Propiverine vs oxybutynin for treating neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.

Abstract:

OBJECTIVE:To compare, in a retrospective observational cohort study, the efficacy, tolerability, safety and clinical effectiveness of propiverine and oxybutynin in children and adolescents with neurogenic detrusor overactivity (NDO). PATIENTS AND METHODS:In all, 255 children and adolescents (aged 1-18 years) with NDO (199 myelomeningocele, 46 spinal cord injury, 10 other diagnoses) were enrolled at 14 study centres. To evaluate the efficacy of propiverine and oxybutynin, urodynamic and clinical variables were assessed before and after at least 12 month of the antimuscarinic agents administered at variable doses. RESULTS:In all, 127 patients given propiverine and 128 given oxybutynin were enrolled. The primary efficacy outcome, i.e. reductions in urodynamically assessed individual maximum detrusor pressure (P(detmax)), was assumed to indicate success in 74.2% of those on propiverine vs 49.6% on oxybutynin. The mean P(detmax) was significantly reduced during treatment, from 59.8 to 36.7 cmH(2)O in the propiverine and from 65.2 to 54.9 cmH(2)O in the oxybutynin groups. The mean maximum cystometric bladder capacity increased from 146 to 242 mL in the propiverine and from 222 to 310 mL in the oxybutynin group. Propiverine was better tolerated than oxybutynin, having fewer adverse drug reactions (9.4% vs 17.2%, odds ratio 2.04), and for its severity grades and premature treatment termination (none vs 11 cases). CONCLUSION:In this non-interventional study, reflecting 'real-life' clinical practice, comparing the efficacy, tolerability and safety of propiverine and oxybutynin in children and adolescents with NDO, propiverine was at least as effective as oxybutynin, but better tolerated, resulting in superior clinical effectiveness than for oxybutynin.

journal_name

BJU Int

journal_title

BJU international

authors

Madersbacher H,Mürtz G,Alloussi S,Domurath B,Henne T,Körner I,Niedeggen A,Nounla J,Pannek J,Schulte-Baukloh H,Schultz-Lampel D,Bock P,Strugala G

doi

10.1111/j.1464-410X.2008.08093.x

subject

Has Abstract

pub_date

2009-03-01 00:00:00

pages

776-81

issue

6

eissn

1464-4096

issn

1464-410X

pii

BJU8093

journal_volume

103

pub_type

杂志文章,多中心研究
  • Biopsy-confirmed de novo renal cell carcinoma (RCC) in renal grafts: a single-centre management experience in a 2396 recipient cohort.

    abstract:OBJECTIVE:To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management. PATIENTS AND METHODS:We report a single-centre series of de novo RCC in allografts from a cohort of 2396 consecutive renal transplant recipients. RESULTS:In all, 17 RCCs were detected in 12 patients,...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10315.x

    authors: Ploussard G,Chambade D,Meria P,Gaudez F,Tariel E,Verine J,De Bazelaire C,Peraldi MN,Glotz D,Desgrandchamps F,Mongiat-Artus P

    更新日期:2012-01-01 00:00:00

  • Glucose-regulated protein 78 expression in urothelial carcinoma of the upper urinary tract.

    abstract:OBJECTIVE:To examine glucose-regulated protein 78 (GRP78; a major molecular chaperone at the endoplasmic reticulum, strongly expressed in several tumours) expression in urothelial carcinoma (UC) of the upper urinary tract (UUT) and to evaluate the diagnostic and progressive importance of GRP78 expression in UC-UUT. PA...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.09144.x

    authors: Uematsu K,Ogata S,Nakanishi K,Hiroi S,Tominaga S,Aida S,Kawai T

    更新日期:2010-09-01 00:00:00

  • Endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of goserelin acetate administered every 13 weeks to patients with advanced prostate cancer.

    abstract:OBJECTIVE:To determine the endocrine effects, efficacy and tolerability of a 10.8-mg depot formulation of Zoladextrade mark (goserelin acetate, Zeneca Pharmaceuticals, Wilmington, Delaware, USA), a luteinizing hormone-releasing hormone agonist analogue, when administration was extended from every 12 weeks to every 13 w...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1046/j.1464-410x.1999.00028.x

    authors: Sarosdy MF,Schellhammer PF,Soloway MS,Vogelzang NJ,Crawford ED,Presti J,Chodak GW,Mitchell P,Porter L

    更新日期:1999-05-01 00:00:00

  • Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.

    abstract:OBJECTIVE:To investigate the mechanisms of neurokinin A- and substance P-induced contractions of rat urinary bladder smooth muscle, and to compare them with those of the muscarinic agonist carbachol. MATERIALS AND METHODS:Rat urinary bladder strips were suspended under 1 g of tension in a physiological buffer at 37 de...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05017.x

    authors: Quinn T,Collins C,Baird AW

    更新日期:2004-09-01 00:00:00

  • The management of secondary pelvi-ureteric junction obstruction - a comparison of pyeloplasty and endopyelotomy.

    abstract:OBJECTIVE:To review our experience in the management of secondary pelvi-ureteric junction obstruction (PUJO) comparing endopyelotomy with pyeloplasty. PATIENTS AND METHODS:We retrospectively analysed our database of 58 patients having undergone operative management of PUJO after failed primary management, including 41...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12454

    authors: Vannahme M,Mathur S,Davenport K,Timoney AG,Keeley FX Jr

    更新日期:2014-01-01 00:00:00

  • DNA topoisomerase I and IIalpha expression in penile carcinomas: assessing potential tumour chemosensitivity.

    abstract:OBJECTIVE:To examine the tissue expression of DNA topoisomerase I (Topo I) and IIalpha (Topo II), to pursue the possibility of future chemotherapy regimens for squamous cell carcinoma of the penis (SCCP), as high expression of Topo I might indicate sensitivity to the camptothecins, whereas high Topo II might indicate s...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07698.x

    authors: Berney DM,Stankiewicz E,Adlan AM,Kudahetti S,Biedrzycki OJ,Hadway P,Watkin N,Corbishley C

    更新日期:2008-09-01 00:00:00

  • Nocturia in the Dutch adult population.

    abstract:OBJECTIVE:To estimate the prevalence of nocturia in the Dutch adult population, its association with sociodemographic and health characteristics, and to assess problems experienced by persons with nocturia. SUBJECTS AND METHODS:In spring 2001 a telephone survey was conducted among a representative sample of 4721 Dutch...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.03011.x

    authors: van Dijk L,Kooij DG,Schellevis FG

    更新日期:2002-11-01 00:00:00

  • Posterior tibial nerve stimulation in patients with intractable interstitial cystitis.

    abstract:OBJECTIVE:To evaluate the efficacy of intermittent percutaneous posterior tibial nerve stimulation (PPTNS) in patients with refractory interstitial cystitis. PATIENTS AND METHODS:One man and 13 women (mean age 58.3 years) with suprapubic or perineal pain were enrolled in a prospective open study, in which they had 10 ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.04909.x

    authors: Zhao J,Nordling J

    更新日期:2004-07-01 00:00:00

  • Schistosoma haematobium infection in children in Britain.

    abstract:OBJECTIVE:To highlight the existence of Schistosoma haematobium in certain ethnic minority groups in Britain and in English citizens who have recently visited Africa and the Middle East, so that general practitioners and paediatric nephrologists/urologists are aware of its occurrence and consider it among the different...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00477.x

    authors: Samuel M,Misra D,Larcher V,Price E

    更新日期:2000-02-01 00:00:00

  • Dicoumarol enhances doxorubicin-induced cytotoxicity in p53 wild-type urothelial cancer cells through p38 activation.

    abstract:OBJECTIVE:To investigate the effectiveness of a combined treatment of 3-30-methylene-bis[4-hydroxycoumarin] (dicoumarol) with doxorubicin for the treatment of urothelial cancer, as doxorubicin is a common chemotherapeutic agent but its therapeutic efficacy is limited. MATERIALS AND METHODS:The synergistic effect of di...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08732.x

    authors: Matsui Y,Watanabe J,Ding S,Nishizawa K,Kajita Y,Ichioka K,Saito R,Kobayashi T,Ogawa O,Nishiyama H

    更新日期:2010-02-01 00:00:00

  • Cost-effectiveness analysis of degarelix for advanced hormone-dependent prostate cancer.

    abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10434.x

    authors: Lu L,Peters J,Roome C,Stein K

    更新日期:2012-04-01 00:00:00

  • The effects of recreational ketamine cystitis on urinary tract reconstruction - a surgical challenge.

    abstract:OBJECTIVES:To identify the rate of postoperative complications in patients who require surgical reconstruction for ketamine-induced urinary tract dysfunction and to identify any predictors for poor postoperative outcome with subsequent management strategies. PATIENTS AND METHODS:A retrospective review of data collecte...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14094

    authors: Sihra N,Ockrim J,Wood D

    更新日期:2018-03-01 00:00:00

  • The relationship of ultrasensitive measurements of prostate-specific antigen levels to prostate cancer recurrence after radical prostatectomy.

    abstract:OBJECTIVE:To evaluate ultrasensitive (US) measurements of prostate-specific antigen (PSA) level in men with prostate cancer, and to correlate the findings with currently accepted values for PSA recurrence, as PSA is widely accepted as a surrogate marker for disease recurrence after treatment for prostate cancer, and al...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06294.x

    authors: Taylor JA 3rd,Koff SG,Dauser DA,McLeod DG

    更新日期:2006-09-01 00:00:00

  • Poor prognosis of bladder cancer patients with occult lymph node metastases treated with neoadjuvant chemotherapy.

    abstract:OBJECTIVES:To characterise the outcomes of neoadjuvant chemotherapy (NAC) pre-treated patients found to be lymph node (LN)-positive at the time of radical cystectomy and pelvic lymph node dissection (RC/PLND) for urothelial carcinoma of the bladder (UCB). PATIENTS AND METHODS:Of 1484 patients treated with RC/PLND for ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14242

    authors: Cha EK,Sfakianos JP,Sukhu R,Yee AM,Sjoberg DD,Bochner BH

    更新日期:2018-10-01 00:00:00

  • Frequency of zoledronic acid to prevent further bone loss in osteoporotic patients undergoing androgen deprivation therapy for prostate cancer.

    abstract:OBJECTIVE:To evaluate the efficacy of zoledronic acid (ZA) in osteoporotic patients with prostate cancer receiving either luteinizing hormone-releasing hormone agonists (LHRHA, which accelerate bone loss) or bicalutamide (which preserves bone mineral density, BMD) as androgen-deprivation therapy is the mainstay of trea...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2009.08956.x

    authors: Wadhwa VK,Weston R,Parr NJ

    更新日期:2010-04-01 00:00:00

  • Impact of risk factors on the performance of the nuclear matrix protein 22 point-of-care test for bladder cancer detection.

    abstract:OBJECTIVES:To evaluate the impact of different risk factors and symptoms on the performance characteristics of the nuclear matrix protein 22 (NMP22) BladderChek test (Matritech Inc., Newton, MA, USA) for the detection of bladder cancer, as this is a point-of-care assay that measures NMPs in voided urine. PATIENTS AND ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2008.07473.x

    authors: Lotan Y,Shariat SF,NMP22 Study Group.

    更新日期:2008-06-01 00:00:00

  • Construction of tissue-engineered corpus cavernosum with muscle-derived stem cells and transplantation in vivo.

    abstract:OBJECTIVE:• To investigate the feasibility of tissue-engineered corpus cavernosum (TECC) with muscle-derived stem cells (MDSCs) as seed cells and determine the growth potential in vivo. MATERIALS AND METHODS:• Acellular corporal collagen matrices (ACCMs) were obtained from adult rabbit penis by a cell removal procedur...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09695.x

    authors: Ji C,Min F,Liang W,Chen Y,Pan S,Bin L,Chen S,Wei Z,He T,Gu Y,Zhang J

    更新日期:2011-05-01 00:00:00

  • Increased use of partial nephrectomy to treat high-risk disease.

    abstract:OBJECTIVES:To evaluate partial nephrectomy (PN) use in patients at higher risk for clinical progression, using a large national database of American patients. PATIENTS AND METHODS:We performed a retrospective review of patients with cN0/cM0 renal cell carcinoma from 2003 to 2011 using the National Cancer Data Base. Ou...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13262

    authors: Maurice MJ,Zhu H,Kim SP,Abouassaly R

    更新日期:2016-06-01 00:00:00

  • The ageing male and erectile dysfunction.

    abstract::Erectile dysfunction is common in the ageing man and reliable therapies are needed. The pathophysiology of erectile dysfunction in this group mainly includes chronic ischaemia, which triggers the deterioration of cavernosal smooth muscle and the development of corporeal fibrosis. Assessing the ageing man with erectile...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1046/j.1464-410x.2003.04378.x

    authors: Montorsi F,Briganti A,Salonia A,Deho' F,Zanni G,Cestari A,Guazzoni G,Rigatti P,Stief C

    更新日期:2003-09-01 00:00:00

  • Improved sacral neuromodulation in the treatment of the hyperactive detrusor: signal modification in an animal model.

    abstract:OBJECTIVE:To investigate different stimulation signals for the peripheral nerve evaluation test (PNE, carried out before implanting a sacral neuromodulator for functional voiding dysfunction) in an animal model and to determine their efficacy, as up to 80% of patients do not respond to the PNE test. MATERIALS AND METH...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04185.x

    authors: Seif C,Cherwon E,Martinez Portilló FJ,Alken P,Jünemann KP,Braun PM

    更新日期:2003-05-01 00:00:00

  • Qualitative exploration of the renal stone patients' experience and development of the renal stone-specific patient-reported outcome measure.

    abstract:OBJECTIVES:To investigate the experience of patients living with renal calculi via a qualitative methodology, aiming to develop and validate a disease-specific patient-reported outcome measure (PROM) for renal stones, the Cambridge Renal Stone PROM (CReSP). PATIENTS, SUBJECTS AND METHODS:Patients with radiologically c...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14873

    authors: Ragab M,Baldin N,Collie J,Tran MGB,Al-Hayek S,S Parsy K,Armitage J,Wiseman O

    更新日期:2020-01-01 00:00:00

  • The 'top 10' urological procedures: a study of hospital episodes statistics 1998-99.

    abstract:OBJECTIVE:To summarize the urological procedures recorded in Hospital Episodes Statistics (HES, 1998-99) and to examine the accuracy of coding and HES. MATERIALS AND METHODS:Data on the 10 commonest urological procedures from the Department of Health website (www.doh.gov.uk/hes) were extracted, summarized and presente...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.02833.x

    authors: Lee F,Patel HR,Emberton M

    更新日期:2002-07-01 00:00:00

  • Volume-outcome relationship in penile cancer treatment: a population based patterns of care and outcomes study from Australia.

    abstract:OBJECTIVES:To study the patterns of care of penile cancer diagnosed in the state of New South Wales (NSW) over a 10 year period and determine factors that are associated with differences in survival. PATIENTS AND METHODS:All invasive penile cancer diagnosed between 2001 and 2009 in NSW, Australia, were identified from...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13626

    authors: Patel MI,Yuminaga Y,Bang A,Lawrentschuk N,Skyring T,Smith DP

    更新日期:2016-10-01 00:00:00

  • Testosterone administration to men with testosterone deficiency syndrome after external beam radiotherapy for localized prostate cancer: preliminary observations.

    abstract:OBJECTIVE:To assess the effects of testosterone supplementation in men with testosterone deficiency syndrome (TDS) after external beam radiotherapy (EBRT) for localized prostate cancer. PATIENTS AND METHODS:Five men with significant signs of TDS after treatment for localized prostate cancer with EBRT were treated with...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07882.x

    authors: Morales A,Black AM,Emerson LE

    更新日期:2009-01-01 00:00:00

  • Human immunodeficiency virus-associated prostate cancer: clinicopathological findings and outcome in a multi-institutional study.

    abstract:OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cance...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2008.07474.x

    authors: Pantanowitz L,Bohac G,Cooley TP,Aboulafia D,Dezube BJ

    更新日期:2008-06-01 00:00:00

  • Predicting metastasized seminoma using gene expression.

    abstract:UNLABELLED:Treatment options for testis cancer depend on the histological subtype as well as on the clinical stage. An accurate staging is essential for correct treatment. The 'golden standard' for staging purposes is CT, but occult metastasis cannot be detected with this method. Currently, parameters such as primary t...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10778.x

    authors: Ruf CG,Linbecker M,Port M,Riecke A,Schmelz HU,Wagner W,Meineke V,Abend M

    更新日期:2012-07-01 00:00:00

  • Outcomes of surgical treatment of Peyronie's disease.

    abstract::The aims of the present review were to assess the literature on published outcomes and complications associated with surgical treatments for Peyronie's disease (PD) and to assist clinicians in the effective management of PD by increasing understanding and awareness of the outcomes associated with current surgical trea...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12565

    authors: Carson CC,Levine LA

    更新日期:2014-05-01 00:00:00

  • Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes.

    abstract:OBJECTIVE:To characterise the clinical, radiological and histological features of mucinous tubular and spindle cell carcinoma (MTSCC), as well as oncological outcomes. PATIENTS AND METHODS:This is a single institution retrospective analysis of all patients with MTSCC from 2002 to 2011. Patients were excluded if MTSCC ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12992

    authors: Kenney PA,Vikram R,Prasad SR,Tamboli P,Matin SF,Wood CG,Karam JA

    更新日期:2015-07-01 00:00:00

  • Natural history of 'second' biochemical failure after salvage radiation therapy for prostate cancer: a multi-institution study.

    abstract:OBJECTIVES:To describe the natural history of prostate cancer in men who experience a second biochemical recurrence (BCR) after salvage radiotherapy (SRT) after prostatectomy. PATIENTS AND METHODS:After undergoing SRT at one of two institutions between 1986 and 2013, 286 patients experienced a second BCR, defined as t...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.13926

    authors: Tumati V,Jackson WC,Abugharib AE,Raj G,Roehrborn C,Lotan Y,Courtney K,Bagrodia A,Gahan JC,Zumsteg ZS,Folkert MR,Laine AM,Hannan R,Spratt DE,Desai NB

    更新日期:2018-03-01 00:00:00

  • The CAG trinucleotide repeat length in the androgen receptor does not predict the early onset of prostate cancer.

    abstract:OBJECTIVE:To relate the repeat length of the androgen-receptor CAG trinucleotide to the age of onset of prostate cancer, stage and grade of disease. PATIENTS AND METHODS:After obtaining ethical approval, 265 patients with locally confined or locally advanced/metastatic prostate cancer were identified and evaluated for...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.02981.x

    authors: Mir K,Edwards J,Paterson PJ,Hehir M,Underwood MA,Bartlett JM

    更新日期:2002-10-01 00:00:00