Bartsch G,Strasser H

    更新日期:2008-03-01 00:00:00

  • Retrospective cohort study on patterns of care and outcomes of surgical treatment for lower urinary-genital tract fistula among English National Health Service hospitals between 2000 and 2009.

    abstract:OBJECTIVES:To examine patterns of care among women with urogenital fistula treated in the English National Health Service (NHS) between 2000 and 2009. To assess whether failure of repair was associated with hospital or surgeon workload. PATIENTS AND METHODS:We conducted a retrospective cohort study using data from Hos...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Cromwell D,Hilton P

    更新日期:2013-04-01 00:00:00

  • Botulinum toxin (OnabotulinumtoxinA) in the male non-neurogenic overactive bladder: clinical and quality of life outcomes.

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    journal_title:BJU international

    pub_type: 杂志文章


    authors: Habashy D,Losco G,Tse V,Collins R,Chan L

    更新日期:2015-10-01 00:00:00

  • 'Mohs surgery of the prostate': the utility of in situ frozen section analysis during robotic prostatectomy.

    abstract::OBJECTIVE • To evaluate a novel technique to lower positive surgical margin rates while preserving as much of the neurovascular bundles as possible during nerve-sparing robotic prostatectomy. MATERIALS AND METHODS • In situ intraoperative frozen section (IFS) was performed during robotic-assisted laparoscopic prostate...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Lavery HJ,Xiao GQ,Nabizada-Pace F,Mikulasovich M,Unger P,Samadi DB

    更新日期:2011-03-01 00:00:00

  • Comorbidity in patients with prostate cancer and its relevance to treatment choice.

    abstract:OBJECTIVE:To evaluate the prevalence of comorbidity among patients with prostate cancer in relation to tumour and patient characteristics and to assess if comorbidity was a determining factor in the treatment choice for patients with localized prostate cancer. PATIENTS AND METHODS:Serious comorbidity was recorded in t...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Post PN,Kil PJ,Hendrikx AJ,Janssen-Heijnen ML,Crommelin MA,Coebergh JW

    更新日期:1999-10-01 00:00:00

  • Does the surgical technique for management of the distal ureter influence the outcome after nephroureterectomy?

    abstract::Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The resection of the distal ureter and its orifice is an oncological principle during radical nephroureterectomy which is based on the fact that it represents a part of the urinary tract exposed to a consid...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Phé V,Cussenot O,Bitker MO,Rouprêt M

    更新日期:2011-07-01 00:00:00

  • Preliminary evidence that the allogeneic response might trigger antitumour immunity in patients with advanced prostate cancer.

    abstract:OBJECTIVE:To explore the possibility that allogeneic responses might, by chance, encompass cross-reactive T cell clones specific for neo-antigenic tumour determinants, and thereby activate antitumour immunity; such cross-reactions are well documented for antiviral immunity, and genetic instability in developing cancers...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章


    authors: Muir G,Rajbabu K,Callen C,Fabre JW

    更新日期:2006-11-01 00:00:00

  • Safety and feasibility of early single-dose mitomycin C bladder instillation after robot-assisted radical nephroureterectomy.

    abstract:OBJECTIVES:To assess the safety and feasibility of early single-dose mitomycin C (MMC) bladder instillation after robot-assisted radical nephroureterectomy (RARNU) at a tertiary kidney cancer centre. RARNU with bladder cuff excision and subsequent MMC bladder instillation to reduce recurrence risk is the 'gold standard...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Gulamhusein A,Silva P,Cullen D,Tran M,Mumtaz F,Patki P,Barod R,Bex A

    更新日期:2020-12-01 00:00:00

  • Zoledronic acid is effective in preventing and delaying skeletal events in patients with bone metastases secondary to genitourinary cancers.

    abstract::Patients with metastatic bone disease often have severe bone pain and debilitating skeletal complications. Zoledronic acid is the only bisphosphonate shown to be safe and effective in reducing skeletal-related events (SREs), including pathological fractures, spinal cord compression, and radiation or surgery to bone in...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Saad F,Lipton A

    更新日期:2005-11-01 00:00:00

  • The role of reactive oxygen species in testicular dysfunction associated with varicocele.

    abstract:OBJECTIVE:To determine the level of malondialdehyde (MDA), an indirect indicator of lipid peroxidation-induced injury by reactive oxygen species, in testicular biopsy specimens from infertile patients with and without varicocele. PATIENTS AND METHODS:Levels of MDA were measured in the testicular biopsy specimens from ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Köksal IT,Tefekli A,Usta M,Erol H,Abbasoglu S,Kadioglu A

    更新日期:2000-09-01 00:00:00

  • Assessing the minimum number of lymph nodes needed at radical cystectomy in patients with bladder cancer.

    abstract:OBJECTIVE:To identify the likelihood of finding one or more positive lymph nodes (LNs) according to the number of LNs removed at radical cystectomy (RC), as the number of LNs removed affects disease progression and survival after RC. PATIENTS AND METHODS:Between 1984 and 2003, 731 assessable patients had RC and bilate...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Capitanio U,Suardi N,Shariat SF,Lotan Y,Palapattu GS,Bastian PJ,Gupta A,Vazina A,Schoenberg M,Lerner SP,Sagalowsky AI,Karakiewicz PI

    更新日期:2009-05-01 00:00:00

  • Structural and functional investigations of the murine cavernosal nerve: a model system for serial spatio-temporal study of autonomic neuropathy.

    abstract:OBJECTIVE:To illustrate the ultrastructural fibre composition of the rat cavernosal nerve at serial levels, from its origin in the main pelvic ganglion to its termination in the corpus cavernosum of the distal penile shaft, and to develop a technique that permits repeated electrophysiological recording from the fibres ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Schaumburg HH,Zotova E,Cannella B,Raine CS,Arezzo J,Tar M,Melman A

    更新日期:2007-04-01 00:00:00