Abstract:
OBJECTIVES:To test the hypothesis that observation with early salvage radiotherapy (SRT) is not inferior to 'standard' treatment with adjuvant RT (ART) with respect to biochemical failure in patients with pT3 disease and/or positive surgical margins (SMs) after radical prostatectomy (RP). To compare the following secondary endpoints between the two arms: patient-reported outcomes, adverse events, biochemical failure-free survival, overall survival, disease-specific survival, time to distant failure, time to local failure, cost utility analysis, quality adjusted life years and time to androgen deprivation. PATIENTS AND METHODS:The Radiotherapy - Adjuvant Versus Early Salvage (RAVES) trial is a phase III multicentre randomised controlled trial led by the Trans Tasman Radiation Oncology Group (TROG), in collaboration with the Urological Society of Australia and New Zealand (USANZ), and the Australian and New Zealand Urogenital and Prostate Cancer Trials Group (ANZUP). In all, 470 patients are planned to be randomised 1:1 to either ART commenced at ≤4 months of RP (standard of care) or close observation with early SRT triggered by a PSA level of >0.20 ng/mL (experimental arm). Eligible patients have had a RP for adenocarcinoma of the prostate with at least one of the following risk factors: positive SMs ± extraprostatic extension ± seminal vesicle involvement. The postoperative PSA level must be ≤0.10 ng/mL. Rigorous investigator credentialing and a quality assurance programme are designed to promote consistent RT delivery among patients. RESULTS:Trial is currently underway, with 258 patients randomised as of 31 October 2013. International collaborations have developed, including a planned meta-analysis to be undertaken with the UK Medical Research Council/National Cancer Institute of Canada Clinical Trials Group RADICALS (Radiotherapy and Androgen Deprivation In Combination with Local Surgery) trial and an innovative psycho-oncology sub-study to investigate a patient decision aid resource. CONCLUSION:On the current evidence available, it remains unclear if ART is equivalent or superior to observation with early SRT.
journal_name
BJU Intjournal_title
BJU internationalauthors
Pearse M,Fraser-Browne C,Davis ID,Duchesne GM,Fisher R,Frydenberg M,Haworth A,Jose C,Joseph DJ,Lim TS,Matthews J,Millar J,Sidhom M,Spry NA,Tang CI,Turner S,Williams SG,Wiltshire K,Woo HH,Kneebone Adoi
10.1111/bju.12623subject
Has Abstractpub_date
2014-03-01 00:00:00pages
7-12eissn
1464-4096issn
1464-410Xjournal_volume
113 Suppl 2pub_type
杂志文章,多中心研究,随机对照试验abstract::The aim of revalidation (or maintenance of certification) is to reassure patients, the general public, employers and other healthcare professionals that an individual is fit to practice. It may lead to a reduction in near misses or adverse events. The process of revalidation entails a commitment to the provision of li...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10375.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVES:To assess atypical cytology as a positive bladder tumour marker and to determine if indexing atypical cytology to nuclear matrix protein-22 (NMP22) can decrease the false-positive results or increase the positive predictive value (PPV). PATIENTS AND METHODS:In all, 197 patients at risk of bladder cancer wer...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07789.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:To assess the expression of the tumour markers stromelysin 3, MUC1, p53 and cytokeratin-7 in papillary renal cell carcinoma (pRCC, for which two histological subtypes are distinguished, i.e. type 1 and type 2, the latter appearing to be associated with a poorer prognosis) and to determine whether any of these...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07605.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVES:To present our experience with bladder cancer among a renal transplant population and to review critically the relevant literature. PATIENTS AND METHODS:In all, 1865 renal graft recipients were followed for a mean (SD) of 6.5 (5) years. Seven recipients (all men) developed a urothelial bladder tumour. The s...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07210.x
更新日期:2008-01-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? The relationship between high levels of BMI and changes in altered standard semen analysis parameters are described in the literature. However, the functional characteristics of the sperm are essential to complete the evaluation of male infertility. T...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10813.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To compare in vivo the potency and bladder-vascular selectivity of ATP-sensitive potassium channel openers (KCOs) (-)-cromakalim, WAY-133537 and ZD6169 and a muscarinic antagonist, tolterodine in rats. MATERIALS AND METHODS:Bladder and arterial pressures were monitored simultaneously, before and after increa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03069.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVE:To ascertain the prevalence of lower urinary tract symptoms (LUTS) and urinary incontinence (UI) in Canada, using a cross-Canada telephone survey, as there is a wide discrepancy in the reported prevalence of these conditions. SUBJECTS AND METHODS:A random survey with a standardized questionnaire was conducte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07198.x
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVE:To determine whether the rate of change in total serum prostate-specific antigen (PSA) levels accurately detects prostate cancer and to evaluate whether it adds any predictive value to a single measurement of serum PSA alone, in general practice settings. MATERIALS AND METHODS:A retrospective cohort of 219,3...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11651.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVES:To evaluate the impact of different risk factors and symptoms on the performance characteristics of the nuclear matrix protein 22 (NMP22) BladderChek test (Matritech Inc., Newton, MA, USA) for the detection of bladder cancer, as this is a point-of-care assay that measures NMPs in voided urine. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07473.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To examine the chemopreventive effects of a selective cyclooxygenase (COX)-2 inhibitor, meloxicam, and a selective epidermal growth factor (EGF)-receptor tyrosine kinase inhibitor, gefitinib (as a single agent) on a carcinogen-induced rodent bladder carcinogenesis model. MATERIALS AND METHODS:The study compr...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06053.x
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVE:To assess the sensitivity and specificity of blue-light cystoscopy (BLC) with hexaminolevulinate as an adjunct to white-light cystoscopy (WLC) vs WLC alone for the detection of non-muscle-invasive bladder cancer (NMIBC), in routine clinical practice in Spain. PATIENTS AND METHOD:An intra-patient comparative,...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.13020
更新日期:2015-07-01 00:00:00
abstract:OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level durin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
abstract::Novel oral anti-coagulants (NOACs) are increasingly being used in clinical practice and are set to almost entirely replace the vitamin K antagonists, such as warfarin, in the near future. Similarly, new antiplatelet agents are now regularly used in place of older agents, such as aspirin and clopidogrel. In an ageing p...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.13131
更新日期:2015-11-01 00:00:00
abstract:OBJECTIVE:To report the 2-year follow-up results on patients treated with a novel minimally invasive outpatient procedure for placing a mid-urethral sling, using porcine small intestinal submucosa (SIS). PATIENTS AND METHODS:Thirty-four women with urodynamic evidence of stress urinary incontinence (SUI, 19) or of SUI ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05576.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:To describe the surgical technique of transcorporal artificial urinary sphincter (AUS) implantation. To assess the efficacy of the AUS on continence and erectile function. PATIENTS AND METHODS:A prospective evaluation was conducted between December 2007 and October 2012 at a tertiary referral centre of all ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12386
更新日期:2013-12-01 00:00:00
abstract:OBJECTIVE:• To determine (i) the presence of fatty acid amide hydrolase (FAAH) in the urinary bladder; (ii) whether or not endogenous fatty acid ethanolamides are synthesized by the bladder; (iii) the effects of FAAH inhibition on referred hyperalgesia associated with acute bladder inflammation in rats. MATERIALS AND ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09583.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:• To assess and compare the economic burden of open radical cystectomy (OC) vs robotic-assisted laparoscopic radical cystectomy (RC) with pelvic lymph node dissection and urinary diversion. PATIENTS AND METHODS:• A series of 103 and 83 consecutive patients undergoing OC and RC, respectively, were prospective...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10114.x
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the long-term results and predictive risk factors for efficacy after the tension-free vaginal tape (TVT) procedure for treating female stress urinary incontinence (SUI). PATIENTS AND METHODS:Inall, 306 women (mean age 50.7 years, sd 8.7) who had a TVT procedure for SUI were selected and followed ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2009.08504.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To determine the changes in body composition, muscle function and energy expenditure after radical cystectomy (RC). PATIENTS AND METHODS:Eleven consecutive men (median age 66 years, range 44-79) who had a RC over a 1-year period had measurements made of their total body protein, by neutron-activation analysi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07337.x
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:• To investigate the oncological efficacy of retroperitoneal laparoscopic radical nephrectomy (RLRN) compared with transperitoneal laparoscopic radical nephrectomy (TLRN) for the management of clear-cell renal cell carcinoma (RCC). PATIENTS AND METHODS:• With emphasis on survival and disease recurrence, a re...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2010.09636.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility, tolerability, safety and efficacy of using a new surgical technique for the repair of anterior urethral strictures to preserve vascular supply to the urethra and its entire muscular and neurogenic support. PATIENTS AND METHODS:In all, 24 patients (mean age 46 years) underwent ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08590.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09808.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:To evaluate the value of multiparametric magnetic resonance imaging (mpMRI) in the detection of significant prostate cancer (PCa) and to compare transperineal MRI/ultrasonography fusion biopsy (fusPbx) with conventional transrectal systematic biopsy (sysPbx) in biopsy-naïve patients. PATIENTS AND METHODS:Th...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/bju.14017
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVES:To determine the prevalence of extended-spectrum β-lactamase (ESBL) in patients undergoing transrectal prostate biopsy, to assess the incidence of postoperative sepsis, to correlate the development of sepsis with the presence of preoperative ESBL on rectal swabs, and to assess the adequacy of prophylactic an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14745
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVE:To explore the meaning that men attach to their experiences of having lower urinary tract symptoms (LUTS) and to understand 'bother' in the context of those meanings. PATIENTS AND METHODS:Sixteen men with symptoms suggestive of LUTS and/or an enlarged prostate were recruited from the outpatient urology clini...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05720.x
更新日期:2005-10-01 00:00:00
abstract:OBJECTIVE:To examine whether gene profiles can provide a molecular evaluation of the quality and therapeutic potential in patients with myelomeningocele (MM), by comparing genetic profiles of smooth muscle cells (SMCs) from healthy bladders and bladders from patients, to identify genes that are over- and under-expresse...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07606.x
更新日期:2008-09-01 00:00:00
abstract:OBJECTIVE:To determine the metabolic characteristics of elderly patients with recurrent calcium oxalate stones. PATIENTS AND METHODS:Metabolic abnormalities were investigated in 88 patients with recurrent calcium oxalate stones, including 70 aged <60 years and 18 aged >/=60 years. The frequency of each metabolic abnor...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00057.x
更新日期:1999-06-01 00:00:00
abstract:OBJECTIVE:To describe our experience of inguinal exploration in patients who had a reasonable chance of having a benign testicular lesion. PATIENTS AND METHODS:From 1995 to 2002, 11 patients (mean age 43 years, range 27-63) with testicular masses that were suspected to be benign underwent inguinal exploration. RESULT...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04080.x
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:To report the experience of the last 4 years from a centre to which women with voiding difficulties and urinary retention were referred nationally, describing what investigations were helpful in making a diagnosis and the management strategies used. PATIENTS AND METHODS:Women with voiding difficulties and ur...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06009.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To assess whether the optimal use of combined treatment with chemotherapy and appropriately timed surgical intervention by a specialized team might improve the outcome for patients with poor- and intermediate-prognosis (International Germ Cell Consensus Classification, IGCCC) nonseminomatous germ cell tumours...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04261.x
更新日期:2003-07-01 00:00:00