Abstract:
OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mice. After determination of the optimal conditions of electric pulse voltage and bleomycin dose, tumour growth in mice treated with EP plus bleomycin was compared with that in mice receiving EP alone, bleomycin alone or no treatment. In all four groups, apoptosis in the tumours was assessed. RESULTS:There was a significant reduction in tumour growth in mice that received EP with bleomycin. Apoptotic cells in tumours at 24 h after treatment with EP plus bleomycin showed a significant difference compared with the other three groups, but not at 12 h after treatment. CONCLUSIONS:These results indicate the possibility that EP with bleomycin could be effective as an ablation therapy for prostate cancer, especially androgen-independent cancer.
journal_name
BJU Intjournal_title
BJU internationalauthors
Ueki T,Uemura H,Nagashima Y,Ohta S,Ishiguro H,Kubota Ydoi
10.1111/j.1464-410X.2008.07793.xsubject
Has Abstractpub_date
2008-11-01 00:00:00pages
1467-71issue
10eissn
1464-4096issn
1464-410Xpii
BJU7793journal_volume
102pub_type
杂志文章abstract:OBJECTIVES:To describe the most recent data from phase I and II clinical trials of stereotactic body radiation therapy (SBRT) using image-guided robotic radiosurgery, specifically the Cyberknife(®) (Accuracy Incorporated, Sunnyvale, CA, USA). To better determine thecurrent role of this type of radiosurgery in prostate ...
journal_title:BJU international
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
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abstract:OBJECTIVES:To determine the risk of failure during drug development in castration-resistant prostate cancer (CRPC) and to identify factors that could improve outcomes. METHODS:We investigated CRPC by analysing compounds in phase I to phase III clinical trials between 1998 and April 2011. Drug development failures were...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12309
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journal_title:BJU international
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pub_type: 杂志文章
doi:10.1111/bju.12489
更新日期:2016-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14387
更新日期:2018-10-01 00:00:00
abstract::The aim of revalidation (or maintenance of certification) is to reassure patients, the general public, employers and other healthcare professionals that an individual is fit to practice. It may lead to a reduction in near misses or adverse events. The process of revalidation entails a commitment to the provision of li...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10375.x
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04243.x
更新日期:2003-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02357.x
更新日期:2001-10-01 00:00:00
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pub_type: 共识发展会议,杂志文章
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章,meta分析
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pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2002.03025.x
更新日期:2002-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10207.x
更新日期:2011-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06532.x
更新日期:2007-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09013.x
更新日期:2010-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08208.x
更新日期:2009-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08473.x
更新日期:2009-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.08093.x
更新日期:2009-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02906.x
更新日期:2002-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14182
更新日期:2018-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,随机对照试验
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更新日期:2007-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07708.x
更新日期:2008-08-05 00:00:00
abstract::Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07594.x
更新日期:2008-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-4096.2001.01817.x
更新日期:2002-02-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2020-09-01 00:00:00