The quality of life of men with locally advanced prostate cancer during neoadjuvant hormone therapy: data from the Medical Research Council RT01 trial (ISRCTN 47772397).


OBJECTIVE:To explore patients' quality of life (QoL) during neoadjuvant hormone therapy (HT) using data from the Medical Research Council RT01 trial of standard- (64 Gy/32-fraction) and high- (74 Gy/37-fraction) dose radiotherapy (RT, both given conformally). PATIENTS AND METHODS:Of the 843 patients randomized to the RT01 trial, 316 completed the Functional Assessment Of Cancer Therapy core questionnaire with its additional prostate subscale, and the Short Form-36 Health Survey questionnaire with the University of California-Los Angeles Prostate Cancer Index before HT and again before starting RT. Three predefined QoL hypotheses were generated to focus the analyses. RESULTS:For the three primary QoL analyses there was evidence that sexual functioning deteriorated, urinary function did not change, and there was a slight decline in physical well-being after > or = 3 months of HT. Sensitivity analyses confirmed these findings. Exploratory analyses also suggested that role functioning deteriorated, sleep was more disturbed, and there was an increase in fatigue. However, overall QoL was not reported to be affected and patients indicated an improvement in attitude and satisfaction with treatment. CONCLUSIONS:In this group of men, many of whom reported reduced sexual functioning before treatment, the additional decline during HT seemed to be generally accepted as the price to pay for an appropriate cancer treatment. Nevertheless, these changes need to be discussed with patients before HT is commenced.




BJU international


Stephens RJ,Dearnaley DP,Cowan R,Sydes M,Naylor S,Fallowfield L,RT01 collaborators.




Has Abstract


2007-02-01 00:00:00














  • Telomerase activity in disseminated prostate cancer cells.

    abstract:OBJECTIVE:To analyse telomerase activity in disseminated prostate cancer cells isolated from bone marrow aspirates taken from men with localized prostate cancer before radical prostatectomy (RP). PATIENTS AND METHODS:Disseminated epithelial prostate cancer cells were isolated from bone marrow aspirates from 69 men wit...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Pfitzenmaier J,Ellis WJ,Arfman EW,Hawley S,McLaughlin PO,Lange PH,Vessella RL

    更新日期:2006-06-01 00:00:00

  • The utility of lactate dehydrogenase in the follow-up of testicular germ cell tumours.

    abstract:OBJECTIVE:To evaluate the utility of lactate dehydrogenase (LDH), a tumour marker that is frequently elevated at diagnosis and relapse of testicular germ cell tumours (TGCTs), in the follow-up of TGCTs for detecting tumour relapse, as it has role as a prognostic factor but its role in follow-up is less certain. PATIEN...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Venkitaraman R,Johnson B,Huddart RA,Parker CC,Horwich A,Dearnaley DP

    更新日期:2007-07-01 00:00:00

  • Frozen section during partial nephrectomy: does it predict positive margins?

    abstract:OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Gordetsky J,Gorin MA,Canner J,Ball MW,Pierorazio PM,Allaf ME,Epstein JI

    更新日期:2015-12-01 00:00:00

  • Recovery of erectile function after radical prostatectomy is quantitatively related to the response to intraoperative cavernous nerve stimulation.

    abstract:OBJECTIVE:To correlate the results of intraoperative cavernous nerve stimulation (CaNS) at radical prostatectomy (RP), with preoperative erectile function (EF) and to determine the significance of the results of stimulation after RP in predicting the recovery of EF. PATIENTS AND METHODS:The study included 183 potent m...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Rabbani F,Patel M,Cozzi P,Mulhall JP,Scardino PT

    更新日期:2009-11-01 00:00:00

  • Laparoendoscopic single-site nephroureterectomy for upper urinary tract urothelial carcinoma: outcomes of an international multi-institutional study of 101 patients.

    abstract:OBJECTIVE:To report a large multi-institutional series of laparoendoscopic single-site (LESS) nephroureterectomy (NU). MATERIALS AND METHODS:Data on all cases of LESS-NU performed between 2008 and 2012 at 15 institutions were retrospectively gathered. The main demographic data and perioperative outcomes were analysed....

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Park SY,Rha KH,Autorino R,Derweesh I,Liastikos E,Tsai YC,Seo IY,Nagele U,Abdel-Karim AM,Herrmann T,Han DH,Rais-Bahrami S,Lee SW,Kim KS,Fornara P,Kallidonis P,Springer C,Élsalmy S,Chueh SC,Ho CH,Panumatrassamee K,

    更新日期:2013-09-01 00:00:00

  • Does information provided to men before a urodynamic study affect their expectation of pain?

    abstract:OBJECTIVE:To evaluate the effect of a routine explanation provided to men on their expectation of pain associated with a urodynamic study (UDS). PATIENTS AND METHODS:The purpose of UDS is to reproduce patient's symptoms during the urine storage and voiding phases, and thus understand the causes of the patient's sympto...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Greenstein A,Bar-Yosef Y,Chen J,Matzkin H

    更新日期:2005-12-01 00:00:00

  • Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy confirmed Gleason score 3 + 4 prostate cancer.

    abstract:OBJECTIVE:To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). PATIENTS AND METHODS:We identified 131...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Gondo T,Poon BY,Matsumoto K,Bernstein M,Sjoberg DD,Eastham JA

    更新日期:2015-01-01 00:00:00

  • Severity categories of the International Prostate Symptom Score before, and urinary morbidity after, permanent prostate brachytherapy.

    abstract:OBJECTIVE:To determine if the International Prostate Symptom Score (IPSS) before seed implantation, stratified into mild (0-7), moderate (8-19) and severe (>20) categories, predicts brachytherapy-related morbidity in terms of IPSS resolution, catheter dependency and the need for surgical intervention after brachytherap...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Gutman S,Merrick GS,Butler WM,Wallner KE,Allen Z,Galbreath RW,Adamovich E

    更新日期:2006-01-01 00:00:00

  • The pitfalls of vaginal construction.

    abstract:OBJECTIVE:To evaluate a group of young women undergoing complex vaginoplasty, which may be defined as where there has already been previous complex pelvic surgery and the patient is unsuitable for conservative treatment or minor surgical revision. PATIENTS AND METHODS:All patients who had undergone a complex vaginopla...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Davies MC,Creighton SM,Woodhouse CR

    更新日期:2005-06-01 00:00:00

  • Clomiphene citrate is safe and effective for long-term management of hypogonadism.

    abstract:OBJECTIVE:To assess the efficacy and safety of long-term clomiphene citrate (CC) therapy in symptomatic patients with hypogonadism (HG). PATIENTS AND METHODS:Serum T, oestradiol and luteinizing hormone (LH) were measured in patients who were treated with CC for over 12 months. Additionally, bone densitometry (BD) resu...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Moskovic DJ,Katz DJ,Akhavan A,Park K,Mulhall JP

    更新日期:2012-11-01 00:00:00

  • A Phase III trial to investigate the timing of radiotherapy for prostate cancer with high-risk features: background and rationale of the Radiotherapy -- Adjuvant Versus Early Salvage (RAVES) trial.

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    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pearse M,Fraser-Browne C,Davis ID,Duchesne GM,Fisher R,Frydenberg M,Haworth A,Jose C,Joseph DJ,Lim TS,Matthews J,Millar J,Sidhom M,Spry NA,Tang CI,Turner S,Williams SG,Wiltshire K,Woo HH,Kneebone A

    更新日期:2014-03-01 00:00:00

  • Evaluation of urinary prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG score changes when starting androgen-deprivation therapy with triptorelin 6-month formulation in patients with locally advanced and metastatic prostate cancer.

    abstract:OBJECTIVE:To assess prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG scores in patients with advanced and metastatic prostate cancer at baseline and after 6 months of treatment with triptorelin 22.5 mg, and analyse these scores in patient-groups defined by different disease characteristics. PATIENTS AND METHODS:The Tr...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Martínez-Piñeiro L,Schalken JA,Cabri P,Maisonobe P,de la Taille A,Triptocare Study Group.

    更新日期:2014-10-01 00:00:00

  • Growth of bone marrow stromal cells on small intestinal submucosa: an alternative cell source for tissue engineered bladder.

    abstract:OBJECTIVE:To assess the potential use of bone marrow stromal cell (BMSC)-seeded biodegradable scaffold for bladder regeneration in a canine model, by characterizing BMSCs and comparing them to bladder smooth muscle cells (SMCs) by immunohistochemistry, growth capability, and contractility. MATERIALS AND METHODS:Bone m...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Zhang Y,Lin HK,Frimberger D,Epstein RB,Kropp BP

    更新日期:2005-11-01 00:00:00

  • Have phosphodiesterase-5 inhibitors changed the indications for penile implants?

    abstract::OBJECTIVE To evaluate the indications for penile prosthesis implantation in the treatment of erectile dysfunction (ED) before and after the introduction of sildenafil. PATIENTS AND METHODS Penile prosthesis implantation was indicated in 144 men with ED at our institution between 1992 and 2007; 83 (55.6%) accepted the ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Cortés-González JR,Glina S

    更新日期:2009-06-01 00:00:00

  • The role of targeted prophylactic antimicrobial therapy before transrectal ultrasonography-guided prostate biopsy in reducing infection rates: a systematic review.

    abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Cussans A,Somani BK,Basarab A,Dudderidge TJ

    更新日期:2016-05-01 00:00:00

  • Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?

    abstract::Advanced adrenal carcinoma remains a significant therapeutic challenge, with conventional approaches to systemic therapy having failed to achieve sustained objective remissions or major survival benefit in most instances. Several systemic therapies, including mitotane, suramin and gossypol, as well as cytotoxic agents...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Costa R,Wesolowski R,Raghavan D

    更新日期:2011-11-01 00:00:00

  • Effects of bariatric surgery on urinary and sexual function.

    abstract:OBJECTIVE:To investigate the effects of weight loss and time post laparoscopic gastric banding surgery (LGB) on urinary and sexual function. MATERIALS AND METHODS:653 females and 145 males who underwent LGB over the last 10 years at a single centre in Australia were contacted by post and asked to complete validated qu...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Ranasinghe WK,Wright T,Attia J,McElduff P,Doyle T,Bartholomew M,Hurley K,Persad RA

    更新日期:2011-01-01 00:00:00

  • Investigation of poorer bladder cancer survival in women in NSW, Australia: a data linkage study.

    abstract:OBJECTIVE:To investigate the associations of a range of personal and clinical variables with bladder cancer survival in men and women in NSW to see if we could explain why bladder cancer survival is consistently poorer in women than in men. PATIENTS AND METHODS:All 6880 cases of bladder cancers diagnosed in NSW betwee...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Tracey E,Watt H,Currow D,Young J,Armstrong B

    更新日期:2014-03-01 00:00:00

  • The incidence of detrusor instability before and after colposuspension: a study using conventional and ambulatory urodynamic monitoring.

    abstract:OBJECTIVE:To determine the incidence of detrusor instability (DI) detected by conventional and ambulatory bladder pressure monitoring, any link between urodynamic findings before and after colposuspension, and between patients' symptoms and the urodynamic findings. PATIENTS AND METHODS:Sixty-five patients, scheduled t...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Brown K,Hilton P

    更新日期:1999-12-01 00:00:00

  • Incidence of bone fracture in patients receiving luteinizing hormone-releasing hormone agonists for prostate cancer.

    abstract:OBJECTIVE:To investigate the incidence of bone fractures in patients receiving luteinizing hormone-releasing hormone agonists (LHRH-a) for prostate cancer (in whom a continued low testosterone level after the long-term administration of these drugs reduces bone mineral density), and thus determine the risk of secondary...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Hatano T,Oishi Y,Furuta A,Iwamuro S,Tashiro K

    更新日期:2000-09-01 00:00:00

  • Penile lichen sclerosus (balanitis xerotica obliterans).

    abstract:UNLABELLED:What's known on the subject? and What does the study add? The clinical presentation and complications of lichen sclerosus are well known. What is less well known is the true incidence of the condition. The published figures are all based on attendance at general medical clinics or specialist clinics, but it ...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Clouston D,Hall A,Lawrentschuk N

    更新日期:2011-11-01 00:00:00

  • Medium-term experience of sacral neuromodulation by tined lead implantation.

    abstract:OBJECTIVE:To describe patient selection for sacral neuromodulation, also known as Interstim therapy, and the results of tined-lead implantation in the medium term. PATIENTS AND METHODS:In all, 49 patients, 39 with refractory overactive bladder symptoms and 10 with urinary retention, were implanted with the tined lead ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Van Voskuilen AC,Oerlemans DJ,Weil EH,van den Hombergh U,van Kerrebroeck PE

    更新日期:2007-01-01 00:00:00

  • Current role of image-guided robotic radiosurgery (Cyberknife(®) ) for prostate cancer treatment.

    abstract:OBJECTIVES:To describe the most recent data from phase I and II clinical trials of stereotactic body radiation therapy (SBRT) using image-guided robotic radiosurgery, specifically the Cyberknife(®) (Accuracy Incorporated, Sunnyvale, CA, USA). To better determine thecurrent role of this type of radiosurgery in prostate ...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Seisen T,Drouin SJ,Phé V,Parra J,Mozer P,Bitker MO,Cussenot O,Rouprêt M

    更新日期:2013-05-01 00:00:00

  • Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients.

    abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Salomon G,Drews N,Autier P,Beckmann A,Heinzer H,Hansen J,Michl U,Schlomm T,Haese A,Steuber T,Graefen M,Becker A

    更新日期:2014-04-01 00:00:00

  • Lymphovascular invasion and presence of embryonal carcinoma as risk factors for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour: a systematic review and meta-analysis.

    abstract:OBJECTIVE:To systematically review the literature on the prognostic value of lymphovascular invasion (LVI) and embryonal carcinoma (EC) for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour (CS I NSGCT). MATERIALS AND METHODS:The PubMed, Embase (OVID) and SCOPUS databases were searched up ...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析


    authors: Blok JM,Pluim I,Daugaard G,Wagner T,Jóźwiak K,Wilthagen EA,Looijenga LHJ,Meijer RP,Bosch JLHR,Horenblas S

    更新日期:2020-03-01 00:00:00

  • Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.

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    journal_title:BJU international

    pub_type: 杂志文章,meta分析,评审


    authors: Shelley MD,Cleves A,Wilt TJ,Mason MD

    更新日期:2011-07-01 00:00:00

  • Beyond the cluster: methodological and clinical implications in the Boston Area Community Health survey and EPIC studies.

    abstract:OBJECTIVE:To test the replicability and robustness of findings about urological symptoms in men and women, classified using an objective statistical method, cluster analysis, by planned sensitivity analyses conducted within and across two large, epidemiological studies of lower urinary tract symptoms. METHODS:Sensitiv...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Rosen RC,Coyne KS,Henry D,Link CL,Cinar A,Aiyer LP,Mollon P,Kaplan SA,Roehrborn CG,Thompson C

    更新日期:2008-05-01 00:00:00

  • Interrogation of ERG gene rearrangements in prostate cancer identifies a prognostic 10-gene signature with relevant implication to patients' clinical outcome.

    abstract:OBJECTIVES:ERG-gene rearrangement defines a distinct molecular subtype of PCA with potential biological and clinical implications. To identify a molecular signature reflective of the downstream effects of ERG-mediated transcriptional regulation with prognostic implication in patients with prostate cancer (PCA). MATERI...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Bismar TA,Alshalalfa M,Petersen LF,Teng LH,Gerke T,Bakkar A,Al-Mami A,Liu S,Dolph M,Mucci LA,Alhajj R

    更新日期:2014-02-01 00:00:00

  • Optimizing collagenase Clostridium histolyticum therapy for Peyronie's disease using a novel approach with percutaneous needle tunnelling.

    abstract:OBJECTIVES:To compare the efficacy and safety of a combined treatment of percutaneous needle tunnelling (PNT) and a modified collagenase Clostridium histolyticum (CCH) protocol (PNT/CCH) vs the modified protocol alone (CCH) in the treatment of Peyronie's disease (PD). PATIENTS AND METHODS:A prospective registry of pat...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Fernández-Pascual E,González-García FJ,Angulo J,Cerezo E,Quintana LM,Turo J,Martínez-Ballesteros C,Carballido J,Martínez-Salamanca JI

    更新日期:2019-12-01 00:00:00

  • Preoperative predictors of renal function decline after radical nephroureterectomy for upper tract urothelial carcinoma.

    abstract:OBJECTIVES:To model renal function after radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). To identify predictors of renal function decline after surgery, thereby allowing the identification of patients likely to be ineligible for cisplatin-based chemotherapy in the adjuvant setting. PATIEN...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kaag M,Trost L,Thompson RH,Favaretto R,Elliott V,Shariat SF,Maschino A,Vertosick E,Raman JD,Dalbagni G

    更新日期:2014-11-01 00:00:00