Prognostic value of the Gleason score in prostate cancer.

Abstract:

OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level during this period. The mean (range) age at diagnosis was 73.7 (52-95) years and the mean follow-up was 6.4 (0-22) years. The influence of Gleason score and the percentage of the specimen area with tumour (% cancer) on disease-specific survival were assessed using Kaplan-Meier analyses. RESULTS:Of 305 cancers, 22% had a Gleason score of 4-5, 29% of 6, 18% of 7 and 32% of 8-10. At the follow-up, 89% of the men had died, of whom 42% had died from prostate cancer. The disease-specific 10-year survival was 56%. The disease-specific mean survival (DSMS) for Gleason score 4-5, 6, 7 and 8-10 was 20, 16, 10 and 5 years, respectively (P < 0.001). The DSMS did not differ significantly between Gleason 4 and 5 or between 8-10. There was a trend towards shorter survival for Gleason 4 + 3=7 (DSMS 9 years) than GS 3 + 4=7 (DSMS 13 years; P = 0.16). Gleason score and % cancer were independent predictors of DSMS (P < 0.001). CONCLUSION:The long-term prognosis of prostate cancer on deferred treatment is predicted well by the Gleason score. Four prognostic categories of prostate cancer are suggested, i.e. Gleason score 4-5, 6, 7 and 8-10.

journal_name

BJU Int

journal_title

BJU international

authors

Egevad L,Granfors T,Karlberg L,Bergh A,Stattin P

doi

10.1046/j.1464-410x.2002.02669.x

keywords:

subject

Has Abstract

pub_date

2002-04-01 00:00:00

pages

538-42

issue

6

eissn

1464-4096

issn

1464-410X

pii

2669

journal_volume

89

pub_type

杂志文章
  • 'Mohs surgery of the prostate': the utility of in situ frozen section analysis during robotic prostatectomy.

    abstract::OBJECTIVE • To evaluate a novel technique to lower positive surgical margin rates while preserving as much of the neurovascular bundles as possible during nerve-sparing robotic prostatectomy. MATERIALS AND METHODS • In situ intraoperative frozen section (IFS) was performed during robotic-assisted laparoscopic prostate...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09595.x

    authors: Lavery HJ,Xiao GQ,Nabizada-Pace F,Mikulasovich M,Unger P,Samadi DB

    更新日期:2011-03-01 00:00:00

  • Evaluating the role of the FSH receptor gene Thr307-Ala and Asn680-Ser polymorphisms in male infertility and their association with semen quality and reproductive hormones.

    abstract:OBJECTIVE:To determine whether Thr(307)-Asn(680) and Ala(307)-Ser(680) polymorphisms of the follicle-stimulating hormone receptor (FSH-R) gene are associated with male infertility, semen quality, and reproductive hormones. PATIENTS AND METHODS:The FSH-R polymorphisms at codons 680 and 307 were analysed by restriction-...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09890.x

    authors: Safarinejad MR,Shafiei N,Safarinejad S

    更新日期:2011-07-01 00:00:00

  • A population-based study of urinary symptoms and incontinence: the Canadian Urinary Bladder Survey.

    abstract:OBJECTIVE:To ascertain the prevalence of lower urinary tract symptoms (LUTS) and urinary incontinence (UI) in Canada, using a cross-Canada telephone survey, as there is a wide discrepancy in the reported prevalence of these conditions. SUBJECTS AND METHODS:A random survey with a standardized questionnaire was conducte...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.07198.x

    authors: Herschorn S,Gajewski J,Schulz J,Corcos J

    更新日期:2008-01-01 00:00:00

  • Reduced estimated glomerular filtration rate (eGFR

    abstract:OBJECTIVE:To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression. PATIENTS AND METHODS:A multi-institutional database identified patients with serum creat...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13904

    authors: Blute ML Jr,Kucherov V,Rushmer TJ,Damodaran S,Shi F,Abel EJ,Jarrard DF,Richards KA,Messing EM,Downs TM

    更新日期:2017-09-01 00:00:00

  • Extracorporeal shock-wave therapy for treating chronic pelvic pain syndrome: a feasibility study and the first clinical results.

    abstract:OBJECTIVE:To investigate the feasibility and clinical outcome of extracorporeal shock-wave therapy (ESWT) for patients suffering from chronic pelvic pain syndrome (CPPS). PATIENTS AND METHODS:The study included 34 patients who had had CPPS for >or=3 months, who were investigated in two subsequent studies. ESWT was adm...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07742.x

    authors: Zimmermann R,Cumpanas A,Hoeltl L,Janetschek G,Stenzl A,Miclea F

    更新日期:2008-09-01 00:00:00

  • Probiotics, dendritic cells and bladder cancer.

    abstract::What's known on the subject? and What does the study add? The suppressor effect of probiotics on superficial bladder cancer is an observed phenomenon but the specific mechanism is poorly understood. The evidence strongly suggests natural killer (NK) cells are the anti-tumour effector cells involved and NK cell activit...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2011.10749.x

    authors: Feyisetan O,Tracey C,Hellawell GO

    更新日期:2012-06-01 00:00:00

  • Increasing age is not associated with toxicity leading to discontinuation of treatment in patients with urothelial non-muscle-invasive bladder cancer randomised to receive 3 years of maintenance bacille Calmette-Guérin: results from European Organisation

    abstract:OBJECTIVE:To determine the relationship of age to side-effects leading to discontinuation of treatment in patients with stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with maintenance bacille Calmette-Guérin (BCG). PATIENTS AND METHODS:We evaluated toxicity for 487 eligible patients with intermediate- ...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/bju.13474

    authors: Oddens JR,Sylvester RJ,Brausi MA,Kirkels WJ,van de Beek C,van Andel G,de Reijke TM,Prescott S,Alfred Witjes J,Oosterlinck W

    更新日期:2016-09-01 00:00:00

  • Comparison of the effects of oestrogen deficiency and old age on primary bladder afferent activity and voiding behaviour in the ageing female rat.

    abstract:OBJECTIVE:To determine if a decrease in oestrogen (E) levels increases activity in bladder afferent nerves, by investigating the effects of E loss on afferent nerve activity in ovariectomized (OVX) rats, and making comparisons with findings in ageing female rats. MATERIALS AND METHODS:Female Sprague-Dawley rats were d...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09689.x

    authors: Aizawa N,Iijima K,Rosenbaum JS,Downs TR,Igawa Y,Andersson KE,Wyndaele JJ

    更新日期:2011-07-01 00:00:00

  • Risk of urinary tract infection after detrusor botulinum toxin A injections for refractory neurogenic detrusor overactivity in patients with no antibiotic treatment.

    abstract:OBJECTIVE:To determine if antibiotic prophylaxis is required for intradetrusor botulinum toxin A (BoNT-A) injections. PATIENTS AND METHODS:This was a prospective non-randomized study. Inclusion criteria were adult patients with neurogenic detrusor overactivity who failed anticholinergic-based first-line treatment and ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09435.x

    authors: Mouttalib S,Khan S,Castel-Lacanal E,Guillotreau J,De Boissezon X,Malavaud B,Marque P,Rischmann P,Gamé X

    更新日期:2010-12-01 00:00:00

  • Lymph node mapping in patients with bladder cancer undergoing radical cystectomy and lymph node dissection to the level of the inferior mesenteric artery.

    abstract:OBJECTIVE:To evaluate extended lymph node dissection (LND) as a nodal staging tool in the treatment of invasive carcinoma of the urinary bladder and to suggest a reasonable proximal limit of the dissection. PATIENTS AND METHODS:In all, 170 patients underwent radical cystectomy with extended LND up to the level of the ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.09118.x

    authors: Jensen JB,Ulhøi BP,Jensen KM

    更新日期:2010-07-01 00:00:00

  • Risk of prostate cancer-specific death in men with baseline metabolic aberrations treated with androgen deprivation therapy for biochemical recurrence.

    abstract:OBJECTIVES:To investigate the associations of host metabolic factors and metabolic syndrome on prostate cancer-specific death (PCSD) and overall survival (OS) in patients treated with androgen deprivation therapy (ADT) for biochemically recurrent disease. PATIENTS AND METHODS:The analysis included 273 patients with pr...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13428

    authors: Rudman SM,Gray KP,Batista JL,Pitt MJ,Giovannucci EL,Harper PG,Loda M,Mucci LA,Sweeney CJ

    更新日期:2016-12-01 00:00:00

  • Prostate histotripsy: evaluation of prostatic urethral treatment parameters in a canine model.

    abstract:OBJECTIVE:To assess the impact of histotripsy treatment parameters (pulse number and pulse-repetition frequency [PRF]) on the efficiency of histotripsy induced homogenisation of the prostatic urethra. MATERIALS AND METHODS:In all, 34 transabdominal prostate histotripsy treatments were applied along a perpendicular pla...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12333

    authors: Schade GR,Styn NR,Ives KA,Hall TL,Roberts WW

    更新日期:2014-03-01 00:00:00

  • Long-term oncological outcome after post-chemotherapy retroperitoneal lymph node dissection in men with metastatic nonseminomatous germ cell tumour.

    abstract:OBJECTIVE:To determine whether conformity to standard recommendations of retroperitoneal lymph node dissection (RPLND) after chemotherapy for testicular and primary retroperitoneal nonseminomatous germ cell tumours (NSGCT) and completeness of surgical excision have an effect on oncological outcome. PATIENTS AND METHOD...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.09175.x

    authors: Fléchon A,Tavernier E,Boyle H,Meeus P,Rivoire M,Droz JP

    更新日期:2010-09-01 00:00:00

  • Importance of HOX genes in normal prostate gland formation, prostate cancer development and its early detection.

    abstract::The aims of this paper were to review the published literature on the role of HOX genes in the development of the normal prostate gland and in prostate cancer and to discuss the potential role of the HOX family member, Engrailed-2 (EN2), as a diagnostic test of PCa. Hox genes were first described in the fruit fly Dros...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.12269

    authors: Javed S,Langley SE

    更新日期:2014-04-01 00:00:00

  • Outcomes for patients with high-grade prostate cancer treated with a combination of brachytherapy, external beam radiotherapy and hormonal therapy.

    abstract:OBJECTIVE:To assess the outcomes for patients with Gleason score 8-10 prostate cancer treated with brachytherapy, external beam radiotherapy (EBRT) and hormonal therapy (HT). PATIENTS AND METHODS:In all, 181 patients with Gleason scores 8-10 prostate cancer were treated from 1994 to 2006 with a (103)Pd implant (prescr...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08661.x

    authors: Stock RG,Cesaretti JA,Hall SJ,Stone NN

    更新日期:2009-12-01 00:00:00

  • Testicular histopathology as a predictor of a positive sperm retrieval in men with non-obstructive azoospermia.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: The management of patients with non-obstructive azoospermia (NOA) involves testicular sperm extraction (TESE or microdissection TESE) combined with intracytoplasmic sperm injection (ICSI). Sperm retrieval is successful in up to 50% of men with NOA; h...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11203.x

    authors: Abdel Raheem A,Garaffa G,Rushwan N,De Luca F,Zacharakis E,Abdel Raheem T,Freeman A,Serhal P,Harper JC,Ralph D

    更新日期:2013-03-01 00:00:00

  • Phase II study of cytarabine in men with docetaxel-refractory, castration-resistant prostate cancer with evaluation of TMPRSS2-ERG and SPINK1 as serum biomarkers.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? To date, there has been limited impetus to examine the use of cytarabine in prostate cancer. We presented preliminary laboratory data to suggest its utility in the castration refractory prostate cancer (CRPC) population which, combined with a previous...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10922.x

    authors: Dhani NC,Emmenegger U,Adams L,Jongstra J,Tannock IF,Sridhar SS,Knox JJ,Day JR,Groskopf J,Joshua AM

    更新日期:2012-09-01 00:00:00

  • Sigmoid orthotopic neobladder after radical cystectomy for bladder tumour: an Indian experience.

    abstract:OBJECTIVE:To determine the long-term results of constructing a sigmoid neobladder after radical cystectomy for transitional cell carcinoma (TCC) of the urinary bladder. PATIENTS AND METHODS:The study included 170 patients with TCC of the bladder and a normal sigmoid colon. After radical cystectomy the neobladder was f...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06541.x

    authors: Yadav SS,Sadadukhi TC,Sharma KK,Yadav RG,Mathur R

    更新日期:2007-02-01 00:00:00

  • The role of imaging in urinary incontinence.

    abstract::A detailed history, physical examination, symptom and quality-of-life assessment, and urine analysis are unanimously considered essential components of the initial evaluation of urinary incontinence. Beyond these assessments, there are no universally accepted recommendations and, to date, imaging is not recommended in...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2005.05433.x

    authors: Artibani W,Cerruto MA

    更新日期:2005-04-01 00:00:00

  • Is robotically assisted laparoscopic radical prostatectomy less invasive than retropubic radical prostatectomy? Results from a prospective, unrandomized, comparative study.

    abstract:OBJECTIVES:To evaluate whether robotically assisted laparoscopic prostatectomy (RALP) is less invasive than radical retropubic prostatectomy (RRP), as experimental studies suggest that the acute phase reaction is proportional to surgery-induced tissue damage. PATIENTS AND METHODS:Between May and November 2006, all pat...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07513.x

    authors: Fracalanza S,Ficarra V,Cavalleri S,Galfano A,Novara G,Mangano A,Plebani M,Artibani W

    更新日期:2008-05-01 00:00:00

  • Association of hospital volume with conditional 90-day mortality after cystectomy: an analysis of the National Cancer Data Base.

    abstract:OBJECTIVE:To examine the association of hospital volume and 90-day mortality after cystectomy, conditional on survival for 30 days. PATIENTS AND METHODS:The National Cancer Data Base was used to evaluate 30- and 90-day mortality for 35,055 patients who underwent cystectomy for bladder cancer at one of 1118 hospitals. ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.12566

    authors: Nielsen ME,Mallin K,Weaver MA,Palis B,Stewart A,Winchester DP,Milowsky MI

    更新日期:2014-07-01 00:00:00

  • Should the upper tracts be imaged for microscopic haematuria?

    abstract:OBJECTIVE:To determine the relative prevalence of various definitions of microscopic haematuria (MH) in patients with renal neoplasms and controls, and to predict the likely outcome of renal imaging for those definitions. PATIENTS AND METHODS:In a retrospective case-control study 278 adult men and woman seen between 1...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05694.x

    authors: Feldstein MS,Hentz JG,Gillett MD,Novicki DE

    更新日期:2005-09-01 00:00:00

  • Testicular-sparing surgery: a reasonable option in selected patients with testicular lesions.

    abstract:OBJECTIVE:To describe our experience of inguinal exploration in patients who had a reasonable chance of having a benign testicular lesion. PATIENTS AND METHODS:From 1995 to 2002, 11 patients (mean age 43 years, range 27-63) with testicular masses that were suspected to be benign underwent inguinal exploration. RESULT...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2003.04080.x

    authors: Passarella M,Usta MF,Bivalacqua TJ,Hellstrom WJ,Davis R

    更新日期:2003-03-01 00:00:00

  • Technique for office-based, ultrasonography-guided percutaneous biopsy of renal cortical neoplasms using a novel transducer for facilitated ultrasound targeting.

    abstract:OBJECTIVES:To help clarify which small renal cortical neoplasms (RCNs) require surgery by using office-based, ultrasonography-guided percutaneous renal biopsy. PATIENTS AND METHODS:Biopsies were performed using facilitated ultrasound targeting (FUT) technology, which incorporates a needle guide and onscreen beam-steer...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12489

    authors: Menhadji AD,Nguyen V,Okhunov Z,Bucur P,Chu WH,Cho J,Billingsley J,Morrison D,Kelly CR,Landman J

    更新日期:2016-06-01 00:00:00

  • Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Acute urinary retention (AUR) and catheterization for AUR (AURC) or drainage of the urine is a well established cause of bladder dysfunction. Previously, we reported that the induction of AURC significantly reduced contractile responses to both carbac...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.10965.x

    authors: Ohmasa F,Saito M,Oiwa H,Tsounapi P,Shomori K,Kitatani K,Dimitriadis F,Kinoshita Y,Satoh K

    更新日期:2012-09-01 00:00:00

  • Three-dimensional virtual imaging of renal tumours: a new tool to improve the accuracy of nephrometry scores.

    abstract:OBJECTIVES:To apply the standard PADUA and RENAL nephrometry score variables to three-dimensional (3D) virtual models (VMs) produced from standard bi-dimensional imaging, thereby creating three-dimensional (3D)-based (PADUA and RENAL) nephrometry scores/categories for the reclassification of the surgical complexity of ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14894

    authors: Porpiglia F,Amparore D,Checcucci E,Manfredi M,Stura I,Migliaretti G,Autorino R,Ficarra V,Fiori C

    更新日期:2019-12-01 00:00:00

  • Validity of prostate-specific antigen as a tumour marker in men with prostate cancer managed by watchful-waiting: correlation with findings at serial endorectal magnetic resonance imaging and spectroscopic imaging.

    abstract:OBJECTIVE:To investigate the validity of prostate-specific antigen (PSA) as a tumour marker in men with clinically localized prostate cancer who have selected watchful waiting, by determining if serial PSA level measurements are correlated with findings of malignancy or benign prostatic hyperplasia (BPH) at serial endo...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06515.x

    authors: Coakley FV,Chen I,Qayyum A,Westphalen AC,Carroll PR,Hricak H,Chen MH,Kurhanewicz J

    更新日期:2007-01-01 00:00:00

  • Perioperative outcomes of 6042 nephrectomies in 2012: surgeon-reported results in the UK from the British Association of Urological Surgeons (BAUS) nephrectomy database.

    abstract:OBJECTIVE:To present the perioperative outcomes from the British Association of Urological Surgeons (BAUS) nephrectomy dataset for 2012, the first year of public reporting of individual surgeon outcomes in the UK. PATIENTS AND METHODS:All nephrectomies performed in the year 2012 and recorded in the database were analy...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12770

    authors: Henderson JM,Fowler S,Joyce A,Dickinson A,Keeley FX,BAUS.

    更新日期:2015-01-01 00:00:00

  • Sexually responsive vascular tissue of the vulva.

    abstract:OBJECTIVE:To better understand the genital changes that occur during the female sexual response, using a gross anatomical and histological study of the vascular tissue of the vulva, supplemented with magnetic resonance imaging (MRI). MATERIALS AND METHODS:Seven cadaveric vulvectomy specimens were used; they were seria...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05961.x

    authors: Yang CC,Cold CJ,Yilmaz U,Maravilla KR

    更新日期:2006-04-01 00:00:00

  • The quality of life of men with locally advanced prostate cancer during neoadjuvant hormone therapy: data from the Medical Research Council RT01 trial (ISRCTN 47772397).

    abstract:OBJECTIVE:To explore patients' quality of life (QoL) during neoadjuvant hormone therapy (HT) using data from the Medical Research Council RT01 trial of standard- (64 Gy/32-fraction) and high- (74 Gy/37-fraction) dose radiotherapy (RT, both given conformally). PATIENTS AND METHODS:Of the 843 patients randomized to the ...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/j.1464-410X.2006.06560.x

    authors: Stephens RJ,Dearnaley DP,Cowan R,Sydes M,Naylor S,Fallowfield L,RT01 collaborators.

    更新日期:2007-02-01 00:00:00