Abstract:
OBJECTIVES:To identify biomarkers that predict the response to standard androgen deprivation therapy (ADT) of patients newly diagnosed with metastatic castration-sensitive prostate cancer (CSPC) in order to improve therapeutic decision-making, and to investigate whether the characterization of baseline circulating tumour cells (CTCs) would predict the effective period of standard ADT. MATERIALS AND METHODS:The study included 108 patients newly diagnosed with high-volume metastatic CSPC. Enumeration and characterization of patients' baseline CTCs (CTCs+ and CTCs-, indicating detectable and undetectable CTCs, respectively) were performed using the CanPatrol technique, which detects markers of the epithelial to mesenchymal transition (EMT) in CTCs, and classifies CTCs into epithelial, biophenotypic and mesenchymal phenotypes. RESULTS:After a median follow-up of 24 months, 90 patients (83.3%) progressed to castration-resistant prostate cancer (CRPC), 93 patients (86.1%) had detectable CTCs, and the median number of CTCs was 4. The rate of progression to CRPC was significantly higher for patients with mesenchymal CTCs+ than for patients with CTCs+/mesenchymal CTCs- and CTCs- (93.1% vs 71.4% and 73.3%; P = 0.013). The median time to CRPC for patients with mesenchymal CTCs+ was significantly shorter than for those with CTCs+/mesenchymal CTCs- and CTCs- (10.5 months vs 18.0 and 14.0 months; P = 0.003). Multivariate Cox regression analysis suggested that the CTC phenotype was the only independent prognostic factor influencing the progression of disease from CSPC to CRPC. CONCLUSIONS:Characterization of baseline CTCs according to the EMT phenotype predicted the effective period of standard ADT for patients newly diagnosed with metastatic CSPC. These findings are important for counselling patients and designing clinical trials.
journal_name
BJU Intjournal_title
BJU internationalauthors
Yang YJ,Kong YY,Li GX,Wang Y,Ye DW,Dai Bdoi
10.1111/bju.14642subject
Has Abstractpub_date
2019-08-01 00:00:00pages
258-267issue
2eissn
1464-4096issn
1464-410Xjournal_volume
124pub_type
杂志文章abstract:OBJECTIVES:The aim of the present paper was to determine the impact of testicular cancer (TC) and its treatments on fertility and to review the current management options for the infertile patient with TC, both before diagnosis and after treatment, with the aim of providing practical recommendations to update contempor...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14455
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. PATIENTS AND METHODS:Using electronic and paper medical records, 89 patients were identified who underwent radical cystectomy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12384
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abstract:OBJECTIVE:To evaluate the epidemiology of lower urinary tract symptoms (LUTS) among men and women, as there are significant unanswered questions about the prevalence and impact of LUTS in different populations. SUBJECTS AND METHODS:A population-based, cross-sectional survey was completed in Boxmeer (the Netherlands), ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2003.04369.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2000.00979.x
更新日期:2000-12-01 00:00:00
abstract:OBJECTIVE:To identify predictors for long-term urinary leakage after radical prostatectomy. PATIENTS AND METHODS:A consecutive series of 1411 patients who underwent radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital between 2002 and 2006 were invited to comple...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10231.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To evaluate the diffusion of nephron-sparing modalities (NSM) for the treatment of renal neoplasms in the USA over the last decade and to identify the factors associated with renal procedure selection. PATIENTS AND METHODS:The Nationwide Inpatient Sample was utlized to identify patients undergoing cryo/radio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11497.x
更新日期:2013-06-01 00:00:00
abstract::• Renal angiomyolipomas (AMLs) are usually easy to diagnose with imaging alone. They have unique characteristics on ultrasonography, computerised tomography and magnetic resonance imaging that usually allow AMLs to be differentiated from other renal masses. • If this is not possible on imaging criteria then biopsy can...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11618.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To assess the long-term outcome of forearm free-flap phalloplasty in transsexuals, as obtaining a satisfying neophallus in female-to-male transsexuals is a surgical challenge. PATIENTS AND METHODS:We analysed retrospectively 56 transsexuals who had a phalloplasty using a radial forearm free-flap in our depar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07362.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00254.x
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To determine the acceptability and patient satisfaction of transrectal biopsy undertaken with the patient under sedation. Patients and methods A retrospective questionnaire was sent to 100 patients who had undergone transrectal biopsy between January and August 1998. Levels of patient acceptability and satisf...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02221.x
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVE:To characterise the surgical feasibility and outcomes of robot-assisted radical cystectomy (RARC) for pathological T4 bladder cancer. PATIENTS AND METHODS:Retrospective evaluation of a prospectively maintained International Radical Cystectomy Consortium database was conducted for 1118 patients who underwent ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12569
更新日期:2014-07-01 00:00:00
abstract:OBJECTIVE:To present early outcome data from patients treated for invasive penile cancers with organ-sparing surgery, as the treatment of such malignancies has traditionally either been amputative surgery or radical radiotherapy, both associated with significant physical and psychosexual morbidity. PATIENTS AND METHOD...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05153.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To assess fibroblast growth factor-2 (FGF2/bFGF), which is important in the development and maintenance of the normal prostate and in the development of human benign prostatic hyperplasia (BPH) and prostatic carcinoma, in an animal model of experimentally induced diabetes. Materials and methods Using Western ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00597.x
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00028.x
更新日期:1999-05-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? Patient-reported quality of life (QoL) in prostate cancer is recognized as an important outcome, and has been shown in multiple studies to capture the incidence and timing of patient symptoms more acc...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11117.x
更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.13437
更新日期:2016-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09992.x
更新日期:2011-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00484.x
更新日期:2000-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06069.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06496.x
更新日期:2006-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12000
更新日期:2013-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10728.x
更新日期:2012-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06430.x
更新日期:2006-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04237.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVES:To explore the role of transient receptor potential vanilloid 1 (TRPV1) in the excitatory effects of chronic administration of nerve growth factor (NGF) on bladder-generated sensory input and reflex activity. To explore new therapeutic targets for bladder dysfunction. MATERIALS AND METHODS:Wild-type (WT) an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11187.x
更新日期:2012-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14775
更新日期:2019-11-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/bju.14703
更新日期:2019-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06350.x
更新日期:2006-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10159.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To determine whether the use of nephron-sparing surgery (NSS) for treatment of stage 1 renal cell carcinoma (RCC) changed between 2009 and the end of 2013 in Australia. PATIENTS AND METHODS:All adult cases of RCC diagnosed in 2009, 2012 and 2013 were identified through the population-based Victorian Cancer ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13889
更新日期:2017-11-01 00:00:00