Abstract:
OBJECTIVE:To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression. PATIENTS AND METHODS:A multi-institutional database identified patients with serum creatinine values prior to first transurethral resection of bladder tumour (TURBT). The CKD-epidemiology collaboration formula calculated patient eGFR. Cox proportional hazards models evaluated associations with recurrence-free (RFS) and progression-free survival (PFS). RESULTS:In all, 727 patients were identified with a median (interquartile range [IQR]) patient age of 69.8 (60.1-77.6) years. Data for eGFR were available for 632 patients. During a median (IQR) follow-up of 3.7 (1.5-6.5) years, 400 (55%) patients had recurrence and 145 (19.9%) patients had progression of tumour stage or grade. Moderate or severe CKD was identified in 183 patients according to eGFR. Multivariable analysis identified an eGFR of <60 mL/min/1.73 m2 (hazard ratio [HR] 1.5, 95% confidence interval [CI]: 1.2-1.9; P = 0.002) as a predictor of tumour recurrence. The 5-year RFS rate was 46% for patients with an eGFR of ≥60 mL/min/1.73 m2 and 27% for patients with an eGFR of <60 mL/min/1.73 m2 (P < 0.001). Multivariable analysis showed that an eGFR of <60 mL/min/1.73 m2 (HR 3.7, 95% CI: 1.75-7.94; P = 0.001) was associated with progression to muscle-invasive disease. The 5-year PFS rate was 83% for patients with an eGFR of ≥60 mL/min/1.73 m2 and 71% for patients with an eGFR of <60 mL/min/1.73 m2 (P = 0.01). CONCLUSION:Moderate CKD at first TURBT is associated with reduced RFS and PFS. Patients with reduced renal function should be considered for increased surveillance.
journal_name
BJU Intjournal_title
BJU internationalauthors
Blute ML Jr,Kucherov V,Rushmer TJ,Damodaran S,Shi F,Abel EJ,Jarrard DF,Richards KA,Messing EM,Downs TMdoi
10.1111/bju.13904subject
Has Abstractpub_date
2017-09-01 00:00:00pages
387-393issue
3eissn
1464-4096issn
1464-410Xjournal_volume
120pub_type
杂志文章abstract:OBJECTIVE:To explore the predictors of the quality of marriage of men with prostate cancer, as being diagnosed with prostate cancer affects the quality of life of the man and his partner, and while some aspects are known about the impact of the disease and its treatments on the man's quality of life, less is known abou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.06807.x
更新日期:2007-06-01 00:00:00
abstract:OBJECTIVE:To investigate the potential utility of a new combined immunostaining technique for diagnosing prostate cancer from histological analysis of needle biopsy specimens. MATERIALS AND METHODS:Tissue was immunostained with a combination of antibodies against a basal cell marker (p63), and an enzyme commonly overe...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06069.x
更新日期:2006-05-01 00:00:00
abstract:OBJECTIVE:To describe the surgical management of patients with renal cell carcinoma (RCC) in a solitary kidney (managed preferentially by nephron-sparing surgery, NSS, to avoid dialysis) and extending into the renal vein or inferior vena cava (T3b). PATIENTS AND METHODS:We identified 13 patients treated surgically bet...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05566.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of various prostate tumour volume (TV) estimation methods. To determine the most appropriate estimation method for current clinical practice. PATIENTS AND METHODS:Radical prostatectomy (RP) specimens from multiple institutions were analysed by a single uro-pathologist between Septemb...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12458
更新日期:2014-03-01 00:00:00
abstract::Accurate prediction is essential for patient counselling, appropriate selection of treatments and determination of eligibility for clinical trials. In this review we assess the available determinants of oncological outcome after radical cystectomy (RC) for transitional cell carcinoma of the urinary bladder. We reviewe...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07594.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To report a simplified and effective method for substratification of M1 castrate-resistant prostate cancer (CRPC) by correlating progression-free (PFS) and overall survival (OS) with simple quantification of skeletal metastases. PATIENTS AND METHODS:In all, 561 men with M1 CRPC were studied longitudinally. I...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12717
更新日期:2014-12-01 00:00:00
abstract:OBJECTIVE:To assess the prevalence of obstructive sleep apnoea (OSA) in men presenting with erectile dysfunction (ED) at a single centre. PATIENTS AND METHODS:All men attending a specialised andrology outpatient department with a new diagnosis of ED were included in this prospective study. All patients completed three...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13961
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the efficacy of vardenafil in patients previously unresponsive to sildenafil. PATIENTS AND METHODS:A multicentre, double-blind, 12-week, flexible-dose, placebo-controlled trial was conducted, involving 463 men aged > or = 18 years with moderate-to-severe erectile dysfunction (ED) and who were unr...
journal_title:BJU international
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2004.05161.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.2002.02674.x
更新日期:2002-05-01 00:00:00
abstract:OBJECTIVE:To investigate the associations of a range of personal and clinical variables with bladder cancer survival in men and women in NSW to see if we could explain why bladder cancer survival is consistently poorer in women than in men. PATIENTS AND METHODS:All 6880 cases of bladder cancers diagnosed in NSW betwee...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12496
更新日期:2014-03-01 00:00:00
abstract:UNLABELLED:OBJECTIVE • To determine how the presence of MP on T1 biopsy specimens affects the outcome of patients undergoing RC as compared to when no MP is identified in the TURBT specimen. PATIENTS AND METHODS:• Patients were retrospectively identified from the Columbia University Urologic Oncology Database. • From ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09893.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:• To investigate the oncological efficacy of retroperitoneal laparoscopic radical nephrectomy (RLRN) compared with transperitoneal laparoscopic radical nephrectomy (TLRN) for the management of clear-cell renal cell carcinoma (RCC). PATIENTS AND METHODS:• With emphasis on survival and disease recurrence, a re...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2010.09636.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVES:To compare, in a retrospective study, pathological specimens of prostate cancer detected in additional areas of a 12-core biopsy with tumours detected using traditional sextant biopsy. PATIENTS AND METHODS:The study included 27 patients who had undergone radical prostatectomy (RP) for prostate cancer. Prost...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00558.x
更新日期:2000-04-01 00:00:00
abstract::Urothelial cell carcinomas (UCC), including bladder cancer and upper urinary tract cancer, are the second most common malignancy of the urogenital tract after prostate cancer. It is a critical issue to differentiate accurately those patients whose tumour will recur and/or progress after initial treatment from those wi...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.08696.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To investigate the feasibility of using a ganglial culture system to screen various growth factors as potential therapeutic agents for pelvic nerve injuries. MATERIALS AND METHODS:The major pelvic ganglia (MPG) were isolated from male rats and attached to culture dishes with the aid of Matrigel (Becton Dicki...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04439.x
更新日期:2003-10-01 00:00:00
abstract:OBJECTIVE:To compare interpretations of electromyographic (EMG) recordings from perineal surface patch electrodes (PSPEs) to those from urethral concentric needle electrodes (CNEs) during voiding. PATIENTS AND METHODS:Consenting women underwent urodynamic testing with a 30 G, 3.8 cm CNE at the 12 o'clock position in t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05890.x
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:To compare the outcomes for laparoscopic vascular hitch (VH) and dismembered pyeloplasty in patients with pelvi-ureteric junction obstruction (PUJO) secondary to crossing vessels (CV). PATIENTS AND METHODS:Patients who underwent laparoscopic management of CV at our institution were identified between 2008 an...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.15342
更新日期:2021-01-19 00:00:00
abstract:OBJECTIVES:• To investigate a new method of vas deferens radiography for ejaculatory duct obstruction (EDO). • To evaluate the effect of a procedure involving dilation of the ejaculatory duct by F9 seminal vesicoscopy. PATIENTS AND METHODS:• Twenty-two patients with EDO were diagnosed using semen analysis, semen fruct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09775.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVES:To determine the outcomes of complete surgical resection of T4 prostate cancer after inductive androgen-deprivation therapy (ADT), as inductive ADT and subsequent radical prostatectomy (RP) is not recommended by any guideline yet. PATIENTS AND METHODS:A monocentric RP database was queried for patients initi...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14393
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To report our 12-year experience with radiological treatment (ureteric embolization) for refractory urinary fistula, as malignancy, radiation therapy, and/or chronic inflammation increase the risk of lower urinary tract fistula after surgical urinary diversion, which can lead to significant morbidity, and for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06569.x
更新日期:2007-02-01 00:00:00
abstract:OBJECTIVE:To analyse tumour extent as a predictor of cancer progression after radical prostatectomy (RP), using a multivariate Cox regression model, as several variables (e.g. Gleason grade and tumour stage) are well-established prognostic factors in prostate cancer but it is uncertain if the visual estimation of tumou...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05825.x
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To compare the outcome of a modified one-layer and two-layer vasovasotomy (VV) in two groups of similar men undergoing vasectomy reversal. PATIENTS AND METHODS:The charts and surgical records of all surgical procedures performed on men undergoing a modified one- or two-layer VV between June 1992 and July 199...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00668.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVES:ERG-gene rearrangement defines a distinct molecular subtype of PCA with potential biological and clinical implications. To identify a molecular signature reflective of the downstream effects of ERG-mediated transcriptional regulation with prognostic implication in patients with prostate cancer (PCA). MATERI...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12262
更新日期:2014-02-01 00:00:00
abstract:OBJECTIVE:To assess prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG scores in patients with advanced and metastatic prostate cancer at baseline and after 6 months of treatment with triptorelin 22.5 mg, and analyse these scores in patient-groups defined by different disease characteristics. PATIENTS AND METHODS:The Tr...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12542
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVES:To study whether androgen deprivation therapy (ADT), the mainstay treatment for advanced and disseminated prostate cancer, is associated with risk of dementia. METHODS:Risk of dementia in men with prostate cancer primarily managed with ADT or watchful waiting (WW) in the Prostate Cancer Database Sweden, PCB...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14666
更新日期:2019-07-01 00:00:00
abstract:OBJECTIVE:To assess the impact on patterns of recurrence of adjuvant chemotherapy in patients with stage 1 nonseminomatous germ cell tumours (NSGCT) of the testis, who have a high likelihood of relapse on surveillance if certain risk factors are identified in the orchidectomy specimen, and thus the theoretical need for...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00722.x
更新日期:2000-07-01 00:00:00
abstract:OBJECTIVE:To review our experience of percutaneous nephrolithotomy (PCNL) in children before school age, and determine its efficacy and safety in this age group. PATIENTS AND METHODS:The records of children aged < or = 5 years undergoing PCNL were reviewed. Variables assessed included stone number, size, location and ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05173.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:To assess the risk factors for haemorrhage and renal fracture associated with renal cryoablation. MATERIALS AND METHODS:In a porcine model, 120 cryoablations were administered in 26 pigs, with five groups of 24 ice-balls each; in groups 1 and 2 asynchronous cryoprobe activation was evaluated for the 1.47- an...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07735.x
更新日期:2008-09-01 00:00:00
abstract::While patient age and gender are important factors in the clinical decision-making for treating urothelial carcinoma of the bladder (UCB), there are no evidence-based recommendations to guide healthcare professionals. We review previous reports on the influence of age and gender on the incidence, biology, mortality an...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2009.09076.x
更新日期:2010-02-01 00:00:00
abstract::Detrusor sphincter dyssynergia (DSD) is variant of neurogenic bladder dysfunction caused by suprasacral neurological abnormalities and may be associated with serious complications if unrecognised. This paper focuses on the clinical features as well as challenges and limitations in the diagnosis of DSD. ...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11042.x
更新日期:2012-04-01 00:00:00