Phenotypes of circulating tumour cells predict time to castration resistance in metastatic castration-sensitive prostate cancer.

Abstract:

OBJECTIVES:To identify biomarkers that predict the response to standard androgen deprivation therapy (ADT) of patients newly diagnosed with metastatic castration-sensitive prostate cancer (CSPC) in order to improve therapeutic decision-making, and to investigate whether the characterization of baseline circulating tumour cells (CTCs) would predict the effective period of standard ADT. MATERIALS AND METHODS:The study included 108 patients newly diagnosed with high-volume metastatic CSPC. Enumeration and characterization of patients' baseline CTCs (CTCs+ and CTCs-, indicating detectable and undetectable CTCs, respectively) were performed using the CanPatrol technique, which detects markers of the epithelial to mesenchymal transition (EMT) in CTCs, and classifies CTCs into epithelial, biophenotypic and mesenchymal phenotypes. RESULTS:After a median follow-up of 24 months, 90 patients (83.3%) progressed to castration-resistant prostate cancer (CRPC), 93 patients (86.1%) had detectable CTCs, and the median number of CTCs was 4. The rate of progression to CRPC was significantly higher for patients with mesenchymal CTCs+ than for patients with CTCs+/mesenchymal CTCs- and CTCs- (93.1% vs 71.4% and 73.3%; P = 0.013). The median time to CRPC for patients with mesenchymal CTCs+ was significantly shorter than for those with CTCs+/mesenchymal CTCs- and CTCs- (10.5 months vs 18.0 and 14.0 months; P = 0.003). Multivariate Cox regression analysis suggested that the CTC phenotype was the only independent prognostic factor influencing the progression of disease from CSPC to CRPC. CONCLUSIONS:Characterization of baseline CTCs according to the EMT phenotype predicted the effective period of standard ADT for patients newly diagnosed with metastatic CSPC. These findings are important for counselling patients and designing clinical trials.

journal_name

BJU Int

journal_title

BJU international

authors

Yang YJ,Kong YY,Li GX,Wang Y,Ye DW,Dai B

doi

10.1111/bju.14642

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

258-267

issue

2

eissn

1464-4096

issn

1464-410X

journal_volume

124

pub_type

杂志文章
  • Fertility managment in testicular cancer: the need to establish a standardized and evidence-based patient-centric pathway.

    abstract:OBJECTIVES:The aim of the present paper was to determine the impact of testicular cancer (TC) and its treatments on fertility and to review the current management options for the infertile patient with TC, both before diagnosis and after treatment, with the aim of providing practical recommendations to update contempor...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14455

    authors: Moody JA,Ahmed K,Yap T,Minhas S,Shabbir M

    更新日期:2019-01-01 00:00:00

  • USANZ: Time-trends in use and impact on outcomes of perioperative chemotherapy in patients treated with radical cystectomy for urothelial bladder cancer.

    abstract:OBJECTIVE:To review time-trends in the use of perioperative chemotherapy and its impact on oncological outcomes in patients with bladder urothelial cancer (UC) at a single tertiary institution. PATIENTS AND METHODS:Using electronic and paper medical records, 89 patients were identified who underwent radical cystectomy...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12384

    authors: Liew MS,Azad A,Tafreshi A,Eapen R,Bolton D,Davis ID,Sengupta S

    更新日期:2013-11-01 00:00:00

  • The prevalence of lower urinary tract symptoms in men and women in four centres. The UrEpik study.

    abstract:OBJECTIVE:To evaluate the epidemiology of lower urinary tract symptoms (LUTS) among men and women, as there are significant unanswered questions about the prevalence and impact of LUTS in different populations. SUBJECTS AND METHODS:A population-based, cross-sectional survey was completed in Boxmeer (the Netherlands), ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-410x.2003.04369.x

    authors: Boyle P,Robertson C,Mazzetta C,Keech M,Hobbs FD,Fourcade R,Kiemeney L,Lee C,UrEpik Study Group.

    更新日期:2003-09-01 00:00:00

  • The control of haemolysis during transurethral resection of the prostate when water is used for irrigation: monitoring absorption by the ethanol method.

    abstract:OBJECTIVE:To determine whether the addition of ethanol to water for irrigation during transurethral resection of the prostate (TURP) and monitoring breath ethanol could be used to detect irrigant absorption and to limit free plasma haemoglobin in cases of absorption. PATIENTS AND METHODS:One hundred patients (46 in Pi...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00979.x

    authors: Hultén JO,Tran VT,Pettersson G

    更新日期:2000-12-01 00:00:00

  • Age at surgery, educational level and long-term urinary incontinence after radical prostatectomy.

    abstract:OBJECTIVE:To identify predictors for long-term urinary leakage after radical prostatectomy. PATIENTS AND METHODS:A consecutive series of 1411 patients who underwent radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital between 2002 and 2006 were invited to comple...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10231.x

    authors: Nilsson AE,Schumacher MC,Johansson E,Carlsson S,Stranne J,Nyberg T,Wiklund NP,Steineck G

    更新日期:2011-11-01 00:00:00

  • Trends in the surgical management of localized renal masses: thermal ablation, partial and radical nephrectomy in the USA, 1998-2008.

    abstract:OBJECTIVE:To evaluate the diffusion of nephron-sparing modalities (NSM) for the treatment of renal neoplasms in the USA over the last decade and to identify the factors associated with renal procedure selection. PATIENTS AND METHODS:The Nationwide Inpatient Sample was utlized to identify patients undergoing cryo/radio...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11497.x

    authors: Woldrich JM,Palazzi K,Stroup SP,Sur RL,Parsons JK,Chang D,Derweesh IH

    更新日期:2013-06-01 00:00:00

  • Renal angiomyolipoma.

    abstract::• Renal angiomyolipomas (AMLs) are usually easy to diagnose with imaging alone. They have unique characteristics on ultrasonography, computerised tomography and magnetic resonance imaging that usually allow AMLs to be differentiated from other renal masses. • If this is not possible on imaging criteria then biopsy can...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2012.11618.x

    authors: Lienert AR,Nicol D

    更新日期:2012-12-01 00:00:00

  • Long-term outcome of forearm flee-flap phalloplasty in the treatment of transsexualism.

    abstract:OBJECTIVE:To assess the long-term outcome of forearm free-flap phalloplasty in transsexuals, as obtaining a satisfying neophallus in female-to-male transsexuals is a surgical challenge. PATIENTS AND METHODS:We analysed retrospectively 56 transsexuals who had a phalloplasty using a radial forearm free-flap in our depar...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07362.x

    authors: Leriche A,Timsit MO,Morel-Journel N,Bouillot A,Dembele D,Ruffion A

    更新日期:2008-05-01 00:00:00

  • Evaluation of nuclear matrix protein 22 as a tumour marker in the detection of transitional cell carcinoma of the bladder.

    abstract:OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00254.x

    authors: Sánchez-Carbayo M,Herrero E,Megías J,Mira A,Soria F

    更新日期:1999-10-01 00:00:00

  • Increased patient satisfaction from transrectal ultrasonography and biopsy under sedation.

    abstract:OBJECTIVE:To determine the acceptability and patient satisfaction of transrectal biopsy undertaken with the patient under sedation. Patients and methods A retrospective questionnaire was sent to 100 patients who had undergone transrectal biopsy between January and August 1998. Levels of patient acceptability and satisf...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02221.x

    authors: Peters JL,Thompson AC,McNicholas TA,Hines JE,Hanbury DC,Boustead GB

    更新日期:2001-06-01 00:00:00

  • Efficacy of robot-assisted radical cystectomy (RARC) in advanced bladder cancer: results from the International Radical Cystectomy Consortium (IRCC).

    abstract:OBJECTIVE:To characterise the surgical feasibility and outcomes of robot-assisted radical cystectomy (RARC) for pathological T4 bladder cancer. PATIENTS AND METHODS:Retrospective evaluation of a prospectively maintained International Radical Cystectomy Consortium database was conducted for 1118 patients who underwent ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12569

    authors: Al-Daghmin A,Kauffman EC,Shi Y,Badani K,Balbay MD,Canda E,Dasgupta P,Ghavamian R,Grubb R 3rd,Hemal A,Kaouk J,Kibel AS,Maatman T,Menon M,Mottrie A,Nepple K,Pattaras JG,Peabody JO,Poulakis V,Pruthi R,Palou Redorta J

    更新日期:2014-07-01 00:00:00

  • Organ-sparing surgery for invasive penile cancer: early follow-up data.

    abstract:OBJECTIVE:To present early outcome data from patients treated for invasive penile cancers with organ-sparing surgery, as the treatment of such malignancies has traditionally either been amputative surgery or radical radiotherapy, both associated with significant physical and psychosexual morbidity. PATIENTS AND METHOD...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05153.x

    authors: Pietrzak P,Corbishley C,Watkin N

    更新日期:2004-12-01 00:00:00

  • Expression and localization of basic fibroblast growth factor in diabetic rat prostate.

    abstract:OBJECTIVE:To assess fibroblast growth factor-2 (FGF2/bFGF), which is important in the development and maintenance of the normal prostate and in the development of human benign prostatic hyperplasia (BPH) and prostatic carcinoma, in an animal model of experimentally induced diabetes. Materials and methods Using Western ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00597.x

    authors: Wang Z,Ikeda K,Wada Y,Foster HE,Weiss RM,Latifpour J

    更新日期:2000-05-01 00:00:00

  • Endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of goserelin acetate administered every 13 weeks to patients with advanced prostate cancer.

    abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1464-410x.1999.00028.x

    authors: Sarosdy MF,Schellhammer PF,Soloway MS,Vogelzang NJ,Crawford ED,Presti J,Chodak GW,Mitchell P,Porter L

    更新日期:1999-05-01 00:00:00

  • Patient-reported quality of life during radiation treatment for localized prostate cancer: results from a prospective phase II trial.

    abstract:UNLABELLED:Study Type--Therapy (cohort) Level of Evidence 2a. What's known on the subject? and What does the study add? Patient-reported quality of life (QoL) in prostate cancer is recognized as an important outcome, and has been shown in multiple studies to capture the incidence and timing of patient symptoms more acc...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11117.x

    authors: Chen RC,Zhang Y,Chen MH,McMahon E,Loffredo M,McPherson CP,Nguyen AU,Nguyen PL,D'Amico AV

    更新日期:2012-12-01 00:00:00

  • European Randomised Study of Screening for Prostate Cancer (ERSPC) risk calculators significantly outperform the Prostate Cancer Prevention Trial (PCPT) 2.0 in the prediction of prostate cancer: a multi-institutional study.

    abstract:OBJECTIVE:To analyse the performance of the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and two iterations of the European Randomised Study of Screening for Prostate Cancer (ERSPC) Risk Calculator, one of which incorporates prostate volume (ERSPC-RC) and the other of which incorporates prostate volume an...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/bju.13437

    authors: Foley RW,Maweni RM,Gorman L,Murphy K,Lundon DJ,Durkan G,Power R,O'Brien F,O'Malley KJ,Galvin DJ,Brendan Murphy T,William Watson R

    更新日期:2016-11-01 00:00:00

  • Introduction to biodegradable polylactic acid ureteral stent application for treatment of ureteral war injury.

    abstract:OBJECTIVE:• To study the operability and effectiveness of a biodegradable ureteral stent for clinical treatment of ureteral war injury using a canine model. MATERIALS AND METHODS:• A device was designed and employed to generate firearm fragment wounds in unilateral ureters (on randomly chosen sides) of nine beagles (G...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09992.x

    authors: Li G,Wang ZX,Fu WJ,Hong BF,Wang XX,Cao L,Xu FQ,Song Q,Cui FZ,Zhang X

    更新日期:2011-09-01 00:00:00

  • Artificial sphincter insertion after radiotherapy: is it worthwhile?

    abstract:OBJECTIVE:To determine the influence of radiotherapy on the outcome of artificial urinary sphincter implantation. PATIENTS AND METHODS:A series of 72 men who had an artificial urinary sphincter inserted were reviewed retrospectively, analysing in detail the information from 15 patients with a past history of pelvic ra...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00484.x

    authors: Manunta A,Guillé F,Patard JJ,Lobel B

    更新日期:2000-03-01 00:00:00

  • Diagnostic utility of a p63/alpha-methyl coenzyme A racemase (p504s) cocktail in ambiguous lesions of the prostate upon needle biopsy.

    abstract:OBJECTIVE:To investigate the potential utility of a new combined immunostaining technique for diagnosing prostate cancer from histological analysis of needle biopsy specimens. MATERIALS AND METHODS:Tissue was immunostained with a combination of antibodies against a basal cell marker (p63), and an enzyme commonly overe...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06069.x

    authors: Molinié V,Hervé JM,Lugagne PM,Lebret T,Botto H

    更新日期:2006-05-01 00:00:00

  • Cisplatin, methotrexate and bleomycin for treating advanced penile carcinoma.

    abstract:OBJECTIVE:To retrospectively evaluate the efficacy and toxicity of chemotherapy with cisplatinum, methotrexate and bleomycin (CMB) in the adjuvant and palliative setting, and its effect on survival in patients with locally advanced or metastatic penile carcinoma, which carries a very poor prognosis. PATIENTS AND METHO...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06496.x

    authors: Hakenberg OW,Nippgen JB,Froehner M,Zastrow S,Wirth MP

    更新日期:2006-12-01 00:00:00

  • Current role of image-guided robotic radiosurgery (Cyberknife(®) ) for prostate cancer treatment.

    abstract:OBJECTIVES:To describe the most recent data from phase I and II clinical trials of stereotactic body radiation therapy (SBRT) using image-guided robotic radiosurgery, specifically the Cyberknife(®) (Accuracy Incorporated, Sunnyvale, CA, USA). To better determine thecurrent role of this type of radiosurgery in prostate ...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.12000

    authors: Seisen T,Drouin SJ,Phé V,Parra J,Mozer P,Bitker MO,Cussenot O,Rouprêt M

    更新日期:2013-05-01 00:00:00

  • Androgen deprivation therapy before radical prostatectomy is associated with poorer postoperative erectile function outcomes.

    abstract:UNLABELLED:Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen de...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10728.x

    authors: Mazzola CR,Deveci S,Heck M,Mulhall JP

    更新日期:2012-07-01 00:00:00

  • The use of robotically assisted surgery for treating urachal anomalies.

    abstract:OBJECTIVE:To report the management of urachal anomalies using a robotically assisted approach. PATIENTS AND METHODS:Between January 2005 and February 2006, five patients (mean age 51 years, range 24-68) were diagnosed with urachal anomalies. Two basic robot-assisted surgical approaches were used for excising the urach...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06430.x

    authors: Madeb R,Knopf JK,Nicholson C,Donahue LA,Adcock B,Dever D,Tan BJ,Valvo JR,Eichel L

    更新日期:2006-10-01 00:00:00

  • Contralateral adrenal metastasis of renal cell carcinoma: treatment, outcome and a review.

    abstract:OBJECTIVE:To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04237.x

    authors: Lau WK,Zincke H,Lohse CM,Cheville JC,Weaver AL,Blute ML

    更新日期:2003-06-01 00:00:00

  • Transient receptor potential vanilloid 1 mediates nerve growth factor-induced bladder hyperactivity and noxious input.

    abstract:OBJECTIVES:To explore the role of transient receptor potential vanilloid 1 (TRPV1) in the excitatory effects of chronic administration of nerve growth factor (NGF) on bladder-generated sensory input and reflex activity. To explore new therapeutic targets for bladder dysfunction. MATERIALS AND METHODS:Wild-type (WT) an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11187.x

    authors: Frias B,Charrua A,Avelino A,Michel MC,Cruz F,Cruz CD

    更新日期:2012-10-01 00:00:00

  • Long-term oncological outcomes of patients with paratesticular sarcoma.

    abstract:OBJECTIVES:To present long-term oncological outcomes of patients with paratesticular sarcoma treated by a multidisciplinary team. PATIENTS AND METHODS:Patients managed at the Princess Margaret Cancer Centre, between 1990 and 2012, were analysed. A sarcoma expert performed central pathology review. Kaplan-Meier graphs ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14775

    authors: Goldberg H,Wong LM,Dickson B,Catton C,Yap SA,Alkasab T,Evans A,van der Kwast T,Jewett MAS,Hamilton RJ

    更新日期:2019-11-01 00:00:00

  • Aquablation for benign prostatic hyperplasia in large prostates (80-150 mL): 6-month results from the WATER II trial.

    abstract:OBJECTIVE:To present 6-month safety and effectiveness data from a multicentre prospective study of aquablation in men with lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH) with prostate volumes between 80 and 150 mL. METHODS:Between September and December 2017, 101 men with LUTSat...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/bju.14703

    authors: Desai M,Bidair M,Zorn KC,Trainer A,Arther A,Kramolowsky E,Doumanian L,Elterman D,Kaufman RP Jr,Lingeman J,Krambeck A,Eure G,Badlani G,Plante M,Uchio E,Gin G,Goldenberg L,Paterson R,So A,Humphreys M,Roehrborn C,K

    更新日期:2019-08-01 00:00:00

  • The expression of prostate stem cell antigen in human clear cell renal cell carcinoma: a quantitative reverse transcriptase-polymerase chain reaction analysis.

    abstract:OBJECTIVES:To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression o...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06350.x

    authors: Elsamman EM,Fukumori T,Tanimoto S,Nakanishi R,Takahashi M,Toida K,Kanayama HO

    更新日期:2006-09-01 00:00:00

  • Effect of statin use on biochemical outcome following radical prostatectomy.

    abstract:OBJECTIVE:•To determine the relationship between statin use and biochemical recurrence (BCR) following radical prostatectomy (RP). PATIENTS AND METHODS:•A retrospective analysis was performed on 3198 RP patients between 1990 and 2008. •Exclusion criteria were neo-adjuvant or adjuvant therapy, follow-up <2 years, and i...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10159.x

    authors: Ritch CR,Hruby G,Badani KK,Benson MC,McKiernan JM

    更新日期:2011-10-01 00:00:00

  • Trends in the surgical management of stage 1 renal cell carcinoma: findings from a population-based study.

    abstract:OBJECTIVES:To determine whether the use of nephron-sparing surgery (NSS) for treatment of stage 1 renal cell carcinoma (RCC) changed between 2009 and the end of 2013 in Australia. PATIENTS AND METHODS:All adult cases of RCC diagnosed in 2009, 2012 and 2013 were identified through the population-based Victorian Cancer ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13889

    authors: White V,Marco DJT,Bolton D,Davis ID,Jefford M,Hill D,Prince HM,Millar JL,Winship IM,Coory M,Giles GG

    更新日期:2017-11-01 00:00:00