Abstract:
OBJECTIVES:To evaluate the sensitivity and specificity of urinary nuclear matrix protein-22 (NMP22) in detecting bladder cancer, to compare the diagnostic performance of NMP22 alone and when corrected by urinary creatinine level, and to correlate NMP22 level with the histological and clinical characteristics of bladder cancer. PATIENTS, SUBJECTS AND METHODS:The study included 267 patients classified into five groups: group 1 comprised 111 patients with active transitional cell carcinoma (TCC) of the bladder; group 2 included 76 patients who had had bladder TCC but were being followed and were free of disease, as confirmed by cystoscopy; group 3 comprised 25 patients with benign urological diseases; group 4 included 25 patients with other malignant pathological conditions; group 5 constituted a control group of 30 healthy subjects free of urological diseases. Urinary NMP22 was measured using an enzyme-linked immunosorbent assay. Receiver operating characteristic (ROC) curves were constructed to obtain the thresholds which gave optimal sensitivity and specificity for combinations of NMP22 alone and when corrected by urinary creatinine level. Stage, grade, tumour size, pattern of growth, focality and the presence of recurrence were recorded and their associations with NMP22 evaluated. RESULTS:The mean levels of NMP22 were 122.8, 5.1, 3.7, 2.3 and 0.3 U/mL for groups 1-5, respectively; overall, these values were significantly different (P<0.001). The mean (95% CI) optimal combination of 78.2% (69.3-85.5) sensitivity and 95.5% (87.3-99.0) specificity was obtained from the ROC analysis with a threshold value of 13.7 U/mL NMP22. When values were corrected by urinary creatinine levels, the threshold given by the best combination of sensitivity and specificity, at 73.2% (63.2-81.7) and 97.0% (89.6-99.5), respectively, was 3.0 U/mg creatinine. NMP22 level was statistically associated with stage, grade, tumour size and focality. CONCLUSIONS:Urinary NMP22 appeared to be a potential tumour marker for detecting TCC of the bladder; when corrected by urinary creatinine level, it might provide a better interpretation than when used alone. NMP22 correlated with the most relevant variables in bladder cancer. As a noninvasive adjunct, NMP22 might have a role in guiding urologists about the need for cystoscopy in such patients.
journal_name
BJU Intjournal_title
BJU internationalauthors
Sánchez-Carbayo M,Herrero E,Megías J,Mira A,Soria Fdoi
10.1046/j.1464-410x.1999.00254.xkeywords:
subject
Has Abstractpub_date
1999-10-01 00:00:00pages
706-13issue
6eissn
1464-4096issn
1464-410Xpii
bju254journal_volume
84pub_type
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00558.x
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To determine the incidence and treatment of lymphoceles after retropubic radical prostatectomy (RP). PATIENTS AND METHODS:Up to January 2004, 260 patients who had a retropubic RP in one institution by one surgeon were assessed retrospectively, using the patients' notes or the computerized results system to d...
journal_title:BJU international
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更新日期:2005-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the difference between radiographic size on computed tomography (CT) and the pathological size of renal tumours, in contemporary patients. PATIENTS AND METHODS:We retrospectively reviewed the records of 521 patients undergoing surgical resection of a renal mass between 2000 and 2007, who had tumo...
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doi:10.1111/bju.12309
更新日期:2014-05-01 00:00:00
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journal_title:BJU international
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doi:10.1111/j.1464-410X.2006.06009.x
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abstract:OBJECTIVE:To determine the relationship of age to side-effects leading to discontinuation of treatment in patients with stage Ta-T1 non-muscle-invasive bladder cancer (NMIBC) treated with maintenance bacille Calmette-Guérin (BCG). PATIENTS AND METHODS:We evaluated toxicity for 487 eligible patients with intermediate- ...
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pub_type: 杂志文章,随机对照试验
doi:10.1111/bju.13474
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journal_title:BJU international
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2003-11-01 00:00:00
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更新日期:2003-12-01 00:00:00
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更新日期:2009-12-01 00:00:00
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doi:10.1111/j.1464-410X.2012.11203.x
更新日期:2013-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2005.05488.x
更新日期:2005-06-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1046/j.1464-410x.1999.00252.x
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:To help clarify which small renal cortical neoplasms (RCNs) require surgery by using office-based, ultrasonography-guided percutaneous renal biopsy. PATIENTS AND METHODS:Biopsies were performed using facilitated ultrasound targeting (FUT) technology, which incorporates a needle guide and onscreen beam-steer...
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更新日期:2006-02-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00162.x
更新日期:1999-08-01 00:00:00
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更新日期:2010-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:2009-03-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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更新日期:2018-02-01 00:00:00
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更新日期:2005-07-01 00:00:00
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更新日期:2000-09-01 00:00:00
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更新日期:2008-12-01 00:00:00
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更新日期:2008-08-01 00:00:00
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更新日期:2008-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:2001-11-01 00:00:00