Abstract:
OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated were: (i) monthly injection of degarelix and (ii) 3-monthly triptorelin therapy plus short-term flutamide, cyproterone or bicalutamide treatment. The model consisted of a decision tree monitoring a hypothetical cohort of patients aged 70 years from the start of hormonal treatment to the end of the first month, and a Markov model monitoring patients from the end of month 1 for a time horizon of 10 years (i.e. when 96% of patients are assumed to have died). The base-case analysis assumed patients present with asymptomatic metastatic prostate cancer. Costs and outcomes were collected over the model time horizon. Outcome measures were quality-adjusted life years (QALYs), lifetime costs and incremental cost-effectiveness ratios. Sensitivity analyses (one-way and multi-way) and probabilistic sensitivity analyses were conducted to explore the uncertainties around the assumptions. RESULTS:In the base-case analysis, the incremental cost-effectiveness ratio (ICER) for degarelix vs triptorelin plus antiandrogen was £59,000 per QALY gained. The model was most sensitive to the rate of significant adverse events in the triptorelin plus antiandrogen group. The model was also sensitive to the assumed survival of patients with metastatic prostate cancer and the price of degarelix. The results of the probabilistic sensitivity analyses suggested that there was a low probability (9.6%) of degarelix being the most cost-effective treatment option when a willingness-to-pay threshold of £30,000 per QALY gained is assumed. CONCLUSION:Degarelix is unlikely to be cost-effective compared to triptorelin plus short-term antiandrogen in the management of advanced prostate cancer with respect to the usual thresholds of cost-effectiveness used in the UK: £20,000-30,000 per QALY gained (used by the National Institute for Health and Clinical Excellence).
journal_name
BJU Intjournal_title
BJU internationalauthors
Lu L,Peters J,Roome C,Stein Kdoi
10.1111/j.1464-410X.2011.10434.xsubject
Has Abstractpub_date
2012-04-01 00:00:00pages
1183-92issue
8eissn
1464-4096issn
1464-410Xjournal_volume
109pub_type
杂志文章abstract:OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level durin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To explore the safety and clinical efficacy of continuous-wave laser vaporesection for the treatment of obstructive benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:We treated 72 consecutive patients with obstructive BPH using a 70 W 2-microm continuous-wave laser. The mean (range) age of the patient...
journal_title:BJU international
pub_type: 临床试验,杂志文章
doi:10.1111/j.1464-410X.2008.08040.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, type and treatment behaviour of women with urinary incontinence in four European countries. SUBJECTS AND METHODS:Data were collected using a postal survey which was sent to 29,500 community-dwelling women aged > or = 18 years in France, Germany, Spain and the UK. Subjects were as...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410x.2003.04609.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To investigate the possibility of using urodynamic variables to predict upper urinary tract dilatation (UUTD) in children with neurogenic bladder-sphincter dysfunction (NBSD). PATIENTS AND METHODS:The study included 200 children with NBSD, of whom 103 had UUTD and 97 did not; they were examined using routine...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06402.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To compare directly the performance of the ADXBLADDER test with that of cytology in the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences. BACKGROUND:ADXBLADDER is a urine test based on the detection of MCM5, a DNA licensing factor expressed in all cells capable of dividing. Expression is u...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15194
更新日期:2020-08-03 00:00:00
abstract:UNLABELLED:Study Type - Therapy (economic analysis). LEVEL OF EVIDENCE:1b. OBJECTIVE:To assess and compare the costs and effects value of either starting with sacral neuromodulation (SNM) or botulinum toxin A (BTX) treatment in patients with refractory idiopathic overactive bladder from a societal perspective. MATER...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09905.x
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:To determine the relationship of preoperatively measured cardiorespiratory function, to the development of postoperative complications and length of hospital stay (LOS) in a cohort of patients undergoing radical cystectomy (RC), as RC and conduit formation is curative but is associated with significant postop...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12219
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To examine, in a retrospective analysis of outcome based on prostate-specific antigen (PSA) levels, whether the 1992 and revised 1997 staging criteria for prostate cancer can be used to predict progression-free survival for patients after radical prostatectomy for pT2 and pT3 prostate cancer. PATIENTS AND ME...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.02420.x
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVES:To: (i) calculate traditional compliance (CTrad) for a normal bladder by DeltaV/DeltaPdet, where DeltaV is the mean volumetric capacity and DeltaPdet is the detrusor pressure rise; (ii) assess its usefulness; (iii) identify the variables that are necessary for correctly assessing bladder compliance; and (iv)...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05054.x
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:• To systematically review the literature on gemcitabine chemotherapy for advanced or metastatic bladder cancer. MATERIALS AND METHODS:• The Medical Literature Analysis and Retrieval System Onlinedatabase (MEDLINE), the Excerpta Medicadatabase (EMBASE), the Cumulative Index to Nursing and Allied Health Liter...
journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
doi:10.1111/j.1464-410X.2011.10341.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To explore whether a panel of kallikrein markers in blood: total, free and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2, could be used as a non-invasive alternative for predicting prostate cancer on biopsy in a screening setting. SUBJECTS AND METHODS:The study cohort comprised pr...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2012.11690.x
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVE:To investigate the pharmacology and functionality of alpha(1)-adrenoceptors in human corpus cavernosum, and to determine the predominant subtype. MATERIALS AND METHODS:Cavernosal tissue specimens were obtained from the penises of 22 men (mean age 37.4 years) removed during gender re-assignment surgery. The m...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05956.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To examine the association between diabetes and metastasis risk after radical prostatectomy (RP) and to determine if race or obesity modifies this relationship. PATIENTS AND METHODS:Patients comprised 2058 US veterans with prostate cancer (PCa) enrolled in the Shared Equal-Access Regional Cancer Hospital (SE...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11687.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Diethylstilbestrol (DES) was the first hormone treatment used for prostate cancer and has also shown effectiveness in castration-resistant disease in small studies; however, concerns over thromboembolic toxicity have restricted its use in the past. Ov...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2012.11546.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the prevalence of depression, anxiety and distress among active surveillance (AS) and radical prostatectomy (RP) patients. To evaluate the impact of these symptoms at baseline on urinary and sexual quality of life at follow-up. PATIENTS AND METHODS:Patients managed with AS or RP who completed val...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12209
更新日期:2013-07-01 00:00:00
abstract:OBJECTIVE:To assess the long-term outcome of forearm free-flap phalloplasty in transsexuals, as obtaining a satisfying neophallus in female-to-male transsexuals is a surgical challenge. PATIENTS AND METHODS:We analysed retrospectively 56 transsexuals who had a phalloplasty using a radial forearm free-flap in our depar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07362.x
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:To evaluate extended lymph node dissection (LND) as a nodal staging tool in the treatment of invasive carcinoma of the urinary bladder and to suggest a reasonable proximal limit of the dissection. PATIENTS AND METHODS:In all, 170 patients underwent radical cystectomy with extended LND up to the level of the ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.09118.x
更新日期:2010-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect on quality of life of being discharged home with a catheter before definitive treatment in patients with acute urinary retention (AUR). PATIENTS AND METHODS:Patients attending the emergency department with AUR were assessed and discharged home with a catheter if they fulfilled predeter...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00666.x
更新日期:2000-06-01 00:00:00
abstract::To compare the incidence of infective complications after transrectal ultrasonography (TRUS)-guided biopsy with either empirical fluoroquinolone or culture-based targeted antimicrobial prophylaxis, and the prevalence of fluoroquinolone resistance (FQ-R) in men undergoing prostate biopsy. A systematic review of the lit...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.13402
更新日期:2016-05-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09439.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To examine the feasibility and reproducibility of laser interstitial thermotherapy (LITT) as a minimally invasive method for the treatment of prostate cancer. MATERIALS AND METHODS:Heterotopic tumours of prostatic adenocarcinoma (Dunning R3327-AT2) were induced in 10 male Copenhagen rats. After preoperative ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10406.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To review the incidence of venous thromboembolism (VTE) after radical retropubic prostatectomy (RRP) and evaluate the need for heparinoid prophylaxis as opposed to mechanical compression devices after RRP. PATIENTS AND METHODS:RRP is classified as a category 1 (high risk) procedure for VTE by the American Co...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05783.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility of laparoscopic augmentation cystoplasty (LAC) in the porcine model and to compare LAC using standard bowel vs a small intestinal submucosa (SIS) allograft. MATERIALS AND METHODS:Fourteen female pigs underwent LAC; six had standard ileal AC and eight AC with SIS. All the pigs ha...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06662.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility of transcript profiling in diagnostic formalin-fixed and paraffin-embedded (FFPE) biopsies for prostate cancer. MATERIALS AND METHODS:Laser-capture microdissection (LCM) was used to microdissect glandular epithelium as well as stromal tissue in archival prostate needle biopsies...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07627.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To describe our experience of inguinal exploration in patients who had a reasonable chance of having a benign testicular lesion. PATIENTS AND METHODS:From 1995 to 2002, 11 patients (mean age 43 years, range 27-63) with testicular masses that were suspected to be benign underwent inguinal exploration. RESULT...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04080.x
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To examine the chemopreventive effects of a selective cyclooxygenase (COX)-2 inhibitor, meloxicam, and a selective epidermal growth factor (EGF)-receptor tyrosine kinase inhibitor, gefitinib (as a single agent) on a carcinogen-induced rodent bladder carcinogenesis model. MATERIALS AND METHODS:The study compr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06053.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To assess, in a retrospective study, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of digital rectal examination (DRE), transrectal ultrasonography (TRUS) and the combination of both in unilateral clinical T3a (cT3a) prostate cancer. PATIENTS AND METHODS:Th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06452.x
更新日期:2006-11-01 00:00:00
abstract:OBJECTIVE:To determine if athermal methods are as effective in preventing blood transfusions as the use of cautery across various prostate volumes following prostate tissue resection for benign prostatic hyperplasia using Aquablation. PATIENTS AND METHODS:The current commercial AQUABEAM robot that performs Aquablation...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.14990
更新日期:2020-04-01 00:00:00