Qualitative exploration of the renal stone patients' experience and development of the renal stone-specific patient-reported outcome measure.


OBJECTIVES:To investigate the experience of patients living with renal calculi via a qualitative methodology, aiming to develop and validate a disease-specific patient-reported outcome measure (PROM) for renal stones, the Cambridge Renal Stone PROM (CReSP). PATIENTS, SUBJECTS AND METHODS:Patients with radiologically confirmed renal calculi who had undergone a range of management options were invited to focus groups or semi-structured interviews to elicit patient input and generate the PROM content. The developed renal stone PROM underwent validity studies included Cronbach's α for internal consistency, Spearman's and Pearson's correlation coefficients for test-retest reliability. Discriminant validity was assessed by Pearson's correlation coefficients vs the EuroQol five-dimensional five-level questionnaire (EQ-5D-5L). Our project has Health and Social Care Research Ethics Committee approval. RESULTS:A total of 106 subjects participated in creating the newly developed PROM. In all, 36 patients were invited to 22 semi-structured interviews and four focus groups, until reaching saturation. Major issues reported, and themes selected for the renal stone PROM included pain, anxiety, limitations to social life and tiredness, urinary symptoms, dietary changes' impacts, and gastrointestinal tract symptoms. Reliability analysis for 30 patients to determine internal consistency using Cronbach's α with a mean (range) of 0.91 (0.90-0.93) within domains and Cronbach's α between domains was 0.92. Average inter-item Pearson's and Spearman's correlation within domains was performed, with a Pearson's correlation mean (range) of 0.77 (0.73-0.85) and Spearman's correlation mean (range) of 0.72 (0.63-0.77). The test-retest Pearson's correlation mean (range) was 0.85 (0.57-0.95). Validity assessment was performed for 20 patients vs 20 controls. Pearson's correlation with EQ-5D-5L was -0.74, showing the newly developed PROM successfully discriminated patients with kidney stones. Our final renal stone PROM consists of 14 questions that are rated on a Likert scale; the higher the score, the worse the effect on a patient's quality of life. CONCLUSIONS:Although pain was the most frequent symptom, other health-related and social well-being issues significantly impacted patients' lives. Our validated patient-derived CReSP is a new instrument, specifically tailored to measure renal stone disease health outcomes from the patient's point of view.




BJU international


Ragab M,Baldin N,Collie J,Tran MGB,Al-Hayek S,S Parsy K,Armitage J,Wiseman O




Has Abstract


2020-01-01 00:00:00












  • Correlation of the International Prostate Symptom Score bother question with the Benign Prostatic Hyperplasia Impact Index in a clinical practice setting.

    abstract:OBJECTIVE:To evaluate the association between the International Prostate Symptom Score (IPSS) bother question (BQ) and a validated disease-specific quality-of-life questionnaire, the Benign Prostatic Hyperplasia (BPH) Impact Index (BPH-II), using the BPH Registry and Patient Survey database. PATIENTS AND METHODS:The B...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: O'Leary MP,Wei JT,Roehrborn CG,Miner M,BPH Registry and Patient Survey Steering Committee.

    更新日期:2008-06-01 00:00:00

  • Proportion of tadalafil-treated patients with clinically meaningful improvement in lower urinary tract symptoms associated with benign prostatic hyperplasia – integrated data from 1,499 study participants.

    abstract:OBJECTIVES:To evaluate the proportion of patients achieving clinically meaningful improvement of lower urinary tract symptoms suggestive of benign prostatic hyperplasia (BPH-LUTS) with tadalafil using two definitions of response. PATIENTS AND METHODS:Post hoc integrated analysis of four placebo-controlled studies in m...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验


    authors: Nickel JC,Brock GB,Herschorn S,Dickson R,Henneges C,Viktrup L

    更新日期:2015-05-01 00:00:00

  • Large-conductance calcium-activated potassium channel activity, as determined by whole-cell patch clamp recording, is decreased in urinary bladder smooth muscle cells from male rats with partial urethral obstruction.

    abstract:OBJECTIVES:To examine the effect of partial urethral obstruction (PUO) on bladder smooth muscle outward potassium current and the contribution of the large-conductance calcium-activated potassium (Maxi-K, BKCa) channel to this activity in smooth muscle cells isolated from bladders of sham-operated and PUO male rats usi...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Aydin M,Wang HZ,Zhang X,Chua R,Downing K,Melman A,DiSanto ME

    更新日期:2012-10-01 00:00:00

  • Staging laparoscopic pelvic lymphadenectomy in prostate cancer.

    abstract:OBJECTIVE:To assess the results of transperitoneal laparoscopic pelvic lymphadenectomy as a separate staging procedure in patients with early prostate cancer. PATIENTS AND METHODS:The results were reviewed from the first 27 patients with prostate cancer admitted for laparoscopic lymphadenectomy between January 1994 an...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Shackley DC,Irving SO,Brough WA,O'Reilly PH

    更新日期:1999-02-01 00:00:00

  • Urological litigation in the UK National Health Service (NHS): an analysis of 14 years of successful claims.

    abstract:OBJECTIVES:• To present a summary of the collected data on urological litigation within the UK National Health Service (NHS). • Knowledge of the main areas of litigation is essential for maintaining good clinical practice as well as risk management procedures in any specialty. MATERIALS AND METHODS:• Details of all cl...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Osman NI,Collins GN

    更新日期:2011-07-01 00:00:00

  • Reduced estimated glomerular filtration rate (eGFR

    abstract:OBJECTIVE:To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression. PATIENTS AND METHODS:A multi-institutional database identified patients with serum creat...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Blute ML Jr,Kucherov V,Rushmer TJ,Damodaran S,Shi F,Abel EJ,Jarrard DF,Richards KA,Messing EM,Downs TM

    更新日期:2017-09-01 00:00:00

  • Does working channel position influence the effectiveness of flexible ureteroscopy? Results from an in vitro study.

    abstract:OBJECTIVE:To evaluate whether the position of the working channel affects the effectiveness of flexible ureteroscopy. MATERIALS AND METHODS:We compared the ureteroscopes Flex-X2S and Flex-XC (working channel at the 9 and 3 o'clock positions, respectively) in eight cavities of a K-Box model, simulating the distribution...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Villa L,Ventimiglia E,Proietti S,Giusti G,Briganti A,Salonia A,Montorsi F,Doizi S,Traxer O

    更新日期:2020-03-01 00:00:00

  • Primary magnetic resonance imaging/ultrasonography fusion-guided biopsy of the prostate.

    abstract:OBJECTIVE:To examine the performance of a primary magnetic resonance imaging (MRI)/ultrasonography (US) fusion-guided targeted biopsy (TB), and in combination with an added systematic biopsy (SB). PATIENTS AND METHODS:Analysis of 318 consecutive biopsy-naïve men with suspicious multiparametric MRI (mpMRI; Prostate Ima...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Maxeiner A,Kittner B,Blobel C,Wiemer L,Hofbauer SL,Fischer T,Asbach P,Haas M,Penzkofer T,Fuller F,Miller K,Cash H

    更新日期:2018-08-01 00:00:00

  • Treatment of lower urinary tract symptoms suggestive of benign prostatic hyperplasia in relation to the patient's risk profile for progression.

    abstract::Lower urinary tract symptoms suggestive of benign prostatic hyperplasia (LUTS/BPH) is a slowly progressing disease, with some patients progressing more rapidly than others. In 80% of patients who progress this is caused by the worsening of symptoms. The physician can predict the risk of progression from the patient's ...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Trachtenberg J

    更新日期:2005-06-01 00:00:00

  • Chemical- and radiation-induced haemorrhagic cystitis: current treatments and challenges.

    abstract::• To review the published data on predisposing risk factors for cancer treatment-induced haemorrhagic cystitis (HC) and the evidence for the different preventive and therapeutic measures that have been used in order to help clinicians optimally define and manage this potentially serious condition. • Despite recognitio...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Payne H,Adamson A,Bahl A,Borwell J,Dodds D,Heath C,Huddart R,McMenemin R,Patel P,Peters JL,Thompson A

    更新日期:2013-11-01 00:00:00

  • Tension-free vaginal tape for primary genuine stress incontinence: a two-centre follow-up study.

    abstract:OBJECTIVE:To assess the safety and efficacy of the tension-free vaginal tape procedure in the treatment of primary genuine stress incontinence. PATIENTS AND METHODS:A two-centre follow-up study was conducted on 40 women with urodynamically confirmed primary genuine stress incontinence who had a tension-free vaginal ta...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Moran PA,Ward KL,Johnson D,Smirni WE,Hilton P,Bibby J

    更新日期:2000-07-01 00:00:00

  • Pelvic exenteration surgery in patients with locally advanced castration-naïve and castration-resistant, symptomatic prostate cancer.

    abstract:OBJECTIVES:To evaluate retrospectively the surgical, symptomatic and oncological outcomes of pelvic exenteration surgery (PES) in men with significant intrapelvic complications of locally advanced castration-sensitive (CSPC) and castration-resistant prostate cancer (CRPC). PATIENTS AND METHODS:A total of 103 patients ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Heidenreich A,Bludau M,Bruns C,Nestler T,Porres D,Pfister DJKP

    更新日期:2020-09-01 00:00:00

  • Sexual function before and after various treatments for symptomatic benign prostatic hyperplasia.

    abstract:OBJECTIVE:To determine the effect of various treatments for benign prostatic hyperplasia (BPH) on sexual function. PATIENTS AND METHODS:In a longitudinal multicentre study carried out in the Netherlands, 670 consecutive patients with BPH (aged > or = 50 years) were examined at baseline and 9 months after inclusion. Al...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Leliefeld HH,Stoevelaar HJ,McDonnell J

    更新日期:2002-02-01 00:00:00

  • Gemcitabine chemotherapy for the treatment of metastatic bladder carcinoma.

    abstract:OBJECTIVE:• To systematically review the literature on gemcitabine chemotherapy for advanced or metastatic bladder cancer. MATERIALS AND METHODS:• The Medical Literature Analysis and Retrieval System Onlinedatabase (MEDLINE), the Excerpta Medicadatabase (EMBASE), the Cumulative Index to Nursing and Allied Health Liter...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析,评审


    authors: Shelley MD,Cleves A,Wilt TJ,Mason MD

    更新日期:2011-07-01 00:00:00

  • Results of buccal mucosa grafts for repairing long bulbar urethral strictures.

    abstract:OBJECTIVES:To report the medium-term results at our institution of repairing long bulbar urethral strictures with buccal mucosal grafts. PATIENTS AND METHODS:Between January 2003 and June 2007, a buccal mucosa graft repair was used in 34 patients with recurrent bulbar strictures >2 cm. The follow-up included uroflowme...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Fransis K,Vander Eeckt K,Van Poppel H,Joniau S

    更新日期:2010-04-01 00:00:00

  • The impact of prostate-specific antigen persistence after radical prostatectomy on the efficacy of salvage radiotherapy in patients with primary N0 prostate cancer.

    abstract:OBJECTIVE:To test whether salvage radiotherapy (SRT) in patients with lymph node negative (N0) prostate cancer is equally effective with persistent prostate-specific antigen (PSA) and PSA rising from the undetectable range (<0.1 ng/mL) after radical prostatectomy (RP). PATIENTS AND METHODS:We assessed post-SRT PSA pro...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Bartkowiak D,Siegmann A,Böhmer D,Budach V,Wiegel T

    更新日期:2019-11-01 00:00:00

  • Detection of urinary leakage after radical retropubic prostatectomy by contrast enhanced ultrasound - do we still need conventional retrograde cystography?

    abstract:INTRODUCTION:To prospectively evaluate the accuracy of transvesical contrast-enhanced ultrasound (CEUS) as an alternative method for the detection of anastomotic leakage after radical retropubic prostatectomy (RRP) in comparison with the current standard method of conventional retrograde cystography (CG). PATIENTS AND...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Schoeppler GM,Buchner A,Zaak D,Khoder W,Staehler M,Stief CG,Reiser MF,Clevert DA

    更新日期:2010-12-01 00:00:00

  • Early observations of the effect of extracorporeal shockwave lithotripsy on blood pressure: a prospective randomized control clinical trial.

    abstract:OBJECTIVE:To determine, in a randomized controlled clinical trial, the effect of extracorporeal shock wave lithotripsy (ESWL) on blood pressure. PATIENTS AND METHODS:The trial included 228 patients with small (< 15 mm) asymptomatic calyceal stones who were randomised to undergo ESWL (113 patients) or to an untreated (...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Elves AW,Tilling K,Menezes P,Wills M,Rao PN,Feneley RC

    更新日期:2000-04-01 00:00:00

  • Kidneys from patients with small renal tumours: a novel source of kidneys for transplantation.

    abstract:OBJECTIVE:To report the use of a novel donor source as a further option to increase the number of patients who might be able to receive a renal transplant. PATIENTS AND METHODS:Between May 1996 and July 2007, 43 kidneys were transplanted using kidneys obtained from patients with small (<3 cm diameter) incidentally det...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Nicol DL,Preston JM,Wall DR,Griffin AD,Campbell SB,Isbel NM,Hawley CM,Johnson DW

    更新日期:2008-07-01 00:00:00

  • Clinically unconfirmed positive urinary cytology: diagnostic implications and oncological outcomes.

    abstract:OBJECTIVE:•To evaluate the natural history of patients presenting with positive urinary cytology in the absence of clinically identifiable disease. PATIENTS AND METHODS:•A surgical database was queried to identify 48 patients with positive urinary cytology of undetermined source. •All patients underwent a thorough uro...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Aharony S,Baniel J,Yossepowitch O

    更新日期:2011-10-01 00:00:00

  • An in vivo evaluation of the therapeutic potential of sympatholytic agents on premature ejaculation.

    abstract:OBJECTIVE:To evaluate the therapeutic potential of sympatholytic agents on premature ejaculation in an animal model, using monitoring of rat seminal vesicle pressure change in response to electrical stimulation of the lesser splanchnic nerve. MATERIALS AND METHODS:Male Wistar rats (aged 12-14 weeks) were injected intr...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Hsieh JT,Liu SP,Hsieh CH,Cheng JT

    更新日期:1999-09-01 00:00:00

  • Novel anticoagulants and antiplatelet agents; a guide for the urologist.

    abstract::Novel oral anti-coagulants (NOACs) are increasingly being used in clinical practice and are set to almost entirely replace the vitamin K antagonists, such as warfarin, in the near future. Similarly, new antiplatelet agents are now regularly used in place of older agents, such as aspirin and clopidogrel. In an ageing p...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Ellis G,John Camm A,Datta SN

    更新日期:2015-11-01 00:00:00

  • Erectile response with vardenafil in sildenafil nonresponders: a multicentre, double-blind, 12-week, flexible-dose, placebo-controlled erectile dysfunction clinical trial.

    abstract:OBJECTIVE:To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil. PATIENTS AND METHODS:A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled trial was conducted, involving 463 men aged > or = 18 years with moderate-to-severe erectile dysfunction (ED) and who were unr...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Carson CC,Hatzichristou DG,Carrier S,Lording D,Lyngdorf P,Aliotta P,Auerbach S,Murdock M,Wilkins HJ,McBride TA,Colopy MW,Patient Response with Vardenafil in Slidenafil Non-Responders (PROVEN) Study Group.

    更新日期:2004-12-01 00:00:00

  • The significance of the expression of dihydropyrimidine dehydrogenase in prostate cancer.

    abstract:OBJECTIVE:To measure dihydropyrimidine dehydrogenase (DPD), an enzyme involved in the metabolism of 5-fluorouracil (5-FU), expression in prostate cancer and determine whether 5-chloro-2,4-dihydroxypyridine (CDHP), a potent inhibitor of DPD, enhances the antitumoral activity of 5-FU against prostate cancer. PATIENTS, M...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Li Y,Mizutani Y,Shiraishi T,Nakamura T,Mikami K,Takaha N,Okihara K,Kawauchi A,Sakai T,Miki T

    更新日期:2007-03-01 00:00:00

  • Sex differences in bladder cancer outcomes among smokers with advanced bladder cancer.

    abstract:OBJECTIVE:To study the effect of smoking on bladder cancer presentation and outcome in a large cystectomy population. PATIENTS AND METHODS:A database including 546 patients from the University Health Network (Toronto, Canada) and Turku University Hospital (Turku, Finland) was studied. In addition to the association of...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Boström PJ,Alkhateeb S,Trottier G,Athanasopoulos PZ,Mirtti T,Kortekangas H,Laato M,van Rhijn B,van der Kwast T,Fleshner NE,Jewett MA,Finelli A,Zlotta AR

    更新日期:2012-01-01 00:00:00

  • Management of elderly patients with urothelial carcinoma of the bladder: guideline concordance and predictors of overall survival.

    abstract:OBJECTIVE:To study guideline recommendation (GR)-concordance rates of treatment in elderly patients with urothelial carcinoma of the bladder (UCB) and to identify predictors of survival. PATIENTS AND METHODS:The records of 206 consecutive patients aged ≥ 75 years (median age 79 years; range 75-95) were reviewed. All p...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Bolenz C,Ho R,Nuss GR,Ortiz N,Raj GV,Sagalowsky AI,Lotan Y

    更新日期:2010-11-01 00:00:00

  • Does perineural invasion on prostate biopsy predict adverse prostatectomy outcomes?

    abstract:OBJECTIVE:To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. PATIENTS AND METHODS:From 2002 to 2007, 1256 men ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Loeb S,Epstein JI,Humphreys EB,Walsh PC

    更新日期:2010-06-01 00:00:00

  • Long-term outcome of antiandrogen monotherapy in advanced prostate carcinoma: 12-year results of a phase II study.

    abstract:OBJECTIVE:To present the long-term outcome of patients with locally advanced or metastatic prostate carcinoma treated by first-line antiandrogen monotherapy. PATIENTS AND METHODS:From 1983 to 1990, 41 patients with advanced prostate carcinoma were treated with flutamide monotherapy until progression or the appearance ...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章


    authors: Serretta V,Daricello G,Dispensa N,Allegro R,Pavone C,Pavone-Macaluso M

    更新日期:2003-10-01 00:00:00

  • Evaluation of nuclear matrix protein 22 as a tumour marker in the detection of transitional cell carcinoma of the bladder.

    abstract:OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Sánchez-Carbayo M,Herrero E,Megías J,Mira A,Soria F

    更新日期:1999-10-01 00:00:00

  • Decision curve analysis assessing the clinical benefit of NMP22 in the detection of bladder cancer: secondary analysis of a prospective trial.

    abstract:OBJECTIVE:• To employ decision curve analysis to determine the impact of nuclear matrix protein 22 (NMP22) on clinical decision making in the detection of bladder cancer using data from a prospective trial. PATIENTS AND METHODS:• The study included 1303 patients at risk for bladder cancer who underwent cystoscopy, uri...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Barbieri CE,Cha EK,Chromecki TF,Dunning A,Lotan Y,Svatek RS,Scherr DS,Karakiewicz PI,Sun M,Mazumdar M,Shariat SF

    更新日期:2012-03-01 00:00:00