Clinicopathological outcomes after radical cystectomy for clinical T2 urothelial carcinoma: further evidence to support the use of neoadjuvant chemotherapy.

Abstract:

OBJECTIVE:To evaluate the clinicopathological outcomes for patients with clinical T2 (cT2) urothelial carcinoma treated with radical cystectomy (RC) without neoadjuvant chemotherapy (NC). PATIENTS AND METHODS:We identified 212 patients with cT2 tumours who underwent RC at our institution without NC. Pathological assessment of RC specimens was correlated with clinical stage. The impact of various clinicopathological factors on the outcome of patients with cT2 disease was analysed. RESULTS:In total, 153/212 (73.2%) patients with cT2 bladder cancer had either pT3/T4 or pN+ tumours at RC. Moreover, only 58/153 (37.9%) of these patients received adjuvant chemotherapy. The median follow-up was 28 (months 0.6-107.5) (range). The 5-year recurrence-free survival and cancer-specific survival (CSS) was 56.5% and 59.5%, respectively. On multivariate analysis, increasing age (hazard ratio [HR] 1.04; P= 0.04), advanced pathological stage (HR 1.83; P= 0.02), and positive lymph nodes (HR 3.72; P= 0.001) were adversely associated with CSS, while receipt of adjuvant chemotherapy was protective of disease-specific mortality (HR 0.45; P= 0.04). CONCLUSIONS:Pathological upstaging is prevalent and survival remains modest in patients with cT2 tumours treated with RC without NC. Unfortunately, only 40% of patients that had locally advanced and/or regionally metastatic disease received adjuvant treatment. These data further support the value of NC for patients with muscle-invasive bladder cancer, even in those with apparent clinically organ-confined tumours.

journal_name

BJU Int

journal_title

BJU international

authors

Canter D,Long C,Kutikov A,Plimack E,Saad I,Oblaczynski M,Zhu F,Viterbo R,Chen DY,Uzzo RG,Greenberg RE,Boorjian SA

doi

10.1111/j.1464-410X.2010.09442.x

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

58-62

issue

1

eissn

1464-4096

issn

1464-410X

pii

BJU9442

journal_volume

107

pub_type

杂志文章
  • Urethral pressure reflectometry; a novel technique for simultaneous recording of pressure and cross-sectional area: a study of feasibility in the prostatic urethra.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? In the 1980s and 1990s, a method for direct measurement of pressure and cross-sectional area in women and men was developed. It was successful in terms of obtaining meaningful results in several studies. But the technique, which was based on the field...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.10997.x

    authors: Aagaard M,Klarskov N,Sønksen J,Bagi P,Colstrup H,Lose G

    更新日期:2012-10-01 00:00:00

  • Predictors of androgen independence in metastatic prostate cancer.

    abstract:OBJECTIVE:To assess the factors that influence the onset of androgen independence (AI, which heralds a dismal outcome) in patients with metastatic prostate carcinoma. PATIENTS AND METHODS:The records of 361 consecutive patients with prostate carcinoma diagnosed and treated in the authors' institution from 1 January 19...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.04863.x

    authors: Sim HG,Lau WK,Cheng CW

    更新日期:2004-06-01 00:00:00

  • Raman spectral imaging of prostate cancer: can Raman molecular imaging be used to augment standard histopathology?

    abstract:OBJECTIVE:To evaluate whether Raman molecular imaging (RMI, which combines digital imaging and analytical spectroscopy to evaluate the biochemical composition of interrogated material) can be used to identify biochemical differences in patients with Gleason 7 prostate cancer who progress to metastatic disease and die f...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09185.x

    authors: Tollefson M,Magera J,Sebo T,Cohen J,Drauch A,Maier J,Frank I

    更新日期:2010-08-01 00:00:00

  • Robot-assisted extraperitoneal laparoscopic radical prostatectomy: experience in a high-volume laparoscopy reference centre.

    abstract:OBJECTIVE:To describe our current procedure of robot-assisted laparoscopic radical prostatectomy (RALP), and to assess the effect of the learning curve on perioperative data, early oncological outcomes and functional results, as RALP has increasingly become a treatment option for men with localized prostate cancer. PA...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.09013.x

    authors: Ploussard G,Xylinas E,Salomon L,Vordos D,Hoznek A,Abbou CC,De La Taille A

    更新日期:2010-04-01 00:00:00

  • Biochemical composition of urolithiasis from stone dust - a matched-pair analysis.

    abstract:OBJECTIVE:To determine if the biochemical composition of a renal calculus can be measured from 'dust' obtained during laser fragmentation. PATIENTS AND METHODS:This pilot study was set in a tertiary referral hospital between 2011 and 2013. Stone dust was aspirated through the ureteroscope during lasering and a stone f...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13448

    authors: Ray ER,Rumsby G,Smith RD

    更新日期:2016-10-01 00:00:00

  • Incremental detection rate of prostate cancer by real-time elastography targeted biopsies in combination with a conventional 10-core biopsy in 1024 consecutive patients.

    abstract:OBJECTIVE:To quantify the incremental detection rate (DR) of a targeted biopsy in addition to a randomized 10-core biopsy. PATIENTS AND METHODS:This retrospective study analysed 1024 patients who consecutively underwent a four-core real-time elastography (RTE) targeted biopsies in addition to a randomized 10-core tran...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12517

    authors: Salomon G,Drews N,Autier P,Beckmann A,Heinzer H,Hansen J,Michl U,Schlomm T,Haese A,Steuber T,Graefen M,Becker A

    更新日期:2014-04-01 00:00:00

  • Management of benign prostatic hyperplasia in the 21st century: temporal trends in Australian population-based data.

    abstract:OBJECTIVE:To examine national trends in the medical and surgical treatment of benign prostatic hyperplasia (BPH) using Australian Medicare Benefits Schedule (MBS) and Pharmaceutical Benefits Scheme (PBS) population data from 2000 to 2018. PATIENTS AND METHODS:Annual data was extracted from the MBS, PBS and Australian ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.15098

    authors: Morton A,Williams M,Perera M,Teloken PE,Donato P,Ranasinghe S,Chung E,Bolton D,Yaxley J,Roberts MJ

    更新日期:2020-09-01 00:00:00

  • Effectiveness of hexaminolevulinate fluorescence cystoscopy for the diagnosis of non-muscle-invasive bladder cancer in daily clinical practice: a Spanish multicentre observational study.

    abstract:OBJECTIVE:To assess the sensitivity and specificity of blue-light cystoscopy (BLC) with hexaminolevulinate as an adjunct to white-light cystoscopy (WLC) vs WLC alone for the detection of non-muscle-invasive bladder cancer (NMIBC), in routine clinical practice in Spain. PATIENTS AND METHOD:An intra-patient comparative,...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.13020

    authors: Palou J,Hernández C,Solsona E,Abascal R,Burgués JP,Rioja C,Cabrera JA,Gutiérrez C,Rodríguez O,Iborra I,Herranz F,Abascal JM,Conde G,Oliva J

    更新日期:2015-07-01 00:00:00

  • Multiparametric magnetic resonance imaging for the detection and localization of prostate cancer: combination of T2-weighted, dynamic contrast-enhanced and diffusion-weighted imaging.

    abstract:OBJECTIVE:• To evaluate the combination of multiple magnetic resonance imaging (MRI) techniques, including T2-weighted imaging (T2W), dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging (DWI), for the detection and localization of prostate cancer. PATIENTS AND METHODS:• In all, 57 patients underwent...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09808.x

    authors: Delongchamps NB,Rouanne M,Flam T,Beuvon F,Liberatore M,Zerbib M,Cornud F

    更新日期:2011-05-01 00:00:00

  • Does pericapsular lignocaine reduce pain during transrectal ultrasonography-guided biopsy of the prostate?

    abstract:OBJECTIVE:To evaluate whether injection with pericapsular lignocaine before transrectal ultrasonography (TRUS)-guided biopsy reduces the perceived pain of prostatic biopsy. PATIENTS AND METHODS:The study included 121 patients referred for TRUS-guided biopsy of the prostate; 27 underwent biopsy with no previous injecti...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.2002.03025.x

    authors: Walker AE,Schelvan C,Rockall AG,Rickards D,Kellett MJ

    更新日期:2002-12-01 00:00:00

  • Efficacy of percutaneous vas occlusion compared with conventional vasectomy.

    abstract:OBJECTIVES:To determine the efficacy, evaluate the safety and assess side-effects (swelling, haematoma and pain) of percutaneous vas occlusion compared with vasectomy in Dutch men. PATIENTS AND METHODS:Vas occlusion and vasectomy procedures (attempted in 58 and 50 men, respectively) were conducted at the University Ho...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2000.00875.x

    authors: Zambon JV,Barone MA,Pollack AE,Mehta M

    更新日期:2000-10-01 00:00:00

  • Staging laparoscopic pelvic lymphadenectomy in prostate cancer.

    abstract:OBJECTIVE:To assess the results of transperitoneal laparoscopic pelvic lymphadenectomy as a separate staging procedure in patients with early prostate cancer. PATIENTS AND METHODS:The results were reviewed from the first 27 patients with prostate cancer admitted for laparoscopic lymphadenectomy between January 1994 an...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00931.x

    authors: Shackley DC,Irving SO,Brough WA,O'Reilly PH

    更新日期:1999-02-01 00:00:00

  • Predictive factors of ultrasonographic involution of prenatally detected multicystic dysplastic kidney.

    abstract:OBJECTIVE:To evaluate possible predictive factors of involution on ultrasonography (US) or disappearance of a prenatally detected multicystic dysplastic kidney (MCDK). PATIENTS AND METHODS:Forty-five children with unilateral MCDK detected by prenatal ultrasonography between 1989 and 2002 were analysed. All patients ex...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05418.x

    authors: Rabelo EA,Oliveira EA,Silva GS,Pezzuti IL,Tatsuo ES

    更新日期:2005-04-01 00:00:00

  • Retrospective cohort study on patterns of care and outcomes of surgical treatment for lower urinary-genital tract fistula among English National Health Service hospitals between 2000 and 2009.

    abstract:OBJECTIVES:To examine patterns of care among women with urogenital fistula treated in the English National Health Service (NHS) between 2000 and 2009. To assess whether failure of repair was associated with hospital or surgeon workload. PATIENTS AND METHODS:We conducted a retrospective cohort study using data from Hos...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2012.11483.x

    authors: Cromwell D,Hilton P

    更新日期:2013-04-01 00:00:00

  • Holmium:YAG laser vaporization of recurrent papillary tumours of the bladder under local anaesthesia.

    abstract:OBJECTIVES:To evaluate holmium:YAG laser vaporization of papillary tumours of the bladder, focusing on surgical technique, patients' satisfaction, complications and cost-effectiveness when using the technique under local anaesthesia as an outpatient procedure. PATIENTS AND METHODS:In all, 52 consecutive patients with ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.04882.x

    authors: Jønler M,Lund L,Bisballe S

    更新日期:2004-08-01 00:00:00

  • Re-auditing a regional lithotripsy service.

    abstract:OBJECTIVE:To assess, in a repeat audit of a regional lithotripsy service, whether changes implemented after a regional audit in 1994 (which showed disappointing results from shock wave lithotripsy, attributable to both poor patient selection and an inadequate fixed-site lithotripter) have had any effect. PATIENTS AND ...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1046/j.1464-410x.2002.02674.x

    authors: Parkin J,Keeley FX Jr,Timoney AG

    更新日期:2002-05-01 00:00:00

  • Native nephrectomy for autosomal dominant polycystic kidney disease: before or after kidney transplantation?

    abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. What's known on the subject? and What does the study add? The indications and timing of native nephrectomy in patients with autosomal dominant polycystic kidney disease (ADPKD) is controversial, especially for those undergoing renal transplantation. P...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.09938.x

    authors: Kirkman MA,van Dellen D,Mehra S,Campbell BA,Tavakoli A,Pararajasingam R,Parrott NR,Riad HN,McWilliam L,Augustine T

    更新日期:2011-08-01 00:00:00

  • Diagnostic accuracy of magnetic resonance imaging for tumour staging of bladder cancer: systematic review and meta-analysis.

    abstract::The purpose of this study is to evaluate accuracy of magnetic resonance imaging (MRI) for local staging of bladder cancer for four clinical scenarios (T-stage thresholds) considered against current standards for clinical staging and secondarily to identify sources for variability in accuracy. Systematic review of pati...

    journal_title:BJU international

    pub_type: 杂志文章,meta分析

    doi:10.1111/bju.14366

    authors: Gandhi N,Krishna S,Booth CM,Breau RH,Flood TA,Morgan SC,Schieda N,Salameh JP,McGrath TA,McInnes MDF

    更新日期:2018-11-01 00:00:00

  • Cost-effectiveness analysis of degarelix for advanced hormone-dependent prostate cancer.

    abstract:OBJECTIVE:To evaluate the cost-effectiveness of degarelix vs luteinizing hormone-releasing hormone analogue (triptorelin) plus short-term antiandrogen treatment for advanced prostate cancer. METHODS:We developed a decision analytic model based on a clinical trial and literature review. The two interventions evaluated ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10434.x

    authors: Lu L,Peters J,Roome C,Stein K

    更新日期:2012-04-01 00:00:00

  • Mucinous tubular and spindle cell carcinoma (MTSCC) of the kidney: a detailed study of radiological, pathological and clinical outcomes.

    abstract:OBJECTIVE:To characterise the clinical, radiological and histological features of mucinous tubular and spindle cell carcinoma (MTSCC), as well as oncological outcomes. PATIENTS AND METHODS:This is a single institution retrospective analysis of all patients with MTSCC from 2002 to 2011. Patients were excluded if MTSCC ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12992

    authors: Kenney PA,Vikram R,Prasad SR,Tamboli P,Matin SF,Wood CG,Karam JA

    更新日期:2015-07-01 00:00:00

  • Comparative analysis of the frequency of lower urinary tract dysfunction among institutionalised and non-institutionalised children.

    abstract:OBJECTIVES:To evaluate the level of symptoms of lower urinary tract dysfunction (LUTD) in orphans in institutions, and compare these data with schoolchildren of the same age group who were not institutionalised, as LUTD in children is related to factors such as social isolation and low self-esteem, with other psycholog...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06034.x

    authors: Barroso U Jr,Dultra A,De Bessa J Jr,Barros DG,Maron F,Barroso DV,Moreira ED Jr

    更新日期:2006-04-01 00:00:00

  • Postoperative radiation therapy for patients at high-risk of recurrence after radical prostatectomy: does timing matter?

    abstract:OBJECTIVE:To evaluate among radical prostatectomy (RP) patients at high-risk of recurrence whether the timing of postoperative radiation therapy (RT) (adjuvant, early salvage with detectable post-RP prostate-specific antigen [PSA], or 'late' salvage with a PSA level of >1.0 ng/mL) is significantly associated with overa...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13043

    authors: Hsu CC,Paciorek AT,Cooperberg MR,Roach M 3rd,Hsu IC,Carroll PR

    更新日期:2015-11-01 00:00:00

  • Totally intracorporeal robot-assisted radical cystectomy: optimizing total outcomes.

    abstract::We performed a systematic literature review to assess the current status of a totally intracorporeal robot-assisted radical cystectomy (RARC) approach. The current 'gold standard' for radical cystectomy remains open radical cystectomy. RARC has lagged behind robot-assisted prostatectomy in terms of adoption and percei...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.12558

    authors: Collins JW,Wiklund NP

    更新日期:2014-09-01 00:00:00

  • The optimal form of urinary drainage after acute retention of urine.

    abstract:OBJECTIVE:To assess the outcome of different forms of urinary drainage, particularly for urinary tract infection (UTI), operative findings and patient preference, in patients treated for acute urinary retention (AUR). PATIENTS AND METHODS:A feasibility trial was conducted of men presenting with AUR; after a short peri...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2001.02253.x

    authors: Patel MI,Watts W,Grant A

    更新日期:2001-07-01 00:00:00

  • Positive surgical margins in radical prostatectomy patients do not predict long-term oncological outcomes: results from the Shared Equal Access Regional Cancer Hospital (SEARCH) cohort.

    abstract:OBJECTIVE:To assess the impact of positive surgical margins (PSMs) on long-term outcomes after radical prostatectomy (RP), including metastasis, castrate-resistant prostate cancer (CRPC), and prostate cancer-specific mortality (PCSM). PATIENTS AND METHODS:Retrospective study of 4,051 men in the Shared Equal Access Reg...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.13181

    authors: Mithal P,Howard LE,Aronson WJ,Terris MK,Cooperberg MR,Kane CJ,Amling C,Freedland SJ

    更新日期:2016-02-01 00:00:00

  • Post-stroke urinary incontinence with impaired awareness of the need to void: clinical and urodynamic features.

    abstract:OBJECTIVE:To describe a clinical subtype of urinary incontinence (UI) after a stroke, i.e. with impaired awareness of the need to void (IA-UI), and to compare it to urge UI after a stroke for the risk factors and medium-term outcome. PATIENTS AND METHODS:In a consecutive sample of 315 hospitalized stroke patients who ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2007.06754.x

    authors: Pettersen R,Stien R,Wyller TB

    更新日期:2007-05-01 00:00:00

  • Cross-cultural validation of a prognostic tool: example of the Kattan preoperative nomogram as a predictor of prostate cancer recurrence after radical prostatectomy.

    abstract:OBJECTIVE:To establish the predictive accuracy of the Kattan preoperative nomogram by comparing predictions at 5 years with actual progression in patients who had a radical prostatectomy (RP). MATERIALS AND METHODS:We reviewed the data for 928 patients treated by RP as a first-line treatment for localized prostate can...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2009.08473.x

    authors: Rouprêt M,Hupertan V,Comperat E,Drouin SJ,Phé V,Xylinas E,Demanse D,Sibony M,Richard F,Cussenot O

    更新日期:2009-09-01 00:00:00

  • Buccal mucosal grafts in the treatment of ureteric lesions.

    abstract:OBJECTIVE:To devise a procedure capable of curing complicated ureteric strictures and replacing segments of lost ureter, without the long-term infective complications of bowel interposition or the surgical magnitude of autotransplantation. PATIENTS AND METHODS:Four patients with complicated strictures and one with seg...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00019.x

    authors: Naude JH

    更新日期:1999-05-01 00:00:00

  • Evaluation of nuclear matrix protein 22 as a tumour marker in the detection of transitional cell carcinoma of the bladder.

    abstract:OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00254.x

    authors: Sánchez-Carbayo M,Herrero E,Megías J,Mira A,Soria F

    更新日期:1999-10-01 00:00:00

  • Outcomes for patients with high-grade prostate cancer treated with a combination of brachytherapy, external beam radiotherapy and hormonal therapy.

    abstract:OBJECTIVE:To assess the outcomes for patients with Gleason score 8-10 prostate cancer treated with brachytherapy, external beam radiotherapy (EBRT) and hormonal therapy (HT). PATIENTS AND METHODS:In all, 181 patients with Gleason scores 8-10 prostate cancer were treated from 1994 to 2006 with a (103)Pd implant (prescr...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2009.08661.x

    authors: Stock RG,Cesaretti JA,Hall SJ,Stone NN

    更新日期:2009-12-01 00:00:00