Abstract:
OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent endorectal MRI at 1.5 T before radical prostatectomy (RP) for localized prostate cancer. • On T2W images and histological whole-mount analysis, the peripheral zone (PZ) and transition zone (TZ) were divided into upper and lower glands, as well as left and right halves, thus yielding four quadrants for each zone. • On histological analysis, the total number of tumour foci, their location and larger diameter were recorded. T2W alone, T2W + DWI, T2W + DCE and all three techniques combined were scored for the likelihood of tumour in each area and results were compared with whole-mount analysis. • The area under the receiver operating characteristic curve (A(z)) was used to evaluate accuracy for tumour detection. The association between MR accuracy and Gleason score was statistically assessed. RESULTS:• Of the 456 prostate octants analysed, 145 showed cancer on whole-mount analysis, 120 (83%) of them with a diameter assumed to correspond to a volume >0.2 cm³. Gleason score was ≥7 in 68 (47%) tumours. • In the PZ, the A(z) value was significantly higher for T2W + DWI, T2W + DCE and all three techniques combined than for T2W alone (P < 0.05). • In the TZ, the A(z) value was higher for T2W + DWI than for T2W alone, but the difference was not significant. • The A(z) value for T2W + DWI was significantly higher than that for T2W + DCE or for the three sequences combined. • Gleason score was significantly associated with cancer detection in the PZ. CONCLUSIONS:• Adding DWI and DCE to T2W imaging increased MRI performance in cancer detection in the PZ significantly. • However, this multiparametric model failed to improve performance in the TZ. • Gleason score significantly influenced cancer detection in the PZ but not in the TZ.
journal_name
BJU Intjournal_title
BJU internationalauthors
Delongchamps NB,Rouanne M,Flam T,Beuvon F,Liberatore M,Zerbib M,Cornud Fdoi
10.1111/j.1464-410X.2010.09808.xsubject
Has Abstractpub_date
2011-05-01 00:00:00pages
1411-8issue
9eissn
1464-4096issn
1464-410Xjournal_volume
107pub_type
杂志文章abstract:OBJECTIVE:• To evaluate the safety and efficacy of once-daily trospium chloride extended release (ER) in overactive bladder syndrome (OAB) in subjects aged ≥ 75 years. SUBJECTS AND METHODS:• The analysis included subjects ≥ 75 years of age with OAB. • A subgroup analysis of pooled data was performed for subjects aged ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2010.09519.x
更新日期:2011-02-01 00:00:00
abstract:OBJECTIVE:To assess the expression of the tumour markers stromelysin 3, MUC1, p53 and cytokeratin-7 in papillary renal cell carcinoma (pRCC, for which two histological subtypes are distinguished, i.e. type 1 and type 2, the latter appearing to be associated with a poorer prognosis) and to determine whether any of these...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07605.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07164.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:To determine the effectiveness of Uromune® in preventing recurrent urinary tract infections (UTIs) in women. PATIENTS AND METHODS:A total of 77 women with microbiology-proven recurrent UTIs were given Uromune sublingual vaccine for a period of 3 months. Time to first UTI recurrence since treatment and adver...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14067
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abstract:OBJECTIVE:To characterize a newly established human testicular carcinoma cell line that continuously produces alpha-fetoprotein (AFP), and to investigate the effects of retinoic acid on AFP production. MATERIALS AND METHODS:A 24-year-old man underwent a radical orchidectomy for a right testicular tumour and was found ...
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02357.x
更新日期:2001-10-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2011.10124.x
更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.14642
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-11-01 00:00:00
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doi:10.1111/j.1464-410X.2012.11316.x
更新日期:2013-03-01 00:00:00
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更新日期:2012-12-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06681.x
更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.14226
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.09042.x
更新日期:2010-06-01 00:00:00
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doi:10.1111/j.1464-410X.2005.05828.x
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05970.x
更新日期:2006-04-01 00:00:00
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更新日期:2012-06-01 00:00:00
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doi:10.1046/j.1464-410x.2001.02212.x
更新日期:2001-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11716.x
更新日期:2013-01-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05522.x
更新日期:2005-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10406.x
更新日期:2012-02-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/bju.14703
更新日期:2019-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02809.x
更新日期:2002-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2005-10-01 00:00:00
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doi:10.1046/j.1464-410x.2003.04261.x
更新日期:2003-07-01 00:00:00
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doi:10.1111/bju.13034
更新日期:2016-03-01 00:00:00
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更新日期:2018-01-01 00:00:00
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更新日期:2014-11-01 00:00:00