Abstract:
OBJECTIVE:To examine national trends in the medical and surgical treatment of benign prostatic hyperplasia (BPH) using Australian Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) population data from 2000 to 2018. PATIENTS AND METHODS:Annual data was extracted from the MBS, PBS and Australian Institute of Health and Welfare databases for the years 2000-2018. Population-adjusted rates of BPH procedures and medical therapies were calculated and compared in relation to age. Cost analysis was performed to estimate financial burden due to BPH. RESULTS:Overall national hospital admissions due to BPH declined between 2000 and 2018, despite an increased proportion of admissions due to private procedures (42% vs 77%). Longitudinal trends in the medical management of BPH showed an increased prescription rate of dutasteride/tamsulosin combined therapy (111 vs 7649 per 100 000 men) and dutasteride monotherapy (149 vs 336 per 100 000 men) since their introduction to the PBS in 2011. Trends in BPH surgery showed an overall progressive increase in rate of total procedures between 2000 and 2018 (92 vs 133 per 100 000 men). Transurethral resection of the prostate (TURP) remained the most commonly performed surgical procedure, despite reduced utilisation since 2009 (118 vs 89 per 100 000 men), offset by a higher uptake of photoselective vaporisation of prostate, holmium:YAG laser enucleation of prostate, and later likely due to minimally invasive surgical therapies including prostatic urethral lift and ablative technologies (including Rezūm™). Financial burden due to BPH surgery has remained steady since 2009, whilst the burden due to medical therapy has risen sharply. CONCLUSION:Despite reduced national BPH-related hospitalisations, overall treatment for BPH has increased due to medical therapy and surgical alternatives to TURP. Further exploration into motivators for particular therapies and effect of medical therapy on BPH progression in clinical practice outside of clinical trials is warranted.
journal_name
BJU Intjournal_title
BJU internationalauthors
Morton A,Williams M,Perera M,Teloken PE,Donato P,Ranasinghe S,Chung E,Bolton D,Yaxley J,Roberts MJdoi
10.1111/bju.15098subject
Has Abstractpub_date
2020-09-01 00:00:00pages
18-26eissn
1464-4096issn
1464-410Xjournal_volume
126 Suppl 1pub_type
杂志文章abstract:OBJECTIVE:To assess fibroblast growth factor-2 (FGF2/bFGF), which is important in the development and maintenance of the normal prostate and in the development of human benign prostatic hyperplasia (BPH) and prostatic carcinoma, in an animal model of experimentally induced diabetes. Materials and methods Using Western ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00597.x
更新日期:2000-05-01 00:00:00
abstract:OBJECTIVE:To assess the long-term outcome of forearm free-flap phalloplasty in transsexuals, as obtaining a satisfying neophallus in female-to-male transsexuals is a surgical challenge. PATIENTS AND METHODS:We analysed retrospectively 56 transsexuals who had a phalloplasty using a radial forearm free-flap in our depar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07362.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To establish the predictive accuracy of the Kattan preoperative nomogram by comparing predictions at 5 years with actual progression in patients who had a radical prostatectomy (RP). MATERIALS AND METHODS:We reviewed the data for 928 patients treated by RP as a first-line treatment for localized prostate can...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08473.x
更新日期:2009-09-01 00:00:00
abstract:OBJECTIVE:To analyse the technical details and the long-term results of laparoscopic ureterolithotomy. PATIENTS AND METHODS:Laparoscopic ureterolithotomy was undertaken in 101 patients between 1991 and 2001; in only one patient with retroperitoneal fibrous adhesions was the procedure transperitoneal, being retroperito...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01562.x
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abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12517
更新日期:2014-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15019
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVE:To assess the predictive value of serial bone scans as a surveillance tool for bone metastasis in men with clinically localized prostate cancer and managed with watchful observation. PATIENTS AND METHODS:A prospective single-arm study was conducted to assess the feasibility of a watchful observation protocol...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04169.x
更新日期:2003-05-01 00:00:00
abstract:OBJECTIVE:• To systematically review the literature on gemcitabine chemotherapy for advanced or metastatic bladder cancer. MATERIALS AND METHODS:• The Medical Literature Analysis and Retrieval System Onlinedatabase (MEDLINE), the Excerpta Medicadatabase (EMBASE), the Cumulative Index to Nursing and Allied Health Liter...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2011.10341.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To assess the overall and disease-specific survival rates of patients undergoing robot-assisted radical cystectomy (RARC) compared with historical open cystectomy. PATIENTS AND METHODS:Survival, pathological and demographic data were collected on all patients undergoing RARC for bladder cancer from both Tula...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.09042.x
更新日期:2010-06-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2019-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10210.x
更新日期:2011-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14426
更新日期:2019-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07338.x
更新日期:2008-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10053.x
更新日期:2011-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14775
更新日期:2019-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05339.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To study the effect of smoking on bladder cancer presentation and outcome in a large cystectomy population. PATIENTS AND METHODS:A database including 546 patients from the University Health Network (Toronto, Canada) and Turku University Hospital (Turku, Finland) was studied. In addition to the association of...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2011.10371.x
更新日期:2012-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2020-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05641.x
更新日期:2005-08-01 00:00:00
abstract::Advanced adrenal carcinoma remains a significant therapeutic challenge, with conventional approaches to systemic therapy having failed to achieve sustained objective remissions or major survival benefit in most instances. Several systemic therapies, including mitotane, suramin and gossypol, as well as cytotoxic agents...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10464.x
更新日期:2011-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.03011.x
更新日期:2002-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12992
更新日期:2015-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06905.x
更新日期:2007-07-01 00:00:00
abstract:OBJECTIVE:To investigate the expression of thymidylate synthase (TS), a key enzyme in DNA synthesis that is over-expressed in several cancer cells, in bladder cancer and its association with patient prognosis and the response to adjuvant therapy. PATIENTS AND METHODS:In all, 67 bladder tissue specimens were obtained f...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08099.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of urodynamic variables with continence and upper tract status after reconstruction in patients with classical bladder exstrophy. PATIENTS AND METHODS:Thirty-one patients with bladder exstrophy were assessed 1 year after a modified bladder neck reconstruction. The evaluation inclu...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02338.x
更新日期:2001-09-01 00:00:00
abstract:OBJECTIVE:To determine the relationship of preoperatively measured cardiorespiratory function, to the development of postoperative complications and length of hospital stay (LOS) in a cohort of patients undergoing radical cystectomy (RC), as RC and conduit formation is curative but is associated with significant postop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12219
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14393
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To establish a consensus on the utility of multiparametric magnetic resonance imaging (mpMRI) to identify patients for focal therapy. METHODS:Urological surgeons, radiologists, and basic researchers, from Europe and North America participated in a consensus meeting about the use of mpMRI in focal therapy of ...
journal_title:BJU international
pub_type: 共识发展会议,杂志文章
doi:10.1111/bju.12243
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To report our experience with the use of 95% ethanol as sclerotherapy for symptomatic simple renal cysts. PATIENTS AND METHODS:Sixty patients with 64 symptomatic simple renal cysts were treated by ultrasonography (US)-guided percutaneous aspiration and injection of 95% ethanol (31 men and 29 women, mean age ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05851.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To examine the effect of age on the biochemical and functional properties, and regional distribution of endothelin (ET) receptors in the rabbit renal pelvis. MATERIALS AND METHODS:The properties of ET receptors in 6-week-old and 6-month-old male rabbit renal pelves were examined using isolated muscle-bath an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.2441.x
更新日期:2001-12-01 00:00:00