Abstract:
OBJECTIVE:To present 6-month safety and effectiveness data from a multicentre prospective study of aquablation in men with lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH) with prostate volumes between 80 and 150 mL. METHODS:Between September and December 2017, 101 men with LUTSattributable to BPHwere prospectively enrolled at 16 centres in Canada and the USA. RESULTS:The mean prostate volume was 107 mL. The mean length of hospital stay after the aquablation procedure was 1.6 days (range: same day to 6 days). The primary safety endpoint (Clavien-Dindo grade 2 or higher or any grade 1 event resulting in persistent disability) at 3 months occurred in 45.5% of men, which met the study design goal of < 65% (P < 0.001). At 6 months, 22% of the patients had experienced a Clavien-Dindo grade 2, 14% a grade 3 and 5% a grade 4 adverse event. Bleeding complications requiring intervention and/or transfusion were recorded in eight patients prior to discharge and in six patients after discharge. The mean International Prostate Symptom Score improved from 23.2 ± 6.3 at baseline to 6.7 ± 5.1 at 3 months, meeting the study's primary efficacy endpoint goal (P < 0.001). The maximum urinary flow rate increased from 8.7 to 18.8 mL/s (P < 0.001) and post-void residual urine volume decreased from 131 at baseline to 47 at 6 months (P < 0.0001). At 6 months, prostate-specific antigen concentration reduced from 7.1 ± 5.9 ng/mL at baseline to 4.0 ± 3.9 ng/mL, a 44% reduction. CONCLUSIONS:Aquablation is safe and effective in treating men with larger prostates (80-150 mL), without significant increase in procedure or resection time.
journal_name
BJU Intjournal_title
BJU internationalauthors
Desai M,Bidair M,Zorn KC,Trainer A,Arther A,Kramolowsky E,Doumanian L,Elterman D,Kaufman RP Jr,Lingeman J,Krambeck A,Eure G,Badlani G,Plante M,Uchio E,Gin G,Goldenberg L,Paterson R,So A,Humphreys M,Roehrborn C,Kdoi
10.1111/bju.14703subject
Has Abstractpub_date
2019-08-01 00:00:00pages
321-328issue
2eissn
1464-4096issn
1464-410Xjournal_volume
124pub_type
临床试验,杂志文章,多中心研究abstract:OBJECTIVE:To test the hypothesis that three-dimensional hypofractionated radiotherapy (3D-HFRT) is well tolerated and not worse than 3-D conventional RT (3D-CRT) for oncological outcome. PATIENTS AND METHODS:In all, 162 men with hystologically confirmed prostate adenocarcinoma were included in the analysis. In all, 82...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09418.x
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To investigate whether fluid shear stress (FSS) induces endothelial nitric oxide synthase (eNOS) activity and NO production in isolated human corpus cavernosal endothelial cells (HCCECs), and whether this response is altered during hyperglycaemia in vitro, as haemodynamic signalling during penile erection ind...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06059.x
更新日期:2006-05-01 00:00:00
abstract:UNLABELLED:A comparison of laparoscopic and open donor nephrectomy is presented by authors from the UK. They found that the laparoscopic approach could safely be offered to patients treated in experienced units and after adequate training fo the surgeon, with no increase in complications or decrease in efficacy. OBJEC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05264.x
更新日期:2005-01-01 00:00:00
abstract:OBJECTIVE:To determine the acceptability and patient satisfaction of transrectal biopsy undertaken with the patient under sedation. Patients and methods A retrospective questionnaire was sent to 100 patients who had undergone transrectal biopsy between January and August 1998. Levels of patient acceptability and satisf...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02221.x
更新日期:2001-06-01 00:00:00
abstract:OBJECTIVES:To investigate long-term oncological outcomes after laparoscopic radical prostatectomy (LRP). To identify parameters influencing recurrence-free survival in a single-institution series. PATIENTS AND METHODS:All patients underwent LRP using the transperitoneal retrograde Heilbronn technique. High-risk patien...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11317.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To compare transurethral resection in saline (TURIS), Greenlight laser vapo-enucleation of the prostate (GL.PVEP), and holmium laser enucleation of the prostate (HoLEP), for controlling lower urinary tract symptoms secondary to large benign prostatic hyperplasia (BPH) and to assess non-inferiority of 3-year r...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15161
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To correlate the results of intraoperative cavernous nerve stimulation (CaNS) at radical prostatectomy (RP), with preoperative erectile function (EF) and to determine the significance of the results of stimulation after RP in predicting the recovery of EF. PATIENTS AND METHODS:The study included 183 potent m...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08519.x
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00028.x
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09695.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To assess the effects of testosterone supplementation in men with testosterone deficiency syndrome (TDS) after external beam radiotherapy (EBRT) for localized prostate cancer. PATIENTS AND METHODS:Five men with significant signs of TDS after treatment for localized prostate cancer with EBRT were treated with...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07882.x
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:To investigate the associations of host metabolic factors and metabolic syndrome on prostate cancer-specific death (PCSD) and overall survival (OS) in patients treated with androgen deprivation therapy (ADT) for biochemically recurrent disease. PATIENTS AND METHODS:The analysis included 273 patients with pr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13428
更新日期:2016-12-01 00:00:00
abstract:OBJECTIVE:To conduct a meta-analysis of the literature on the peri-operative outcomes of both robot-assisted partial nephrectomy (RAPN) and laparoscopic partial nephrectomy (LPN). MATERIALS AND METHODS:An electronic database search of MEDLINE, EMBASE, Google Scholar and the Cochrane Library was performed for publicati...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/bju.12255
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term outcome in children who had an artificial urinary sphincter (AUS) placed, after a minimum of 10 years of follow-up. PATIENTS AND METHODS:The medical records of patients who had an AUS placed at the Children's Hospital of Michigan were reviewed and a telephone questionnaire was then ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00077.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVES:To determine the efficacy, evaluate the safety and assess side-effects (swelling, haematoma and pain) of percutaneous vas occlusion compared with vasectomy in Dutch men. PATIENTS AND METHODS:Vas occlusion and vasectomy procedures (attempted in 58 and 50 men, respectively) were conducted at the University Ho...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00875.x
更新日期:2000-10-01 00:00:00
abstract:OBJECTIVE:To assess the effect of antimuscarinic treatment with tolterodine combined with behavioural modification as a first-line treatment, before invasive investigation, in children with non-neurogenic voiding dysfunction but no obvious anatomical or neurogenic cause. PATIENTS AND METHODS:The study comprised 44 chi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05641.x
更新日期:2005-08-01 00:00:00
abstract::Docetaxel-based therapy is established as the standard first-line chemotherapy in patients with metastatic castration-resistant prostate cancer (mCRPC), based on results from two landmark Phase III studies. However, prognosis remains poor, with a median survival of less than 2 years. There is no standard of care for p...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10036.x
更新日期:2011-04-01 00:00:00
abstract:OBJECTIVE:To determine, using a postal questionnaire survey of practising British consultant urologists, the duration and type of antibiotic deemed most effective in patients with an existing indwelling catheter before transurethral resection of the prostate (TURP), as the value of prophylactic antibiotics before TURP ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04429.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To explore the predictors of the quality of marriage of men with prostate cancer, as being diagnosed with prostate cancer affects the quality of life of the man and his partner, and while some aspects are known about the impact of the disease and its treatments on the man's quality of life, less is known abou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06807.x
更新日期:2007-06-01 00:00:00
abstract::Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The resection of the distal ureter and its orifice is an oncological principle during radical nephroureterectomy which is based on the fact that it represents a part of the urinary tract exposed to a consid...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2010.09835.x
更新日期:2011-07-01 00:00:00
abstract::The development of new imaging techniques and the refinement of established methods in uroradiological imaging is proceeding rapidly. In the last few years several important developments have been implemented in the routine diagnostic evaluation of urological patients.A milestone is the recent advent of multidetector ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2002.02620.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVES:To analyse the gene expression level of prostate stem cell antigen (PSCA) in human clear cell renal cell carcinoma (CC-RCC) and its relationship with conventional clinicopathological manifestations, to evaluate its prognostic value for patient outcome, and to determine the effect of PSCA on the progression o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06350.x
更新日期:2006-09-01 00:00:00
abstract:OBJECTIVES:To investigate whether ureteroscopy (URS) before radical nephroureterectomy (RNU) for upper tract urothelial carcinomas (UTUCs) has an impact on oncological outcomes. PATIENTS AND METHODS:We performed a systematic literature search of PubMed, Web of Science, and EMBASE for citations published prior to Septe...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/bju.14053
更新日期:2018-02-01 00:00:00
abstract::Data from the Japanese Urological Society showed that, in Japan, almost half of patients with localized prostate cancer are treated with hormone therapy (HT), regardless of disease stage, and that radiation therapy (RT) is also widely used to treat high-risk patients. A retrospective study was undertaken in Japan to e...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.06592.x
更新日期:2007-01-01 00:00:00
abstract:OBJECTIVES:To evaluate robotic dry laboratory (dry lab) exercises in terms of their face, content, construct and concurrent validities. To evaluate the applicability of the Global Evaluative Assessment of Robotic Skills (GEARS) tool to assess dry lab performance. MATERIALS AND METHODS:Participants were prospectively c...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12559
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To evaluate the safety and effectiveness of the Seldinger technique by non-urology trained (NUT) doctors for difficult male indwelling urinary catheter (IDC) insertions. PATIENTS AND METHODS:In all, 115 patients and 57 participating NUT doctors were recruited by the urologist or urology registrar, when conta...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13928
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVE:To report the experience of the last 4 years from a centre to which women with voiding difficulties and urinary retention were referred nationally, describing what investigations were helpful in making a diagnosis and the management strategies used. PATIENTS AND METHODS:Women with voiding difficulties and ur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06009.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To investigate whether the antioxidant protection attributed to small heat-shock proteins (sHSPs) affects calcium oxalate stone formation, a pro-oxidant disease. MATERIALS AND METHODS:Canine distal tubular epithelial cells (Madin-Darby canine kidney, MDCK cells) were grown as confluent monolayers. Treatment ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06478.x
更新日期:2006-11-01 00:00:00
abstract:UNLABELLED:To determine whether dendritic cells (DC) transduced with the prostate-specific antigen (PSA) gene can induce PSA-specific cytotoxic lymphocytes (CTL) against prostate cancer cells, and whether bacillus Calmette-Guérin (BCG) cell-wall skeleton (CWS) can enhance the maturation of DC-PSA and the killing activi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410x.2009.08703.x
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:To assess the association between serum prostate-specific antigen (PSA) level and age, liver function tests (LFTs) including alkaline phosphatase (ALP), total bilirubin (TB), lipid profile (total cholesterol, TC, triglycerides, TG, high-density lipoprotein, HDL) and fasting blood sugar (FBS), and to determine...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07774.x
更新日期:2008-11-01 00:00:00