Abstract:
OBJECTIVE:To characterize the effect of preserving the neurovascular bundle (NVB) and of potency on urinary continence after open radical retropubic prostatectomy (ORRP). PATIENTS AND METHODS:Between October 2000 to September 2005, 1110 consecutive continent men had ORRP by one surgeon. The University of California Los Angeles Prostate Cancer Index was self-administered at baseline and 3, 6, 12, and 24 months after ORRP. Men were considered continent if they responded that they had total urinary control or had occasional urinary leakage. Men were considered potent if they engaged in sexual intercourse with or without the use of phosphodiesterase inhibitors at least once in the month before or after ORRP. Of the 1110 men, 728 (66%) were potent and continent at baseline. Men undergoing adjuvant hormonal therapy, radiation therapy or chemotherapy were excluded. The potency status was evaluated in 610 men at 24 months after ORRP, and the number of NVBs preserved was recorded at the time of ORRP. RESULTS:Of men who were potent at baseline and had bilateral vs unilateral nerve sparing, 96% and 99% were continent at 24 months, respectively (P = 0.50). Of the men who were potent and impotent at 24 months, 98% and 96% were continent at 24 months, respectively (P = 0.25). Continence did not depend on whether men regained potency or whether they had a bilateral or a unilateral nerve-sparing procedure. CONCLUSION:Our observation that only 60% of men undergoing bilateral nerve-sparing ORRP regain potency suggests that the NVBs are often inadvertently injured, despite efforts to preserve them. We feel that potency status is the best indicator of the true extent of NVB preservation. That men undergoing bilateral vs unilateral nerve-sparing procedures, and that potent vs impotent men at 24 months have similar continence rates, provides compelling evidence that nerve-sparing is not associated with better continence. Based on these findings, NVBs should not be preserved in men with baseline erectile dysfunction, with the expectation of improving continence.
journal_name
BJU Intjournal_title
BJU internationalauthors
Marien TP,Lepor Hdoi
10.1111/j.1464-410X.2008.07921.xsubject
Has Abstractpub_date
2008-12-01 00:00:00pages
1581-4issue
11eissn
1464-4096issn
1464-410Xpii
BJU7921journal_volume
102pub_type
杂志文章abstract:OBJECTIVE:To systematically review the literature on the prognostic value of lymphovascular invasion (LVI) and embryonal carcinoma (EC) for occult metastatic disease in clinical stage I nonseminomatous germ cell tumour (CS I NSGCT). MATERIALS AND METHODS:The PubMed, Embase (OVID) and SCOPUS databases were searched up ...
journal_title:BJU international
pub_type: 杂志文章,meta分析
doi:10.1111/bju.14967
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVES:To investigate long-term oncological outcomes after laparoscopic radical prostatectomy (LRP). To identify parameters influencing recurrence-free survival in a single-institution series. PATIENTS AND METHODS:All patients underwent LRP using the transperitoneal retrograde Heilbronn technique. High-risk patien...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11317.x
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To study the effect of 3 weeks of partial bladder outlet obstruction (BOO), compared to a sham operation, on the cholinergic and purinergic components of detrusor contractile responses to agonists and to electrical field stimulation (EFS); the expression of P2X receptor subtypes was also examined. MATERIALS ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06010.x
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:To report the events during and after radical cystectomy and urinary diversion for bladder cancer, in terms of major and minor complications, comparing a minimal with an extended lymphadenectomy, as more lymph nodes obtained during radical cystectomy may improve staging and thus the outcome. PATIENTS AND MET...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410x.2004.04557.x
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVE:To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). PATIENTS AND METHODS:We identified 131...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12769
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:To examine the effects of castration and continuous gonadotrophin releasing-hormone (GnRH) agonist and antagonist therapy on the expression of GnRH-receptors type I (GnRH-RI) in rat ventral prostate (VP) and pituitary tissue, and to compare the effects on prostate morphology. MATERIAL AND METHODS:Mature Spra...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03054.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:To report a case series of Fournier's gangrene (FG) from our institution, and to investigate its mortality over the past 25 years. PATIENTS AND METHODS:Case notes of men presenting to our institution from 2013 to 2016 with FG were reviewed. As well as age, diabetic history, length of stay, length of stay in...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14998
更新日期:2020-04-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? Positive surgical margins (PSMs) after radical prostatectomy are common, although their impact on the risk of disease recurrence is unknown. We examined the impact of PSMs on the risk of 'significant' biochemical recurrence stratified by their risk of...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10868.x
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVES:To identify the rate of postoperative complications in patients who require surgical reconstruction for ketamine-induced urinary tract dysfunction and to identify any predictors for poor postoperative outcome with subsequent management strategies. PATIENTS AND METHODS:A retrospective review of data collecte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14094
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:• To investigate a new method of vas deferens radiography for ejaculatory duct obstruction (EDO). • To evaluate the effect of a procedure involving dilation of the ejaculatory duct by F9 seminal vesicoscopy. PATIENTS AND METHODS:• Twenty-two patients with EDO were diagnosed using semen analysis, semen fruct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09775.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To investigate the detection rate and extent of high-grade prostatic intraepithelial neoplasia (HGPIN) and atypical glands (AG) suspicious for prostate cancer, and the cancer risk in subsequent biopsies, diagnosed by a first 24-core saturation biopsy, as although the optimum extent of biopsy is controversial ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06728.x
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To demonstrate an ergonomic fourth arm technique to oversew the dorsal vascular complex (DVC) during robot-assisted laparoscopic prostatectomy (RALP). PATIENTS AND METHODS:Balloon of a Foley catheter inflated in the bulbar urethra. Fourth arm cranial traction via suture in the tip of the catheter. DVC overse...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11716.x
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVE:To examine the effects of mirabegron, a selective β3 -adrenoceptor agonist that has recently been approved for the treatment of overactive bladder (OAB), on erectile function. Stimulation of β3 -adrenoceptors localised in cavernosal smooth muscle cells may play a physiological role in mediating penile erectio...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13515
更新日期:2016-09-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of chronic and debilitating symptoms of the overactive bladder, defined here as the presence of chronic frequency, urgency and urge incontinence (either alone or in any combination), and presumed to be caused by involuntary detrusor contractions. Subjects and methods Data were coll...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02228.x
更新日期:2001-06-01 00:00:00
abstract::What's known on the subject? and What does the study add? Angiosarcomas are histological subtype of sarcomas and rarely involve the prostate gland. Only ten cases of prostate angiosarcoma have been reported in the literature to date. Occurrence of post-irradiation prostate angiosarcoma is rare considering the frequenc...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2012.11202.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To investigate the prognostic value of the Gleason score in prostate cancer. PATIENTS AND METHODS:A consecutive series of 305 men with prostate cancer diagnosed at transurethral resection (1975-1990) and with no curative treatment was analysed. There was no assessment of prostate-specific antigen level durin...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02669.x
更新日期:2002-04-01 00:00:00
abstract:OBJECTIVE:To determine the changes in cyclooxygenase-2 (COX-2), E-cadherin and alpha-catenin expression after partial bladder outlet obstruction (PBOO), and whether a selective COX-2 inhibitor (celecoxib) might inhibit COX-2 expression and have beneficial effects on urothelial cell-to-cell interactions in rats subjecte...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05359.x
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:To explore the expression of transforming growth factor-beta(1) (TGF-beta1) in penile tissue from rats after bilateral cavernosal nerve (CN) ablation, mimicking patients who have had no nerve-sparing during prostatectomy. MATERIALS AND METHODS:Ten adult male rats (neurectomy group) had a bilateral CN resecti...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.04969.x
更新日期:2004-08-01 00:00:00
abstract::What is known on the subject? and What does the study add? Substantial experience of the outcomes has been gathered regarding the acute and sub-acute experience with various types of corrective procedures for POP. These include long-term POP correction as well as more recent recognition of improvement in functional di...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10123.x
更新日期:2011-06-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05408.x
更新日期:2005-04-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04103.x
更新日期:2003-03-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06405.x
更新日期:2006-10-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? There appears to be a clear difference in cancer control outcomes for patients with Gleason scores of 3+4 and those with scores of 4+3 after radical prostatectomy. It has been documented that patients with Gleason 4+3 prostate cancer have higher incid...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11057.x
更新日期:2012-11-01 00:00:00
abstract:OBJECTIVE:To compare the outcome of a modified one-layer and two-layer vasovasotomy (VV) in two groups of similar men undergoing vasectomy reversal. PATIENTS AND METHODS:The charts and surgical records of all surgical procedures performed on men undergoing a modified one- or two-layer VV between June 1992 and July 199...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2000.00668.x
更新日期:2000-06-01 00:00:00
abstract:OBJECTIVE:To determine whether the density of CD4(+) and CD8(+) T-lymphocytes in a transrectal ultrasonography (TRUS) biopsy of the prostate can be used to predict the progression of lower urinary tract symptoms (LUTS) in benign prostatic hyperplasia (BPH). PATIENTS AND METHODS:In total, 100 patients were randomly sel...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09787.x
更新日期:2011-07-01 00:00:00
abstract:OBJECTIVE:To determine the relative prevalence of various definitions of microscopic haematuria (MH) in patients with renal neoplasms and controls, and to predict the likely outcome of renal imaging for those definitions. PATIENTS AND METHODS:In a retrospective case-control study 278 adult men and woman seen between 1...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2005.05694.x
更新日期:2005-09-01 00:00:00
abstract:OBJECTIVES:To investigate the matrix metalloproteinases (MMPs) 2 and 9 in bladder cancer cell lines stimulated with epidermal growth factor (EGF), and to investigate the presence of gelatinases in the urine of patients with bladder tumours, in relation to the stage and grade of tumour and the EGF receptor (EGFR) status...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04020.x
更新日期:2003-01-01 00:00:00
abstract:OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and sympt...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2010.09321.x
更新日期:2010-10-01 00:00:00
abstract:OBJECTIVE:To investigate the pharmacological effects of ethanol and its metabolite acetaldehyde on isolated rat bladder muscle, and thus assess the potential influence of ethanol ingestion on the risk of urinary retention in patients with benign prostatic hyperplasia. MATERIALS AND METHODS:Isometric tension changes of...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00968.x
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:To examine the outcome of 23 consecutive patients with Fournier's gangrene. PATIENTS AND METHODS:Patients' charts were reviewed retrospectively from all those treated for Fournier's gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. RESULTS:Twenty-three patients were identified (mean...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00140.x
更新日期:1999-07-01 00:00:00