Abstract:
OBJECTIVE:To assess the sensitivity and specificity of blue-light cystoscopy (BLC) with hexaminolevulinate as an adjunct to white-light cystoscopy (WLC) vs WLC alone for the detection of non-muscle-invasive bladder cancer (NMIBC), in routine clinical practice in Spain. PATIENTS AND METHOD:An intra-patient comparative, multicentre, prospective, observational study. Adults with suspected or documented primary or recurrent NMIBC at eight Spanish centres were included in the study. All patients were examined with WLC followed by BLC with hexaminolevulinate. We evaluated the detection rate of bladder cancer lesions by WLC and BLC with hexaminolevulinate, overall and by tumour stage and compared with histological examination of the biopsied lesions. Sensitivity and specificity was calculated. RESULTS:In all, 1,569 lesions were identified from 283 patients: 621 were tumour lesions according to histology and 948 were false-positives. Of the 621 tumour lesions, 475 were detected by WLC (sensitivity 76.5%, 95% confidence interval [CI] 73.2-79.8) and 579 were detected by BLC (sensitivity 93.2%, 95% CI 91.0-95.1; P < 0.001). There was a significant improvement in the sensitivity in the detection of all types of NMIBC lesions with BLC compared with WLC. Of 219 patients with tumours, 188 had NMIBC [highest grade: carcinoma in situ (CIS), n = 36; Ta, n = 87; T1, n = 65). CIS lesions were identified more with BLC (n = 27) than with WLC [n = 19; sensitivity: BLC 75.0% (95% CI 57.8-87.9) vs WLC 52.8% (95% CI 35.5-69.6); P = 0.021]. Results varied across centres. CONCLUSIONS:This study shows that improvement in diagnosis of NMIBC, mainly CIS and Ta tumours, obtained with BLC with hexaminolevulinate as an adjunct to WLC vs WLC alone can be shown in routine clinical practice.
journal_name
BJU Intjournal_title
BJU internationalauthors
Palou J,Hernández C,Solsona E,Abascal R,Burgués JP,Rioja C,Cabrera JA,Gutiérrez C,Rodríguez O,Iborra I,Herranz F,Abascal JM,Conde G,Oliva Jdoi
10.1111/bju.13020subject
Has Abstractpub_date
2015-07-01 00:00:00pages
37-43issue
1eissn
1464-4096issn
1464-410Xjournal_volume
116pub_type
杂志文章,多中心研究abstract:OBJECTIVE:To compare the effectiveness and safety of standard percutaneous nephrolithotomy (sPCNL) and super-mini PCNL (SMP). PATIENTS AND METHODS:A total of 150 patients presenting with renal calculi of <2 cm were randomised to either sPCNL (Group 1) or SMP (Group 2). Randomisation was based on centralised computer-g...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.15144
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abstract:UNLABELLED:What's known on the subject? and What does the study add? The common clinical practice for advanced prostatic adenocarcinoma is combination therapy of zoledronic acid (ZA) and docetaxel (TAX). Little is known about the consequences of this combination therapy with regard to osteonecrosis of the jaw (ONJ). Th...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11205.x
更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05586.x
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abstract:OBJECTIVES:To review our experience at a children's hospital over a 10-year period with the Palomo, Ivanissevich, subinguinal and laparoscopic techniques for varicocele, assessing the success and complication rates according to specific procedure, and the added effect that the modifications of microsurgery and artery-s...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08288.x
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abstract:OBJECTIVE:To assess the totality of prostate cancer eradication in radical prostatectomy (RP) specimens from men with a unilaterally positive prostate biopsy, and who would currently qualify for subtotal prostate ablation with controlled thermal energy such as cryoablation or high-intensity focused ultrasound. MATERIA...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08359.x
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To determine whether clinicians discuss bone-specific side-effects with patients on androgen-deprivation therapy (ADT) for prostate cancer, or prescribe lifestyle and pharmacological interventions for low bone mineral density (BMD), as decreased BMD is a common side-effect of ADT, leading to increased risk of...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08156.x
更新日期:2009-03-01 00:00:00
abstract:OBJECTIVES:To analyze pathological and short-term oncological outcomes in men undergoing open and minimally-invasive radical prostatectomy (MIRP) for high-risk prostate cancer (HRPC; prostate-specific antigen level [PSA] >20 ng/mL, ≥ cT2c, Gleason score 8-10) in a contemporaneous series. PATIENTS AND METHODS:In total,...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11757.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02833.x
更新日期:2002-07-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章,评审
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更新日期:2015-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07789.x
更新日期:2008-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04222.x
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01562.x
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journal_title:BJU international
pub_type: 杂志文章
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journal_title:BJU international
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2000-10-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2010-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09435.x
更新日期:2010-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,meta分析
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更新日期:2018-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-4096.2001.01871.x
更新日期:2002-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,meta分析,评审
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更新日期:2006-08-01 00:00:00
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更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2007-07-01 00:00:00