Antitumour effect of electrochemotherapy with bleomycin on human prostate cancer xenograft.

Abstract:

OBJECTIVE:To investigate the antitumour effect of electroporation (EP), a drug delivery system that has been shown to be effective synergistically with antitumour drugs, with bleomycin on the growth of prostate cancer xenografts in nude mice. MATERIALS AND METHODS:PC-3 cells were implanted subcutaneously into nude mice. After determination of the optimal conditions of electric pulse voltage and bleomycin dose, tumour growth in mice treated with EP plus bleomycin was compared with that in mice receiving EP alone, bleomycin alone or no treatment. In all four groups, apoptosis in the tumours was assessed. RESULTS:There was a significant reduction in tumour growth in mice that received EP with bleomycin. Apoptotic cells in tumours at 24 h after treatment with EP plus bleomycin showed a significant difference compared with the other three groups, but not at 12 h after treatment. CONCLUSIONS:These results indicate the possibility that EP with bleomycin could be effective as an ablation therapy for prostate cancer, especially androgen-independent cancer.

journal_name

BJU Int

journal_title

BJU international

authors

Ueki T,Uemura H,Nagashima Y,Ohta S,Ishiguro H,Kubota Y

doi

10.1111/j.1464-410X.2008.07793.x

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

1467-71

issue

10

eissn

1464-4096

issn

1464-410X

pii

BJU7793

journal_volume

102

pub_type

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