Abstract:
OBJECTIVE:To explore whether a panel of kallikrein markers in blood: total, free and intact prostate-specific antigen (PSA) and kallikrein-related peptidase 2, could be used as a non-invasive alternative for predicting prostate cancer on biopsy in a screening setting. SUBJECTS AND METHODS:The study cohort comprised previously unscreened men who underwent sextant biopsy owing to elevated PSA (≥3 ng/mL) in two different centres of the European Randomized Study of Screening for Prostate Cancer, Rotterdam (n = 2914) and Göteborg (n = 740). A statistical model, based on kallikrein markers, was compared with one based on established clinical factors for the prediction of biopsy outcome. RESULTS:The clinical tests were found to be no better than blood markers, with an area under the curve in favour of the blood measurements of 0.766 vs. 0.763 in Rotterdam and 0.809 vs. 0.774 in Göteborg. Adding digital rectal examination (DRE) or DRE plus transrectal ultrasonography (TRUS) volume to the markers improved discrimination, although the increases were small. Results were similar for predicting high-grade cancer. There was a strong correlation between the blood measurements and TRUS-estimated prostate volume (Spearman's correlation 0.60 in Rotterdam and 0.57 in Göteborg). CONCLUSIONS:In previously unscreened men, each with indication for biopsy, a statistical model based on kallikrein levels was similar to a clinical model in predicting prostate cancer in a screening setting, outside the day-to-day clinical practice. Whether a clinical approach can be replaced by laboratory analyses or used in combination with decision models (nomograms) is a clinical judgment that may vary from clinician to clinician depending on how they weigh the different advantages and disadvantages (harms, costs, time, invasiveness) of both approaches.
journal_name
BJU Intjournal_title
BJU internationalauthors
Carlsson SV,Peltola MT,Sjoberg D,Schröder FH,Hugosson J,Pettersson K,Scardino PT,Vickers AJ,Lilja H,Roobol MJdoi
10.1111/j.1464-410X.2012.11690.xsubject
Has Abstractpub_date
2013-09-01 00:00:00pages
602-9issue
5eissn
1464-4096issn
1464-410Xjournal_volume
112pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:• To investigate the role of c-kit-positive interstitial cells (ICCs) in mediating muscarinic receptor-induced phasic contractions of isolated bladder strips from streptozotocin(STZ)-induced diabetic rats and to confirm the expression and location of ICCs in the rat bladder. MATERIALS AND METHODS:• Bladders ...
journal_title:BJU international
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journal_title:BJU international
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pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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更新日期:2004-12-01 00:00:00
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journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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pub_type: 临床试验,杂志文章
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.00990.x
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pub_type: 杂志文章
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更新日期:2004-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-07-01 00:00:00
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更新日期:2009-02-01 00:00:00