Angiogenic peptides in prostatic disease.

Abstract:

OBJECTIVE:To determine the value of measuring serum concentrations of vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in patients with benign prostatic hyperplasia (BPH), advanced and localized prostate cancer, and thus assess the role of angiogenesis factors as markers of malignancy and the formation of metastasis. PATIENTS AND METHODS:Serum was obtained from 106 suitable patients who attended a routine clinic during the study period. A histological diagnosis was confirmed for each patient and a bone scan was positive in those with metastatic disease. The level of serum prostate specific antigen (PSA) was measured and the serum concentrations of VEGF and bFGF measured using a quantitative sandwich immunoassay technique. RESULTS:There was a significant difference (1.6-fold) in the serum concentration of bFGF between patients with local and advanced prostate cancer (P=0.006), but there was no significant difference for either of the growth factors between patients with BPH and metastatic prostate cancer (Mann-Whitney test). CONCLUSION:The serum levels of VEGF and bFGF could not be used to distinguish benign from malignant prostatic disease; the serum PSA level is of more value than either, but the serum concentration of bFGF may be of some value in differentiating patients with local and advanced malignancy.

journal_name

BJU Int

journal_title

BJU international

authors

Walsh K,Sherwood RA,Dew TK,Mulvin D

doi

10.1046/j.1464-410x.1999.00363.x

keywords:

subject

Has Abstract

pub_date

1999-12-01 00:00:00

pages

1081-3

issue

9

eissn

1464-4096

issn

1464-410X

pii

bju363

journal_volume

84

pub_type

杂志文章
  • The immunohistochemical assessment of occult regional lymph node metastases in patients with T3pN0M0 prostate cancer before definitive radiotherapy.

    abstract:OBJECTIVE:To detect occult regional lymph node metastases in patients with T3pN0M0 prostate cancer not recognized by routine haematoxylin and eosin staining, and to evaluate the clinical relevance of this finding. PATIENTS AND METHODS:Formalin-fixed and paraffin-embedded pelvic lymph nodes (1118) from 92 patients were...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00406.x

    authors: Clobes H,Fossâ SD,Waehre H,Jocham D,Berner A

    更新日期:2000-02-01 00:00:00

  • The impact of lower urinary tract symptoms on male sexual health: EpiLUTS.

    abstract:OBJECTIVE:To evaluate the association between International Continence Society categories of lower urinary tract symptoms (LUTS; storage, voiding, and postmicturition) and individual LUTS (associated with decreased sexual activity and sexual satisfaction in men) with erectile dysfunction (ED), ejaculatory dysfunction (...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2009.08447.x

    authors: Wein AJ,Coyne KS,Tubaro A,Sexton CC,Kopp ZS,Aiyer LP

    更新日期:2009-04-01 00:00:00

  • Transcorporal artificial urinary sphincter implantation as a salvage surgical procedure for challenging cases of male stress urinary incontinence: surgical technique and functional outcomes in a contemporary series.

    abstract:OBJECTIVES:To describe the surgical technique of transcorporal artificial urinary sphincter (AUS) implantation. To assess the efficacy of the AUS on continence and erectile function. PATIENTS AND METHODS:A prospective evaluation was conducted between December 2007 and October 2012 at a tertiary referral centre of all ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12386

    authors: Wiedemann L,Cornu JN,Haab E,Peyrat L,Beley S,Cathelineau X,Haab F

    更新日期:2013-12-01 00:00:00

  • A cohort study reporting clinical risk factors and individual risk perceptions of prostate cancer: implications for PSA testing.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Prostate cancer has three known clinical risk factors: age, ethnicity and family history. Men's knowledge of prostate cancer is low. This study demonstrates that men rely on family and friends to learn about prostate cancer and help them interpret th...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11316.x

    authors: Forbat L,Place M,Kelly D,Hubbard G,Boyd K,Howie K,Leung HY

    更新日期:2013-03-01 00:00:00

  • The incidence and treatment of lymphoceles after radical retropubic prostatectomy.

    abstract:OBJECTIVE:To determine the incidence and treatment of lymphoceles after retropubic radical prostatectomy (RP). PATIENTS AND METHODS:Up to January 2004, 260 patients who had a retropubic RP in one institution by one surgeon were assessed retrospectively, using the patients' notes or the computerized results system to d...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05398.x

    authors: Pepper RJ,Pati J,Kaisary AV

    更新日期:2005-04-01 00:00:00

  • Expression and localization of basic fibroblast growth factor in diabetic rat prostate.

    abstract:OBJECTIVE:To assess fibroblast growth factor-2 (FGF2/bFGF), which is important in the development and maintenance of the normal prostate and in the development of human benign prostatic hyperplasia (BPH) and prostatic carcinoma, in an animal model of experimentally induced diabetes. Materials and methods Using Western ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00597.x

    authors: Wang Z,Ikeda K,Wada Y,Foster HE,Weiss RM,Latifpour J

    更新日期:2000-05-01 00:00:00

  • Lack of prognostic significance of prostate biopsies in metastatic androgen independent prostate cancer.

    abstract:OBJECTIVE:To assess the significance of viable tumour in the prostate of patients with metastatic androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:We evaluated the clinicopathological features, including follow-up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate. RESULTS:P...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2007.07173.x

    authors: Aragon-Ching JB,Gillespie J,Price DK,Chuaqui R,Rodriguez-Canales J,Steinberg SM,Dahut WL,Figg WD

    更新日期:2007-12-01 00:00:00

  • The significance of serum levels of insulin-like growth factor-1 in patients with prostate cancer.

    abstract:OBJECTIVES:To compare the serum levels of insulin-like growth factor-1 (IGF-1) in patients with prostate cancer and in control patients with no malignancy, and to evaluate any possible influence of testicular androgen withdrawal on the level of IGF-1 in patients with prostate cancer. PATIENTS AND METHODS:IGF-1 was mea...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00350.x

    authors: Kurek R,Tunn UW,Eckart O,Aumüller G,Wong J,Renneberg H

    更新日期:2000-01-01 00:00:00

  • Virtual reality flexible cystoscopy: a validation study.

    abstract:OBJECTIVES:To validate a flexible cystoscopy simulator by determining if it could differentiate between expert and novice cystoscopists. SUBJECTS AND METHODS:Seventeen subjects (10 novices with no previous endoscopic experience and seven urologists who had all carried out > 1000 flexible cystoscopies each) were asked ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.03090.x

    authors: Shah J,Darzi A

    更新日期:2002-12-01 00:00:00

  • Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort.

    abstract:OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and sympt...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09321.x

    authors: Mishra GD,Cardozo L,Kuh D

    更新日期:2010-10-01 00:00:00

  • A double-blind randomized controlled trial and economic evaluation of transurethral resection vs contact laser vaporization for benign prostatic enlargement: a 3-year follow-up.

    abstract:OBJECTIVE:To evaluate the effect of contact laser prostate surgery in the treatment of benign prostatic hyperplasia. PATIENTS AND METHODS:A prospective double-blind randomized controlled trial of transurethral resection of the prostate (TURP) and contact laser prostatectomy was conducted, with an economic evaluation o...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2000.00407.x

    authors: Keoghane SR,Lawrence KC,Gray AM,Doll HA,Hancock AM,Turner K,Sullivan ME,Dyar O,Cranston D

    更新日期:2000-01-01 00:00:00

  • Bladder calculi in children who perform clean intermittent catheterization.

    abstract:OBJECTIVE:To examine the role of clean intermittent catheterization (CIC) as a possible predisposing risk factor for bladder calculi, assessing risk factors in patients with and without bladder augmentation, and to evaluate management options for bladder calculi in these patients. PATIENTS AND METHODS:The records of 4...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00625.x

    authors: Barroso U,Jednak R,Fleming P,Barthold JS,González R

    更新日期:2000-05-01 00:00:00

  • Chemo-prevention in superficial bladder cancer using mitomycin C: a survey of the practice patterns of British urologists.

    abstract:OBJECTIVE:To assess the use of mitomycin C, by urologists within the UK, as a single-dose intravesical agent. Current European recommendations are to use one dose after any new tumour resection. METHODS:We assessed the current patterns of mitomycin C usage amongst British urologists, particularly with reference to one...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.05970.x

    authors: Clarke NS,Basu S,Prescott S,Puri R

    更新日期:2006-04-01 00:00:00

  • Transrectal ultrasonography-guided biopsy does not reliably identify dominant cancer location in men with low-risk prostate cancer.

    abstract:UNLABELLED:Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The widespread use of serum PSA testing followed by TRUS-guided biopsy have resulted in profound prostate cancer stage migration with many patients presenting with focal rather than mul...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10704.x

    authors: Washington SL,Bonham M,Whitson JM,Cowan JE,Carroll PR

    更新日期:2012-07-01 00:00:00

  • Super-mini percutaneous nephrolithotomy (PCNL) vs standard PCNL for the management of renal calculi of

    abstract:OBJECTIVE:To compare the effectiveness and safety of standard percutaneous nephrolithotomy (sPCNL) and super-mini PCNL (SMP). PATIENTS AND METHODS:A total of 150 patients presenting with renal calculi of <2 cm were randomised to either sPCNL (Group 1) or SMP (Group 2). Randomisation was based on centralised computer-g...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bju.15144

    authors: Guddeti RS,Hegde P,Chawla A,de la Rosette JJMCH,Laguna Pes MP,Kapadia A

    更新日期:2020-08-01 00:00:00

  • Effect of positioning on ureteric stone retropulsion: 'gravity works'.

    abstract:OBJECTIVE:To evaluate the potential impact of alterations in 'patient' position on laser-induced ureteric stone retropulsion in an in vitro model. MATERIALS AND METHODS:A ceramic (phantom) stone was placed in a water-filled clear polymer tube and subjected to continuous laser energy until the stone had retropulsed a d...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14510

    authors: Patel RM,Walia AS,Grohs E,Okhunov Z,Landman J,Clayman RV

    更新日期:2019-01-01 00:00:00

  • Prediction of stone disease by discriminant analysis and artificial neural networks in genetic polymorphisms: a new method.

    abstract:OBJECTIVE:To use information from genetic polymorphisms and from patients (drinking/exercise habits) to identify their association with stone disease, the main analytical and predictive tools being discriminant analysis (DA) and artificial neural networks (ANNs). PATIENTS, SUBJECTS AND METHODS:Urinary stone disease is...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1464-410x.2003.03067.x

    authors: Chiang D,Chiang HC,Chen WC,Tsai FJ

    更新日期:2003-05-01 00:00:00

  • Antitumour effect of electrochemotherapy with bleomycin on human prostate cancer xenograft.

    abstract:OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mic...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07793.x

    authors: Ueki T,Uemura H,Nagashima Y,Ohta S,Ishiguro H,Kubota Y

    更新日期:2008-11-01 00:00:00

  • Cannabinoids for treating neurogenic lower urinary tract dysfunction in patients with multiple sclerosis: a systematic review and meta-analysis.

    abstract:OBJECTIVES:To review systematically all the available evidence on efficacy and safety of cannabinoids for treating neurogenic lower urinary tract dysfunction (NLUTD) in patients with multiple sclerosis (MS). PATIENTS AND METHODS:The review was performed according to the Preferred Reporting Items for Systematic Reviews...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/bju.13759

    authors: Abo Youssef N,Schneider MP,Mordasini L,Ineichen BV,Bachmann LM,Chartier-Kastler E,Panicker JN,Kessler TM

    更新日期:2017-04-01 00:00:00

  • Recovery of erectile function after radical prostatectomy is quantitatively related to the response to intraoperative cavernous nerve stimulation.

    abstract:OBJECTIVE:To correlate the results of intraoperative cavernous nerve stimulation (CaNS) at radical prostatectomy (RP), with preoperative erectile function (EF) and to determine the significance of the results of stimulation after RP in predicting the recovery of EF. PATIENTS AND METHODS:The study included 183 potent m...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08519.x

    authors: Rabbani F,Patel M,Cozzi P,Mulhall JP,Scardino PT

    更新日期:2009-11-01 00:00:00

  • Technique for office-based, ultrasonography-guided percutaneous biopsy of renal cortical neoplasms using a novel transducer for facilitated ultrasound targeting.

    abstract:OBJECTIVES:To help clarify which small renal cortical neoplasms (RCNs) require surgery by using office-based, ultrasonography-guided percutaneous renal biopsy. PATIENTS AND METHODS:Biopsies were performed using facilitated ultrasound targeting (FUT) technology, which incorporates a needle guide and onscreen beam-steer...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12489

    authors: Menhadji AD,Nguyen V,Okhunov Z,Bucur P,Chu WH,Cho J,Billingsley J,Morrison D,Kelly CR,Landman J

    更新日期:2016-06-01 00:00:00

  • Long-term follow-up of the treatment of renal angiomyolipomas after selective arterial embolization with alcohol.

    abstract:STUDY TYPE:Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To present our institution's experience of selective embolization of renal angiomyolipomas with alcohol and the long-term follow up data. PATIENTS AND METHODS:This retrospective study included 34 patients treated between October 1997 and October 2007 (...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08813.x

    authors: Chick CM,Tan BS,Cheng C,Taneja M,Lo R,Tan YH,Lin SE,Tay KH

    更新日期:2010-02-01 00:00:00

  • Comparison of an adjustable anchored single-incision mini-sling, Ajust(®) , with a standard mid-urethral sling, TVT-O(TM) : a health economic evaluation.

    abstract:OBJECTIVES:To assess the cost, quality of life (QoL) and cost-effectiveness of a single-incision mini-sling (SIMS; Ajust(®) , C. R. Bard Inc., New Providence, NJ, USA) compared with a standard mid-urethral sling (SMUS; TVT-O™, Ethicon Inc., Somerville, NJ, USA) in the surgical management of female stress urinary incont...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bju.12388

    authors: Boyers D,Kilonzo M,Mostafa A,Abdel-Fattah M

    更新日期:2013-12-01 00:00:00

  • Sexual dysfunction in women with ketamine cystitis: a case-control study.

    abstract:OBJECTIVE:• To conduct a case-control study evaluating clinical symptom severity and sexual dysfunction in women with ketamine cystitis (KC). PATIENTS AND METHODS:• In total, 29 patients with KC and 27 controls completed the symptoms survey. • Participants completed a visual pelvic pain analogue scale, an O'Leary-Sant...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10780.x

    authors: Jang MY,Long CY,Chuang SM,Huang CH,Lin HY,Wu WJ,Juan YS

    更新日期:2012-08-01 00:00:00

  • Impact of serum 25-OH vitamin D level on lower urinary tract symptoms in men: a step towards reducing overactive bladder.

    abstract:OBJECTIVES:To evaluate the impact of serum vitamin D level on male lower urinary tract symptoms (LUTS). PATIENTS AND METHODS:Men with LUTS who visited the outpatient clinic of the urology department at one of two hospitals between March 2014 and April 2017 were eligible for inclusion in the study. The impact of vitami...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14387

    authors: Yoo S,Oh S,Kim HS,Choi HS,Park J,Cho SY,Son H,Jeong H,Lee HW,Cho MC

    更新日期:2018-10-01 00:00:00

  • Current and emerging treatment modalities for metastatic castration-resistant prostate cancer.

    abstract::Docetaxel-based therapy is established as the standard first-line chemotherapy in patients with metastatic castration-resistant prostate cancer (mCRPC), based on results from two landmark Phase III studies. However, prognosis remains poor, with a median survival of less than 2 years. There is no standard of care for p...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.10036.x

    authors: Bracarda S,Logothetis C,Sternberg CN,Oudard S

    更新日期:2011-04-01 00:00:00

  • Comparison of the performances of the ADXBLADDER test and urinary cytology in the follow-up of non-muscle-invasive bladder cancer: a blinded prospective multicentric study.

    abstract:OBJECTIVE:To compare directly the performance of the ADXBLADDER test with that of cytology in the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences. BACKGROUND:ADXBLADDER is a urine test based on the detection of MCM5, a DNA licensing factor expressed in all cells capable of dividing. Expression is u...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.15194

    authors: Gontero P,Montanari E,Roupret M,Longo F,Stockley J,Kennedy A,Rodriguez O,McCracken SRC,Dudderidge T,Sieverink C,Vanié F,Allasia M,Witjes JA,Sylvester R,Colombel M,Palou J

    更新日期:2020-08-03 00:00:00

  • Thrombotic risk factors associated with transurethral prostatectomy.

    abstract:OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00075.x

    authors: Bell CR,Murdock PJ,Pasi KJ,Morgan RJ

    更新日期:1999-06-01 00:00:00

  • Mortality associated with Fournier's gangrene remains unchanged over 25 years.

    abstract:OBJECTIVES:To report a case series of Fournier's gangrene (FG) from our institution, and to investigate its mortality over the past 25 years. PATIENTS AND METHODS:Case notes of men presenting to our institution from 2013 to 2016 with FG were reviewed. As well as age, diabetic history, length of stay, length of stay in...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14998

    authors: Radcliffe RS,Khan MA

    更新日期:2020-04-01 00:00:00

  • Current status of validation for robotic surgery simulators - a systematic review.

    abstract::To analyse studies validating the effectiveness of robotic surgery simulators. The MEDLINE(®), EMBASE(®) and PsycINFO(®) databases were systematically searched until September 2011. References from retrieved articles were reviewed to broaden the search. The simulator name, training tasks, participant level, training d...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2012.11270.x

    authors: Abboudi H,Khan MS,Aboumarzouk O,Guru KA,Challacombe B,Dasgupta P,Ahmed K

    更新日期:2013-02-01 00:00:00