Abstract:
:Novel oral anti-coagulants (NOACs) are increasingly being used in clinical practice and are set to almost entirely replace the vitamin K antagonists, such as warfarin, in the near future. Similarly, new antiplatelet agents are now regularly used in place of older agents, such as aspirin and clopidogrel. In an ageing population, with an increasing burden of complex comorbidities, urologists will frequently encounter patients who will be using such agents. Some background knowledge, and an understanding, of these drugs and the issues that surround their usage, is essential. The present article will provide readers with an understanding of these new drugs, including their mechanisms of action, the up-to-date evidence justifying their recent introduction into clinical practice and the appropriate interval for stopping them before surgery. It will also consider the risks of perioperative bleeding for patients taking these drugs and the risks of venous thromboembolism in those in whom they are stopped. Strategies to manage anticoagulant-associated bleeding are discussed.
journal_name
BJU Intjournal_title
BJU internationalauthors
Ellis G,John Camm A,Datta SNdoi
10.1111/bju.13131subject
Has Abstractpub_date
2015-11-01 00:00:00pages
687-96issue
5eissn
1464-4096issn
1464-410Xjournal_volume
116pub_type
杂志文章,评审abstract:OBJECTIVE:To characterize a newly established human testicular carcinoma cell line that continuously produces alpha-fetoprotein (AFP), and to investigate the effects of retinoic acid on AFP production. MATERIALS AND METHODS:A 24-year-old man underwent a radical orchidectomy for a right testicular tumour and was found ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02357.x
更新日期:2001-10-01 00:00:00
abstract::Urothelial cell carcinomas (UCC), including bladder cancer and upper urinary tract cancer, are the second most common malignancy of the urogenital tract after prostate cancer. It is a critical issue to differentiate accurately those patients whose tumour will recur and/or progress after initial treatment from those wi...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08696.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVES:To compare the results of retroperitoneal laparoscopic with open partial nephroureterectomy. PATIENTS AND METHODS:Laparoscopic retroperitoneal partial nephroureterectomy was undertaken in 15 children (13 upper and two lower poles; median age at the time of surgery 61 months, range 5-212). A three-trocar ret...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04126.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:To assess psychometrically a new questionnaire for measuring the psychosocial morbidity in patients with prostate cancer and in their partners, and to compare the morbidity of patients and their partners. PATIENTS AND METHODS:A sequential sample of patients with any stage of prostate cancer and attending gen...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00914.x
更新日期:2000-11-01 00:00:00
abstract:OBJECTIVE:To identify predictors for long-term urinary leakage after radical prostatectomy. PATIENTS AND METHODS:A consecutive series of 1411 patients who underwent radical prostatectomy (open surgery or robot-assisted laparoscopic surgery) at Karolinska University Hospital between 2002 and 2006 were invited to comple...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10231.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine if antibiotic prophylaxis is required for intradetrusor botulinum toxin A (BoNT-A) injections. PATIENTS AND METHODS:This was a prospective non-randomized study. Inclusion criteria were adult patients with neurogenic detrusor overactivity who failed anticholinergic-based first-line treatment and ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09435.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To report the outcomes of >1000 men with low-risk prostate cancer treated with low-dose-rate (LDR) brachytherapy at three large UK cancer centres. PATIENTS AND METHODS:A total of 1038 patients with low-risk prostate cancer (prostate-specific antigen [PSA] ≤10 ng/mL, Gleason score 6, ≤T2b disease) were treate...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12358
更新日期:2014-05-01 00:00:00
abstract:OBJECTIVE:To determine, using magnetic resonance imaging (MRI), the incidence of retropubic haematoma and any associated clinically significant effects after a xenograft (porcine dermis) sling (XS) or the tension-free vaginal tape (TVT) procedure. PATIENTS AND METHODS:Between October 2003 and March 2004, 24 consecutiv...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05779.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To examine the feasibility and reproducibility of laser interstitial thermotherapy (LITT) as a minimally invasive method for the treatment of prostate cancer. MATERIALS AND METHODS:Heterotopic tumours of prostatic adenocarcinoma (Dunning R3327-AT2) were induced in 10 male Copenhagen rats. After preoperative ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10406.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the early results of hand-assisted radical nephrectomy and nephroureterectomy in our institution. PATIENTS AND METHODS:The records of 13 patients with malignant disease of the kidney who underwent hand-assisted laparoscopic radical nephrectomy and nephroureterectomy were reviewed retrospectively....
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02955.x
更新日期:2002-09-01 00:00:00
abstract:OBJECTIVES:To determine the feasibility of laparoscopic augmentation cystoplasty (LAC) in the porcine model and to compare LAC using standard bowel vs a small intestinal submucosa (SIS) allograft. MATERIALS AND METHODS:Fourteen female pigs underwent LAC; six had standard ileal AC and eight AC with SIS. All the pigs ha...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06662.x
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVES:To determine if cells expressing prostate-specific antigen (PSA) can be detected in blood collected by a cell-saver during radical prostatectomy (RP) or in the peripheral blood after intraoperative autotransfusion (IAT). PATIENTS AND METHODS:In all, 112 men with clinical T1c-T2 prostate cancer undergoing RP...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05621.x
更新日期:2005-08-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? In the 1980s and 1990s, a method for direct measurement of pressure and cross-sectional area in women and men was developed. It was successful in terms of obtaining meaningful results in several studies. But the technique, which was based on the field...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10997.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To compare changes in regional cerebral blood flow (rCBF), using positron emission tomography (PET), during chronic and acute sacral neuromodulation (SN). SN is an effective long-term treatment for chronic urge incontinence due to urinary bladder hyperactivity, as sensory nerves, spinal and supraspinal struct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06521.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of alterations in 'patient' position on laser-induced ureteric stone retropulsion in an in vitro model. MATERIALS AND METHODS:A ceramic (phantom) stone was placed in a water-filled clear polymer tube and subjected to continuous laser energy until the stone had retropulsed a d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14510
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cance...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2008.07474.x
更新日期:2008-06-01 00:00:00
abstract:OBJECTIVE:To review the clinical and laboratory features and response to treatment of patients with acute brucellar epididymo-orchitis reporting to a tertiary care hospital in Riyadh, and to compare these with other cases reported previously. PATIENTS AND METHODS:In this retrospective study, records of all 26 adult pa...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2001.02243.x
更新日期:2001-07-01 00:00:00
abstract:OBJECTIVE:To determine the relative prevalence of various definitions of microscopic haematuria (MH) in patients with renal neoplasms and controls, and to predict the likely outcome of renal imaging for those definitions. PATIENTS AND METHODS:In a retrospective case-control study 278 adult men and woman seen between 1...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05694.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVE:To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC). PATIENTS AND METHODS:We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological asses...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09442.x
更新日期:2011-01-01 00:00:00
abstract::The development of new imaging techniques and the refinement of established methods in uroradiological imaging is proceeding rapidly. In the last few years several important developments have been implemented in the routine diagnostic evaluation of urological patients.A milestone is the recent advent of multidetector ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1046/j.1464-410x.2002.02620.x
更新日期:2002-03-01 00:00:00
abstract:OBJECTIVE:To determine the 5-year oncological outcomes of endoscopic extraperitoneal radical prostatectomy (EERPE) from a medium-volume centre, thereby providing much needed data on outcomes from the UK. PATIENTS AND METHODS:From January 2006 to January 2012, 575 patients underwent EERPE for localized prostate cancer,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12260
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:To simplify the original Preoperative Aspects and Dimensions Used for an Anatomical (PADUA) classification of renal tumours, generating a new system able to predict equally or better the risk of overall complications in patients undergoing partial nephrectomy (PN); and to test if the addition of the contact s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14772
更新日期:2019-04-09 00:00:00
abstract:OBJECTIVE:• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic. PATIENTS AND METHODS:• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 c...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2010.09801.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To report our experience with the Safyre (Promedon, Cordoba, Argentina), a new re-adjustable and minimally invasive sling for treating stress urinary incontinence (SUI), which combines the efficacy of slings with re-adjustability. PATIENTS AND METHODS:In all, 126 consecutive patients with a clinical and urod...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/j.1464-410X.2005.05295.x
更新日期:2005-02-01 00:00:00
abstract:OBJECTIVE:To evaluate whether injection with pericapsular lignocaine before transrectal ultrasonography (TRUS)-guided biopsy reduces the perceived pain of prostatic biopsy. PATIENTS AND METHODS:The study included 121 patients referred for TRUS-guided biopsy of the prostate; 27 underwent biopsy with no previous injecti...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2002.03025.x
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12517
更新日期:2014-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the epidemiology of lower urinary tract symptoms (LUTS) among men and women, as there are significant unanswered questions about the prevalence and impact of LUTS in different populations. SUBJECTS AND METHODS:A population-based, cross-sectional survey was completed in Boxmeer (the Netherlands), ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2003.04369.x
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:To compare directly the performance of the ADXBLADDER test with that of cytology in the detection of non-muscle-invasive bladder cancer (NMIBC) recurrences. BACKGROUND:ADXBLADDER is a urine test based on the detection of MCM5, a DNA licensing factor expressed in all cells capable of dividing. Expression is u...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15194
更新日期:2020-08-03 00:00:00
abstract:OBJECTIVES:To evaluate if the obesity paradox, wherein obesity portends worse overall prognosis for a disease but improved outcomes for patients receiving immunotherapy, exists for patients receiving bacillus Calmette-Guérin (BCG) in a contemporary cohort. PATIENTS AND METHODS:We performed an Institutional Review Boar...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15296
更新日期:2020-11-14 00:00:00
abstract:OBJECTIVE:•To compare the Prostate Cancer Prevention Trial Risk Calculator (PCPT-RC) and European Randomized Study of Screening for Prostate Cancer Risk Calculator (ERSPC-RC) in a single-institution Canadian cohort. PATIENTS AND METHODS:•At Princess Margaret Hospital, 982 consecutive patients with PCPT-RC and ERSPC-RC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10207.x
更新日期:2011-10-01 00:00:00