Effectiveness of hexaminolevulinate fluorescence cystoscopy for the diagnosis of non-muscle-invasive bladder cancer in daily clinical practice: a Spanish multicentre observational study.


OBJECTIVE:To assess the sensitivity and specificity of blue-light cystoscopy (BLC) with hexaminolevulinate as an adjunct to white-light cystoscopy (WLC) vs WLC alone for the detection of non-muscle-invasive bladder cancer (NMIBC), in routine clinical practice in Spain. PATIENTS AND METHOD:An intra-patient comparative, multicentre, prospective, observational study. Adults with suspected or documented primary or recurrent NMIBC at eight Spanish centres were included in the study. All patients were examined with WLC followed by BLC with hexaminolevulinate. We evaluated the detection rate of bladder cancer lesions by WLC and BLC with hexaminolevulinate, overall and by tumour stage and compared with histological examination of the biopsied lesions. Sensitivity and specificity was calculated. RESULTS:In all, 1,569 lesions were identified from 283 patients: 621 were tumour lesions according to histology and 948 were false-positives. Of the 621 tumour lesions, 475 were detected by WLC (sensitivity 76.5%, 95% confidence interval [CI] 73.2-79.8) and 579 were detected by BLC (sensitivity 93.2%, 95% CI 91.0-95.1; P < 0.001). There was a significant improvement in the sensitivity in the detection of all types of NMIBC lesions with BLC compared with WLC. Of 219 patients with tumours, 188 had NMIBC [highest grade: carcinoma in situ (CIS), n = 36; Ta, n = 87; T1, n = 65). CIS lesions were identified more with BLC (n = 27) than with WLC [n = 19; sensitivity: BLC 75.0% (95% CI 57.8-87.9) vs WLC 52.8% (95% CI 35.5-69.6); P = 0.021]. Results varied across centres. CONCLUSIONS:This study shows that improvement in diagnosis of NMIBC, mainly CIS and Ta tumours, obtained with BLC with hexaminolevulinate as an adjunct to WLC vs WLC alone can be shown in routine clinical practice.




BJU international


Palou J,Hernández C,Solsona E,Abascal R,Burgués JP,Rioja C,Cabrera JA,Gutiérrez C,Rodríguez O,Iborra I,Herranz F,Abascal JM,Conde G,Oliva J




Has Abstract


2015-07-01 00:00:00












  • Increased use of partial nephrectomy to treat high-risk disease.

    abstract:OBJECTIVES:To evaluate partial nephrectomy (PN) use in patients at higher risk for clinical progression, using a large national database of American patients. PATIENTS AND METHODS:We performed a retrospective review of patients with cN0/cM0 renal cell carcinoma from 2003 to 2011 using the National Cancer Data Base. Ou...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Maurice MJ,Zhu H,Kim SP,Abouassaly R

    更新日期:2016-06-01 00:00:00

  • Improved quality of life in patients with overactive bladder symptoms treated with solifenacin.

    abstract:OBJECTIVE:To assess the effect of solifenacin succinate treatment on quality of life (QoL) measured in clinical trials in patients with overactive bladder (OAB). PATIENTS AND METHODS:QoL data using the King's Health Questionnaire (KHQ) were analysed from two phase-3, 12-week studies (1984 patients) and a long-term ext...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析


    authors: Kelleher CJ,Cardozo L,Chapple CR,Haab F,Ridder AM

    更新日期:2005-01-01 00:00:00

  • Matrix metalloproteinases (MMPs) in bladder cancer: the induction of MMP9 by epidermal growth factor and its detection in urine.

    abstract:OBJECTIVES:To investigate the matrix metalloproteinases (MMPs) 2 and 9 in bladder cancer cell lines stimulated with epidermal growth factor (EGF), and to investigate the presence of gelatinases in the urine of patients with bladder tumours, in relation to the stage and grade of tumour and the EGF receptor (EGFR) status...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Nutt JE,Durkan GC,Mellon JK,Lunec J

    更新日期:2003-01-01 00:00:00

  • One-sided anterior urethroplasty: a new dorsal onlay graft technique.

    abstract:OBJECTIVE:To investigate the feasibility, tolerability, safety and efficacy of using a new surgical technique for the repair of anterior urethral strictures to preserve vascular supply to the urethra and its entire muscular and neurogenic support. PATIENTS AND METHODS:In all, 24 patients (mean age 46 years) underwent ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kulkarni S,Barbagli G,Sansalone S,Lazzeri M

    更新日期:2009-10-01 00:00:00

  • alpha-Adrenoceptor subtypes in isolated corporal tissue from patients undergoing gender re-assignment.

    abstract:OBJECTIVE:To investigate the pharmacology and functionality of alpha(1)-adrenoceptors in human corpus cavernosum, and to determine the predominant subtype. MATERIALS AND METHODS:Cavernosal tissue specimens were obtained from the penises of 22 men (mean age 37.4 years) removed during gender re-assignment surgery. The m...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: El-Gamal OM,Sandhu DP,Terry T,Elliott RA

    更新日期:2006-02-01 00:00:00

  • Biofeedback vs verbal feedback as learning tools for pelvic muscle exercises in the early management of urinary incontinence after radical prostatectomy.

    abstract:OBJECTIVE:To evaluate the comparative effectiveness of electromyographic (EMG) biofeedback with verbal instructions as learning tools of pelvic muscle exercises (PMEs) in the early management of urinary incontinence after radical prostatectomy. PATIENTS AND METHODS:Forty-two consecutive patients (mean age 64 years, sd...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Floratos DL,Sonke GS,Rapidou CA,Alivizatos GJ,Deliveliotis C,Constantinides CA,Theodorou C

    更新日期:2002-05-01 00:00:00

  • Defining a glycated haemoglobin (HbA1c) level that predicts increased risk of penile implant infection.

    abstract:OBJECTIVES:To re-evaluate the role of diabetes mellitus (DM) as a risk factor for penile implant infection by exploring the association between glycated haemoglobin (HbA1c) levels and penile implant infection rates and to define a threshold value that predicts implant infection. PATIENTS AND METHODS:We conducted a mul...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Habous M,Tal R,Tealab A,Soliman T,Nassar M,Mekawi Z,Mahmoud S,Abdelwahab O,Elkhouly M,Kamr H,Remeah A,Binsaleh S,Ralph D,Mulhall J

    更新日期:2018-02-01 00:00:00

  • Systematic review and network meta-analysis on the relative efficacy of osteoporotic medications: men with prostate cancer on continuous androgen-deprivation therapy to reduce risk of fragility fractures.

    abstract::Androgen-deprivation therapy (ADT) is an effective treatment for men with advanced prostate cancer, but loss of bone mineral density (BMD) is a major risk factor for fractures. This review compared the efficacy of available treatments to provide prescribing guidance to healthcare professionals. This is the first revie...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Poon Y,Pechlivanoglou P,Alibhai SMH,Naimark D,Hoch JS,Papadimitropoulos E,Hogan ME,Krahn M

    更新日期:2018-01-01 00:00:00

  • Venous thromboembolism in radical prostatectomy: is heparinoid prophylaxis warranted?

    abstract:OBJECTIVE:To review the incidence of venous thromboembolism (VTE) after radical retropubic prostatectomy (RRP) and evaluate the need for heparinoid prophylaxis as opposed to mechanical compression devices after RRP. PATIENTS AND METHODS:RRP is classified as a category 1 (high risk) procedure for VTE by the American Co...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Koya MP,Manoharan M,Kim SS,Soloway MS

    更新日期:2005-11-01 00:00:00

  • Prospective evaluation of irrigation fluid absorption during pure transurethral bipolar plasma vaporisation of the prostate using expired-breath ethanol measurements.

    abstract:OBJECTIVES:To investigate if absorption of irrigation fluid occurs during bipolar plasma vaporisation (BPV) of the prostate. To examine the clinical predictors of increased risk of fluid absorption and to assess if changes in serum electrolytes, venous pH, haemoglobin or haematocrit are able to detect intra-operative f...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Hermanns T,Fankhauser CD,Hefermehl LJ,Kranzbühler B,Wong LM,Capol JC,Zimmermann M,Sulser T,Müller A

    更新日期:2013-09-01 00:00:00

  • Androgen-suppression therapy for prostate cancer and the risk of death in men with a history of myocardial infarction or stroke.

    abstract:OBJECTIVE:To examine the effect of short-course androgen-suppression therapy (AST) before brachytherapy on all-cause mortality (ACM) rates, stratified by the presence or absence of a history of myocardial infarction (MI) or stroke. AST is used to reduce prostate size to enable men with favourable-risk prostate cancer t...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Hayes JH,Chen MH,Moran BJ,Braccioforte MH,Dosoretz DE,Salenius S,Katin MJ,Ross R,Choueiri TK,D'Amico AV

    更新日期:2010-10-01 00:00:00

  • Novel method of full-thickness bladder closure with an endoscopic suturing machine: a survival study in a porcine model.

    abstract:OBJECTIVE:To assess the feasibility of a pure endoscopic closure method for vesical perforations using fully absorbable material. MATERIALS AND METHODS:A pilot experimental study was performed in eight anaesthetized female pigs. Four 10-mm and four 20-mm endoscopic full thickness cystotomies were created. An endoscopi...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Oliveira C,Autorino R,Ferreira C,Cicione A,Damiano R,De Sio M,Correia-Pinto J,Lima E

    更新日期:2015-02-01 00:00:00

  • Long-term oncological outcomes after laparoscopic radical prostatectomy.

    abstract:OBJECTIVES:To investigate long-term oncological outcomes after laparoscopic radical prostatectomy (LRP). To identify parameters influencing recurrence-free survival in a single-institution series. PATIENTS AND METHODS:All patients underwent LRP using the transperitoneal retrograde Heilbronn technique. High-risk patien...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Hruza M,Bermejo JL,Flinspach B,Schulze M,Teber D,Rumpelt HJ,Rassweiler JJ

    更新日期:2013-02-01 00:00:00

  • Delayed therapy with curative intent in a contemporary prostate cancer watchful-waiting cohort.

    abstract:OBJECTIVE:To identify predictors of delayed therapy with curative intent, an increasingly common option in contemporary patients with prostate cancer who initially choose watchful waiting. PATIENTS AND METHODS:The characteristics of all patients at one institution and diagnosed with T1-4NXM0 prostate cancer between 19...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: el-Geneidy M,Garzotto M,Panagiotou I,Hsieh YC,Mori M,Peters L,Klein T,Beer TM

    更新日期:2004-03-01 00:00:00

  • Evaluation of urinary prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG score changes when starting androgen-deprivation therapy with triptorelin 6-month formulation in patients with locally advanced and metastatic prostate cancer.

    abstract:OBJECTIVE:To assess prostate cancer antigen-3 (PCA3) and TMPRSS2-ERG scores in patients with advanced and metastatic prostate cancer at baseline and after 6 months of treatment with triptorelin 22.5 mg, and analyse these scores in patient-groups defined by different disease characteristics. PATIENTS AND METHODS:The Tr...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Martínez-Piñeiro L,Schalken JA,Cabri P,Maisonobe P,de la Taille A,Triptocare Study Group.

    更新日期:2014-10-01 00:00:00

  • Angiotensin II in child urinary bladder: functional and autoradiographic studies.

    abstract:OBJECTIVES:To investigate the receptors for angiotensin II (AII, reported to be a potent contractile agent in human urinary bladder), using functional and autoradiographic techniques in child and adult bladder specimens. Materials and methods Bladder specimens were obtained from 61 children (aged 4 months to 12 years) ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Lam DS,Dias LS,Moore KH,Burcher E

    更新日期:2000-09-01 00:00:00

  • The 7-year outcome of the tension-free vaginal tape procedure for treating female stress urinary incontinence.

    abstract:OBJECTIVE:To evaluate the long-term results and predictive risk factors for efficacy after the tension-free vaginal tape (TVT) procedure for treating female stress urinary incontinence (SUI). PATIENTS AND METHODS:Inall, 306 women (mean age 50.7 years, sd 8.7) who had a TVT procedure for SUI were selected and followed ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究


    authors: Song PH,Kim YD,Kim HT,Lim HS,Hyun CH,Seo JH,Yoo ES,Park CH,Jung HC,Gomelsky A

    更新日期:2009-10-01 00:00:00

  • Protein kinase C inhibitor prevents renal apoptotic and fibrotic changes in response to partial ureteric obstruction.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Protein kinase C inhibitor (PKCI) can decrease glomerular and tubular cell apoptosis and mitosis and attenuate collagen accumulation and fibronectin expression in a PUUO rat model. Although the role of PKC has been well studied in diabetic nephropathy...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Juan YS,Chuang SM,Long CY,Lin RJ,Liu KM,Wu WJ,Huang CH

    更新日期:2012-07-01 00:00:00

  • Superficial tunica albuginea excision, using geometric principles, for the correction of congenital penile curvature.

    abstract:UNLABELLED:Study Type--Therapy (practise pattern survey) Level of Evidence 3b. What's known on the subject? and What does the study add? Congenital penile deviation has become a relatively frequent finding due to a greater awareness of the problem among patients and physicians. Since the first surgical correction for c...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kuehhas FE,Egydio PH

    更新日期:2012-12-01 00:00:00

  • Does perineural invasion on prostate biopsy predict adverse prostatectomy outcomes?

    abstract:OBJECTIVE:To determine the relationship between perineural invasion (PNI) on prostate biopsy and radical prostatectomy (RP) outcomes in a contemporary RP series, as there is conflicting evidence on the prognostic significance of PNI in prostate needle biopsy specimens. PATIENTS AND METHODS:From 2002 to 2007, 1256 men ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Loeb S,Epstein JI,Humphreys EB,Walsh PC

    更新日期:2010-06-01 00:00:00

  • Long-term functional and morphological outcome after pyeloplasty for huge renal pelvis.

    abstract:OBJECTIVE:• To evaluate the functional and morphological outcome after open pyeloplasty for ureteropelvic junction obstruction (UPJO) with huge renal pelvis. PATIENTS AND METHODS:• A retrospective review of all cases who underwent pyeloplasty for huge renal pelvis was conducted. • Records were evaluated with respect t...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Sarhan O,Helmy T,Abou-El Ghar M,Baky MA,El-Assmy A,Dawaba M

    更新日期:2011-03-01 00:00:00

  • Lower urinary tract symptoms and sexual dysfunction: epidemiology and pathophysiology.

    abstract::There is ample evidence from many epidemiological studies that lower urinary tract symptoms (LUTS) and sexual dysfunction are strongly linked, independently of age and comorbidities such as hypertension, diabetes, dyslipidaemia and coronary heart disease. However, a causal link between both conditions is not yet estab...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: McVary K

    更新日期:2006-04-01 00:00:00

  • Chemotherapy for advanced adrenal cancer: improvement from a molecular approach?

    abstract::Advanced adrenal carcinoma remains a significant therapeutic challenge, with conventional approaches to systemic therapy having failed to achieve sustained objective remissions or major survival benefit in most instances. Several systemic therapies, including mitotane, suramin and gossypol, as well as cytotoxic agents...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Costa R,Wesolowski R,Raghavan D

    更新日期:2011-11-01 00:00:00

  • Sigmoid orthotopic neobladder after radical cystectomy for bladder tumour: an Indian experience.

    abstract:OBJECTIVE:To determine the long-term results of constructing a sigmoid neobladder after radical cystectomy for transitional cell carcinoma (TCC) of the urinary bladder. PATIENTS AND METHODS:The study included 170 patients with TCC of the bladder and a normal sigmoid colon. After radical cystectomy the neobladder was f...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Yadav SS,Sadadukhi TC,Sharma KK,Yadav RG,Mathur R

    更新日期:2007-02-01 00:00:00

  • Contemporary imaging of patients with a renal mass: does size on computed tomography equal pathological size?

    abstract:OBJECTIVE:To evaluate the difference between radiographic size on computed tomography (CT) and the pathological size of renal tumours, in contemporary patients. PATIENTS AND METHODS:We retrospectively reviewed the records of 521 patients undergoing surgical resection of a renal mass between 2000 and 2007, who had tumo...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kurta JM,Thompson RH,Kundu S,Kaag M,Manion MT,Herr HW,Russo P

    更新日期:2009-01-01 00:00:00

  • Transrectal ultrasonography-guided biopsy does not reliably identify dominant cancer location in men with low-risk prostate cancer.

    abstract:UNLABELLED:Study Type - Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? The widespread use of serum PSA testing followed by TRUS-guided biopsy have resulted in profound prostate cancer stage migration with many patients presenting with focal rather than mul...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Washington SL,Bonham M,Whitson JM,Cowan JE,Carroll PR

    更新日期:2012-07-01 00:00:00

  • Cost-effectiveness analysis of treatments for phimosis: a comparison of surgical and medicinal approaches and their economic effect.

    abstract:OBJECTIVE:To compare the cost-effectiveness of surgery and topical steroids as treatments for phimosis (defined as a clinically verifiable, pathological, cicatricial stenosis of the prepuce) and to evaluate the financial basis of these treatments. METHODS:Data on treatment using topical steroids was obtained from publ...

    journal_title:BJU international

    pub_type: 杂志文章,评审


    authors: Berdeu D,Sauze L,Ha-Vinh P,Blum-Boisgard C

    更新日期:2001-02-01 00:00:00

  • Contemporary role of ureterolysis in retroperitoneal fibrosis: treatment of last resort or first intent? An analysis of 50 cases.

    abstract:OBJECTIVE:To determine the outcomes of open ureterolysis in a contemporary cohort of patients presenting with ureteric obstruction secondary to retroperitoneal fibrosis (RPF). PATIENTS AND METHODS:We conducted a prospective analysis of 50 patients undergoing open ureterolysis and omental wrap between January 2012 and ...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: O'Brien T,Fernando A

    更新日期:2017-10-01 00:00:00

  • TURP and sex: patient and partner prospective 12 years follow-up study.

    abstract:OBJECTIVE:• To evaluate the effect of transurethral resection of the prostate (TURP) on sexual function in the short (6 months), medium (6 years) and long (12 years) term and assess the conformity between patient and partner regarding sexual function. PATIENTS AND METHODS:• A prospective cohort study set at the Aberde...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Mishriki SF,Grimsley SJ,Lam T,Nabi G,Cohen NP

    更新日期:2012-03-01 00:00:00

  • The significance of serum levels of insulin-like growth factor-1 in patients with prostate cancer.

    abstract:OBJECTIVES:To compare the serum levels of insulin-like growth factor-1 (IGF-1) in patients with prostate cancer and in control patients with no malignancy, and to evaluate any possible influence of testicular androgen withdrawal on the level of IGF-1 in patients with prostate cancer. PATIENTS AND METHODS:IGF-1 was mea...

    journal_title:BJU international

    pub_type: 杂志文章


    authors: Kurek R,Tunn UW,Eckart O,Aumüller G,Wong J,Renneberg H

    更新日期:2000-01-01 00:00:00