Aquablation for benign prostatic hyperplasia in large prostates (80-150 mL): 6-month results from the WATER II trial.

Abstract:

OBJECTIVE:To present 6-month safety and effectiveness data from a multicentre prospective study of aquablation in men with lower urinary tract symptoms (LUTS) attributable to benign prostatic hyperplasia (BPH) with prostate volumes between 80 and 150 mL. METHODS:Between September and December 2017, 101 men with LUTSattributable to BPHwere prospectively enrolled at 16 centres in Canada and the USA. RESULTS:The mean prostate volume was 107 mL. The mean length of hospital stay after the aquablation procedure was 1.6 days (range: same day to 6 days). The primary safety endpoint (Clavien-Dindo grade 2 or higher or any grade 1 event resulting in persistent disability) at 3 months occurred in 45.5% of men, which met the study design goal of < 65% (P < 0.001). At 6 months, 22% of the patients had experienced a Clavien-Dindo grade 2, 14% a grade 3 and 5% a grade 4 adverse event. Bleeding complications requiring intervention and/or transfusion were recorded in eight patients prior to discharge and in six patients after discharge. The mean International Prostate Symptom Score improved from 23.2 ± 6.3 at baseline to 6.7 ± 5.1 at 3 months, meeting the study's primary efficacy endpoint goal (P < 0.001). The maximum urinary flow rate increased from 8.7 to 18.8 mL/s (P < 0.001) and post-void residual urine volume decreased from 131 at baseline to 47 at 6 months (P < 0.0001). At 6 months, prostate-specific antigen concentration reduced from 7.1 ± 5.9 ng/mL at baseline to 4.0 ± 3.9 ng/mL, a 44% reduction. CONCLUSIONS:Aquablation is safe and effective in treating men with larger prostates (80-150 mL), without significant increase in procedure or resection time.

journal_name

BJU Int

journal_title

BJU international

authors

Desai M,Bidair M,Zorn KC,Trainer A,Arther A,Kramolowsky E,Doumanian L,Elterman D,Kaufman RP Jr,Lingeman J,Krambeck A,Eure G,Badlani G,Plante M,Uchio E,Gin G,Goldenberg L,Paterson R,So A,Humphreys M,Roehrborn C,K

doi

10.1111/bju.14703

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

321-328

issue

2

eissn

1464-4096

issn

1464-410X

journal_volume

124

pub_type

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