Abstract:
OBJECTIVE:To report on the failure of thalidomide to inhibit tumour growth in an animal model of human renal cell carcinoma (RCC). MATERIALS AND METHODS:An orthotopic xenograft model of human RCC was used in which tumour cells were implanted in the left kidney of male 'severe combined immunodeficient' mice. Thalidomide was administered by intraperitoneal injection and after 34 days the mice were killed. The extent of tumour growth was compared in treated and untreated mice. Total RNA was extracted from both tumour-affected and contralateral kidneys, and analysed by reverse transcription-polymerase chain reaction for various genes implicated in angiogenesis and metastasis in RCC. RESULTS:Thalidomide failed to inhibit the growth of xenograft tumours. The expression of angiogenic genes, e.g. vascular endothelial growth factor and fibroblast growth factor type 2 (FGF-2) within normal and tumour-affected kidney tissue was not reduced by thalidomide. Intratumoral transcription of beta3-integrin, a critical component of angiogenesis, was significantly increased in response to thalidomide treatment (P < 0.01). There was also a trend to increased expression of FGF-2 and tumour necrosis factor-alpha in thalidomide-treated tumours. CONCLUSIONS:These findings suggest that RCC is capable of adapting to the inhibitory effects of thalidomide. The current uncertainty surrounding the action of thalidomide in vivo warrants caution about its use in humans. Further studies of thalidomide should be carried out in animal models, particularly to establish its safety and effectiveness as part of a combined therapeutic strategy.
journal_name
BJU Intjournal_title
BJU internationalauthors
Douglas ML,Reid JL,Hii SI,Jonsson JR,Nicol DLdoi
10.1046/j.1464-410x.2002.02666.xkeywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
591-5issue
6eissn
1464-4096issn
1464-410Xpii
2666journal_volume
89pub_type
杂志文章abstract:OBJECTIVES:To address challenges in the diagnosis and classification of storage lower urinary tract symptoms (LUTS), we sought to define the fundamental features of overactive bladder (OAB) and interstitial cystitis/bladder pain syndrome (IC/BPS), two conditions with considerable symptomatic overlap. Through retrospect...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14568
更新日期:2019-04-01 00:00:00
abstract:OBJECTIVE:To examine the association of hospital volume and 90-day mortality after cystectomy, conditional on survival for 30 days. PATIENTS AND METHODS:The National Cancer Data Base was used to evaluate 30- and 90-day mortality for 35,055 patients who underwent cystectomy for bladder cancer at one of 1118 hospitals. ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12566
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abstract:OBJECTIVE:To review our experience in the management of secondary pelvi-ureteric junction obstruction (PUJO) comparing endopyelotomy with pyeloplasty. PATIENTS AND METHODS:We retrospectively analysed our database of 58 patients having undergone operative management of PUJO after failed primary management, including 41...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.12454
更新日期:2014-01-01 00:00:00
abstract:OBJECTIVE:To describe the surgical technique and report early outcomes of transurethral assisted laparoendoscopic single-site (LESS) radical prostatectomy (RP) and LESS radical cystectomy (RC) in a single institution. MATERIALS AND METHODS:Between December 2014 and March 2016, a total of 114 LESS RPs and RCs were perf...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13965
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:To examine the outcome of 23 consecutive patients with Fournier's gangrene. PATIENTS AND METHODS:Patients' charts were reviewed retrospectively from all those treated for Fournier's gangrene between July 1994 and July 1997 at the UCLA affiliated hospitals. RESULTS:Twenty-three patients were identified (mean...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1046/j.1464-410x.1999.00140.x
更新日期:1999-07-01 00:00:00
abstract:OBJECTIVE:To investigate the immunology of host-tumour interaction, critical for the development of immunotherapy against cancers, by assessing the major histocompatibility complex (MHC) class I expression in both benign and malignant prostate disease, and the relationship between their expression and degree of tumour-...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2002.02993.x
更新日期:2002-11-01 00:00:00
abstract:OBJECTIVE:To describe our experience of penile urethral repair and reconstruction, cataloguing the change in practice from one-stage flap to two-stage free graft procedures for anterior urethroplasty. PATIENTS AND METHODS:Between January 1992 and December 1996, 79 patients underwent anterior urethroplasty. Of the 45 o...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.1999.00010.x
更新日期:1999-04-01 00:00:00
abstract:OBJECTIVE:To assess the relationship between symptom severity and patient perceptions in patients with overactive bladder (OAB), as estimated by OAB Symptom Score (OABSS) and patient-reported outcome measures, respectively. PATIENTS AND METHODS:Post-hoc analyses were conducted on the existing data from patients with O...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2009.08498.x
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:To assess the use of mitomycin C, by urologists within the UK, as a single-dose intravesical agent. Current European recommendations are to use one dose after any new tumour resection. METHODS:We assessed the current patterns of mitomycin C usage amongst British urologists, particularly with reference to one...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.05970.x
更新日期:2006-04-01 00:00:00
abstract::Lymphatic drainage in renal cell carcinoma (RCC) is unpredictable, however, basic patterns can be observed in cadaveric and sentinel lymph node mapping studies in patients with RCC. The existence of peripheral lymphovenous communications at the level of the renal vein has been shown in mammals but remains unknown in h...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12814
更新日期:2014-12-01 00:00:00
abstract::Advanced adrenal carcinoma remains a significant therapeutic challenge, with conventional approaches to systemic therapy having failed to achieve sustained objective remissions or major survival benefit in most instances. Several systemic therapies, including mitotane, suramin and gossypol, as well as cytotoxic agents...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/j.1464-410X.2011.10464.x
更新日期:2011-11-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? In the 1980s and 1990s, a method for direct measurement of pressure and cross-sectional area in women and men was developed. It was successful in terms of obtaining meaningful results in several studies. But the technique, which was based on the field...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.10997.x
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the association of patient age with pathological and long-term oncological outcomes after radical cystectomy (RC) for bladder carcinoma, as this disease, like many others, increases in incidence with age. PATIENTS AND METHODS:We retrospectively reviewed 241 consecutive patients with invasive blad...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2008.08033.x
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVE:To systematically review the literature regarding clinical outcomes of 180-W XPS GreenLight laser (GL) vaporisation for the treatment of lower urinary tract symptoms (LUTS) related to benign prostatic hyperplasia (BPH). METHODS:Recent publications were identified in the field of 180-W GL vaporisation for the...
journal_title:BJU international
pub_type: 杂志文章,评审
doi:10.1111/bju.12955
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVE:To assess the influence of the 2012 US Preventive Services Task Force (USPSTF) recommendation against prostate-specific antigen (PSA)-based screening on oncological and functional outcomes following robot-assisted laparoscopic prostatectomy (RALP). MATERIALS AND METHODS:We retrospectively analysed patients w...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.15051
更新日期:2020-06-01 00:00:00
abstract:OBJECTIVES:To compare the performance of two established androgen receptor splice variant 7 (AR-V7) mRNA detection systems, as paradoxical responses to next-generation androgen-deprivation therapy in AR-V7 mRNA-positive circulating tumour cells (CTC) of patients with castration-resistant prostate cancer (CRPC) could be...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.14146
更新日期:2018-08-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2011.10114.x
更新日期:2011-12-01 00:00:00
abstract:OBJECTIVE:To compare changes in regional cerebral blood flow (rCBF), using positron emission tomography (PET), during chronic and acute sacral neuromodulation (SN). SN is an effective long-term treatment for chronic urge incontinence due to urinary bladder hyperactivity, as sensory nerves, spinal and supraspinal struct...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06521.x
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence, type and treatment behaviour of women with urinary incontinence in four European countries. SUBJECTS AND METHODS:Data were collected using a postal survey which was sent to 29,500 community-dwelling women aged > or = 18 years in France, Germany, Spain and the UK. Subjects were as...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410x.2003.04609.x
更新日期:2004-02-01 00:00:00
abstract:OBJECTIVE:To investigate the validity of prostate-specific antigen (PSA) as a tumour marker in men with clinically localized prostate cancer who have selected watchful waiting, by determining if serial PSA level measurements are correlated with findings of malignancy or benign prostatic hyperplasia (BPH) at serial endo...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2006.06515.x
更新日期:2007-01-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/bju.14849
更新日期:2019-11-01 00:00:00
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journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1464-410X.2012.11687.x
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy and safety of a transportable extracorporeal shock wave lithotripsy (ESWL) machine, the Modulith SLX-F2(TM) (Storz Medical Italia, Rome, Italy), in the management of solitary urinary calculi. PATIENTS AND METHODS:The study included 233 patients (mean age 51 years; 172 male, 61 female) ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2007.07039.x
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:To assess the efficacy of OnabotulinumtoxinA (BTXA) injections in men with drug-refractory non-neurogenic overactive bladder (NNOAB). PATIENTS AND METHODS:A total of 43 men received BTXA injections for NNOAB from 2004 to 2012. Patient Global Impression of Improvement (PGI-I) score was obtained. For men with ...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/bju.13110
更新日期:2015-10-01 00:00:00
abstract:UNLABELLED:What's known on the subject? and What does the study add? There have been few studies evaluating the prognostic value of epithelial-mesenchymal transition markers in renal cell carcinoma (RCC); therefore, the significance of these markers in the prognosis of patients with RCC, particularly that in those with...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11297.x
更新日期:2012-12-01 00:00:00
abstract:OBJECTIVE:To evaluate changes in protein leakage in the glomerular filtration barrier, and in the ability of the tubule to reabsorb proteins during and after acute urinary retention (AUR). PATIENTS AND METHODS:Glomerular and tubular function was investigated in 24 men during AUR (mean age 68 years, mean retention time...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2001.02047.x
更新日期:2001-02-01 00:00:00
abstract:OBJECTIVE:To compare in vivo the potency and bladder-vascular selectivity of ATP-sensitive potassium channel openers (KCOs) (-)-cromakalim, WAY-133537 and ZD6169 and a muscarinic antagonist, tolterodine in rats. MATERIALS AND METHODS:Bladder and arterial pressures were monitored simultaneously, before and after increa...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.03069.x
更新日期:2003-02-01 00:00:00
abstract:OBJECTIVES:To compare the results of retroperitoneal laparoscopic with open partial nephroureterectomy. PATIENTS AND METHODS:Laparoscopic retroperitoneal partial nephroureterectomy was undertaken in 15 children (13 upper and two lower poles; median age at the time of surgery 61 months, range 5-212). A three-trocar ret...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1046/j.1464-410x.2003.04126.x
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:We evaluated survival outcomes of partial nephrectomy (PN) and radical nephrectomy (RN) for clinical T2 renal masses (cT2RM) controlling for R.E.N.A.L. nephrometry score. PATIENTS AND METHODS:A two-centre study comprised of 202 patients with cT2RM who underwent RN (122) or PN (80) between July 2002 and June ...
journal_title:BJU international
pub_type: 杂志文章,多中心研究
doi:10.1111/bju.12580
更新日期:2014-11-01 00:00:00
abstract:UNLABELLED:WHAT'S KNOWN ON THE SUBJECT? AND WHAT DOES THE STUDY ADD?: Prostate cancer has three known clinical risk factors: age, ethnicity and family history. Men's knowledge of prostate cancer is low. This study demonstrates that men rely on family and friends to learn about prostate cancer and help them interpret th...
journal_title:BJU international
pub_type: 杂志文章
doi:10.1111/j.1464-410X.2012.11316.x
更新日期:2013-03-01 00:00:00