Abstract:
OBJECTIVE:To investigate the diagnostic performance of gallium-68 prostate-specific membrane antigen positron emission tomography/computed tomography (68 Ga-PSMA PET/CT) in patients with recurrent prostate cancer with regard to the presence of lymph node metastases (LNM) and local recurrences after primary radiotherapy. PATIENTS AND METHODS:We retrospectively reviewed 142 patients following salvage radical prostatectomy (sRP), 50 of which had a 68 Ga-PSMA PET/CT performed as a preoperative staging module. Predictive clinical parameters were analysed in a multivariate Cox regression analysis. Sensitivity, specificity, positive (PPV) and negative predictive values (NPV) and the accuracy of 68 Ga-PSMA PET/CT were analysed with regard to LNM and local recurrence. RESULTS:In all, 613 lymph nodes were resected in 40 patients and 23 lymph nodes had metastatic deposits in 14 patients. In all patients local recurrence could have been found with 68 Ga-PSMA PET/CT. Sensitivity, specificity, PPV and NPV and accuracy on a per lymph node basis were 34.78% (16.38-57.2%), 100% (99.38-100%), 100%, 97.52% (96.69-98.15%) and 97.55% (96.00-98.62%). For detecting local recurrence, the sensitivity and PPV were both 100% with an accuracy of 100% (92.89-100%). CONCLUSION:68 Ga-PSMA PET/CT should be the standard imaging in biochemical recurrent prostate cancer. With this imaging module one detects first local recurrence and can detect locoregional and distant metastases more precisely than standard CT and bone scan.
journal_name
BJU Intjournal_title
BJU internationalauthors
Pfister D,Haidl F,Nestler T,Verburg F,Schmidt M,Wittersheim M,Steib F,Heidenreich Adoi
10.1111/bju.15135subject
Has Abstractpub_date
2020-12-01 00:00:00pages
679-683issue
6eissn
1464-4096issn
1464-410Xjournal_volume
126pub_type
杂志文章abstract:UNLABELLED:Study Type - Therapy (case series). LEVEL OF EVIDENCE:4. OBJECTIVE:To evaluate the results in terms of functional results and morbidity of Z-shaped ileal neobladder performed in a single center. PATIENTS AND METHODS:329 consecutive male patients who had an orthotopic bladder replacement using the Z-shaped...
journal_title:BJU international
pub_type: 杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2012-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2004.05264.x
更新日期:2005-01-01 00:00:00
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pub_type: 杂志文章
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2011-09-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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更新日期:2012-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06069.x
更新日期:2006-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
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pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14849
更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2007.07442.x
更新日期:2008-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/bju.14226
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08033.x
更新日期:2009-02-01 00:00:00
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更新日期:2008-06-01 00:00:00
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更新日期:2015-02-01 00:00:00
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更新日期:2008-09-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2011-07-01 00:00:00
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更新日期:2020-09-01 00:00:00