Abstract:
OBJECTIVES:To report a case series of Fournier's gangrene (FG) from our institution, and to investigate its mortality over the past 25 years. PATIENTS AND METHODS:Case notes of men presenting to our institution from 2013 to 2016 with FG were reviewed. As well as age, diabetic history, length of stay, length of stay in critical care, and mortality; we calculated (where possible) the Uludag Fournier's Gangrene Severity Index (UFGSI). Published studies and cases series reporting the mortality rates for FG were reviewed from 1993 to 2018. The size of the study, country of origin, average age and gender ratio were collected, alongside mortality. RESULTS:Two of the 11 patients treated for FG at out institution died within 90 days of admission, a mortality rate of 18%. Predicted mortality was significantly higher. A total of 173 publications were identified from the Medical Literature Analysis and Retrieval System Online (MEDLINE) database published between 1993 and 2018, reporting data from 1975 to 2018. Analysis of heterogeneity, by both time and precision, supported exclusion of four retrospective coded database-driven studies from the analysis. From the remaining studies, mortality ranged from 0% to 42%. Of the 6152 reported cases, there were 1220 deaths, giving an overall mortality rate of 19.8%. There was no evidence of a significant change in the mortality rate for FG over time (P = 0.996). CONCLUSIONS:In our case series, the mortality rate for FG was 18%, despite a higher predicated mortality (based on UFGSI scores). The treatment of FG remains appropriate resuscitation, aggressive surgical debridement, and critical care management. Perceived high risk of mortality should not deter aggressive management. Mortality due to FG does not appear to have changed over the past 25 years, and is estimated at 19.8%. In studies identifying cases of FG, careful attention should be paid to case definition, particularly when cases are being abstracted retrospectively from large coded databases.
journal_name
BJU Intjournal_title
BJU internationalauthors
Radcliffe RS,Khan MAdoi
10.1111/bju.14998subject
Has Abstractpub_date
2020-04-01 00:00:00pages
610-616issue
4eissn
1464-4096issn
1464-410Xjournal_volume
125pub_type
杂志文章abstract:OBJECTIVE:To investigate the effectiveness of a combined treatment of 3-30-methylene-bis[4-hydroxycoumarin] (dicoumarol) with doxorubicin for the treatment of urothelial cancer, as doxorubicin is a common chemotherapeutic agent but its therapeutic efficacy is limited. MATERIALS AND METHODS:The synergistic effect of di...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08732.x
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To report on the failure of thalidomide to inhibit tumour growth in an animal model of human renal cell carcinoma (RCC). MATERIALS AND METHODS:An orthotopic xenograft model of human RCC was used in which tumour cells were implanted in the left kidney of male 'severe combined immunodeficient' mice. Thalidomid...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02666.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To assess the severity of both stress urinary incontinence (SUI) and overactive bladder (OAB) symptoms during and after the first pregnancy, using a self-reported health-related quality-of-life questionnaire, and to assess the effect of pregnancy and childbirth on bothersome lower urinary tract symptoms (LUTS...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06211.x
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:To assess the influence of the 2012 US Preventive Services Task Force (USPSTF) recommendation against prostate-specific antigen (PSA)-based screening on oncological and functional outcomes following robot-assisted laparoscopic prostatectomy (RALP). MATERIALS AND METHODS:We retrospectively analysed patients w...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15051
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of a selective type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, IC486051, on bladder activity in normal rats and those with and bladder outlet obstruction (BOO), as inhibition of PDE4 leads to elevation of intracellular cAMP levels and relaxation of smooth muscle. MATER...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06643.x
更新日期:2007-03-01 00:00:00
abstract:UNLABELLED:Study Type--Therapy (outcomes) Level of Evidence 2a. What's known on the subject? and What does the study add? Erectile dysfunction (ED) is a well known implication of radical prostatectomy (RP). Despite the search for technical improvement in the surgical procedure (e.g. nerve-sparing surgery, robot-assiste...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11484.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To characterise the incidence, onset, management, predictors, and clinical impact of mammalian target of rapamycin (mTOR) inhibitor-associated non-infectious pneumonitis (NIP) on patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:Retrospective review of 310 patients with mRCC who rece...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12420
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To report the surgical treatment of patients with renal cell carcinoma (RCC) metastatic to the contralateral adrenal gland and compare our experience with previous reports, as such metastases are found in 2.5% of patients with metastatic RCC at autopsy, and the role of resecting metastatic RCC at this site is...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04237.x
更新日期:2003-06-01 00:00:00
abstract:OBJECTIVE:To describe the clinical and magnetic resonance imaging (MRI) characteristics of vaginal and paraurethral leiomyomas. PATIENTS AND METHODS:All patients with pathologically confirmed paraurethral and vaginal wall leiomyomas from January 2006 to August 2007 were reviewed. Patients with no preoperative MRI of t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09046.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVES:To report several samples of invasive human prostate cancer showing angiotropism, and to use human prostate cancer cells stably expressing green fluorescence protein (GFP) in in vitro and in vivo models to assess the dissemination pathway of prostate cancer cells. MATERIALS AND METHODS:Malignant melanoma an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05474.x
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVE:To explore the predictors of the quality of marriage of men with prostate cancer, as being diagnosed with prostate cancer affects the quality of life of the man and his partner, and while some aspects are known about the impact of the disease and its treatments on the man's quality of life, less is known abou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06807.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To compare directly the performance of the ADXBLADDER test with that of cytology in the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences. BACKGROUND:ADXBLADDER is a urine test based on the detection of MCM5, a DNA licensing factor expressed in all cells capable of dividing. Expression is u...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15194
更新日期:2020-08-03 00:00:00
abstract::Lymphatic drainage in renal cell carcinoma (RCC) is unpredictable, however, basic patterns can be observed in cadaveric and sentinel lymph node mapping studies in patients with RCC. The existence of peripheral lymphovenous communications at the level of the renal vein has been shown in mammals but remains unknown in h...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12814
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To determine if the International Prostate Symptom Score (IPSS) before seed implantation, stratified into mild (0-7), moderate (8-19) and severe (>20) categories, predicts brachytherapy-related morbidity in terms of IPSS resolution, catheter dependency and the need for surgical intervention after brachytherap...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05887.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVES:To describe the surgical technique of transcorporal artificial urinary sphincter (AUS) implantation. To assess the efficacy of the AUS on continence and erectile function. PATIENTS AND METHODS:A prospective evaluation was conducted between December 2007 and October 2012 at a tertiary referral centre of all ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12386
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVES:To examine the effect of partial urethral obstruction (PUO) on bladder smooth muscle outward potassium current and the contribution of the large-conductance calcium-activated potassium (Maxi-K, BKCa) channel to this activity in smooth muscle cells isolated from bladders of sham-operated and PUO male rats usi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11137.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To ascertain the potential thrombotic risk associated with transurethral prostatectomy (TURP). PATIENTS AND METHODS:The changes in coagulation variables were assessed in a prospective study of 40 patients undergoing TURP. RESULTS:There was a significant increase in thrombin-antithrombin complexes 6 h after ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00075.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:• To investigate the relationship between pretreatment testosterone levels and pathological specimen characteristics, by prospectively examining serum androgen concentrations in a well-studied cohort of patients who underwent radical prostatectomy (RP) for localized prostate cancer. PATIENTS AND METHODS:• A ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09816.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To present the results of endopyelotomy using endoluminal ultrasonography (EUS) to identify crossing vessels, as the success rates of endopyelotomy are generally lower than pyeloplasty, especially in patients with crossing vessels. PATIENTS AND METHODS:Forty-one consecutive patients who underwent EUS before ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04103.x
更新日期:2003-03-01 00:00:00
abstract:UNLABELLED:Study Type - Therapy (RCT) Level of Evidence 1b What's known on the subject? and What does the study add? Men with prostate cancer have higher rates of non-cancer mortality and CV morbidity and some of that excess risk has been attributed to the treatment they receive. ADT is an established treatment option ...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2011.10555.x
更新日期:2012-05-01 00:00:00
abstract:STUDY TYPE:Therapy (case series) Level of Evidence 4. OBJECTIVE:To report our analysis of the oncological outcome, side-effects and complications after (125)I-brachytherapy, based on 10 years of experience, as low dose-rate (LDR) prostate brachytherapy is an accepted, effective and safe therapy for localized prostate ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09096.x
更新日期:2010-07-01 00:00:00
abstract::Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07594.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To study guideline recommendation (GR)-concordance rates of treatment in elderly patients with urothelial carcinoma of the bladder (UCB) and to identify predictors of survival. PATIENTS AND METHODS:The records of 206 consecutive patients aged ≥ 75 years (median age 79 years; range 75-95) were reviewed. All p...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09417.x
更新日期:2010-11-01 00:00:00
abstract:OBJECTIVE:To compare outcomes of minimally invasive radical nephrectomy (MIS-RN) and robot-assisted partial nephrectomy (RAPN) in clinical T2a renal mass (cT2aRM). PATIENTS AND METHODS:Retrospective, multicentre, propensity score-matched (PSM) comparison of RAPN and MIS-RN for cT2aRM (T2aN0M0). Cohorts were PSM for ag...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.15064
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06606.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To define changes in the clinical pathway for open radical retropubic prostatectomy (RRP) and to determine their impact on patient care under the indirect influence of minimally invasive prostatectomy after implementing robotically assisted laparoscopic prostatectomy (RALP) at our institution and modifying th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05993.x
更新日期:2006-03-01 00:00:00
abstract::Prostate cancer (PCa) is the most common form of cancer in men in the developed world and the second leading cause of cancer-related deaths. While advanced PCa is initially controlled with hormonal therapies targeting the androgen receptor (AR) pathway, recurrence occurs because of the emergence of lethal castration-r...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.14207
更新日期:2018-10-01 00:00:00
abstract:OBJECTIVE:To address concerns about the impact of training on patient outcomes during the 'learning curve' for laparoscopic radical prostatectomy (LRP), we compare the results of our patients undergoing LRP with and without trainees performing a substantial proportion of the cases. PATIENTS AND METHODS:In all, 771 con...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08262.x
更新日期:2009-05-01 00:00:00
abstract:OBJECTIVE:To determine the effect of combined finasteride and flutamide therapy on haemoglobin and haematocrit values in men with advanced prostate cancer. PATIENTS AND METHODS:Nineteen men, previously untreated by hormone therapy, with histologically confirmed adenocarcinoma of the prostate and clinical evidence of a...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00844.x
更新日期:1999-01-01 00:00:00
abstract::What's known on the subject? and What does the study add? The suppressor effect of probiotics on superficial bladder cancer is an observed phenomenon but the specific mechanism is poorly understood. The evidence strongly suggests natural killer (NK) cells are the anti-tumour effector cells involved and NK cell activit...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10749.x
更新日期:2012-06-01 00:00:00