Abstract:
OBJECTIVE:To assess the results of transperitoneal laparoscopic pelvic lymphadenectomy as a separate staging procedure in patients with early prostate cancer. PATIENTS AND METHODS:The results were reviewed from the first 27 patients with prostate cancer admitted for laparoscopic lymphadenectomy between January 1994 and March 1998. Initially, all patients with a negative bone scan and either a negative computed tomography or negative magnetic resonance scan were admitted for laparoscopic staging. After several reports detailing ways of reducing the number of negative lymphadenectomy operations, from July 1996 only those patients with a preoperative prostate specific antigen (PSA) serum level of >10 ng/mL were admitted to the study. All procedures were performed by one experienced laparoscopic surgeon. A radical retropubic prostatectomy was performed as a separate procedure by a consultant urologist within 2 weeks. The effectiveness of the staging operation was analysed by assessing the nodal yield, and the results, including operative duration, complications and length of stay, were compared with other published series. Further analysis was provided by reviewing the PSA levels, Gleason grade sum and clinical digital staging. RESULTS:The nodal yield was similar to that published in series from other institutions, with a median (range) of 6.5 (0-12). However, the operation was significantly quicker, at a median (range) of 55 (40-110) min for a bilateral dissection. There were only minor complications, with no detectable reduction in complications with experience; the median (range) postoperative stay was 1 (1-4) days. Two of the 27 patients had metastatic disease within the lymph nodes. If a PSA level of >10 ng/mL had been instituted as an entry criteria at the start of the study, six patients would have been excluded and thus the positive lymphadenectomy rate would have been two of 21 patients (10%). Of 54 patients eligible to enter the study, half did not require a lymphadenectomy. CONCLUSIONS:Laparoscopic transperitoneal lymphadenectomy can be performed expeditiously and safely. A two-stage procedure in some patients with prostate cancer is the management of choice. Attention to carefully closing the peritoneum with sutures minimizes any retropubic adhesions and no problems associated with the staging procedure were encountered during subsequent radical retropubic prostatectomy. In efforts to reduce negative staging lymphadenectomies, the exclusion values for staging should not be set too high (PSA and Gleason grading sum). Such practice, despite a relatively safe staging procedure, would lead to unnecessary radical prostatectomy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Shackley DC,Irving SO,Brough WA,O'Reilly PHdoi
10.1046/j.1464-410x.1999.00931.xkeywords:
subject
Has Abstractpub_date
1999-02-01 00:00:00pages
260-4issue
3eissn
1464-4096issn
1464-410Xjournal_volume
83pub_type
杂志文章abstract:OBJECTIVE:To investigate the immunology of host-tumour interaction, critical for the development of immunotherapy against cancers, by assessing the major histocompatibility complex (MHC) class I expression in both benign and malignant prostate disease, and the relationship between their expression and degree of tumour-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02993.x
更新日期:2002-11-01 00:00:00
abstract::Patients with metastatic bone disease often have severe bone pain and debilitating skeletal complications. Zoledronic acid is the only bisphosphonate shown to be safe and effective in reducing skeletal-related events (SREs), including pathological fractures, spinal cord compression, and radiation or surgery to bone in...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2005.05740.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVES:• To compare the influence of a 4-week course of empirical antimicrobial therapy or observation on the prostate-specific antigen (PSA) levels of asymptomatic patients with a raised baseline PSA. • To identify whether a decrease in PSA can predict the risk of prostate cancer (PCa) detection on prostate biopsy...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09948.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:To study the effect of smoking on bladder cancer presentation and outcome in a large cystectomy population. PATIENTS AND METHODS:A database including 546 patients from the University Health Network (Toronto, Canada) and Turku University Hospital (Turku, Finland) was studied. In addition to the association of...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2011.10371.x
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:• To study the association between specific clinical symptoms (e.g. low libido and erectile dysfunction) and testosterone levels and age in order to define symptom-specific testosterone thresholds. MATERIALS AND METHODS:• Serum samples for testosterone determination were obtained from 675 healthy men. • Part...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09986.x
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:• To investigate the influence of baseline variables on the 4-year incidence of acute urinary retention (AUR), benign prostatic hyperplasia (BPH)-related surgery and overall clinical progression in men treated with tamsulosin, dutasteride, or a combination of both. PATIENTS AND METHODS:• The 4-year Combinati...
journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1464-410X.2011.10124.x
更新日期:2011-03-01 00:00:00
abstract:OBJECTIVE:To investigate the clinical utility of frozen section (FS) analysis performed during partial nephrectomy (PN) and its influence on intra-operative management. PATIENTS AND METHODS:We performed a retrospective analysis of consecutive PN cases from 2010 to 2013. We evaluated the concordance between the intra-o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13011
更新日期:2015-12-01 00:00:00
abstract:OBJECTIVE:To review the incidence of venous thromboembolism (VTE) after radical retropubic prostatectomy (RRP) and evaluate the need for heparinoid prophylaxis as opposed to mechanical compression devices after RRP. PATIENTS AND METHODS:RRP is classified as a category 1 (high risk) procedure for VTE by the American Co...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05783.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:• To present a novel method of renal ablation using direct current electrolysis, using a porcine model to assess the safety and efficacy of the technique. MATERIALS AND METHODS:• In all, 20 anaesthetised pigs were used, after receiving ethical approval. The pigs were housed and managed in accordance with Ins...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11478.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To review our experience of percutaneous nephrolithotomy (PCNL) in children before school age, and determine its efficacy and safety in this age group. PATIENTS AND METHODS:The records of children aged < or = 5 years undergoing PCNL were reviewed. Variables assessed included stone number, size, location and ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05173.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVE:• To assess and compare the economic burden of open radical cystectomy (OC) vs robotic-assisted laparoscopic radical cystectomy (RC) with pelvic lymph node dissection and urinary diversion. PATIENTS AND METHODS:• A series of 103 and 83 consecutive patients undergoing OC and RC, respectively, were prospective...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10114.x
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of alterations in 'patient' position on laser-induced ureteric stone retropulsion in an in vitro model. MATERIALS AND METHODS:A ceramic (phantom) stone was placed in a water-filled clear polymer tube and subjected to continuous laser energy until the stone had retropulsed a d...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14510
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To examine the outcome of 23 consecutive patients with Fournier's gangrene. PATIENTS AND METHODS:Patients' charts were reviewed retrospectively from all those treated for Fournier's gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. RESULTS:Twenty-three patients were identified (mean...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00140.x
更新日期:1999-07-01 00:00:00
abstract::Interactive case studies formed a key feature of the third annual Interactive Genitourinary Cancer Conference held in April/May 2011 in Budapest, Hungary. These cases were used to discuss the practical aspects of the management of metastatic castration-resistant prostate cancer (mCRPC). Particular emphasis was placed ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10872.x
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To evaluate the relative merits of robotically assisted partial nephrectomy (RPN), using a matched-pair analysis, with laparoscopic PN (LPN). PATIENTS AND METHODS:Between July 2006 and August 2007, 12 patients had RPN for tumour; the outcomes were compared retrospectively with 12 matched patients who had LP...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07580.x
更新日期:2008-07-01 00:00:00
abstract:OBJECTIVE:To review our experience with orthotopic neobladder reconstruction (ONR) in women, highlighting functional and oncological outcomes, as ONR has been used increasingly for urinary diversion in women after radical cystectomy (RC), largely due to a better understanding of the natural history of urothelial cell c...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.07909.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVES:To report a case series of Fournier's gangrene (FG) from our institution, and to investigate its mortality over the past 25 years. PATIENTS AND METHODS:Case notes of men presenting to our institution from 2013 to 2016 with FG were reviewed. As well as age, diabetic history, length of stay, length of stay in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14998
更新日期:2020-04-01 00:00:00
abstract::In the last 3 years there has been a dramatic increase in the treatment options for patients with metastatic renal cancer. In addition to the cytokines interferon and interleukin 2, recently approved agents include sorafenib, sunitinib, temsirolimus and bevacizumab. A plethora of agents that are likely to have clinica...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2008.07670.x
更新日期:2008-07-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Diethylstilbestrol (DES) was the first hormone treatment used for prostate cancer and has also shown effectiveness in castration-resistant disease in small studies; however, concerns over thromboembolic toxicity have restricted its use in the past. Ov...
journal_title:BJU international
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1464-410X.2012.11546.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:• To examine the prevalence and burden of overactive bladder (OAB) with bother in the UK and Sweden compared to OAB without bother and no/minimal OAB/lower urinary tract (LUTS) symptoms, respectively. PATIENTS AND METHODS:• A cross-sectional population-representative survey was conducted via the Internet in ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.10013.x
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine, using magnetic resonance imaging (MRI), the incidence of retropubic haematoma and any associated clinically significant effects after a xenograft (porcine dermis) sling (XS) or the tension-free vaginal tape (TVT) procedure. PATIENTS AND METHODS:Between October 2003 and March 2004, 24 consecutiv...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05779.x
更新日期:2005-11-01 00:00:00
abstract:OBJECTIVE:To assess the possible relationship between treatment with selective serotonin-reuptake inhibitors (SSRIs) and the occurrence of nocturia. SUBJECTS AND METHODS:An unselected group of adult men and women, living in the city of Ostersund, Sweden, were sent a postal questionnaire containing questions on somatic...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05408.x
更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To identify a phenotype that could be informative and prognostic in patients with renal cell carcinoma (RCC) peripheral blood was evaluated for TH1, TH2, regulatory T cells (Tregs), natural killer (NK) and NKT cells and for cytokines/chemokines. PATIENTS AND METHODS:Peripheral blood from 77 patients with RCC...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12068
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To investigate overall survival and prostate cancer-specific mortality in men with prostate cancer presenting with a PSA level <100 ng/mL at the time of diagnosis. PATIENTS:Five-thousand seven hundred and sixteen patients with prostate cancer and a recorded diagnostic PSA level extracted from the South Aust...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13411
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVES:To examine the effect of the dual-action 5alpha-reductase inhibitor dutasteride on benign prostatic hyperplasia (BPH)-specific health status, as measured by the BPH Impact Index (BII), and to identify baseline and treatment risk factors for those most bothered by their BPH symptoms at the end of the protocol...
journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1464-410x.2003.04310.x
更新日期:2003-08-01 00:00:00
abstract:UNLABELLED:Treatment options for testis cancer depend on the histological subtype as well as on the clinical stage. An accurate staging is essential for correct treatment. The 'golden standard' for staging purposes is CT, but occult metastasis cannot be detected with this method. Currently, parameters such as primary t...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10778.x
更新日期:2012-07-01 00:00:00
abstract:OBJECTIVE:To determine the optimal contractile response of isolated ureters to inflammatory mediators and neurotransmitters by evaluating four common methods of ureteric suspension. MATERIALS AND METHODS:Ureters from adult domestic swine were placed immediately in Krebs buffer and cut into 4-5 mm segments. Four method...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00865.x
更新日期:1999-01-01 00:00:00
abstract:OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and sympt...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09321.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00254.x
更新日期:1999-10-01 00:00:00
abstract:OBJECTIVE:To describe the characteristics of patients with and without positive surgical margins (PSMs) and to analyse the impact of PSMs on secondary cancer treatment after radical prostatectomy (RP), with short-term follow-up. PATIENTS AND METHODS:We analysed data from 2385 consecutive patients treated using RP, who...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12509
更新日期:2014-11-01 00:00:00