Reduced estimated glomerular filtration rate (eGFR


OBJECTIVE:To evaluate if moderate chronic kidney disease [CKD; estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m2 ] is associated with high rates of non-muscle-invasive bladder cancer (NMIBC) recurrence or progression. PATIENTS AND METHODS:A multi-institutional database identified patients with serum creatinine values prior to first transurethral resection of bladder tumour (TURBT). The CKD-epidemiology collaboration formula calculated patient eGFR. Cox proportional hazards models evaluated associations with recurrence-free (RFS) and progression-free survival (PFS). RESULTS:In all, 727 patients were identified with a median (interquartile range [IQR]) patient age of 69.8 (60.1-77.6) years. Data for eGFR were available for 632 patients. During a median (IQR) follow-up of 3.7 (1.5-6.5) years, 400 (55%) patients had recurrence and 145 (19.9%) patients had progression of tumour stage or grade. Moderate or severe CKD was identified in 183 patients according to eGFR. Multivariable analysis identified an eGFR of <60 mL/min/1.73 m2 (hazard ratio [HR] 1.5, 95% confidence interval [CI]: 1.2-1.9; P = 0.002) as a predictor of tumour recurrence. The 5-year RFS rate was 46% for patients with an eGFR of ≥60 mL/min/1.73 m2 and 27% for patients with an eGFR of <60 mL/min/1.73 m2 (P < 0.001). Multivariable analysis showed that an eGFR of <60 mL/min/1.73 m2 (HR 3.7, 95% CI: 1.75-7.94; P = 0.001) was associated with progression to muscle-invasive disease. The 5-year PFS rate was 83% for patients with an eGFR of ≥60 mL/min/1.73 m2 and 71% for patients with an eGFR of <60 mL/min/1.73 m2 (P = 0.01). CONCLUSION:Moderate CKD at first TURBT is associated with reduced RFS and PFS. Patients with reduced renal function should be considered for increased surveillance.




BJU international


Blute ML Jr,Kucherov V,Rushmer TJ,Damodaran S,Shi F,Abel EJ,Jarrard DF,Richards KA,Messing EM,Downs TM




Has Abstract


2017-09-01 00:00:00












  • Arteries of the scrotum: a microvascular study and its application to urethral reconstruction with scrotal flaps.

    abstract:OBJECTIVE:To study scrotal microvascularization and apply the findings to the design of reliable skin flaps for reconstructive surgery of complex urethral or panurethral stenoses. MATERIALS AND METHODS:In 15 cryopreserved male cadavers, scrotal skin vascularization was explored using macro- and microdissections, and t...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Carrera A,Gil-Vernet A,Forcada P,Morro R,Llusa M,Arango O

    更新日期:2009-03-01 00:00:00

  • The Z-shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients.

    abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To evaluate the results in terms of functional results and morbidity of Z-shaped ileal neobladder performed in a single center. PATIENTS AND METHODS:329 consecutive male patients who had an orthotopic bladder replacement using the Z-shaped...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Neuzillet Y,Yonneau L,Lebret T,Herve JM,Butreau M,Botto H

    更新日期:2011-08-01 00:00:00

  • Technique for office-based, ultrasonography-guided percutaneous biopsy of renal cortical neoplasms using a novel transducer for facilitated ultrasound targeting.

    abstract:OBJECTIVES:To help clarify which small renal cortical neoplasms (RCNs) require surgery by using office-based, ultrasonography-guided percutaneous renal biopsy. PATIENTS AND METHODS:Biopsies were performed using facilitated ultrasound targeting (FUT) technology, which incorporates a needle guide and onscreen beam-steer...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Menhadji AD,Nguyen V,Okhunov Z,Bucur P,Chu WH,Cho J,Billingsley J,Morrison D,Kelly CR,Landman J

    更新日期:2016-06-01 00:00:00

  • Lack of prognostic significance of prostate biopsies in metastatic androgen independent prostate cancer.

    abstract:OBJECTIVE:To assess the significance of viable tumour in the prostate of patients with metastatic androgen-independent prostate cancer (AIPC). PATIENTS AND METHODS:We evaluated the clinicopathological features, including follow-up, of 40 men with metastatic AIPC who had a transrectal biopsy of the prostate. RESULTS:P...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验


    authors: Aragon-Ching JB,Gillespie J,Price DK,Chuaqui R,Rodriguez-Canales J,Steinberg SM,Dahut WL,Figg WD

    更新日期:2007-12-01 00:00:00

  • Vascular endothelial growth factor and mTOR pathways in renal cell carcinoma: differences and synergies of two targeted mechanisms.

    abstract::Renal cell carcinoma (RCC) is among the most resistant tumours to chemotherapy, radiotherapy and hormonal therapy. Cytokine therapy is effective in a small subset of patients, but it is associated with substantial toxicity and rarely benefits patients with extensive tumour burdens or adverse prognostic factors. Since ...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Mulders P

    更新日期:2009-12-01 00:00:00

  • Detection of clinical unilateral T3a prostate cancer - by digital rectal examination or transrectal ultrasonography?

    abstract:OBJECTIVE:To assess, in a retrospective study, the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of digital rectal examination (DRE), transrectal ultrasonography (TRUS) and the combination of both in unilateral clinical T3a (cT3a) prostate cancer. PATIENTS AND METHODS:Th...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Hsu CY,Joniau S,Oyen R,Roskams T,Van Poppel H

    更新日期:2006-11-01 00:00:00

  • Severe bladder trabeculation obviates the need for bladder outlet procedures during augmentation cystoplasty in incontinent patients with neurogenic bladder.

    abstract:OBJECTIVE:To evaluate whether the degree of preoperative bladder trabeculation in neurogenic bladder (NB) patients is a marker of significant outlet resistance. If so, severe trabeculation may obviate the need for concomitant bladder outlet procedure (BOP) during augmentation cystoplasty (AC). PATIENTS AND METHODS:We ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Khoury AE,Dave S,Peralta-Del Valle MH,Braga LH,Lorenzo AJ,Bägli D

    更新日期:2008-01-01 00:00:00

  • Volume-outcome relationship in penile cancer treatment: a population based patterns of care and outcomes study from Australia.

    abstract:OBJECTIVES:To study the patterns of care of penile cancer diagnosed in the state of New South Wales (NSW) over a 10 year period and determine factors that are associated with differences in survival. PATIENTS AND METHODS:All invasive penile cancer diagnosed between 2001 and 2009 in NSW, Australia, were identified from...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Patel MI,Yuminaga Y,Bang A,Lawrentschuk N,Skyring T,Smith DP

    更新日期:2016-10-01 00:00:00

  • Increased vascular endothelial growth factor expression in patients with bladder pain syndrome/interstitial cystitis: its association with pain severity and glomerulations.

    abstract:OBJECTIVE:To determine the angiogenic profiles in the bladder of patients with bladder pain syndrome (BPS)/interstitial cystitis (IC), and to evaluate the relationship between these profiles and associated clinical features including pelvic pain and glomerulations. PATIENTS AND METHODS:Angiogenesis and angiogenic comp...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kiuchi H,Tsujimura A,Takao T,Yamamoto K,Nakayama J,Miyagawa Y,Nonomura N,Takeyama M,Okuyama A

    更新日期:2009-09-01 00:00:00

  • Thymidylate synthase was associated with patient prognosis and the response to adjuvant therapy in bladder cancer.

    abstract:OBJECTIVE:To investigate the expression of thymidylate synthase (TS), a key enzyme in DNA synthesis that is over-expressed in several cancer cells, in bladder cancer and its association with patient prognosis and the response to adjuvant therapy. PATIENTS AND METHODS:In all, 67 bladder tissue specimens were obtained f...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Li Y,Li X,Dai H,Sun X,Li J,Yang F,Gu H,Yang Y,Jin Z,Chu Y,Jin X,Kakehi Y,Wu X

    更新日期:2009-02-01 00:00:00

  • GreenLight HPS™ 120-W laser vaporization vs transurethral resection of the prostate (

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Photovaporization of the prostate (PVP) is now challenging TURP as the standard treatment for lower LUTS caused by BPH. The learning curve for PVP is short and the main advantages of this method over TURP are a shorter period of hospitalization, a sho...

    journal_title:BJU international

    pub_type: 杂志文章,随机对照试验


    authors: Pereira-Correia JA,de Moraes Sousa KD,Santos JB,de Morais Perpétuo D,Lopes-da-Silva LF,Krambeck RL,Muller VJ,Vaz FP

    更新日期:2012-10-01 00:00:00

  • Natural-fill urodynamics in chronically catheterized patients with spinal-cord injury.

    abstract:OBJECTIVE:To determine whether an indwelling catheter on free drainage provides a constantly low intravesical pressure in patients with a neuropathic bladder. PATIENTS AND METHODS:Thirty patients with complete spinal-cord injury (SCI) whose bladders were managed exclusively with an indwelling catheter were assessed ur...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Jamil F,Williamson M,Ahmed YS,Harrison SC

    更新日期:1999-03-01 00:00:00

  • Twelve prostate biopsies detect significant cancer volumes (> 0.5 mL).

    abstract:OBJECTIVES:To compare, in a retrospective study, pathological specimens of prostate cancer detected in additional areas of a 12-core biopsy with tumours detected using traditional sextant biopsy. PATIENTS AND METHODS:The study included 27 patients who had undergone radical prostatectomy (RP) for prostate cancer. Prost...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Brössner C,Bayer G,Madersbacher S,Kuber W,Klingler C,Pycha A

    更新日期:2000-04-01 00:00:00

  • Comparison of efficacy and satisfaction profile, between penile prosthesis implantation and oral PDE5 inhibitor tadalafil therapy, in men with nerve-sparing radical prostatectomy erectile dysfunction.

    abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Erectile dysfunction after nerve-sparing radical retropubic prostatectomy constitutes a challenge to the urologist. The mainstay of medical treatment after radical prostatectomy to restore spontaneous erectile function remains phosphodiesterase (PDE5...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Megas G,Papadopoulos G,Stathouros G,Moschonas D,Gkialas I,Ntoumas K

    更新日期:2013-07-01 00:00:00

  • FK506-binding protein localizations in human penile innervation.

    abstract:OBJECTIVE:To determine if FK506-binding proteins (FKBPs) are localized to the autonomic nerve supply of the human penis because FK506 (an immunosuppressant drug) has been linked to enhanced nerve regeneration after nerve injury and neurodegenerative diseases by binding to FKBPs, a select group of immunophilins. MATERI...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Lagoda G,Sezen SF,Liu T,Höke A,Burnett AL

    更新日期:2008-03-01 00:00:00

  • Does mirabegron relieve ureteric stent-related discomfort? A prospective, randomized, multicentre study.

    abstract:OBJECTIVES:To evaluate the effects of 50 mg mirabegron once daily for ureteric stent-related discomfort after ureteroscopic procedures by conducting a multicentre randomized study. PATIENTS AND METHODS:A total of 100 patients with indwelling ureteric stents after ureteroscopic stone removal or retrograde intrarenal su...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Tae BS,Cho S,Jeon BJ,Choi H,Park JY,Cho SY,Lee KC,Bae JH

    更新日期:2018-11-01 00:00:00

  • Long-term follow-up of noninvasive bladder tumours (stage Ta): recurrence and progression.

    abstract:OBJECTIVE:To evaluate long-term recurrence-free and progression-free survival of noninvasive bladder tumours (stage Ta), and the significance of simple risk factors, including concomitant epithelial dysplasia. PATIENTS AND METHODS:The study included 217 patients with primary noninvasive bladder tumour (stage Ta) who w...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Zieger K,Wolf H,Olsen PR,Hojgaard K

    更新日期:2000-05-01 00:00:00

  • Novel anticoagulants and antiplatelet agents; a guide for the urologist.

    abstract::Novel oral anti-coagulants (NOACs) are increasingly being used in clinical practice and are set to almost entirely replace the vitamin K antagonists, such as warfarin, in the near future. Similarly, new antiplatelet agents are now regularly used in place of older agents, such as aspirin and clopidogrel. In an ageing p...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Ellis G,John Camm A,Datta SN

    更新日期:2015-11-01 00:00:00

  • Current applications of three-dimensional printing in urology.

    abstract::Three-dimensional (3D) printing or additive manufacturing is a new technology that has seen rapid development in recent years with decreasing costs. 3D printing allows the creation of customised, finely detailed constructs. Technological improvements, increased printer availability, decreasing costs, improved cell cul...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Chen MY,Skewes J,Desselle M,Wong C,Woodruff MA,Dasgupta P,Rukin NJ

    更新日期:2020-01-01 00:00:00

  • Multicentre prospective evaluation of the learning curve of holmium laser enucleation of the prostate (HoLEP).

    abstract:OBJECTIVES:To describe the step-by-step learning curve of the holmium laser enucleation of the prostate (HoLEP) surgical technique. SUBJECTS/PATIENTS AND METHODS:A prospective, multicentre observational study was conducted, involving surgeons experienced in transurethral resection of the prostate and open prostatectom...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Robert G,Cornu JN,Fourmarier M,Saussine C,Descazeaud A,Azzouzi AR,Vicaut E,Lukacs B

    更新日期:2016-03-01 00:00:00

  • Ureteric embolization: an alternative treatment strategy for urinary fistulae complicating advanced pelvic malignancy.

    abstract:OBJECTIVE:To report experience with a minimally invasive technique for palliation of urinary fistula/incontinence complicating advanced pelvic malignancy or its treatment. PATIENTS AND METHODS:We used ureteric embolization with permanent nephrostomy drainage in eight renal units in five patients for palliation of symp...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Natarajan V,Boucher NR,Meiring P,Spencer P,Parys BT,Oakley NE,Stent (Society for Endourology in North Trent) Group.

    更新日期:2007-01-01 00:00:00

  • Analysis of peripheral blood for prostate cells after autologous transfusion given during radical prostatectomy.

    abstract:OBJECTIVES:To determine if cells expressing prostate-specific antigen (PSA) can be detected in blood collected by a cell-saver during radical prostatectomy (RP) or in the peripheral blood after intraoperative autotransfusion (IAT). PATIENTS AND METHODS:In all, 112 men with clinical T1c-T2 prostate cancer undergoing RP...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Stoffel JT,Topjian L,Libertino JA

    更新日期:2005-08-01 00:00:00

  • Androgen deprivation therapy before radical prostatectomy is associated with poorer postoperative erectile function outcomes.

    abstract:UNLABELLED:Study Type - Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Erectile dysfunction is a recognized complication of radical prostatectomy. Androgen deprivation therapy adversely impacts sexual function. Our study shows that the preoperative use of androgen de...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Mazzola CR,Deveci S,Heck M,Mulhall JP

    更新日期:2012-07-01 00:00:00

  • The catheterized patient undergoing transurethral resection of the prostate: a survey of the current practice of British urologists.

    abstract:OBJECTIVE:To determine, using a postal questionnaire survey of practising British consultant urologists, the duration and type of antibiotic deemed most effective in patients with an existing indwelling catheter before transurethral resection of the prostate (TURP), as the value of prophylactic antibiotics before TURP ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Wilson JR,Puri R,Prescott S,Urwin GH

    更新日期:2003-10-01 00:00:00

  • Conservative management of giant symptomatic angiomyolipomas in patients with the tuberous sclerosis complex.

    abstract:OBJECTIVE:To present two patients with the tuberous sclerosis complex in whom giant angiomyolipomas (AMLs) were managed conservatively for >20 years, as large (>4 cm) symptomatic AMLs are generally treated with embolization or nephrectomy because of the risks of haemorrhage. PATIENTS AND METHODS:The first patient init...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Danforth TL,Lane BR,Novick AC

    更新日期:2007-10-01 00:00:00

  • Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort.

    abstract:OBJECTIVE:To assess the impact of positive surgical margins (PSMs) on long-term outcomes after radical prostatectomy (RP), including metastasis, castrate-resistant prostate cancer (CRPC), and prostate cancer-specific mortality (PCSM). PATIENTS AND METHODS:Retrospective study of 4,051 men in the Shared Equal Access Reg...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Mithal P,Howard LE,Aronson WJ,Terris MK,Cooperberg MR,Kane CJ,Amling C,Freedland SJ

    更新日期:2016-02-01 00:00:00

  • Incontinence aids in Sweden: users and costs.

    abstract:OBJECTIVE:To study age- and sex-specific use and costs of incontinence aids distributed free of charge in Sweden. SUBJECTS AND METHODS:The study was conducted in the county of Jämtland, Sweden (132,000 inhabitants). The use and cost of incontinence aids for people living in their homes and the total cost of incontinen...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Samuelsson E,Månsson L,Milsom I

    更新日期:2001-12-01 00:00:00

  • Mortality associated with Fournier's gangrene remains unchanged over 25 years.

    abstract:OBJECTIVES:To report a case series of Fournier's gangrene (FG) from our institution, and to investigate its mortality over the past 25 years. PATIENTS AND METHODS:Case notes of men presenting to our institution from 2013 to 2016 with FG were reviewed. As well as age, diabetic history, length of stay, length of stay in...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Radcliffe RS,Khan MA

    更新日期:2020-04-01 00:00:00

  • Mechanisms of neurokinin A- and substance P-induced contractions in rat detrusor smooth muscle in vitro.

    abstract:OBJECTIVE:To investigate the mechanisms of neurokinin A- and substance P-induced contractions of rat urinary bladder smooth muscle, and to compare them with those of the muscarinic agonist carbachol. MATERIALS AND METHODS:Rat urinary bladder strips were suspended under 1 g of tension in a physiological buffer at 37 de...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Quinn T,Collins C,Baird AW

    更新日期:2004-09-01 00:00:00

  • Posterior tibial nerve stimulation in patients with intractable interstitial cystitis.

    abstract:OBJECTIVE:To evaluate the efficacy of intermittent percutaneous posterior tibial nerve stimulation (PPTNS) in patients with refractory interstitial cystitis. PATIENTS AND METHODS:One man and 13 women (mean age 58.3 years) with suprapubic or perineal pain were enrolled in a prospective open study, in which they had 10 ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Zhao J,Nordling J

    更新日期:2004-07-01 00:00:00