The prognostic significance of advanced age in patients with bladder cancer treated with radical cystectomy.

Abstract:

OBJECTIVE:To evaluate the association of patient age with pathological and long-term oncological outcomes after radical cystectomy (RC) for bladder carcinoma, as this disease, like many others, increases in incidence with age. PATIENTS AND METHODS:We retrospectively reviewed 241 consecutive patients with invasive bladder cancer who had RC between 1990 and 2007. The age at RC was analysed both as a continuous and categorical (< or =50 years, 38 patients; 51-69, 172; or > or =70, 31) variable. Survival was also analysed. RESULTS:Increasing age, analysed as a continuous and categorical variable, was associated with advanced pathological stage (P = 0.009 and 0.006, respectively). The 5-year cancer-specific survival rates for patients according to the age groups were 78.5%, 44.9% and 28.1%, respectively, and Kaplan-Meier analysis showed an increased risk of bladder cancer-specific death with advancing age (P < 0.001). Being older at RC was an important prognostic factor for disease-specific survival in a multivariate Cox regression model. Patients aged > or =70 years had a significantly higher risk of disease than patients aged < or =50 years (P = 0.002). CONCLUSIONS:Higher age at RC is significantly associated with the risk of pathologically advanced disease and poorer cancer-specific survival. More prospective work is needed to examine the impact of age on tumour biology and cancer-specific survival.

journal_name

BJU Int

journal_title

BJU international

authors

Resorlu B,Beduk Y,Baltaci S,Ergun G,Talas H

doi

10.1111/j.1464-410X.2008.08033.x

subject

Has Abstract

pub_date

2009-02-01 00:00:00

pages

480-3

issue

4

eissn

1464-4096

issn

1464-410X

pii

BJU8033

journal_volume

103

pub_type

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