68 Ga-PSMA-PET/CT helps to select patients for salvage radical prostatectomy with local recurrence after primary radiotherapy for prostate cancer.

Abstract:

OBJECTIVE:To investigate the diagnostic performance of gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA PET/CT) in patients with recurrent prostate cancer with regard to the presence of lymph node metastases (LNM) and local recurrences after primary radiotherapy. PATIENTS AND METHODS:We retrospectively reviewed 142 patients following salvage radical prostatectomy (sRP), 50 of which had a 68 Ga-PSMA PET/CT performed as a preoperative staging module. Predictive clinical parameters were analysed in a multivariate Cox regression analysis. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) and the accuracy of 68 Ga-PSMA PET/CT were analysed with regard to LNM and local recurrence. RESULTS:In all, 613 lymph nodes were resected in 40 patients and 23 lymph nodes had metastatic deposits in 14 patients. In all patients local recurrence could have been found with 68 Ga-PSMA PET/CT. Sensitivity, specificity, PPV and NPV and accuracy on a per lymph node basis were 34.78% (16.38-57.2%), 100% (99.38-100%), 100%, 97.52% (96.69-98.15%) and 97.55% (96.00-98.62%). For detecting local recurrence, the sensitivity and PPV were both 100% with an accuracy of 100% (92.89-100%). CONCLUSION:68 Ga-PSMA PET/CT should be the standard imaging in biochemical recurrent prostate cancer. With this imaging module one detects first local recurrence and can detect locoregional and distant metastases more precisely than standard CT and bone scan.

journal_name

BJU Int

journal_title

BJU international

authors

Pfister D,Haidl F,Nestler T,Verburg F,Schmidt M,Wittersheim M,Steib F,Heidenreich A

doi

10.1111/bju.15135

subject

Has Abstract

pub_date

2020-12-01 00:00:00

pages

679-683

issue

6

eissn

1464-4096

issn

1464-410X

journal_volume

126

pub_type

杂志文章
  • The Z-shaped ileal neobladder after radical cystectomy: an 18 years experience with 329 patients.

    abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To evaluate the results in terms of functional results and morbidity of Z-shaped ileal neobladder performed in a single center. PATIENTS AND METHODS:329 consecutive male patients who had an orthotopic bladder replacement using the Z-shaped...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2010.10000.x

    authors: Neuzillet Y,Yonneau L,Lebret T,Herve JM,Butreau M,Botto H

    更新日期:2011-08-01 00:00:00

  • Hand-assisted laparoscopic nephrectomy: complications related to the hand-port site.

    abstract:OBJECTIVE:To evaluate the early results of hand-assisted radical nephrectomy and nephroureterectomy in our institution. PATIENTS AND METHODS:The records of 13 patients with malignant disease of the kidney who underwent hand-assisted laparoscopic radical nephrectomy and nephroureterectomy were reviewed retrospectively....

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.2002.02955.x

    authors: Okeke AA,Timoney AG,Keeley FX

    更新日期:2002-09-01 00:00:00

  • Fluid shear stress-induced nitric oxide production in human cavernosal endothelial cells: inhibition by hyperglycaemia.

    abstract:OBJECTIVE:To investigate whether fluid shear stress (FSS) induces endothelial nitric oxide synthase (eNOS) activity and NO production in isolated human corpus cavernosal endothelial cells (HCCECs), and whether this response is altered during hyperglycaemia in vitro, as haemodynamic signalling during penile erection ind...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06059.x

    authors: Wessells H,Teal TH,Engel K,Sullivan CJ,Gallis B,Tran KB,Chitaley K

    更新日期:2006-05-01 00:00:00

  • Elective segmental ureterectomy for transitional cell carcinoma of the ureter: long-term follow-up in a series of 73 patients.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Upper Urinary Tract (UUT) Transitional Cell Carcinoma (TCC) is an uncommon disease and represents approximately 5% of all urothelial carcinomas. We report our series on 73 patients treated with Kidney Sparing Surgery for UUT TCC. Good results have bee...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2012.11554.x

    authors: Simonato A,Varca V,Gregori A,Benelli A,Ennas M,Lissiani A,Gacci M,De Stefani S,Rosso M,Benvenuto S,Siena G,Belgrano E,Gaboardi F,Carini M,Bianchi G,Carmignani G

    更新日期:2012-12-01 00:00:00

  • Suppression of detrusor overactivity in rats with bladder outlet obstruction by a type 4 phosphodiesterase inhibitor.

    abstract:OBJECTIVE:To investigate the effects of a selective type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, IC486051, on bladder activity in normal rats and those with and bladder outlet obstruction (BOO), as inhibition of PDE4 leads to elevation of intracellular cAMP levels and relaxation of smooth muscle. MATER...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06643.x

    authors: Nishiguchi J,Kwon DD,Kaiho Y,Chancellor MB,Kumon H,Snyder PB,Yoshimura N

    更新日期:2007-03-01 00:00:00

  • Conservative treatment for leg oedema and the effect on nocturnal polyuria in patients with spinal cord injury.

    abstract:OBJECTIVES:To evaluate the possible influence of non-pharmacological interventions, such as compressive bandages and intermittent pneumatic compression (IPC), on leg oedema and nocturnal polyuria (NP), and the possible interrelation between both pathologies in patients with spinal cord injury (SCI), as patients with SC...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14672

    authors: Viaene A,Roggeman S,Goessaert AS,Kessler TM,Mehnert U,Besien VV,De Muynck M,Everaert K

    更新日期:2019-05-01 00:00:00

  • Percutaneous cryoablation of solitary sporadic renal cell carcinomas.

    abstract:UNLABELLED:What's known on the subject? and What does the study add? Percutaneous renal cryoablation is a safe and effective treatment for patients with small renal masses, who are poor surgical candidates. Oncological outcomes from previous percutaneous ablation studies are difficult to interpret because of the large ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11230.x

    authors: Schmit GD,Thompson RH,Kurup AN,Weisbrod AJ,Carter RE,Callstrom MR,Atwell TD

    更新日期:2012-12-01 00:00:00

  • Comparison of laparoscopic and open donor nephrectomy: UK experience.

    abstract:UNLABELLED:A comparison of laparoscopic and open donor nephrectomy is presented by authors from the UK. They found that the laparoscopic approach could safely be offered to patients treated in experienced units and after adequate training fo the surgeon, with no increase in complications or decrease in efficacy. OBJEC...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2004.05264.x

    authors: Wilson CH,Bhatti AA,Rix DA,Soomro NA

    更新日期:2005-01-01 00:00:00

  • Outcomes of transperineal template-guided prostate biopsy in 409 patients.

    abstract:OBJECTIVE:To present the template-guided transperineal prostate biopsy (TPB) outcomes for patients of two urologists from a single institution. PATIENTS AND METHODS:We conducted a prospective study of 409 consecutive men who underwent TPB between December 2006 and June 2008 in a tertiary referral centre using a standa...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2012.11657.x

    authors: Symons JL,Huo A,Yuen CL,Haynes AM,Matthews J,Sutherland RL,Brenner P,Stricker PD

    更新日期:2013-09-01 00:00:00

  • TVT-Secur mini-sling for stress urinary incontinence: a review of outcomes at 12 months.

    abstract::• Synthetic mid-urethral slings (MUSs) are considered the first choice surgical procedure for stress urinary incontinence. Recent publications have raised concerns about the efficacy of third generation single-incision mini-slings. The present paper is a systematic review of studies reporting 12-month outcomes after t...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2011.10333.x

    authors: Walsh CA

    更新日期:2011-09-01 00:00:00

  • Biopsy-confirmed de novo renal cell carcinoma (RCC) in renal grafts: a single-centre management experience in a 2396 recipient cohort.

    abstract:OBJECTIVE:To study the natural history of renal cell carcinoma (RCC) development in renal grafts and their management. PATIENTS AND METHODS:We report a single-centre series of de novo RCC in allografts from a cohort of 2396 consecutive renal transplant recipients. RESULTS:In all, 17 RCCs were detected in 12 patients,...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2011.10315.x

    authors: Ploussard G,Chambade D,Meria P,Gaudez F,Tariel E,Verine J,De Bazelaire C,Peraldi MN,Glotz D,Desgrandchamps F,Mongiat-Artus P

    更新日期:2012-01-01 00:00:00

  • Diagnostic utility of a p63/alpha-methyl coenzyme A racemase (p504s) cocktail in ambiguous lesions of the prostate upon needle biopsy.

    abstract:OBJECTIVE:To investigate the potential utility of a new combined immunostaining technique for diagnosing prostate cancer from histological analysis of needle biopsy specimens. MATERIALS AND METHODS:Tissue was immunostained with a combination of antibodies against a basal cell marker (p63), and an enzyme commonly overe...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2006.06069.x

    authors: Molinié V,Hervé JM,Lugagne PM,Lebret T,Botto H

    更新日期:2006-05-01 00:00:00

  • Lymphatic drainage in renal cell carcinoma: back to the basics.

    abstract::Lymphatic drainage in renal cell carcinoma (RCC) is unpredictable, however, basic patterns can be observed in cadaveric and sentinel lymph node mapping studies in patients with RCC. The existence of peripheral lymphovenous communications at the level of the renal vein has been shown in mammals but remains unknown in h...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.12814

    authors: Karmali RJ,Suami H,Wood CG,Karam JA

    更新日期:2014-12-01 00:00:00

  • Autonomic nerve involvement and venous leakage in diabetic men with impotence.

    abstract:OBJECTIVE:To determine the neurophysiological and vascular factors in diabetic impotence, particularly the role of autonomic neuropathy on venous leakage and erectile impotence. PATIENTS AND METHODS:Thirty-four diabetic men with impotence were investigated using various neurophysiological and radiological methods. The...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1046/j.1464-410x.1999.00916.x

    authors: Colakoglu Z,Kutluay E,Ertekin C,Altay B,Killi R,Alkis A

    更新日期:1999-03-01 00:00:00

  • Effect of tadalafil 5 mg on post-micturition dribble in men with lower urinary tract symptoms: a multicentre, double-blind, randomized, placebo-controlled trial.

    abstract:OBJECTIVES:To compare the effects of taking tadalafil 5 mg and placebo once daily on post-micturition dribble (PMD) in men with lower urinary tract symptoms (LUTS). PATIENTS AND METHODS:Our prospective, randomized, double-blind, placebo-controlled, multicentre trial enrolled 102 men with PMD and other LUTS. PMD was as...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/bju.14849

    authors: Yang DY,Jeong HC,Ko K,Lee SH,Lee SK,Shin TY,Cho JS,Lee WK

    更新日期:2019-11-01 00:00:00

  • Female sexual dysfunction: a new urogynaecological research field.

    abstract:OBJECTIVE:To critically review published data on the urogynaecological aspects of female sexual dysfunction (FSD), as FSD is a developing multidisciplinary issue associated with several biological, medical and psychological factors. METHODS:The reported prevalence of FSD is 19-50% and women with lower urinary tract sy...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/j.1464-410X.2007.07442.x

    authors: Dalpiaz O,Kerschbaumer A,Mitterberger M,Pinggera GM,Colleselli D,Bartsch G,Strasser H

    更新日期:2008-03-01 00:00:00

  • Exploring pathways towards improving patient experience of robot-assisted radical prostatectomy (RARP): assessing patient satisfaction and attitudes.

    abstract:OBJECTIVE:To determine patient satisfaction and experience after robot-assisted radical prostatectomy (RARP) for prostate cancer, using a convergent mixed-method qualitative analysis approach. PATIENTS AND METHODS:412 patients who underwent RARP between January 2014 and June 2016 were mailed questionnaires and invited...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14226

    authors: Reynolds BR,Bulsara C,Zeps N,Codde J,Lawrentschuk N,Bolton D,Vivian J

    更新日期:2018-05-01 00:00:00

  • Prostate cancer detection in men with a 'normal' total prostate-specific antigen (PSA) level using percentage free PSA: a prospective screening study.

    abstract:OBJECTIVE:To assess the utility of percentage free/total prostate-specific antigen (f/tPSA) levels for detecting prostate cancer in a prospectively screened population of men with a 'normal' total PSA level. PATIENTS AND METHODS:Men aged 50-65 years were contacted via their general practitioner and invited for prostat...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2005.05514.x

    authors: Rowe EW,Laniado ME,Walker MM,Patel A

    更新日期:2005-06-01 00:00:00

  • Should the upper tracts be imaged for microscopic haematuria?

    abstract:OBJECTIVE:To determine the relative prevalence of various definitions of microscopic haematuria (MH) in patients with renal neoplasms and controls, and to predict the likely outcome of renal imaging for those definitions. PATIENTS AND METHODS:In a retrospective case-control study 278 adult men and woman seen between 1...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2005.05694.x

    authors: Feldstein MS,Hentz JG,Gillett MD,Novicki DE

    更新日期:2005-09-01 00:00:00

  • The prognostic significance of advanced age in patients with bladder cancer treated with radical cystectomy.

    abstract:OBJECTIVE:To evaluate the association of patient age with pathological and long-term oncological outcomes after radical cystectomy (RC) for bladder carcinoma, as this disease, like many others, increases in incidence with age. PATIENTS AND METHODS:We retrospectively reviewed 241 consecutive patients with invasive blad...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.08033.x

    authors: Resorlu B,Beduk Y,Baltaci S,Ergun G,Talas H

    更新日期:2009-02-01 00:00:00

  • Systematic review and network meta-analysis on the relative efficacy of osteoporotic medications: men with prostate cancer on continuous androgen-deprivation therapy to reduce risk of fragility fractures.

    abstract::Androgen-deprivation therapy (ADT) is an effective treatment for men with advanced prostate cancer, but loss of bone mineral density (BMD) is a major risk factor for fractures. This review compared the efficacy of available treatments to provide prescribing guidance to healthcare professionals. This is the first revie...

    journal_title:BJU international

    pub_type: 杂志文章,评审

    doi:10.1111/bju.14015

    authors: Poon Y,Pechlivanoglou P,Alibhai SMH,Naimark D,Hoch JS,Papadimitropoulos E,Hogan ME,Krahn M

    更新日期:2018-01-01 00:00:00

  • Human immunodeficiency virus-associated prostate cancer: clinicopathological findings and outcome in a multi-institutional study.

    abstract:OBJECTIVE:To characterize the clinicopathological findings and the outcome of human immunodeficiency virus (HIV)-infected patients diagnosed and treated for prostate carcinoma, as HIV-positive men being treated with highly active antiretroviral therapy (HAART) are living longer and thus are more likely to develop cance...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1464-410X.2008.07474.x

    authors: Pantanowitz L,Bohac G,Cooley TP,Aboulafia D,Dezube BJ

    更新日期:2008-06-01 00:00:00

  • Sunitinib-induced hypertension, neutropaenia and thrombocytopaenia as predictors of good prognosis in patients with metastatic renal cell carcinoma.

    abstract:OBJECTIVES:To evaluate the clinical significance of hypertension (HTN), neutropaenia and thrombocytopaenia as possible new biomarkers of sunitinib efficacy in non-trial patients with metastatic renal cell carcinoma (mRCC). PATIENTS AND METHODS:In all, 181 consecutive patients with mRCC were treated with sunitinib; 39 ...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12940

    authors: Rautiola J,Donskov F,Peltola K,Joensuu H,Bono P

    更新日期:2016-01-01 00:00:00

  • Novel method of full-thickness bladder closure with an endoscopic suturing machine: a survival study in a porcine model.

    abstract:OBJECTIVE:To assess the feasibility of a pure endoscopic closure method for vesical perforations using fully absorbable material. MATERIALS AND METHODS:A pilot experimental study was performed in eight anaesthetized female pigs. Four 10-mm and four 20-mm endoscopic full thickness cystotomies were created. An endoscopi...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.12688

    authors: Oliveira C,Autorino R,Ferreira C,Cicione A,Damiano R,De Sio M,Correia-Pinto J,Lima E

    更新日期:2015-02-01 00:00:00

  • Satisfaction rate at 1-year follow-up in patients treated with penile implants: data from the multicentre prospective registry INSIST-ED.

    abstract:OBJECTIVES:To investigate scores and predictors of patient satisfaction at 1 year after penile prosthesis implantation (PPI) using the validated Quality of Life and Sexuality with Penile Prosthesis (QoLSPP) questionnaire. PATIENTS AND METHODS:Analyses were performed for 142 patients prospectively included in the natio...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究

    doi:10.1111/bju.14462

    authors: Capogrosso P,Pescatori E,Caraceni E,Mondaini N,Utizi L,Cai T,Salonia A,Palmieri A,Deho' F

    更新日期:2019-02-01 00:00:00

  • Peroperative transrectal ultrasonography-guided bladder neck dissection eases the learning of robot-assisted laparoscopic prostatectomy.

    abstract:OBJECTIVE:To study the role of peroperative transrectal ultrasonography (peTRUS) for the dissection of the bladder neck during robot-assisted laparoscopic prostatectomy (RALP). PATIENTS AND METHODS:Integrated peTRUS in the da Vinci S system (Intuitive Surgical, Sunnyvale, CA, USA) was used for bladder neck identificat...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/j.1464-410X.2008.07830.x

    authors: van der Poel HG,de Blok W,Bex A,Meinhardt W,Horenblas S

    更新日期:2008-09-01 00:00:00

  • To determine whether the temperature of 2% lignocaine gel affects the initial discomfort which may be associated with its instillation into the male urethra.

    abstract:OBJECTIVE:To determine whether the temperature of 2% lignocaine hydrochloride gel affects the initial discomfort during instillation into the male urethra. PATIENTS AND METHODS:Sixty consenting men were randomized to receive 11 mL of 2% lignocaine hydrochloride gel (Instillagel, Farco-Pharma GmbH, Cologne, Germany) at...

    journal_title:BJU international

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1464-410x.1999.00346.x

    authors: Thompson TJ,Thompson N,O'Brien A,Young MR,McCleane G

    更新日期:1999-12-01 00:00:00

  • First experience in the UK of treating women with recurrent urinary tract infections with the bacterial vaccine Uromune®.

    abstract:OBJECTIVES:To determine the effectiveness of Uromune® in preventing recurrent urinary tract infections (UTIs) in women. PATIENTS AND METHODS:A total of 77 women with microbiology-proven recurrent UTIs were given Uromune sublingual vaccine for a period of 3 months. Time to first UTI recurrence since treatment and adver...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.14067

    authors: Yang B,Foley S

    更新日期:2018-02-01 00:00:00

  • A multicentre, prospective, randomized trial: comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy for distal ureteric stones with renal colic.

    abstract:OBJECTIVE:• To determine the comparative efficacy of tamsulosin and nifedipine in medical expulsive therapy (MET) for distal ureteric stones with renal colic. PATIENTS AND METHODS:• We evaluated the comparative efficacy of tamsulosin and nifedipine in MET in a prospective randomized trial of 3189 outpatients from 10 c...

    journal_title:BJU international

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1111/j.1464-410X.2010.09801.x

    authors: Ye Z,Yang H,Li H,Zhang X,Deng Y,Zeng G,Chen L,Cheng Y,Yang J,Mi Q,Zhang Y,Chen Z,Guo H,He W,Chen Z

    更新日期:2011-07-01 00:00:00

  • Solitary rib lesions showing prostate-specific membrane antigen (PSMA) uptake in pre-treatment staging 68 Ga-PSMA-11 positron emission tomography scans for men with prostate cancer: benign or malignant?

    abstract:OBJECTIVES:To determine the proportion of solitary rib lesions on pre-treatment 68 Gallium-labelled prostate-specific membrane antigen (PSMA)/computed tomography (CT) scans in men with prostate cancer that are malignant and examine any predictive factors. PATIENTS AND METHODS:This retrospective single tertiary referra...

    journal_title:BJU international

    pub_type: 杂志文章

    doi:10.1111/bju.15152

    authors: Chen MY,Franklin A,Yaxley J,Gianduzzo T,McBean R,Wong D,Tatkovic A,McEwan L,Walters J,Kua B

    更新日期:2020-09-01 00:00:00