Menopausal transition and the risk of urinary incontinence: results from a British prospective cohort.

Abstract:

OBJECTIVE:to investigate the effect of menopausal transition and age on symptoms of urinary incontinence in midlife. SUBJECTS AND METHODS:the study included a nationally representative cohort of 1211 women followed up since their birth in 1946 and annually from 48-54 years; their menopausal transition status and symptoms of stress, urge, and severe urinary incontinence (UI) at 7 consecutive years from ages 48-54 were assessed. RESULTS:from Generalized Estimating Equations, women who became perimenopausal ('pre-peri') or those experiencing perimenopause for >1 year ('peri-peri') were more likely to have symptoms of stress UI than were postmenopausal women; the odds ratio (95% confidence interval) was; pre-peri 1.39 (1.11-1.73); and peri-peri 1.39 (1.4-1.71). Menopausal transition status was not associated with urge or severe UI. These relationships were not explained by age, childhood enuresis, reproductive factors, previous health status, body mass index and educational qualifications. CONCLUSION:this study is unique in being able to disentangle the effects of age, menopausal transitions, and other life-long risk factors on UI. Menopausal transition was only related to stress UI, while increasing age was related to both stress and urge UI. This study suggests that there are both shared and distinct aetiological pathways leading to each type of UI.

journal_name

BJU Int

journal_title

BJU international

authors

Mishra GD,Cardozo L,Kuh D

doi

10.1111/j.1464-410X.2010.09321.x

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

1170-5

issue

8

eissn

1464-4096

issn

1464-410X

pii

BJU9321

journal_volume

106

pub_type

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